Category: 112-63-0

Tran, Chinh Hoang; Lee, Min Woong; Kim, Sun A.; Jang, Han Byul; Kim, Il published the artcile< Kinetic and Mechanistic Study of Heterogeneous Double Metal Cyanide-Catalyzed Ring-Opening Multibranching Polymerization of Glycidol>, Application of C19H34O2, the main research area is kinetics mechanistic metal cyanide catalyzed multibranching polymerization glycidol.

Polyglycidols of tunable degree of branching (DB) have been synthesized via ring-opening multibranching polymerization (ROMBP) of glycidol in the absence of any initiators using heterogeneous double metal cyanide (DMC) catalysts. Semi-branched polyglycidols of low DB (less than 0.3) are obtained using simple solvent-free batch polymerizations, whereas hyperbranched analogs of high DB (more than 0.5) are achieved employing semi-batch (or slow monomer addition) polymerizations The rate of DMC-catalyzed ROMBPs of glycidol shows the first-order dependences on monomer and catalyst concentrations, suggesting that the ROMBPs proceed via a coordinative mechanism. The formation of propagating species and the resultant microstructural units are clarified using a conversion vs. time anal. in the NMR-scale.

Macromolecules (Washington, DC, United States) published new progress about Branched polymers, hyperbranched dendritic polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yudasaka, Masaharu; Maruyama, Toshifumi; Yamaguchi, Eiji; Tada, Norihiro; Itoh, Akichika published the artcile< Synthesis, Characterization, and Reaction of a Both Inter- and Intramolecularly Coordinated Pseudocyclic Iodosylbenzene-Trifluoroacetic Acid Complexes>, HPLC of Formula: 112-63-0, the main research area is iodobenzene oxidation; iodosylbenzene trifluoroacetic acid comples preparation oxidant.

An ortho-substituted ether-oxygen-coordinated pseudocyclic iodosylbenzene-trifluoroacetic acid (pcISB-TFA) complex was synthesized and characterized by X-ray crystallog. anal. TFA suppresses the disproportionation by both coordination of the oxygen atom to the iodine(III) center through secondary bonding and by hydrogen bonding to the oxygen anion. This bench-stable reagent is highly soluble in common organic solvents and reacts with various organic substrates under mild reaction conditions to give the corresponding products in good yields.

European Journal of Organic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Piffeteau, Annie; Gaudry, Michel published the artcile< Biotin uptake: influx, efflux and countertransport in Escherichia coli K12>, Related Products of 112-63-0, the main research area is biotin transport Escherichia.

Biotin uptake by E. coli K12 has been reinvestigated. The vitamin uptake is an active process depending on energy and inhibited by uncouplers. The kinetic parameters (Km = 0.27 μM, Vmax = 6.8 pmol/min/mg dry cells) are close to those previously determined for a biotin-dependent strain E. coli C162 (Piffeteau, A., et. al, 1982). By use of biotin p-nitrophenyl ester, an affinity label of the biotin transport system, it was shown, under conditions of steady state, that the efflux of biotin is not energy dependent and is mainly mediated by a diffusion mechanism. Reexamination of the regulation of the biotin transport by biotin, revealed that only 50% of the biotin uptake system is under control by the vitamin.

Biochimica et Biophysica Acta, Biomembranes published new progress about Biological transport. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vinogradov, Serguei V.; Batrakova, Elena V.; Kabanov, Alexander V. published the artcile< Nanogels for oligonucleotide delivery to the brain>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nanogel oligonucleotide delivery brain.

Systemic delivery of oligonucleotides (ODN) to the central nervous system is needed for development of therapeutic and diagnostic modalities for treatment of neurodegenerative disorders. Macromols. injected in blood are poorly transported across the blood-brain barrier (BBB) and rapidly cleared from circulation. In this work we propose a novel system for ODN delivery to the brain based on nanoscale network of cross-linked poly(ethylene glycol) and polyethylenimine (“”nanogel””). The methods of synthesis of nanogel and its modification with specific targeting mols. are described. Nanogels can bind and encapsulate spontaneously neg. charged ODN, resulting in formation of stable aqueous dispersion of polyelectrolyte complex with particle sizes less than 100 nm. Using polarized monolayers of bovine brain microvessel endothelial cells as an in vitro model this study demonstrates that ODN incorporated in nanogel formulations can be effectively transported across the BBB. The transport efficacy is further increased when the surface of the nanogel is modified with transferrin or insulin. Importantly the ODN is transported across the brain microvessel cells through the transcellular pathway; after transport, ODN remains mostly incorporated in the nanogel and ODN displays little degradation compared to the free ODN. Using mouse model for biodistribution studies in vivo, this work demonstrated that as a result of incorporation into nanogel 1 h after i.v. injection the accumulation of a phosphorothioate ODN in the brain increases by over 15 fold while in liver and spleen decreases by 2-fold compared to the free ODN. Overall, this study suggests that nanogel is a promising system for delivery of ODN to the brain.

Bioconjugate Chemistry published new progress about Blood-brain barrier. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Yuan; Liu, Xiao-Chen; Ahrne, Lilia M.; Skibsted, Leif H. published the artcile< Enthalpy-entropy compensation in calcium binding to acid-base forms of glycine tyrosine dipeptides from hydrolysis of α-lactalbumin>, Synthetic Route of 112-63-0, the main research area is alpha lactalbumin hydrolysis calcium binding glycine tyrosine dipeptide; Calcium binding; Calcium bioavailability; Density Functional Theory; Dipeptide; Enthalpy–entropy compensation.

Calcium binding to peptides formed by hydrolysis of whey proteins during digestion is important for calcium uptake in the intestines and affects the antioxidant function of the peptides. For the two dipeptides, Gly-Tyr and Tyr-Gly, potential hydrolysis products of α-lactalbumin, calcium binding to the three forms of each dipeptide in acid-base equilibrium at intestinal pH was determined electrochem. and compared to binding to tyrosine for aqueous 0.16 M NaCl for 5 < pH < 9 at 15°C, 25°C, and 37°C. At milk pH at 25°C, binding of calcium to the zwitterion of GlyTyr dominates, with an association constant Kass2 = 22 M-1 with ΔH0 = -46 kJ·mol-1, while binding to the mononeg. TyrGly dominates for TyrGly with Kass3 = 32 M-1 and ΔH0 = -38 kJ·mol-1. At intestinal conditions, pH = 7 and 37°C, binding of calcium has similar affinity for GlyTyr and TyrGly, while at higher pH and lower temperature, GlyTyr binds stronger. D. Functional Theory calculations confirmed a stronger binding to the zwitterion of GlyTyr than of TyrGly and an increasing affinity with increasing pH for both. Calcium binding to the acid/base forms of the dipeptides is at neutral pH strongly exothermic with ΔH0 becoming less neg. at higher pH, and a linear enthalpy-entropy compensation (r2 = 0.99) results in comparable binding important for calcium bioavailability along the changing distribution among acid-base forms. Calcium binding decreases radical scavenging rate and antioxidative activity of both dipeptides. Food Research International published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghahremani, Milad; Ghasemzadeh, Kamran; Jalilnejad, Elham; Iulianelli, Adolfo published the artcile< A Theoretical Analysis on a Multi-Bed Pervaporation Membrane Reactor during Levulinic Acid Esterification Using the Computational Fluid Dynamic Method>, Product Details of C19H34O2, the main research area is multi bed pervaporation membrane reactor levulinic acid esterification; computational fluid dynamic method; computational fluid dynamic (CFD) method; esterification process; modeling and simulation; pervaporation membrane reactor.

Pervaporation is a peculiar membrane separation process, which is considered for integration with a variety of reactions in promising new applications. Pervaporation membrane reactors have some specific uses in sustainable chem., such as the esterification processes. This theor. study based on the computational fluid dynamics method aims to evaluate the performance of a multi-bed pervaporation membrane reactor (including poly (vinyl alc.) membrane) to produce Et levulinate as a significant fuel additive, coming from the esterification of levulinic acid. For comparison, an equivalent multi-bed traditional reactor is also studied at the same operating conditions of the aforementioned pervaporation membrane reactor. A computational fluid dynamics model was developed and validated by exptl. literature data. The effects of reaction temperature, catalyst loading, feed molar ratio, and feed flow rate on the reactor’s performance in terms of levulinic acid conversion and water removal were hence studied. The simulations indicated that the multi-bed pervaporation membrane reactor results to be the best solution over the multi-bed traditional reactor, presenting the best simulation results at 343 K, 2 bar, catalyst loading 8.6 g, feed flow rate 7 mm3/s, and feed molar ratio 3 with levulinic acid conversion equal to 95.3% and 91.1% water removal.

Membranes (Basel, Switzerland) published new progress about Catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mondal, Biswarup; Rangaiah, Gade Pandu; Jana, Amiya K. published the artcile< Optimizing algal biodiesel production from a novel reactive distillation based unit: Reducing CO2 emission and cost>, Electric Literature of 112-63-0, the main research area is carbon dioxide emission algal biodiesel.

The algal biodiesel as a potential alternative to conventional petroleum fuel and first-generation biofuel has been explored extensively but the efficacy of its production in a reactive distillation (RD) unit is yet to be analyzed thoroughly. In this contribution, the performance of the RD column is enhanced by process intensification and optimization. A multi-objective optimization (MOO) strategy is framed for optimizing the RD column for three conflicting objectives. For this MOO, the elitist non-dominated sorting genetic algorithm (NSGA-II) is employed. From the obtained Pareto-optimal front, one optimal solution for RD design is selected using the technique for order of preference by similarity to ideal solution (TOPSIS) with entropy information for weighting of objectives. To further reduce the environmental impact and optimal usage of internal energy, a novel thermally coupled reactive distillation (TCRD) column is suggested. Finally, a biodiesel production unit is developed by integrating a decanter with the TCRD column, to produce biodiesel product of 99.45 weight% purity. Performance of the TCRD column is better than the conventional RD column, in terms of CO2 emission reduction (14.49%) and total annual cost savings (3.72%). Energetic sustainability of the proposed biodiesel process is determined by net energy ratio (NER) of 1.79, net energy value (NEV) of 18.2 and net renewable energy value (NREV) of 41.4 MJ/kg.

Chemical Engineering and Processing published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

van Putten, Erik H. P.; Kleijn, Anne; van Beusechem, Victor W.; Noske, David; Lamers, Cor H. J.; de Goede, Anna L.; Idema, Sander; Hoefnagel, Daphna; Kloezeman, Jenneke J.; Fueyo, Juan; Lang, Frederick F.; Teunissen, Charlotte E.; Vernhout, Rene M.; Bakker, Cathy; Gerritsen, Winald; Curiel, David T.; Vulto, Arnold; Lamfers, Martine L. M.; Dirven, Clemens M. F. published the artcile< Convection enhanced delivery of the oncolytic adenovirus Delta24-RGD in patients with recurrent GBM: a phase I clinical trial including correlative studies>, Synthetic Route of 112-63-0, the main research area is oncolytic adenovirus human recurrent glioblastoma clin trial.

Testing safety of Delta24-RGD (DNX-2401), an oncolytic adenovirus, locally delivered by convection enhanced delivery (CED) in tumor and surrounding brain of patients with recurrent glioblastoma. Dose-escalation phase I study with 3+3 cohorts, dosing 107 to 1 × 1011 viral particles (vp) in 20 patients. Besides clin. parameters, adverse events, and radiol. findings, blood, cerebrospinal fluid (CSF), brain interstitial fluid, and excreta were sampled over time and analyzed for presence of immune response, viral replication, distribution, and shedding. Of 20 enrolled patients, 19 received the oncolytic adenovirus Delta24-RGD, which was found to be safe and feasible. Four patients demonstrated tumor response on MRI, one with complete regression and still alive after 8 years. Most serious adverse events were attributed to increased intracranial pressure caused by either an inflammatory reaction responding to steroid treatment or viral meningitis being transient and self-limiting. Often viral DNA concentrations in CSF increased over time, peaking after 2 to 4 wk and remaining up to 3 mo. Concomitantly Th1- and Th2-associated cytokine levels and numbers of CD3+ T and natural killer cells increased. Posttreatment tumor specimens revealed increased numbers of macrophages and CD4+ and CD8+ T cells. No evidence of viral shedding in excreta was observed CED of Delta24-RGD not only in the tumor but also in surrounding brain is safe, induces a local inflammatory reaction, and shows promising clin. responses.

Clinical Cancer Research published new progress about Blood. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nunez-Mojica, Guillermo; Rivas-Galindo, Veronica M.; Garza-Gonzalez, Elvira; Miranda, Luis D.; Romo-Perez, Adriana; Pagniez, Fabrice; Picot, Carine; Le Pape, Patrice; Bazin, Marc-Antoine; Marchand, Pascal; Camacho-Corona, Maria del Rayo published the artcile< Antimicrobial and antileishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum Schldl>, Related Products of 112-63-0, the main research area is Solanum leaves antimicrobial antileishmanial.

Abstract: Three organic extracts were prepared from the leaves of Solanum chrysotrichum Schldl. From the methanol extract were isolated two new steroidal saponins (1, 2), and three known compounds (3, 4, and 5). The new saponins were elucidated as 6-α-O-α-L-rhamnopyranosyl-(1 → 3)-β-D-quinovopyranosyl-(25S)-5α-spirostan-3β-ol (1) and 6-α-O-α-L-rhamnopyranosyl-(1 → 3)-β-D-quinovopyranosyl-(23R,25S)-5α-spirostan-3β,23β-ol (2). The structural elucidation of compounds was performed by anal. of 1D and 2D NMR spectral data and HRMS. Antibacterial activity was displayed by the hexane and CH2Cl2 extracts against carbapenem-resistant Pseudomonas aeruginosa (MIC = 250 μg/mL) and carbapenem-resistant Acinetobacter baumannii (MIC = 125 μg/mL). The known saponin (3) was the only compound active against bacteria, showing activity against all the gram-pos. bacteria (MIC = 12.5 μg/mL). Antitubercular activity was observed only for the hexane extract (MIC = 250 μg/mL). The antifungal and antileishmanial activities were determined for the steroidal saponins, but they were devoid of antifungal activity at the concentrations tested. Antileishmanial activity was shown only by the saponin (1) (IC50: 21.64 ± 1.21 μg/mL). [graphic not available: see fulltext]

Medicinal Chemistry Research published new progress about Acinetobacter baumannii (carbapenem-resistant). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hamashima, Toshihiko; Mori, Yoshiaki; Sawada, Kazunori; Kasahara, Yuko; Murayama, Daisuke; Kamei, Yuto; Okuno, Hiroaki; Yokoyama, Yuusaku; Suzuki, Hideharu published the artcile< A practical regioselective synthesis of alkylthio- or arylthioindoles without the use of smelly compounds such as thiols>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is alkylthio arylthio indole thioether preparation; indole alkaloid indole thioether Laurencia brongniartii antibacterial agent.

A convenient method for the synthesis of 3-(methylthio)indole derivatives was established which does not use smelly compounds such as thiol derivatives The method, which introduces an alkylthio-group or arylthio-group into the C3-position of an indole skeleton, was extended to the direct introduction of a methylthio or bromo group at the C2-position using 3-(methylthio)indole derivatives No dimerization occurred and the reaction mechanism was confirmed. The products have the partial structure of potent anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) bromomethylthioindole derivatives (MC 5-8) isolated from marine algae. Furthermore, this reaction could be applied to the synthesis of 3,3-bis(indole) thioether which is a core structure of Echinosulfone A. The synthesis of the target compounds as achieved by a reaction of indole derivatives with (alkyl)[(2,2,2-trifluoroacetyl)oxy]sulfonium 2,2,2-trifluoroacetate (1:1) or (aryl)[(2,2,2-trifluoroacetyl)oxy]sulfonium 2,2,2-trifluoroacetate (1:1) and formation of sulfonium compound intermediates. The title compounds thus formed included 3-(methylthio)-1H-indole, 3-(methylthio)-1H-indole-5-carbonitrile, 2,3-bis(methylthio)-1H-indole, 3-(methylthio)-1H-indole-5-carboxylic acid Et ester, 3-(methylthio)-5-nitro-1H-indole (I).

Chemical & Pharmaceutical Bulletin published new progress about Green chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics