Category: 112-63-0

Parmar, Karnjit; Haghshenas, Pouyan; Gravel, Michel published the artcile< Total Synthesis of (+)-Hyacinthacine A1 Using a Chemoselective Cross-Benzoin Reaction and a Furan Photooxygenation-Amine Cyclization Strategy>, Quality Control of 112-63-0, the main research area is chemoselective cross benzoin furan photooxygenation amine cyclization diastereoselective cascade; hyacinthacine A1 total synthesis.

We report the shortest synthesis of glycosidase inhibitor (+)-hyacinthacine A1 (I) using a highly chemoselective N-heterocyclic carbene-catalyzed cross-benzoin reaction as well as a furan photooxygenation-amine cyclization strategy. This is the first such cyclization on a furylic alc., an unprecedented reaction due to the notorious instability of the formed intermediates. The photooxygenation strategy was eventually incorporated into a three-step one-pot process that formed the requisite pyrrolizidine framework of (+)-hyacinthacine A1.

Organic Letters published new progress about Benzoin condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kanou, Masanobu; Saeki, Ken-ichi; Kato, Taka-aki; Takahashi, Kazuhiko; Mizutani, Takaharu published the artcile< Study of in vitro glucuronidation of hydroxyquinolines with bovine liver microsomes>, HPLC of Formula: 112-63-0, the main research area is hydroxyquinoline glucuronidation bovine liver microsome.

Glucuronidation of drugs by UDP-glucuronosyltransferase (UGT) is a major phase II conjugation reaction. Defects in UGT are associated with Crigler-Najjar syndrome and Gilbert’s syndrome with severe hyperbilirubinemias and jaundice. We analyzed the reactivities of some hydroxyquinoline derivatives, which are naturally produced from quinoline by cytochrome P 450. The analyses were carried out using a microassay system for UGT activity in bovine liver microsomes in the range 0.5-100 pmol/assay with the highly sensitive radio-image analyzer Fuji BAS2500 (Fujifilm, Tokyo, Japan). 3-Hydroxylquinoline is a good substrate for glucuronidation, and the relative Kcat values were 3,1-fold higher than the values for p-nitrophenol. 5,6-Dihydroquinoline-5,6-trans-diol gave a similar Km value to that of 3-hydroxyquinoline, but the Vmax value was approx. 1/15 of that of p-nitrophenol and showed weak reactivity. Quinoline N-oxide gave a low Vmax value and showed marginal activity. The Kcat values of 6-hydroxyquinoline and 5-hydroxyquinoline were 2.1- and 1.2-fold higher than that of p-nitrophenol, resp. Fluoroquinoline (FQ) derivatives, such as 3FQ, 7,8diFQ and 6,7,8triFQ, did not show any substrate activities. These results suggest that there are therapeutic problems in administration of some quinoline drugs to patients with jaundice.

Fundamental & Clinical Pharmacology published new progress about Bos taurus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Can; Sadeghzadeh, Seyed Mohsen published the artcile< CdSnO3/SnD NPs as a Nanocatalyst for Carbonylation of o-Phenylenediamine with CO2>, Computed Properties of 112-63-0, the main research area is phenylenediamine carbonylation cadmium stannate nanocatalyst preparation property.

In order to carbonize o-phenylenediamine with CO2, an effective approach was used with UV light irradiation by Sn(IV) doping DFNS (SnD) supported CdSnO3 as a catalyst (CdSnO3/SnD). In this catalyst, SnD with the ratios of Si/Sn in the range of 6 to 50 were obtained using the Direct Hydrothermal Synthesis (DHS), and the nanoparticles of CdSnO3 on the surfaces of SnD were reduced in situ. Scanning Electron Microscope, X-ray Diffraction, Fourier Transform IR Spectroscopy, X-ray Energy Dispersive Spectroscopy, and Transmission Electron Microscopy were utilized for characterizing CdSnO3/SnD. It was found that CdSnO3/SnD nanostructures could be used for synthesizing o-phenylenediamines due to their effective and novel catalytic behavior through the reaction between o-phenylenediamines and CO2.

Catalysis Letters published new progress about Carbonylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takahagi, Hiroki; Fujibe, Satoshi; Iwasawa, Nobuharu published the artcile< Guest-Induced Dynamic Self-Assembly of Two Diastereomeric Cage-Like Boronic Esters>, Product Details of C19H34O2, the main research area is boronic ester cage guest induced diastereoselective self assembly; crystal structure benzenetriboronate ester cage diastereomer preparation; mol structure benzenetriboronate ester cage diastereomer.

Reaction of racemic tetrol (I) with 1,3,5-benzenetriboronic acid (II) in MeOH gave 90% yield of a solid consisting of a single, highly sym. 3:2 complex of tetrol I and triboronic acid II (homo-[3+2]) which contained no MeOH. Crystals of homo-[3+2]·PhMe grown in PhMe-pentane were analyzed by x-ray crystallog. The complex had the expected cage-like structure with 1 mol. of PhMe in the internal space, suggesting π-π interactions with the Ph rings of the triboronic acid groups. The 3 tetrol units in homo-[3+2] were derived from the same enantiomer of tetrol I, indicating that diastereoselective self-assembly occurred during formation of this structure. Several guest mols. (C6H6, PhMe, cumene, o-, m-, and p-xylene) were examined as templates for cyclic boronic esters; C6H6, PhMe and p-xylene gave only (homo-[3+2]), whereas cumene afforded complex mixtures When 13 equiv o- or m-xylene were used as guest mols., a diastereomeric isomer (hetero-[3+2]) was formed containing 1 mol. of xylene guest compound that could be displaced by CHCl3. The structure of (hetero-[3+2])·CHCl3 was determined by x-ray crystallog. A similar diastereoselectivity was observed by using dicyanobenzenes as guests. E.g., only 0.33 equiv o-C6H4(CN)2 induced the selective formation of hetero-[3+2]. Thus, 2 diastereomeric host mols. were constructed by guest-induced self-assembly with recognition of the substitution pattern of disubstituted benzenes. When I and II were mixed in presence of 2 xylenes in MeOH, completely selective inclusion of o- or m-xylene over p-xylene was achieved during the precipitation process, and o-xylene was included preferentially over m-xylene.

Chemistry – A European Journal published new progress about Cage compounds Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jagadeesh, Rajenahally V.; Wienhoefer, Gerrit; Westerhaus, Felix A.; Surkus, Annette-Enrica; Pohl, Marga-Martina; Junge, Henrik; Junge, Kathrin; Beller, Matthias published the artcile< Efficient and highly selective iron-catalyzed reduction of nitroarenes>, COA of Formula: C19H34O2, the main research area is iron phenanthroline carbon pyrolysis nitroarene reduction supported catalyst; aniline preparation chemoselective.

Pyrolysis of iron-phenanthroline complexes supported on carbon leads to highly selective catalysts for the reduction of structurally diverse nitroarenes to anilines in 90-99% yields. Excellent chemoselectivity for the nitro group reduction is demonstrated.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Takada, Akiomi; Hashimoto, Yoshimitsu; Takikawa, Hiroshi; Hikita, Katsuyoshi; Suzuki, Keisuke published the artcile< Total Synthesis and Absolute Stereochemistry of Seragakinone A>, Synthetic Route of 112-63-0, the main research area is enantioselective synthesis seragakinone A cyclization rearrangement; seragakinone A mol structure absolute configuration.

The first asym. total synthesis of (-)seragakinone A (I) is reported. Noteworthy features of the synthesis include the benzoin-forming reaction which worked well to effect two sep. cyclization, the pinacol-type rearrangement and determination of the absolute configuration of the natural product.

Angewandte Chemie, International Edition published new progress about Absolute configuration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gu, Yiyu; Lu, Xiaoqing; Ma, Xiaodong; Zhang, Haojian; Ji, Yuanyuan; Ding, Wanjing; Shen, Li published the artcile< Design, synthesis and biological evaluation of (quinolinyl-3-pyridinyl) benzenesulfonamide-based hydroxamic acids as PI3K and HDAC dual targeting inhibitors>, Reference of 112-63-0, the main research area is quinolinylpyridinylbenzenesulfonamide hydroxamic acid PI 3K HDAC targeting inhibitor.

Polypharmacol. has emerged as a promising approach to drug discovery, especially antitumor drug. This study reports the design, synthesis, and biol. evaluation of novel phosphatidylinositol 3-kinases (PI3Ks) and histone deacetylases (HDACs) dual inhibitors on the basis of GSK2126458 under clin. evaluation and vorinostat approved. Among these hybrid mols., GYB-4 and GYB-5 possessed potent inhibition against both PI3Kα (1.0 and 1.3 nmol/L, resp.) and HDAC1 (4.2 and 4.8 nmol/L, resp.). Antiproliferative assays with HCT116, PC3 and A2780 cell lines subsequently were performed. The structure-activity relationship study will guide to optimization of dual PI3K and HDAC inhibitors.

Youji Huaxue published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dong, Haiying; Zhang, Jing; Rong, Hua; Zhang, Xiaojie; Dong, Miaoxian published the artcile< Paeoniflorin and Plycyrrhetinic Acid Synergistically Alleviate MPP+/MPTP-Induced Oxidative Stress through Nrf2-Dependent Glutathione Biosynthesis Mechanisms>, Reference of 112-63-0, the main research area is paeoniflorin glycyrrhetinic acid antioxidant antiparkinsonian oxidative stress Parkinsons disease; neuroprotectant Nrf2 glutathione biosynthesis paeoniflorin glycyrrhetinic acid; Paeoniflorin; Parkinson’s disease; glycyrrhetinic acid; oxidative stress; synergism.

Recently, combination therapy has proven to be an effective strategy for treating polygenic/multifactorial/complex disorder such as Parkinson’s disease (PD). Here, we hypothesized that dual up-regulation of glutamate cysteine ligase (GCL) catalytic subunit (GCLc) and GCL modifier subunit (GCLm) via nuclear factor E2-related factor (Nrf2) contribute to the antioxidant effect of paeoniflorin (PF) synergistically with glycyrrhetinic acid (GA) (henceforth called PF/GA) in the context of MPP+/MPTP neurotoxicity. Expectedly, CompuSyn synergism/antagonism anal. showed that PF/GA exerts synergistic neuroprotection. Moreover, the antioxidant effect of PF was significantly enhanced by the combined administration of GA, although GA alone did not confer the effect. Mechanistically, PF triggered extracellular signal-regulated kinase (ERK1/2) phosphorylation, resulting in Nrf2 nuclear translocation from cytoplasmic pool via de novo synthesis in MPP+-challenged SH-SY5Y cells. Concomitantly, GA activates Akt which in turn induces nuclear accumulation of Nrf2. Especially, PF/GA up-regulated glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase modifier subunit (Gclm) are formed via two sep. pathways. Furthermore, these results were confirmed through pathway blockade assays using PD98059 (ERK1/2 inhibitor), LY294002 (phosphatidylinositol-3-kinase inhibitor), and shRNA-induced Nrf2 knockdown. Addnl., using a mouse MPTP-induced model of PD, we demonstrated that PF/GA synergistically ameliorates both motor deficits and oxidative stress in the ventral midbrain. In parallel, PF/GA also up-regulated both GCLc and GCLm expression at levels of transcription and translation. Conversely, antiparkinsonism and antioxidant effects of PF/GA were not observed in Nrf2-knockout MPTP-mice. Collectively, these results show that ERK1/2 and Akt activation contribute to the synergistic antioxidant effect of PF/GA. Hence, PF/GA regimen warrants further preclin. and possible clin. study for PD.

ACS Chemical Neuroscience published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Chengwei; Prichard, Mark N.; Korba, Brent E.; Drach, John C.; Zemlicka, Jiri published the artcile< Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine>, Related Products of 112-63-0, the main research area is fluorinated methylenecyclopropane analog nucleoside preparation antiviral; fluoromethyl hydroxymethyl cyclopropylidene adenine guanine preparation antiviral structure.

Synthesis and antiviral activity of the title fluoromethylenecyclopropane analogs 15a, 15b, 16a, and 16b is described. Methylenecyclopropane carboxylate was first transformed to 2,2-bis-hydroxymethylmethylenecyclopropane. Selective monoacetylation followed by introduction of fluorine gave 2-acetoxymethyl-2-fluoromethylmethylenecyclopropane as the key intermediate. The synthesis of analogs 15a, 15b, 16a, and 16b then followed alkylation-elimination procedure as described previously for other methylenecyclopropane analogs. The adenine Z-isomer 15a was found to be a potent inhibitor of Epstein-Barr virus (EBV) in vitro with EC50/CC50 (μM) 0.5/55.7. Compounds 15b, 16a, and 16b were also active but at higher concentrations, EC50/CC50 (μM) 3.2-7.5/53.6-64.1. Analog 15a inhibited hepatitis C virus by virtue of its cytotoxicity and it moderately inhibited replication of the Towne strain of human cytomegalovirus (HCMV). The E-isomer 16a was a substrate for adenosine deaminase, whereas the Z-isomer 15a was not deaminated.

Bioorganic & Medicinal Chemistry published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Bin; Chansaenpak, Kantapat; Wu, Hongmiao; Zhu, Lin; Wang, Mengzhe; Li, Zibo; Lu, Hongjian published the artcile< Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process>, Reference of 112-63-0, the main research area is oxazolidindione oxazinanone radiofluorinated oxazolidinone preparation; olefin acrylamide cyclization fluorination cascade silver radical.

The intramol. fluorocyclization of unsaturated carbamates is described here using a hypervalent iodine reagent in the presence of a silver catalyst. Both (hetero)aryl-substituted olefins and acrylamides can be utilized as effective substrates. Preliminary mechanistic investigations suggest that the reaction proceeds via a cyclization/1,2-(hetero)aryl migration/fluorination cascade involving an unusual radical process. Furthermore, starting from no-carrier-added [18F]TBAF, a simple one-pot, two-step cascade method was developed for the generation of 18F-labeled heterocycles with high radiochem. purity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics