Category: 112-63-0

Parida, Chandrakanta; Maity, Rajendra; Chandra Sahoo, Subas; Chandra Pan, Subhas published the artcile< α-Nitro-α,β-Unsaturated Ketones: An Electrophilic Acyl Transfer Reagent in Catalytic Asymmetric Friedel-Crafts and Michael Reactions>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nitroethylnaphthyl ester enantioselective preparation; nitroethyl substituted enol ester enantioselective preparation; squaramide catalyst enantioselective tandem Friedel Crafts acyl transfer reaction; nitroenone acyl transfer reagent enantioselective reaction naphthol phenol.

In the presence of a tert-leucine-derived squaramide and mol. sieves, 2-naphthols and electron-rich phenols underwent tandem enantioselective Friedel-Crafts and acyl transfer reactions with α-nitro-α,β-unsaturated ketones such as I (R = Ph, 4-i-PrC6H4, 4-PhOC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-PhC6H4, 3-BrC6H4, 2,4-Me2C6H3, 2-naphthyl, cyclohexyl, i-Pr; R1 = Ph, 4-MeC6H4, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 4-O2NC6H4, 3-ClC6H4, 3-F3CC6H4, 2-FC6H4, 2-ClC6H4, 2-Br-4-MeC6H3, 2-furyl) to yield nitroethylnaphthol ester such as II (R = Ph, 4-i-PrC6H4, 4-PhOC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-PhC6H4, 3-BrC6H4, 2,4-Me2C6H3, 2-naphthyl, cyclohexyl, i-Pr; R1 = Ph, 4-MeC6H4, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4, 4-O2NC6H4, 3-ClC6H4, 3-F3CC6H4, 2-FC6H4, 2-ClC6H4, 2-Br-4-MeC6H3, 2-furyl). Dimedone and a pyrazolone underwent tandem enantioselective Michael and acyl transfer reactions with I (R = R1 = Ph) to yield nitroethyl-substituted enol esters. Further reactions of II (R = R1 = Ph) are disclosed.

Organic Letters published new progress about Alkenes, nitro Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (α-acyl). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Santi, D.; Triyono; Morin, J. V. published the artcile< The preparation of Merbau wood waste ash-based catalyst and its utilization for biodiesel production from low-grade palm oil>, SDS of cas: 112-63-0, the main research area is Merbau wood waste ash catalyst palm oil biodiesel production.

The Merbau wood waste ash-based catalyst was prepared via various calcination temperatures and was applied for biodiesel production from low-grade palm oil. The thermal investigations of calcination of Merbau wood were carried out at temperatures of 500, 600, 700, 800, and 900°C for 3 h. It was led to M700 as a catalyst based on the highest basicity as confirmed by the basicity test and x-ray diffraction anal. The M700 mass toward methanol volume ratio was performed at 5%, 10%, 15%, 20% (w/v) on the application of conversion of LGPO into biodiesel. The products of biodiesel were prepared via reflux at temperature 80°C for 2 h and were characterized by GC-MS. The biodiesel product is predominantly Me palmitate. The ash-methanol ratio of 15% gives the optimum biodiesel fraction conversion (78.7% weight/weight). The optimum selectivity of the yield total of biodiesel given by 10%, namely 48.9% weight/weight, resulted in Me ester (biodiesel) with C15-C19 consisting of Me myristate, Me palmitate, Me linoleate, Me oleic, Me stearate. Moreover, a 10% weight catalyst to methanol showed the optimum decrease of FFA (89.0 ± 0.6%).

Rasayan Journal of Chemistry published new progress about Basicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Jin-ling; Zhang, Wen-chao; Wang, Xiao-dong; Tang, Ming; Huang, Zheng-yong; Li, Jian; Zhang, Han; Yang, Xiao-hui; Guo, Zai-ping; Wang, Yu published the artcile< Revealing the mechanism of saturated ether electrolyte for improving the long-cycling stability of Na-O2 batteries>, HPLC of Formula: 112-63-0, the main research area is sodium oxygen battery saturated ether electrolyte stability revealing mechanism.

Na-O2 batteries have been considered as promising energy storage systems due to their high energy d. and low cost. Their poor cycle life, however, and their unclear interfacial formation mechanisms have greatly hindered the development of Na-O2 batteries. In this work, compared to the commonly used ether-based electrolyte (0.5 M sodium trifluomethanesulfonate in tetraethylene glycol di-Me ether), its saturated electrolyte is employed for Na-O2 batteries to achieve around four times longer cycle life. Both experiments and simulations suggest that the enhanced cycling stability could be attributed to the use of saturated electrolyte, which plays important roles in reducing the dissolution of NaO2, thereby easing the shuttle effect of O2-; sharply decreasing dissolved oxygen, thus eliminating Na anode oxidation; and effectively suppressing Na dendrite growth because of the high Na+ flux in saturated electrolyte, thus relieving the nonuniformity of the Na+ flux.

Nano Energy published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Li; Wang, Han; Yu, Qian-qian; Ge, Jin-ru; Zhang, Xian-zheng; Mei, Dan; Liang, Fa-qin; Cai, Xiao-yu; Zhu, Yue; Shu, Jin-ling; Tai, Yu; Wei, Wei; Zhang, Ling-ling published the artcile< The monomer derivative of paeoniflorin inhibits macrophage pyroptosis via regulating TLR4/ NLRP3/ GSDMD signaling pathway in adjuvant arthritis rats>, Synthetic Route of 112-63-0, the main research area is paeoniflorin macrophage pyroptosis TLR NLRP GSDMD signaling pathway arthritis; Adjuvant arthritis; Macrophage pyroptosis; Monomer derivative of paeoniflorin; Rheumatoid arthritis; TLR4/NLRP3/GSDMD signaling pathway.

This study was aimed to investigate the effect of monomer derivative of paeoniflorin (MDP) on macrophage pyroptosis mediated by TLR4/NLRP3/GSDMD signaling pathway in adjuvant arthritis (AA) rats. Wistar rats were divided into normal group, AA model group, MDP (50 mg/kg) group and MTX (0.5 mg/kg) group. The expression of TLR4, NLRP3 and GSDMD in macrophage were detected by immunofluorescence assay. The expression of TLR4 and the ratio of macrophage pyroptosis were analyzed by flow cytometry. Cell morphol. was observed by SEM. The cytokine levels of IL-18 and IL-1β were detected by ELISA. The expressions of proteins related to macrophage pyroptosis were detected by western blot. MDP has a therapeutic effect on rats AA by reducing the secondary inflammation and improving pathol. changes. The results of X-ray imaging and ultrasound images showed that MDP could inhibit bone erosion, soft tissue swelling, and joint space narrowing. Macrophage pyroptosis was found in secondary inflammation of AA rats. The expressions of TLR4, MyD88, NLRP3, Caspase-1, ASC, and GSDMD-N in macrophage were increased, the levels of IL-18 and IL-1β were enhanced, and the morphol. of pyroptosis could be observed MDP could inhibit macrophage polarization and macrophage pyroptosis, and down-regulated the cytokine levels of IL-18 and IL-1β in AA rats. MDP could regulate the M1/m2 ratio, decreased the ratio of macrophage pyroptosis and down-regulated the expressions of TLR4, MyD88, NLRP3, Caspase-1, ASC, and GSDMD-N in vivo and in vitro. Abnormal activation of TLR4/NLRP3/GSDMD signaling pathway may be involved in macrophage pyroptosis in AA rats. The therapeutic effect of MDP on AA rats is related to the inhibition of macrophage pyroptosis by regulating the TLR4/NLRP3/GSDMD signaling pathway.

International Immunopharmacology published new progress about Arthritis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Wenbo; Yun, Keming published the artcile< Propofol enhances the sensitivity of glioblastoma cells to temozolomide by inhibiting macrophage activation in tumor microenvironment to down-regulate HIF-1α expression>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Glioblastoma; Propofol; Temozolomide; Tumor-associated macrophages.

Temozolomide (TMZ) is the first-line drug for the clin. treatment of glioblastoma (GBM), but drug resistance limits its treatment benefits. This study was intended to investigate whether propofol could restrict the resistance of GBM cells to TMZ and uncover the underlying mechanisms. Human GBM cell line U251 and TMZ-resistant U251/TMZ cell line were transplanted into mice to construct GBM and TMZ-resistant GBM xenograft tumors. Tumor growth in mice was monitored, and the tumor tissues were collected for biochem. anal. THP-1 cell differentiated into M0 subtype macrophage using phorbol 12-myristate 13-acetate (PMA). The culture medium of M0 macrophage was collected for treating U251 cells with the presence or absence of propofol or propofol + DMOG (HIF-1α activator). Results showed that propofol significantly enhanced the inhibitory effect of TMZ on tumor growth, macrophage infiltration and inflammation in TMZ-resistant GBM xenograft tumors in vivo. Compared with GBM xenograft tumors, higher expression of HIF-1α, O6-methylguanine-DNA methyltransferase (MGMT), p-p65 and cyclooxygenase 2 (Cox2) was observed in TMZ-resistant GBM xenograft tumors, but propofol co-treatment markedly reduced the expression of these proteins. In in vitro experiments, culture medium from M0 macrophage promoted U251 cell survival, inflammation and expression of HIF-1α, MGMT, p65 and Cox2, whereas inhibited cell apoptosis. However, propofol suppressed the PMA-induced THP-1 M0 macrophage activation, and propofol-treated culture medium from M0 macrophage blocked all the effects of M0 medium on U251 cells. Addnl., DMOG reversed the effect of propofol-treated M0 medium on U251 cells. In conclusion, Propofol restricted TMZ resistance via inhibiting macrophage activation and down-regulating HIF-1α expression in GBM.

Experimental Cell Research published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Xiaowei; Iwata, Takayuki; Scharf, Adam; Qin, Tian; Reichl, Kyle D.; Porco, John A. published the artcile< Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling>, Category: esters-buliding-blocks, the main research area is asym gonytolide A synthesis aryl halide oxidative coupling.

The first synthesis of the chromanone lactone dimer gonytolide A was achieved employing vanadium(V)-mediated oxidative coupling of the monomer gonytolide C. An o-bromine blocking group strategy was employed to favor para-para coupling and to enable kinetic resolution of (±)-gonytolide C. Asym. conjugate reduction enabled practical kinetic resolution of a chiral, racemic precursor and the asym. synthesis of (+)-gonytolide A and its atropisomer.

Journal of the American Chemical Society published new progress about Atropisomers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jatyan, Reena; Singh, Prabhjeet; Sahel, Deepak Kumar; Karthik, Y. G.; Mittal, Anupama; Chitkara, Deepak published the artcile< Polymeric and small molecule-conjugates of temozolomide as improved therapeutic agents for glioblastoma multiforme>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review glioblastoma multiforme temozolomide therapeutic agent bioavailability nanocarrier liposome; Glioblastoma Multiforme; Polymer drug conjugates; Prodrugs; Small molecules; Temozolomide.

A review. Temozolomide (TMZ), an imidazotetrazine, is a second-generation DNA alkylating agent used as a first-line treatment of glioblastoma multiforme (GBM). It was approved by FDA in 2005 and declared a blockbuster drug in 2008. Although TMZ has shown 100% oral bioavailability and crosses the blood-brain barrier effectively, however it suffers from limitations such as a short half-life (∼1.8 h), rapid metabolism, and lesser accumulation in the brain (∼10-20%). Addnl., development of chemoresistance has been associated with its use. Since it is a potential chemotherapeutic agent with an unmet medical need, advanced delivery strategies have been explored to overcome the associated limitations of TMZ. Nanocarriers including liposomes, solid lipid nanoparticles (SLNs), nanostructure lipid carriers (NLCs), and polymeric nanoparticles have demonstrated their ability to improve its circulation time, stability, tissue-specific accumulation, sustained release, and cellular uptake. Because of the appreciable water solubility of TMZ (∼5 mg/mL), the phys. loading of TMZ in these nanocarriers is always challenging. Alternatively, the conjugation approach, wherein TMZ has been conjugated to polymers or small mols., has been explored with improved outcomes in vitro and in vivo. This review emphasized the practical evidence of the conjugation strategy to improve the therapeutic potential of TMZ in the treatment of glioblastoma multiforme.

Journal of Controlled Release published new progress about Bioavailability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gaynanova, Gulnara A.; Bekmukhametova, Alina M.; Mukhitova, Rezeda K.; Kharlamov, Sergey V.; Ziganshina, Albina Y.; Zakharova, Lucia Ya.; Konovalov, Alexander I. published the artcile< Pyrene fluorescence quenching in supramolecular systems based on dimethylaminomethylated resorcinarene>, Application In Synthesis of 112-63-0, the main research area is pyrene dimethylaminomethylated resorcinarene fluorescence quenching.

The aim of this work is the development of stable fluorophore-quencher pairs with a controlled response for bioassay in the laboratory The widely used in bioanal. pyrene and its water-soluble derivative were selected as organic fluorophores. Water-soluble aminomethylated calixarene with sulfonatoethyl groups at the “”lower rim”” was chosen as a stabilizer. We have established a strong fluorescence quenching in the solution of resorcinarene even at low premicellar concentrations which indicates the pyrene transition into a non-polar microenvironment. The data on the influence of pH, buffer composition, and the macrocyclic platform on the fluorescence quenching of pyrene in the presence of resorcinarene were obtained. The temperature dependence of the fluorescence quenching of pyrene was obtained with the aim of establishing the mechanism of the formation of complex fluorophore-resorcinarene (static vs. dynamic quenching).

Journal of Molecular Liquids published new progress about Fluorescence imaging. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thomson, Jennifer E.; Kyle, Andrew F.; Ling, Kenneth B.; Smith, Siobhan R.; Slawin, Alexandra M. Z.; Smith, Andrew D. published the artcile< Applications of NHC-mediated O- to C-carboxyl transfer: synthesis of (±)-N-benzyl-coerulescine and (±)-horsfiline>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is coerulescine horsfiline oxindole alkaloid synthesis carboxyl transfer rearrangement.

N-Heterocyclic carbene (NHC) promoted O- to C-carboxyl transfer of 3-allylindolyl Ph carbonates generated 3-allyl-3-phenoxycarbonyloxindoles with good catalytic efficiency, which were readily converted into (±)-N-benzylcoerulescine (I) and (±)-horsfiline (II).

Tetrahedron published new progress about Oxindole alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kang, Hyunkoo; Lee, Haksoo; Kim, Dahye; Kim, Byeongsoo; Kang, JiHoon; Kim, Hae Yu; Youn, HyeSook; Youn, BuHyun published the artcile< Targeting Glioblastoma Stem Cells to Overcome Chemoresistance: An Overview of Current Therapeutic Strategies>, Reference of 112-63-0, the main research area is review brain tumor glioblastoma stem cell temozolomide drug repositioning; cancer stem cells; chemoresistance; glioblastoma; temozolomide.

A review. Glioblastoma (GBM) is the most malignant primary brain tumor. The current standard approach in GBM is surgery, followed by treatment with radiation and temozolomide (TMZ); however, GBM is highly resistant to current therapies, and the standard of care has not been revised over the last two decades, indicating an unmet need for new therapies. GBM stem cells (GSCs) are a major cause of chemoresistance due to their ability to confer heterogeneity and tumorigenic capacity. To improve patient outcomes and survival, it is necessary to understand the properties and mechanisms underlying GSC chemoresistance. In this review, we describe the current knowledge on various resistance mechanisms of GBM to therapeutic agents, with a special focus on TMZ, and summarize the recent findings on the intrinsic and extrinsic mechanisms of chemoresistance in GSCs. We also discuss novel therapeutic strategies, including mol. targeting, autophagy inhibition, oncolytic viral therapy, drug repositioning, and targeting of GSC niches, to eliminate GSCs, from basic research findings to ongoing clin. trials. Although the development of effective therapies for GBM is still challenging, this review provides a better understanding of GSCs and offers future directions for successful GBM therapy.

Biomedicines published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics