Category: 112-63-0

Szentirmai, Eva; Kapas, Levente published the artcile< Nicotinic acid promotes sleep through prostaglandin synthesis in mice>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nicotinic acid prostaglandin sleep mice.

Nicotinic acid has been used for decades for its antiatherogenic properties in humans. Its actions on lipid metabolism intersect with multiple sleep regulatory mechanisms, but its effects on sleep have never been documented. For the first time, we investigated the effects of acute systemic administration of nicotinic acid on sleep in mice. I.p. and oral gavage administration of nicotinic acid elicited robust increases in non-rapid-eye movement sleep (NREMS) and decreases in body temperature, energy expenditure and food intake. Preventing hypothermia did not affect its sleep-inducing actions suggesting that altered sleep is not secondary to decreased body temperature Systemic administration of nicotinamide, a conversion product of nicotinic acid, did not affect sleep amounts and body temperature, indicating that it is not nicotinamide that underlies these actions. Systemic administration of monomethyl fumarate, another agonist of the nicotinic acid receptor GPR109A, fully recapitulated the somnogenic and thermoregulatory effects of nicotinic acid suggesting that they are mediated by the GPR109A receptor. The cyclooxygenase inhibitor indomethacin completely abolished the effects of nicotinic acid indicating that prostaglandins play a key role in mediating the sleep and thermoregulatory responses of nicotinic acid.

Scientific Reports published new progress about Electroencephalogram. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Yeongsu; Yun, Jonghyeok; Shin, Hyun-Seop; Jung, Kyu-Nam; Lee, Jong-Won published the artcile< Synergistic nanoarchitecture of mesoporous carbon and carbon nanotubes for lithium-oxygen batteries>, Quality Control of 112-63-0, the main research area is mesoporous carbon lithium oxygen battery elec conductivity; Carbon nanotube; Electrochemistry; Lithium–oxygen battery; Mesoporous carbon.

A rechargeable lithium-oxygen battery (LOB) operates via the electrochem. formation and decomposition of solid-state Li2O2 on the cathode. The rational design of the cathode nanoarchitectures is thus required to realize high-energy-d. and long-cycling LOBs. Here, we propose a cathode nanoarchitecture for LOBs, which is composed of mesoporous carbon (MPC) integrated with carbon nanotubes (CNTs). The proposed design has the advantages of the two components. MPC provides sufficient active sites for the electrochem. reactions and free space for Li2O2storage, while CNT forests serve as conductive pathways for electron and offer addnl. reaction sites. Results show that the synergistic architecture of MPC and CNTs leads to improvements in the capacity ( ~18,400 mAh g- 1), rate capability, and cyclability (~200 cycles) of the CNT-integrated MPC cathode in comparison with MPC.

Nano Convergence published new progress about Current density. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Niu, K.; Wu, X. P.; Fu, Q.; Lang, K. P.; Zou, S. P.; Hu, Z. C.; Liu, Z. Q.; Zheng, Y. G. published the artcile< Effects of lipids and surfactants on the fermentation production of echinocandin B by Aspergillus nidulans>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Aspergillus echinocandin B fermentation lipid; Echinocandin B; lipids; methyl oleate; surfactant; tween 80.

Echinocandin B (ECB) is a kind of lipopeptide antifungal antibiotic, as well as the key precursor of antifungal drug Anidulafungin. Its efficient bioprodn. plays an important role in promoting the industrial production of Anidulafungin. Methods and Results : In this study, Me oleate and Tween 80 were firstly used to enhance the ECB fermentation by Aspergillus nidulans, the results showed that the ECB titer was significantly enhanced with the addition of Me oleate and Tween 80. Among the lipids, Me oleate was found to play a pivotal role in increasing the ECB titer to 2123 mg l-1, which was more than five times higher than that of the control. The addition of Tween 80 in the medium resulted in ECB titer increased to 2584 mg l-1. The scanning electron microscope (SEM) and N-phenyl-1-naphthylamine (NPN) assay indicated that Tween 80 could influence the cell membrane permeability of A. nidulans, and enhance the intracellular and extracellular substance exchange, therefore lead to the increasing of ECB titer. Me oleate and Tween 80 are optimal carbon sources and surfactants for efficient ECB biosynthesis resp. Significance and Impact of the Study : Surfactant was used in ECB fermentation for the first time, which provided feasible ideas for optimizing the fermentation process of other fungi.

Journal of Applied Microbiology published new progress about Aspergillus nidulans. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Tong; Guo, Qing; Li, Ping; Yang, Hua published the artcile< Deep-eutectic solvents/ionic liquids/water mixture as a novel type of green thermo-switchable solvent system for selective extraction and separation of natural products from Rosmarinus officinalis leaves>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Rosmarinus leaf extraction separation natural product deep eutectic solvent; green thermo switchable solvent system; Carnosic acid; Deep-eutectic solvents; Green solvent; Ionic liquid; Rosmarinic acid; Ultrasonic-assisted extraction.

In the present study, we designed a novel type of green thermo-switchable solvent system which is composed of ChCl:LA/[BMIM]PF6/H2O (volume/volume/v, 1/2/1) to extract natural products. When the temperature is 60°C, the system is a homogeneous single-phase system, and when cooling to 25°C, the system is switched into a heterogeneous two-phase system. Based on the thermo-switchable system, an integrated extraction method was developed which could efficiently extract both rosmarinic acid (hydrophilic) and carnosic acid (hydrophobic) from Rosmarinus officinalis leaves at 60°C and in situ sep. the extracted compounds with high recovery yields by cooling the extracts to 25°C. Rosmarinic acid was separated into the upper phase (88.97%) and carnosic acid was separated into the lower phase (97.46%). In addition to enhanced efficiency and no consumption of organic solvents, the method also completed the extraction and separation in a single step which further reduced the operation units.

Food Chemistry published new progress about Deep eutectic solvents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xuechuan; Zhu, Jingbo; Liu, Xinhua; Zhang, Hui Jie; Zhu, Xing published the artcile< Novel Gelatin-based Eco-friendly Adhesive with a Hyperbranched Cross-linked Structure>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is gelatin ecofriendly adhesive hyperbranched crosslinked polyamine polyester epoxy; leather waste collagen hydrolyzate adhesive polyamine polyester dendritic.

Gelatin (GE), a nontoxic and degradable biomass resource, is a multistage hydrolyzate of collagen. However, its application in adhesives was always limited by its brittleness and poor water resistance. In order to overcome this shortcoming, herein, epoxy-terminated hyperbranched polymers (EHPAEs) were first selected as a crosslinking agent to modify the GE extracted from leather solid wastes to prepare a series of novel GE-based environmentally friendly adhesives. First, EHPAE was synthesized and the structure of the hyperbranched polymer was measured by Fourier-transform IR and 1H NMR spectroscopy. Then, the adhesives were obtained using the EHPAE to modify GE. The adhesion effect of the prepared adhesives was evaluated by tensile and T-peel tests on the surface of leather, in order to determine whether this adhesive achieved the quality requirements for footwear and bags. The result indicated that EHPAE-modified GE-based adhesives had higher solid content, superior adhesion ability, and water resistance. Moreover, the bonding layer of this adhesive was tough and ductile, while the bonding layers of the recently reported GE-based adhesives were brittle. This adhesive also surpassed the recently reported GE-based adhesives in terms of water resistance and adhesion performance.

Industrial & Engineering Chemistry Research published new progress about Adhesives. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Broadus, Katherine M.; Kass, Steven R. published the artcile< The Electron as a Protecting Group. 3. Generation of Acenaphthyne Radical Anion and the Determination of the Heat of Formation of a Strained Cycloalkyne>, Quality Control of 112-63-0, the main research area is electron protecting group generation acenaphthyne radical anion; formation heat strained cycloalkyne.

Acenaphthynedicarboxylate (12) was transferred into the gas phase from solution via electrospray ionization and subsequently was sequentially fragmented in a Fourier transform mass spectrometer to afford acenaphthyne radical anion (9). Structural confirmation of 9 was achieved by converting it to acenaphthenone enolate (13) and demonstrating that this species is identical to the ion produced upon deprotonation of acenaphthenone (5). The reactivity of 9 was explored, and since an electron can serve as a protecting group, the authors were able to measure the heat of hydrogenation (98 ± 4 kcal mol-1) and the heat of formation (160 ± 4 kcal mol-1) of acenaphthyne (1) via the application of a thermodn. cycle. Its strain energy (68 kcal mol-1) and acenaphthylene’s (10H) first and second C-H bond dissociation energies (117 ± 4 and 84 ± 2 kcal mol-1) also were obtained. Ab initio and d. functional theory calculations were carried out on the species of interest to explore their geometries and energetics. Results were interpreted in comparison to cyclopentyne, and its predicted heat of formation (98 kcal mol-1) and strain energy (59 kcal mol-1) are reported.

Journal of the American Chemical Society published new progress about Ab initio methods. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peter, David; Brueckner, Reinhard published the artcile< Syntheses of a Pair of Simplified Model Compounds of the Dihydroxycyclopentenone Core of the Kodaistatins A-D>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is transition state kodaistatin synthon aldol condensation oxidation aldolization bromodiketone.

The kodaistatins A-D b are natural products from Aspergillus terreus with the potential of representing leads for a novel cure of type-2 diabetes. They possess an unusually and highly substituted dihydroxycyclopentenone core. Whether its OH groups are cis- or trans-configured remained unknown by spectroscopy. Previous syntheses of kodaistatin model compounds (cis-5, cis- and trans-6) allowed to make NMR comparisons with kodaistatin A. These findings are corroborated by the synthesis and ensuing NMR study of another pair of cis/trans-isomeric kodaistatin models (cis- and trans-7) described here. Its first key-step was a syn-selective aldol addition An oxidation/reduction sequence allowed reaching to the corresponding anti-aldol. Each aldol furnished a kodaistatin model in eight addnl. steps. The most noteworthy transformation was an SmII-induced intramol. aldolization of a bromodiketone.

European Journal of Organic Chemistry published new progress about Aldol addition. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Graham, Samuel L.; Scholz, Thomas H. published the artcile< A new mode of reactivity of N-methoxy-N-methylamides with strongly basic reagents>, HPLC of Formula: 112-63-0, the main research area is methoxymethylamide decomposition formaldehyde; Weinreb ketone synthesis byproduct; thiophenesulfonamide ketone synthesis byproduct; lithium diisopropylamide decomposition methoxymethylamide.

Weinreb ketone synthesis using a thiophenesulfonamide (I, R = R1 = H) and (Me2CH)2NLi followed by MeOCH2CONMeOMe (II) gave, in addition to 49% the expected ketone (I, R = H, R1 = COCH2OMe), 15% an alc. (I, R = H, R1 = CH2OH). A mechanism involving a base catalyzed E2 elimination of CH2O from II followed by reaction with lithiated I (R = R1 = Li) is proposed for the byproduct.

Tetrahedron Letters published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Junheng; Xu, Guangyang; Tang, Shengbiao; Chen, Qun; Sun, Jiangtao published the artcile< Site-Selective Functionalization of 7-Azaindoles via Carbene Transfer and Isolation of N-Aromatic Zwitterions>, Category: esters-buliding-blocks, the main research area is regioselective functionalization azaindole carbene transfer isolation zwitterion; azaindole diazoester alkylation ruthenium catalysis dearomatization aromatization.

The first systematic study on metal-carbene transfer reaction of 7-azaindoles has been conducted, and the unprecedented dearomative N7-alkylation reaction has been accomplished via ruthenium catalysis. Importantly, through a sequential dearomatization-aromatization process, an isolable, and new class of azaindole-based N-aromatic zwitterions has been discovered from the reaction of 7-azaindoles and diazoesters.

Organic Letters published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beichel, Witali; Skrotzki, Julian; Klose, Petra; Njel, Christian; Butschke, Burkhard; Burger, Stephan; Liu, Lili; Thomann, Ralf; Thomann, Yi; Biro, Daniel; Thiele, Simon; Krossing, Ingo published the artcile< An Artificial SEI Layer Based on an Inorganic Coordination Polymer with Self-Healing Ability for Long-Lived Rechargeable Lithium-Metal Batteries>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is rechargeable lithium metal battery SEI layer coordination polymer.

Upon immersion of a lithium (Li) anode into a diluted 0.05 to 0.20 M dimethoxyethane solution of the phosphoric-acid derivative (CF3CH2O)2P(O)OH (HBFEP), an artificial solid-electrolyte interphase (SEI) is generated on the Li-metal surface. Hence, HBFEP reacts on the surface to the corresponding Li salt (LiBFEP), which is a Li-ion conducting inorganic coordination polymer. This film exhibits – due to the reversibly breaking ionic bonds – self-healing ability upon cycling-induced volume expansion of Li. The presence of LiBFEP as the major component in the artificial SEI is proven by ATR-IR and XPS measurements. SEM characterization of HBFEP-treated Li samples reveals porous layers on top of the Li surface with at least 3μm thickness. Li-Li sym. cells with HBFEP-modified Li electrodes show a three- to almost fourfold cycle-lifetime increase at 0.1 mA cm-2 in a demanding model electrolyte that facilitates fast battery failure (1 M LiOTf in TEGDME). Hence, the LiBFEP-enriched layer apparently acts as a Li-ion conducting protection barrier between Li and the electrolyte, enhancing the rechargeability of Li electrodes.

Batteries & Supercaps published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics