Category: 112-63-0

Oh, Gwangseok; Seo, Samuel; Kim, Wonkeun; Cho, Youngsuk; Kwon, Hoimin; Kim, Suhyun; Noh, Seunghyo; Kwon, Eunji; Oh, Yeonjong; Song, Jongchan; Lee, Jiyong; Ryu, Kyounghan published the artcile< Seed Layer Formation on Carbon Electrodes to Control Li2O2 Discharge Products for Practical Li-O2 Batteries with High Energy Density and Reversibility>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is carbon electrode lithium oxide oxygen battery; Li2O2; carbon electrode; interface; lithium air battery; nucleation; seed layer.

The high theor. energy densities of lithium-air batteries (LAB) make this technol. an attractive energy storage system for future mobility applications. Li2O2 growth process on the cathode relies on the surrounding chem. environment of electrolytes. Low conductivity and strong reactivity of Li2O2 discharge products can cause overpotential and induce side reactions in LABs, resp., eventually leading to poor cyclability. The capacity and reversibility of LABs are highly susceptible to the morphol. of the Li2O2 discharge products. Here, we identify for the first time that a seed layer formed by the combination of a cathode and an electrolyte determines the morphol. of Li2O2 discharge products. This seed layer led to its high reversibility with a large areal capacity (up to 10 mAh/cm2). Excellent OER (oxygen evolution reaction) was achieved by the formation of a favorable interface between the carbon electrode and electrolyte, minimizing the decomposition of the electrolyte. These remarkable improvements in LAB performance demonstrate critical progress toward advancing LAB into practical uses, which would exploit good reversibility of LABs in pouch-type cell arrangements with 1.34 Ah.

ACS Applied Materials & Interfaces published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sadeghipour, Negar; Kumar, Sukumar Uday; Massoud, Tarik F.; Paulmurugan, Ramasamy published the artcile< A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma models>, Application of C19H34O2, the main research area is .

Abstract: Glioblastoma (GBM) is the most common malignant brain tumor. Available treatments have limited success because most patients develop chemoresistance. Alternative strategies are required to improve anticancer effects of current chemotherapeutics while limiting resistance. Successful targeting of microRNAs (miRNAs) as regulators of gene expression can help reprogram GBM cells to better respond to chemotherapy. We aimed to identify a panel of miRNAs that target multiple oncogenic pathways to improve GBM therapy. We first identified differentially expressed miRNAs and tested if their target genes play central roles in GBM signaling pathways by analyzing data in the Gene Expression Omnibus and The Cancer Genome Atlas databases. We then studied the effects of different combinations of these miRNAs in GBM cells by delivering synthetic miRNAs using clin. compatible PLGA-PEG nanoparticles prior to treatment with temozolomide (TMZ) or doxorubicin (DOX). The successful miRNA panel was tested in mice bearing U87-MG cells co-treated with TMZ. We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM. We observed significant in vitro and in vivo enhancement of therapeutic efficiency of TMZ and DOX in GBM models. The proposed combination therapy using rationally selected miRNAs and chemotherapeutic drugs is effective owing to the ability of this specific miRNA panel to better target multiple genes associated with the hallmarks of cancer.

Scientific Reports published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stanzione, Marcello; Zhong, Jun; Wong, Edmond; LaSalle, Thomas J.; Wise, Jillian F.; Simoneau, Antoine; Myers, David T.; Phat, Sarah; Sade-Feldman, Moshe; Lawrence, Michael S.; Hadden, M. Kyle; Zou, Lee; Farago, Anna F.; Dyson, Nicholas J.; Drapkin, Benjamin J. published the artcile< Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer>, Application of C19H34O2, the main research area is small cell lung cancer olaparib temozolomide deoxyribonucleic acid synthesis.

In small cell lung cancer (SCLC), acquired resistance to DNA-damaging therapy is challenging to study because rebiopsy is rarely performed. We used patient-derived xenograft models, established before therapy and after progression, to dissect acquired resistance to olaparib plus temozolomide (OT), a promising exptl. therapy for relapsed SCLC. These pairs of serial models reveal alterations in both cell cycle kinetics and DNA replication and demonstrate both inter- and intratumoral heterogeneity in mechanisms of resistance. In one model pair, up-regulation of translesion DNA synthesis (TLS) enabled tolerance of OT-induced damage during DNA replication. TLS inhibitors restored sensitivity to OT both in vitro and in vivo, and similar synergistic effects were seen in addnl. SCLC cell lines. This represents the first described mechanism of acquired resistance to DNA damage in a patient with SCLC and highlights the potential of the serial model approach to investigate and overcome resistance to therapy in SCLC.

Science Advances published new progress about Cell cycle (kinetics). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Wu; Cui, Xinjiang; Junge, Kathrin; Surkus, Annette-Enrica; Kreyenschulte, Carsten; Bartling, Stephan; Beller, Matthias published the artcile< General and Chemoselective Copper Oxide Catalysts for Hydrogenation Reactions>, Electric Literature of 112-63-0, the main research area is hydrogenation unsaturated compound copper alumina catalyst.

Copper oxide catalysts have been prepared by pyrolysis of copper acetate on aluminum oxide. The material resulting from pyrolysis at 800 °C allows for catalytic hydrogenations at low temperature of a variety of unsaturated compounds such as quinolines, alkynes, ketones, imines, polycyclic aromatic hydrocarbons, as well as nitroarenes with good to good activity and selectivity.

ACS Catalysis published new progress about Aliphatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Min, Qingwang; Miao, Penghua; Liu, Jinghan; Ma, Jianjun; Qi, Meijuan; Shamsa, Farzaneh published the artcile< SBA-15 Supported Dendritic ILs as a Green Catalysts for Synthesis of 2-Imidazolidinone from Ethylenediamine and Carbon Dioxide>, Synthetic Route of 112-63-0, the main research area is silica dendritic imidazolium ionic liquid heterogeneous green catalyst; imidazolidinone synthesis ethylenediamine carbon dioxide.

In this work, a simple and facile approach is conducted for preparing many new SBA-15 supported dendritic imidazolium ILs heterogeneous catalysts SBA-15/IL(1-3) having high ionic d. from SBA-15. SBA-15/IL(3) as a green heterogeneous catalyst can be used for synthesis of 2-imidazolidinone from ethylenediamine and carbon dioxide and considering solvent-free condition. SBA-15/IL(3) showed to have the highest catalytic activity besides a pos. dendritic influence on the yields of the synthesis of 2-imidazolidinone in the presence of CO2 is seen because of existing the high-d. peripheral zwitterionic ionic liquid functional groups on the biobased SBA-15/IL(3) catalyst surfaces.

Catalysis Letters published new progress about Hydrophilicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Song, Bo; Lu, Dan; Qin, Anjun; Tang, Ben Zhong published the artcile< Combining Hydroxyl-Yne and Thiol-Ene Click Reactions to Facilely Access Sequence-Defined Macromolecules for High-Density Data Storage>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is click reaction hydroxyl yne thiol ene sequence defined macromol; data storage sequence defined macromol linear star.

Through mimicking the synthesis of hereditary-information-containing nucleic acids, scientists are committed to synthesizing sequence-defined macromols. Herein, a protecting-group-free, metal-free, and atom-economical chem. combining hydroxyl-yne and thiol-ene click reactions was developed to efficiently synthesize sequence-defined oligo(monothioacetals) (overall yield of 54% for an 11-step synthesis) from readily available starting compounds and monomers under ambient conditions. The sequences of linear oligo(monothioacetals) could be easily decoded via a tandem ESI-MS/MS technique, making them new kinds of digital macromols. with a high data storage d. (0.013 bit/Da). Moreover, star oligo(monothioacetals) could also be facilely generated through divergent and convergent strategies and their combination. An unprecedented sequence-defined miktoarm star oligo(monothioacetal) was obtained, which could serve as a new nonlinear digital macromol. to achieve 2D information matrix encoding and hold great potential to be applied for information encryption, anticouterfeiting, secret communication, etc. Thus, this work provides a powerful stepwise iterative approach to facilely access sequence-defined linear and topol. oligo(monothioacetals) for high-d. data storage.

Journal of the American Chemical Society published new progress about Anti-counterfeiting. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schulze, Dennis; Kohlstedt, Michael; Becker, Judith; Cahoreau, Edern; Peyriga, Lindsay; Makowka, Alexander; Hildebrandt, Sarah; Gutekunst, Kirstin; Portais, Jean-Charles; Wittmann, Christoph published the artcile< GC/MS-based 13C metabolic flux analysis resolves the parallel and cyclic photomixotrophic metabolism of Synechocystis sp. PCC 6803 and selected deletion mutants including the Entner-Doudoroff and phosphoketolase pathways>, SDS of cas: 112-63-0, the main research area is GCMS photomixotrophic metabolism Synechocystis doudoroff phosphoketolase pathway; 13C metabolic flux analysis; CO2; Calvin-Benson-Bassham cycle; Cyanobacteria; Entner-Doudoroff pathway; GC–MS; Glucose; Glycolytic shunt; NMR; Oxidative pentose phosphate pathway; Phosphoketolase pathway; TCA cycle, photomixotrophic growth.

Cyanobacteria receive huge interest as green catalysts. While exploiting energy from sunlight, they co-utilize sugar and CO2. This photomixotrophic mode enables fast growth and high cell densities, opening perspectives for sustainable biomanufg. The model cyanobacterium Synechocystis sp. PCC 6803 possesses a complex architecture of glycolytic routes for glucose breakdown that are intertwined with the CO2-fixing Calvin-Benson-Bassham (CBB) cycle. To date, the contribution of these pathways to photomixotrophic metabolism has remained unclear. Here, we developed a comprehensive approach for 13C metabolic flux anal. of Synechocystis sp. PCC 6803 during steady state photomixotrophic growth. Under these conditions, the Entner-Doudoroff (ED) and phosphoketolase (PK) pathways were found inactive but the microbe used the phosphoglucoisomerase (PGI) (63.1%) and the oxidative pentose phosphate pathway (OPP) shunts (9.3%) to fuel the CBB cycle. Mutants that lacked the ED pathway, the PK pathway, or phosphofructokinases were not affected in growth under metabolic steady-state. An ED pathway-deficient mutant (Δeda) exhibited an enhanced CBB cycle flux and increased glycogen formation, while the OPP shunt was almost inactive (1.3%). Under fluctuating light, Δeda showed a growth defect, different to wild type and the other deletion strains. The developed approach, based on parallel 13C tracer studies with GC-MS anal. of amino acids, sugars, and sugar derivatives, optionally adding NMR data from amino acids, is valuable to study fluxes in photomixotrophic microbes to detail. In photomixotrophic cells, PGI and OPP form glycolytic shunts that merge at switch points and result in synergistic fueling of the CBB cycle for maximized CO2 fixation. However, redirected fluxes in an ED shunt-deficient mutant and the impossibility to delete this shunt in a GAPDH2 knockout mutant, indicate that either minor fluxes (below the resolution limit of 13C flux anal.) might exist that could provide catalytic amounts of regulatory intermediates or alternatively, that EDA possesses addnl. so far unknown functions. These ideas require further experiments

Microbial Cell Factories published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lubanska, Dorota; Alrashed, Sami; Mason, Gage T.; Nadeem, Fatima; Awada, Angela; DiPasquale, Mitchell; Sorge, Alexandra; Malik, Aleena; Kojic, Monika; Soliman, Mohamed A. R.; deCarvalho, Ana C.; Shamisa, Abdalla; Kulkarni, Swati; Marquardt, Drew; Porter, Lisa A.; Rondeau-Gagne, Simon published the artcile< Impairing proliferation of glioblastoma multiforme with CD44+ selective conjugated polymer nanoparticles>, Electric Literature of 112-63-0, the main research area is glioblastoma multiforme CD44 polymer nanoparticle proliferation.

Glioblastoma is one of the most aggressive types of cancer with success of therapy being hampered by the existence of treatment resistant populations of stem-like Tumor Initiating Cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable of effectively targeting the TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole-based Conjugated Polymer Nanoparticles (CPNs) with an average diameter of 109 nm. CPNs were designed to include fluorescein-conjugated Hyaluronic Acid (HA), a ligand for the CD44 receptor present on one population of TICs. We demonstrate blood-brain barrier permeability of this system and concentration and cell cycle phase-dependent selective uptake of HA-CPNs in CD44 pos. GBM-patient derived cultures. Interestingly, we found that uptake alone regulated the levels and signaling activity of the CD44 receptor, decreasing stemness, invasive properties and proliferation of the CD44-TIC populations in vitro and in a patient-derived xenograft zebrafish model. This work proposes a novel, CPN- based, and surface moiety-driven selective way of targeting of TIC populations in brain cancer.

Scientific Reports published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nagy, Sandor; Feher, Zsuzsanna; Karpati, Levente; Bagi, Peter; Kisszekelyi, Peter; Koczka, Bela; Huszthy, Peter; Pukanszky, Bela; Kupai, Jozsef published the artcile< Synthesis and Applications of Cinchona Squaramide-Modified Poly(Glycidyl Methacrylate) Microspheres as Recyclable Polymer-Grafted Enantioselective Organocatalysts>, Application of C19H34O2, the main research area is nitro phenylethylpentane dione preparation enantioselective; pentane dione nitrostyrene poly glycidyl methacrylate organocatalyst; cinchona squaramide preparation; Michael addition; immobilization; organocatalysis; polymers; recycling.

This work presents the immobilization of cinchona squaramide organocatalysts on poly(glycidyl methacrylate) solid supports. Preparation of the well-defined monodisperse polymer microspheres was facilitated by comprehensive parameter optimization. By exploiting the reactive epoxy groups of the polymer support, three amino-functionalized cinchona derivatives I [R = Me, 2-aminoethyl; R1 = Me, 1-((4-(aminomethyl)phenyl)methyl)-1H-1,2,3-triazol-4-yl; R2 = 3,5-bis(trifluoromethyl)phenyl, 6-aminohexyl] were immobilized on this carrier. To explore the effect of the amino linker, these structurally varied precatalysts were synthesized by modifying the cinchona skeleton at different positions. The catalytic activities of the immobilized organocatalysts were tested in the Michael addition of pentane-2,4-dione and trans-β-nitrostyrene with excellent yields (up to 98%) and enantioselectivities (up to 96% ee). Finally, the catalysts were easily recovered five times by centrifugation without loss of activity.

Chemistry – A European Journal published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chime, S. A.; Attama, A. A.; Onunkwo, G. C. published the artcile< Application of SRMS 154 as Sustained Release Matrix for the Delivery of Stavudine: In vitro and in vivo Evaluation and Effect of Poloxamer 188 on the Properties of the Tablets>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is stavudine delivery micellar solidification; Area under the curve; HIV; Lipids; Solidified reverse micelles; Stavudine; Tablets..

Objectives: To formulate sustained release lipid based stavudine and to study the properties of the formulations by in vitro and in vivo methods. Methods: Stavudine tablets were formulated by molding using validated tablets molds. The carrier used were solidified reverse micellar solution (SRMS) made up of varying ratios of hydrogenated palm oil and Phospholipid admixtures Evaluation tests were carried out on the tablets using both Pharmacopoeial and non Pharmacopoeial test. Drug release was studied in both simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.2). Results: The results showed that stavudine tablets exhibited weight range of 372 ± 0.14 to 386 ± 0.52 mg, friability ranged from 0.00 to 0.13% and hardness ranged from 4.27 ± 0.25 to 5.30 ± 0.21 Kgf. Tablets formulated with SRMS 1:2 had erosion time range of 60.80 ± 1.23 to 87.90 ± 2.33 min and was affected significantly by the presence of Poloxamer 188 (p < 0.05). The formulations exhibited T100% at 10 to13 h in SIF. Stavudine tablets showed the area under the curve (AUC) of 854.0μg/h/mL, significantly higher than the AUC of the reference (p < 0.05). Conclusion: Stavudine SRMS-based tablets had good stability and sustained release properties. Formulations containing 1% Poloxamer 188 exhibited enhanced in vivo absorption and hence could be used once daily in order to enhance the bioavailability of this drug. Infectious Disorders: Drug Targets published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics