Category: 112-63-0

Luo, Long; Li, Xiang; Crooks, Richard M. published the artcile< Low-Voltage Origami-Paper-Based Electrophoretic Device for Rapid Protein Separation>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is origami paper electrophoresis device protein fluorophore.

We present an origami paper-based electrophoretic device (oPAD-Ep) that achieves rapid (∼5 min) separation of fluorescent mols. and proteins. Due to the innovative design, the required driving voltage is just ∼10 V, which is more than 10 times lower than that used for conventional electrophoresis. The oPAD-Ep uses multiple, thin (180 μm/layer) folded paper layers as the supporting medium for electrophoresis. This approach significantly shortens the distance between the anode and cathode, and this, in turn, accounts for the high elec. field (>1 kV/m) that can be achieved even with a low applied voltage. The multilayer design of the oPAD-Ep enables convenient sample introduction by use of a slip layer as well as easy product anal. and reclamation after electrophoresis by unfolding the origami paper and cutting out desired layers. We demonstrate the use of oPAD-Ep for simple separation of proteins in bovine serum, which illustrates its potential applications for point-of-care diagnostic testing.

Analytical Chemistry (Washington, DC, United States) published new progress about Albumins Role: ANT (Analyte), PUR (Purification or Recovery), ANST (Analytical Study), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pero, Joseph E.; Rossi, Michael A.; Lehman, Hannah D. G. F.; Kelly, Michael J. III; Mulhearn, James J.; Wolkenberg, Scott E.; Cato, Matthew J.; Clements, Michelle K.; Daley, Christopher J.; Filzen, Tracey; Finger, Eleftheria N.; Gregan, Yun; Henze, Darrell A.; Jovanovska, Aneta; Klein, Rebecca; Kraus, Richard L.; Li, Yuxing; Liang, Annie; Majercak, John M.; Panigel, Jacqueline; Urban, Mark O.; Wang, Jixin; Wang, Ying-Hong; Houghton, Andrea K.; Layton, Mark E. published the artcile< Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model>, Application In Synthesis of 112-63-0, the main research area is benzoxazolinone aryl sulfonamide preparation sodium channel inhibitor oral analgesic; Chronic pain; Na(v)1.7 inhibition; Oral bioavailability; Pharmacological selectivity; Voltage-gated sodium channel.

Studies on human genetics have suggested that inhibitors of the Nav1.7 voltage-gated sodium channel hold considerable promise as therapies for the treatment of chronic pain syndromes. Herein, we report novel, peripherally-restricted benzoxazolinone aryl sulfonamides as potent Nav1.7 inhibitors with excellent selectivity against the Nav1.5 isoform, which is expressed in the heart muscle. Elaboration of initial lead compound 3d afforded exemplar 13, which featured attractive physicochem. properties, outstanding lipophilic ligand efficiency and pharmacol. selectivity against Nav1.5 exceeding 1000-fold. Key structure-activity relationships associated with oral bioavailability were leveraged to discover compound 17, which exhibited a comparable potency/selectivity profile as well as full efficacy following oral administration in a preclin. model indicative of antinociceptive behavior.

Bioorganic & Medicinal Chemistry Letters published new progress about Analgesics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yuxuan; Liu, Xintian; Su, Chen; Ding, Yanjun; Pan, Luqing published the artcile< Process optimization for fermented siwu decoction by multi-index-response surface method and exploration of the effects of fermented siwu decoction on the growth, immune response and resistance to Vibrio harveyi of Pacific white shrimp (Litopenaeus vannamei)>, SDS of cas: 112-63-0, the main research area is Vibrio Litopenaeus growth immune response fermented siwu decoction; Bacillus; Fermentation siwu decoction; Gut microbiota; Litopenaeus vannamei; Physiological functions.

The purpose of this study was to explore the optimal fermentation technol. of Chinese herbal medicine formula-Siwu Decoction and the effects of fermented Siwu Decoction (FSW) on the growth performance, immune response, intestinal microflora and anti microbial ability of Litopenaeus vannamei. Response to surface methodol. (RSM) was used to optimize the fermentation process of Siwu Decoction. The optimal fermentation conditions were obtained as follows: inoculation amount of mixed strains was 4.5%, fermentation time was 36 h, and the ratio of material to liquid was 20%. A total of 1260 shrimps were selected and divided into seven groups, three in parallel in each group. The dietary level of each group was as follows: Control (No additions), USW1 (0.2% unfermented herbal medicine), USW2 (0.5% unfermented herbal medicine), USW3 (0.8% unfermented herbal medicine), FSW1 (0.2% fermented herbal medicine), FSW2 (0.5% fermented herbal medicine), FSW3 (0.8% fermented herbal medicine). The immune response and antioxidant defense ability of hemocytes and intestine were measured at 21 and 42 days of feeding and the intestinal flora and growth performance were measured at 42 days of feeding, after that, a 7-day challenge test against Vibrio harveyi was conducted. The results showed that fermented Siwu Decoction significantly improved the growth performance and body composition of Litopenaeus vannamei; significantly increased the total number of hemocytes, phagocytic activity, antibacterial activity and bacteriolytic activity of Litopenaeus vannamei, and improved the antioxidant activity of Litopenaeus vannamei; the addition of fermented Siwu Decoction significantly increased the gene expression level of hemocytes and intestinal tract of Litopenaeus vannamei, and improved the antioxidant activity of Litopenaeus vannamei. The abundance of Bacillus increased, while the abundance of Vibrio decreased. After Vibrio harveyi challenge, the cumulative mortality of FSW group was significantly lower than that of control group. Fermented Siwu Decoction may be a potential physiol. enhancer in aquaculture, and can be widely used in aquaculture.

Fish & Shellfish Immunology published new progress about Actinobacteria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Akazome, Motohiro; Takahashi, Toshiaki; Ogura, Katsuyuki published the artcile< Enantiomeric Inclusion of α-Hydroxy Esters by (R)-(1-Naphthyl)glycyl-(R)-phenylglycine and the Crystal Structures of the Inclusion Cavities>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is enantioselective inclusion hydroxy ester naphthylglycylphenylglycine; stereoselective crystallization hydroxy ester naphthylglycylphenylglycine; crystal structure hydroxy ester naphthylglycylphenylglycine inclusion complex; hydrogen bond hydroxy ester naphthylglycylphenylglycine inclusion complex.

A simple dipeptide, (R)-(1-naphthyl)glycyl-(R)-phenylglycine [(R,R)-I], formed inclusion compounds with several α-hydroxy esters with high enantioselectivity. By crystallization of a mixture of the dipeptide I and racemic MeCH(OH)CO2Me [(RS)-II] from methanol, asym. recognition occurred to give an inclusion compound that contains S-II in 89% ee. X-ray crystallog. study of the inclusion compound elucidated that the dipeptide mols. arrange in a “”folded antiparallel”” β-sheetlike structure to accommodate the α-hydroxy ester in the pocket-type cavity surrounded by naphthyl and Ph groups on the sheet. Similarly, MeCH(OH)CO2Et and dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone were included with high enantioselectivity of the S form. When bulkier Me3CCH(OH)CO2Me was used as a guest mol., the arrangement of dipeptide mols. changed to an “”extended antiparallel”” mode, where the naphthyl and Ph groups arranged in a “”parallel stacked and displaced”” mode and a channel-type cavity was constructed. The guest mols. were accommodated via hydrogen bonding in the channel-type cavity with high enantioselectivity of the S form (82% ee). In the case of Me2CHCH(OH)CO2Me [(RS)-III], optically pure (S)-III formed the dipeptide sheet with the “”folded antiparallel”” structure by cocrystn. with I, while the “”extended antiparallel”” structure appeared in the inclusion of (RS)-III.

Journal of Organic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sasaki, Jun-ichi; Kobayashi, Makoto; Ibe, Yusuke; Nishino, Hiroshi published the artcile< Mn(III)-based oxidative radical ring-expansion reaction using squarate derivatives: selective synthesis of bis(butenolide)s and the acetate monomers>, Product Details of C19H34O2, the main research area is bis butenolide preparation furanone cyclopentenedione crystal structure; aryl alkyl hydroxycyclobutenone oxidative radical ring expansion cyclization.

The Mn(III)-based oxidation of phenyl- and alkyl-substituted hydroxycyclobutenones selectively produced the bis(butenolide)s or the acetate monomers via the 5-endo radical cyclization depending upon the concentration of the reaction. A similar reaction of hydroxycyclobutenones bearing an alkenyl and alkynyl substituent did not produce any bis(butenolide)s or acetate monomers, but the 5-exo and 6-endo radical cyclization products including the unsaturated group. The oxidation of the hydroxycyclobutenones having an unsaturated substituent in the presence of alkenes afforded radical coupling products during the 5-exo radical cyclization. The reaction details, structure determination of the products, and the mechanism for the formation of the products are described.

Heterocycles published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zuriarrain-Ocio, Andoni; Zuriarrain, Juan; Etxebeste, Oier; Duenas, Maria Teresa; Berregi, Inaki published the artcile< Evolution of main polyphenolics during cidermaking>, Category: esters-buliding-blocks, the main research area is polyphenol cidermaking.

This work reports the evolution of polyphenolic compounds content during the cidermaking process in the Basque Country (Northern Spain). Fourteen monovarietal musts were obtained throughout three seasons (13 different, one repeated) using different apple cultivars from the Basque Country. Monovarietal musts were used to cover a wide range of polyphenolic content and to introduce variability. These musts were fermented and matured to obtain 14 monovarietal ciders. The evolution of the musts was monitored during 6-8 mo by measuring the polyphenolic profile with an HPLC method throughout 4 or 5 samplings. Chlorogenic acid, 4-p-coumaroylquinic acid and (-)-epicatechin showed fluctuations during the alc. fermentation (10-40 days), followed by stabilization. With phloretin 2-O-xyloglucoside, an increase or a stable concentration was observed during the alc. fermentation followed by stabilization. Tyrosol, absent in the initial musts, showed an increase during the alc. fermentation and became stable afterwards. These were the only general patterns observed The rest of the phenolic compounds studied, such as procyanidin B1, procyanidin B2 and phloridzin, did not show any general evolution rule.

LWT–Food Science and Technology published new progress about Fermentation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Yu; Wan, Haofang; Yang, Jiehong; Huang, Yan; He, Yu; Wan, Haitong; Li, Chang published the artcile< Ultrasound-assisted preparation of ,Ready-to-use, extracts from Radix Paeoniae Rubra with natural deep eutectic solvents and neuroprotectivity evaluation of the extracts against cerebral ischemic/ reperfusion injury>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ischemic reperfusion injury ultrasound Radix deep eutectic solvent neuroprotectivity; Galloyl paeoniflorin; Ischemic/ reperfusion injury; Natural eutectic solvent; Paeoniflorin; Radix Paeoniae Rubra.

Natural deep eutectic solvent (NaDES) is widely applied in the extraction of nutrients from natural resources as a greener alternative for fossil solvent. In the present work, 27 different NaDESs were screened for the extraction of paeoniflorin (PF) and galloyl paeoniflorin (GPF) from Radix Paeoniae Rubra (RPR). After screening and extraction parameter optimization, the extraction yields of PF and GPF reached up to 182.8 mg/g and 77.4 mg/g with the selected NaDES, ChCl-Sor. Furthermore, the antioxidant activity in vitro and neuroprotectivity in vivo of the ,ready-to-use, extracts were evaluated comprehensively. Especially in vivo, the cerebral ischemic/ reperfusion injury model was established in rats and the protective effects of the RPR extracts were determined The results not only proved that NaDES is a valuable green extraction media, but also indicated the safety and potential pharmaceutical application of NaDES based ,ready-to-use. extracts from medical plants.

Ultrasonics Sonochemistry published new progress about Alcohols Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Cong-Jun; Xue, Dong; Jia, Zhi-Hui; Wang, Chao; Xiao, Jianliang published the artcile< Methanol-promoted borylation of arylamines: a simple and green synthetic method to arylboronic acids and arylboronates>, Electric Literature of 112-63-0, the main research area is aryl boronic acid boronate preparation green chem; methanol promoted borylation arylamine Sandmeyer green chem.

A Sandmeyer borylation of arylamines via a SN2Ar pathway promoted by methanol with sodium nitrite and hydrochloric acid as diazotization agent has been developed, which provide a simple and green synthetic method to arylboronic acids and arylboronates.

Synlett published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Jingjing; Yang, Jin-Dong; Zheng, Hanliang; Xue, Xiao-Song; Mayr, Herbert; Cheng, Jin-Pei published the artcile< Exploration of the Synthetic Potential of Electrophilic Trifluoromethylthiolating and Difluoromethylthiolating Reagents>, COA of Formula: C19H34O2, the main research area is trifluoromethylsulfenylation difluoromethylsulfenylation reagent electrophilicity; difluoromethylthiolation; electrophilicity; linear free-energy relationships; structure-reactivity relationships; trifluoromethylthiolation.

The electrophilicity parameters (E) of some trifluoromethylthiolating and difluoromethylthiolating reagents were determined by following the kinetics of their reactions with a series of enamines and carbanions with known nucleophilicity parameters (N, sN), using the linear free-energy relationship log k2=sN(N+E). The electrophilic reactivities of these reagents cover a range of 17 orders of magnitude, with Shen and Lu’s reagent (PhSO2)2NSCF3 being the most reactive and Billard’s reagent PhNMeSCF3 being the least reactive electrophile. While the observed electrophilic reactivities (E) of the amido-derived trifluoromethylthiolating reagents correlate well with the calculated Gibbs energies for heterolytic cleavage of the X-SCF3 bonds (Tt+DA), the cumol-derived reagents RCMe2OSCF3 (R = Ph, 2-IC6H4) are more reactive than expected from the thermodn. of the O-S cleavage. The E parameters of the tri/difluoromethylthiolating reagents derived in this work provide an ordering principle for their use in synthesis.

Angewandte Chemie, International Edition published new progress about Carbanions Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Arumugam, S.; Baskar, S.; Sankara, Subramanian V.; Shivasankaran, G. published the artcile< Polyolester based lubricant from waste feedstock for sustainable environment: a tribological investigation>, Application of C19H34O2, the main research area is polyolester lubricant waste feedstock environment.

This study reported the tribol. evaluation of polyolester based lubricant synthesized from waste feedstock. The transesterification process was adopted for the formulation of lubricant from waste mango seed kernel oil. The polyols used in this formulation are neopentyl glycol, trimethylolpropane and pentaerythritol. The tribol. investigation was conducted using four ball tribometer as per ASTM D4172. The frictional and wear behavior of vegetable oil-based polyolester was analyzed in addition to the wear morphol. of investigated balls. The results indicated that the average frictional torque and mean wear diameter of pentaerythritol ester of waste mango seed oil was 0.12 Nm and 0.403 mm resp. and also found that the pentaerythritol ester showed improved tribol. results as compared with other polyolesters say neopentyl glycol ester and trimethylolpropane ester of waste mango seed oil. The waste mange seed oil is found suitable candidate for the formulation of polyolester based sustainable lubricant.

IOP Conference Series: Materials Science and Engineering published new progress about Environment. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics