Category: 112-63-0

Cao, Xi; Dong, Heda; Chen, Han; Xu, Qiong; Yin, Dulin published the artcile< Efficient synthesis of γ-valerolactone from ethyl levulinate over Ni/V2O5>, Category: esters-buliding-blocks, the main research area is valerolactone synthesis solid phase grinding.

Valerolactone (GVL) has been recognized as one of the most value-added chems. derived from biomass. In this work, an efficient Ni/V2O5 catalyst was prepared via solid phase grinding and in-situ reduction The Ni/V2O5 catalyst was employed for catalytic transfer hydrogenation (CTH) of Et levulinate (EL) to GVL using 2-propanol as a hydrogen source. An excellent GVL selectivity of 93.04% at EL conversion of 97.40% could be achieved at 180°C in 4 h using 30% Ni/V2O5 as the catalyst. This catalyst was able to be reused for five times with the GVL selectivity decreased a little. A possible adsorption mechanism of generate active H species in CTH of EL over Ni/V2O5 was proposed.

IOP Conference Series: Materials Science and Engineering published new progress about Polyester rubber, butadiene-valerolactone, block, diblock Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Leng, Weinan; Woo, Han Young; Vak, Doojin; Bazan, Guillermo C.; Kelley, Anne Myers published the artcile< Surface-enhanced resonance Raman and hyper-Raman spectroscopy of water-soluble substituted stilbene and distyrylbenzene chromophores>, Formula: C19H34O2, the main research area is SERS hyper Raman substituted stilbene styrylbenzene chromophore.

Surface-enhanced Raman spectra (SERS) are presented for two water-soluble, donor-donor- or donor-acceptor-substituted phenylene vinylene derivatives adsorbed on the surfaces of colloidal silver nanoparticles. The normally water-insoluble, substituted stilbene and distyrylbenzene chromophores have been modified by attaching trimethylammoniumalkyl chains to the amino donor group, creating both aqueous solubility and a net pos. charge that facilitates binding to citrate- or borohydride-reduced silver colloids. A sym. donor-substituted distyrylbenzene exhibits strong electronically pre-resonant SERS spectra that are not highly dependent on excitation wavelength and are qual. similar to the solution-phase resonance Raman (RR) spectra. A donor-acceptor-substituted stilbene exhibits weaker SERS enhancement despite being fully electronically resonant. The spectra vary considerably with excitation wavelength and show new lines not present in the solution-phase spectra, which are attributed to a photoproduct formed on the surface. Two-photon resonant hyper-Raman spectra are also presented for the donor-acceptor stilbene, both with and without surface enhancement.

Journal of Raman Spectroscopy published new progress about Hyper-Raman spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maemoto, Michihiro; Hirata, Yuuki; Hosoe, Shintaro; Ouchi, Jun; Uchii, Masako; Takada, Hidenori; Akizawa, Emi; Yanagisawa, Arata; Shuto, Satoshi published the artcile< Development of potent non-acylhydrazone inhibitors of intestinal sodium-dependent phosphate transport protein 2b (NaPi2b)>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hyperphosphatemia intestine NaPi2b hepatic toxicity pharmacokinetics; Acylhydrazone; Hyperphosphatemia; Low oral bioavailability; NaPi2b; Zwitterionic compound.

Inhibition of intestinal sodium-dependent phosphate transport protein 2b (NaPi2b), responsible for intestinal phosphate absorption, is considered to reduce serum phosphate levels, making it a promising therapeutic approach for hyperphosphatemia. Previously, we aimed to identify new drugs for hyperphosphatemia treatment and obtained zwitterionic compound 3 (IC50 = 64 nM) as a potent selective inhibitor of intestinal NaPi2b. This small-mol. compound is gut-restricted owing to its almost membrane-impermeable property. However, when compound 3, containing an acylhydrazone structure, is exposed to plasma, it is easily metabolized and likely produces an acetylhydrazine compound Clin. studies have shown that acetylhydrazine is a risk factor for hepatic toxicity owing to its microsomal metabolism, wherein toxic reactive intermediates are formed. Therefore, in this study, we aimed to obtain potent NaPi2b inhibitors without an acylhydrazone structure to reduce the risk of hepatic toxicity. We developed compound 18, an anilide compound with zwitterionic property having potent phosphate uptake inhibitory activity in vitro (IC50 = 14 nM) and low bioavailability (FaFg = 5.9%). Oral administration of compound 18 in rats showed a reduction in phosphate absorption comparable to that observed with lanthanum carbonate, a clin. effective phosphate binder used in hyperphosphatemia treatment. Moreover, combined administration of compound 18 and lanthanum carbonate resulted in an additive effect on phosphate absorption inhibition in rats. Our findings suggest that combination therapy with lanthanum carbonate and compound 18 will not only provide better treatment outcomes for hyperphosphatemia but also reduce gastrointestinal side effects in patients.

Bioorganic & Medicinal Chemistry published new progress about Body weight. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Biellmann, Jean-Francois; Ducep, Jean-Bernard published the artcile< Allylic and benzylic carbanions substituted by heteroatoms>, Synthetic Route of 112-63-0, the main research area is review Substituted; review Carbanions; review Benzylic; review Allylic; review Heteroatoms.

A review of the article Allylic and benzylic carbanions substituted by heteroatoms.

Organic Reactions (Hoboken, NJ, United States) published new progress about Organic synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Shuang; Bethel, Travis K.; Kakeshpour, Tayeb; Hubbell, Grace E.; Jackson, James E.; Tepe, Jetze J. published the artcile< Substrate Controlled Regioselective Bromination of Acylated Pyrroles Using Tetrabutylammonium Tribromide (TBABr3)>, Application of C19H34O2, the main research area is acylated pyrrole tetrabutylammonium tribromide bromination; bromopyrrole regioselective preparation.

Electrophilic bromination of pyrroles bearing carbonyl substituents at C-2 typically results in a mixture of the 4- and 5-brominated species, generally favoring the 4-position. Herein, it is describe a substrate-controlled regioselective bromination in which tetra-Bu ammonium tribromide (TBABr3) reacts with pyrrole-2-carboxamide substrates to yield the 5-brominated species as the predominant (up to >10:1) product.

Journal of Organic Chemistry published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ionescu, Andreea; Lento, Raffaella; Mastropietro, Teresa F.; Aiello, Iolinda; Termine, Roberto; Golemme, Attilio; Ghedini, Mauro; Bellec, Nathalie; Pini, Elena; Rimoldi, Isabella; Godbert, Nicolas published the artcile< Electropolymerized Highly Photoconductive Thin Films of Cyclopalladated and Cycloplatinated Complexes>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phenylpyridine cycloplatinated cyclopalladated Schiff base preparation electropolymerized photoconductive film; cyclopalladated cycloplatinated phenylpyridine Schiff base complex preparation electropolymerized film; electropolymerization; palladium(II) complexes; photoconductivity.

The complete characterization of novel electropolymerizable organometallic complexes is presented. These are newly synthesized cyclometalated complexes of general formula (PPy)M(O^N)n (H(PPy) = 2-phenylpyridine, M = Pd(II) or Pt(II), H(O^N)n = Schiff base). Polymeric thin films have been obtained from these complexes by electropolymerization of the triphenylamino group grafted onto the H(O^N)n ancillary ligand. The redox behavior and the photoconductivity of both of the monomers (PPy)M(O^N)n and the electropolymerized species have been investigated. The polymeric films of (PPy)M(O^N)n have shown a very significant enhancement of photoconductivity when compared to their monomeric amorphous counterparts. The high stability of the obtained films strongly suggests that electropolymerization of cyclometalated complexes represents a viable deposition technique of quality thin films with improved photoconduction properties, hence opening the door to a new class of materials with suitable properties for optoelectronic applications.

ACS Applied Materials & Interfaces published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hirokawa, Yoshimi; Kitamura, Maria; Maezaki, Naoyoshi published the artcile< Highly enantioselective [2,3]-Wittig rearrangement of functionalized allyl benzyl ethers: a novel approach to lignan synthesis>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is enantioselective Wittig rearrangement allyl benzyl ether.

Highly enantioselective [2,3]-Wittig rearrangement of functionalized allyl benzyl ethers (E)-ArCH2OCH2C(OSi-iPr3):CHMe [Ar = Ph, 4-MeOC6H4, 3,5-(MeO)2C6H3, etc.] was accomplished using a chiral di-tert-Bu bis(oxazoline) ligand. The reaction proceeded with excellent diastereo- and enantioselectivity when no methoxy substituent was present at the ortho-position on the benzyl group. On the other hand, the enantioselectivity was drastically decreased in the presence of an ortho-methoxy group.

Tetrahedron: Asymmetry published new progress about Lignans Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Huaqing; Sun, Chunrui; Lee, Nam-Kyu; Henry, Roger F.; Lee, Daesung published the artcile< New Methylene Homologation Method for Cyclic Ketones>, Quality Control of 112-63-0, the main research area is cyclic ketone trimethylsilyl diazomethane methylene homologation ring expansion.

An efficient single methylene homologation of a broad range of both sym. and asym. cyclic ketones by adding lithium trimethylsilyl diazomethane (LTMSD), followed by treatment with silica gel as a mild proton source and promoter of ring expansion, is disclosed.

Chemistry – A European Journal published new progress about Cyclic ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hao, Zhonglin; Sekkath Veedu, Janeesh published the artcile< Current Strategies for Extensive Stage Small Cell Lung Cancer Beyond First-line Therapy>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review small cell lung cancer therapy drug combination; Molecular target; Small cell lung cancer; refractory, relapsed; strategy; treatment.

A review. Extensive stage small cell lung cancer carries extremely poor prognosis and adding immune checkpoint inhibitor to platinum etoposide combination in first line only improved outcomes modestly. Once disease recurs, treatment response is only transient in nature. Various strategies that are being explored include dual checkpoint blockade, BiTE and CAR-T cell approaches. Immune checkpoint inhibitors are being combined with PARP inhibitors. Other approaches currently being investigated include liposomal irinotecan and combining known active agents for SCLC in relapsed setting such as newly approved lurbinectedin with doxorubicin, paclitaxel, irinotecan or topotecan with ATR inhibitor (Berzosertib). Temozolomide has also been tested in combination with a Parp inhibitor. New antibody or small mol. drug conjugates are being actively investigated, so is a biomarker based approach. Better understanding of small cell lung cancer disease biol. via high through-put genomic, proteomic and methylation profiling offer glimpse of hope in our efforts to contain this deadly disease. A table of representative mol. targets under investigation is provided in the end.

Clinical Lung Cancer published new progress about Antibody-drug conjugates. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Manning, Morgan A.; Sun, Wei; Light, Mark E.; Harrowven, David C. published the artcile< A photochemical ring expansion of 6- to 8-membered nitrogen heterocycles by [1,3]-sigmatropic rearrangement>, Formula: C19H34O2, the main research area is azocine benzoazocine preparation; furopyridinone sigmatropic rearrangement photochem.

A new route to azocines I [R = Me; R1 = H; RR1 = (CH2)4; R2 = H, Ph; R3 = Me, Bn; R4 = Me, t-Bu] and benzoazocines II [R5 = H, 6,7,8-(OMe)3, 7-CF3, etc.; R6 = Me, t-Bu, Bn; R7 = Me, t-Bu, Si(i-Pr)3] from furopyridinones was described through a photochem. induced [1,3]-sigmatropic rearrangement. The method gave access to these 8-membered nitrogen heterocycles from di-Me squarate in four stages and with excellent atom economy by sequencing thermal and photochem. ring expansion steps under continuous flow.

Chemical Communications (Cambridge, United Kingdom) published new progress about Azocines Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics