Category: 112-63-0

Xiong, Xingquan; Yi, Chao; Han, Qian; Shi, Lin; Li, Sizhong published the artcile< I2/ionic liquid as a highly efficient catalyst for per-O-acetylation of sugar under microwave irradiation>, COA of Formula: C19H34O2, the main research area is peracetylated sugar iodine ionic liquid microwave irradiation.

A practical and highly efficient approach was developed to synthesize peracetylated sugar derivatives using a recyclable iodine/PEG400-based ionic liquid catalyst (I2/IL). The peracetylated sugars were readily obtained in a few minutes in excellent yields (90%-99%, 13 examples)on a multi-gram scale (50.0 mmol) by the reaction of sugar and acetic anhydride under microwave irradiation in the absence of a volatile organic solvent. The desired product was easily obtained by simple extraction with toluene from the reaction mixture, and I2/ILs could be readily recovered and reused at least six times without obvious loss in the yield. When the scale of the per-O-acetylation reaction was increased to 50.0 mmol, the desired product was still obtained in 90%yield after five recycles.

Cuihua Xuebao published new progress about Acetylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Le, Xuyen H.; Lee, Chun Pong; Monachello, Dario; Millar, A. Harvey published the artcile< Metabolic evidence for distinct pyruvate pools inside plant mitochondria>, HPLC of Formula: 112-63-0, the main research area is Arabidopsis mitochondria pyruvate citrate AlaAT NADME.

The majority of the pyruvate inside plant mitochondria is either transported into the matrix from the cytosol via the mitochondria pyruvate carrier (MPC) or synthesized in the matrix by alanine aminotransferase (AlaAT) or NAD-malic enzyme (NAD-ME). Pyruvate from these origins could mix into a single pool in the matrix and contribute indistinguishably to respiration via the pyruvate dehydrogenase complex (PDC), or these mols. could maintain a degree of independence in metabolic regulation. Here we demonstrate that feeding isolated mitochondria with uniformly labeled 13C-pyruvate and unlabeled malate enables the assessment of pyruvate contribution from different sources to intermediate production in the tricarboxylic acid cycle. Imported pyruvate was the preferred source for citrate production even when the synthesis of NAD-ME-derived pyruvate was optimized. Genetic or pharmacol. elimination of MPC activity removed this preference and allowed an equivalent amount of citrate to be generated from the pyruvate produced by NAD-ME. Increasing the mitochondrial pyruvate pool size by exogenous addition affected only metabolites from pyruvate transported by MPC, whereas depleting the pyruvate pool size by transamination to alanine affected only metabolic products derived from NAD-ME. PDC was more membrane-associated than AlaAT and NAD-ME, suggesting that the phys. organization of metabolic machinery may influence metabolic rates. Together, these data reveal that the respiratory substrate supply in plants involves distinct pyruvate pools inside the matrix that can be flexibly mixed on the basis of the rate of pyruvate transport from the cytosol. These pools are independently regulated and contribute differentially to organic acid export from plant mitochondria.

Nature Plants (London, United Kingdom) published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Yanfei; Wu, Yunyan; Yuan, Guangfeng; Hao, Leiduan; Gao, Xiang; Yang, Zhenzhen; Yu, Bo; Zhang, Hongye; Liu, Zhimin published the artcile< Azole-Anion-Based Aprotic Ionic Liquids: Functional Solvents for Atmospheric CO2 Transformation into Various Heterocyclic Compounds>, Reference of 112-63-0, the main research area is cyclic carbonate quinazoline dione benzimidazolone benzothiazoline preparation; azole anion aprotic ionic liquid carbon dioxide; atmospheric chemistry; azoles; carbon dioxide; heterocyclic compounds; ionic liquids.

Herein, azole-anion-based aprotic ionic liquids (ILs) were synthesized by the deprotonation of weak proton donors (e.g., 2-methylimidazole, 4-methylimidazole, and 2,4-dimethylimidazole) with tetrabutylphosphonium hydroxide, [Bu4P][OH]. These ILs, such as [Bu4P][2-MIm], could activate atm. CO2 through the formation of carbamates. The resultant carbamate intermediates could further react with various types of substrate, including propargylic alcs., 2-aminobenzonitriles, ortho-phenylenediamines, and 2-aminothiophenol, thereby producing α-alkylidene cyclic carbonates, quinazoline-2,4(1H,3H)-diones, benzimidazolones, and benzothiazoline, resp., in moderate-to-good yields. The transformation of CO2 at atm. pressure was achieved, and this method is expected to open up new routes for the synthesis of various oxygen-containing heterocyclic compounds under metal-free conditions.

Chemistry – An Asian Journal published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Allcock, Harry R.; Dembek, Alexa A.; Kim, Chulhee; Devine, Robert L. S.; Shi, Yongqiang; Steier, William H.; Spangler, Charles W. published the artcile< Second-order nonlinear optical poly(organophosphazenes): synthesis and nonlinear optical characterization>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is polyorganophosphazene fluoropolymer nonlinear optical property.

The preparation and 2nd-order nonlinear optical properties of a series of fluoropolymer-poly(organophosphazenes) containing covalently attached donor-acceptor-substituted conjugated moieties were reported. The polymers had the general structure [NP(OCH2CF3)x(OR)y]n, where OR = O(CH2CH2O)kC6H4(CH=CH)mC6H4NO2, where k = 1-3 and m = 1-3, O(CH2CH2O)3C6H4CH=CHC6H4CN, OCH2CH2NMeC6H4NO2, or OCH2CH2NEtC6H4N=NC6H4NO2. Model compound studies were done using the cyclic trimers N3P3(OPh)5(OR) and N3P3(OCH2CF3)5(OR), where R = (CH2CH2O)3C6H4CH=CHC6H4NO2. Structural characterization of the polymers was done using 1H- and 31P-NMR, IR and UV spectroscopies, gel permeation chromatog., and thermal anal. The 2nd-order nonlinear optical properties of polymer films were evaluated by 2nd-harmonic generation. Alignment of the nonlinear optical groups was achieved by application of an elec. field by a corona discharge. The 2nd-order nonlinear coefficient, d33, of the polymer films was determined by a Maker fringe anal. of the data and was 4.1-34 pm/V. The 2nd-harmonic generation behavior decayed upon removal of the elec. field. The variation in d33 correlated to the polymer composition and structure.

Macromolecules published new progress about Fluoropolymers, polyphosphazene- Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

van Zanten, Benjamin published the artcile< Synthesis and properties of a series of substituted 4-hydroxycoumarins>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Chlorination of m-xylene with SO2Cl2 (Kharasch and Brown, CA 33, 77288) gave 70% m-MeC6H4CH2Cl, b10 90-2°, which with NaCN in EtOH-H2O yielded 86% m-MeC6H4CH2CN, b10 125-30°. 2,3-Me2C6H3NH2 was diazotized in 40% HBr, converted into 45% 2,3-Me2C6H3Br, b14 88-92°, with Cu bronze (Harms, Dissertation, Vrije Univ., Amsterdam, 1956), converted by treatment of the Grignard compound with solid CO2 into 76% 2,3-Me2C6H3CO2H, m. 146°, and then with SOCl2 to 95% acid chloride, b11 107-11°. Chloromethylation of m-xylene with paraformaldehyde in concentrated HCl (Akin, et al., CA 31, 57915) gave 72% 2,4-Me2C6H3CH2Br, b12 99-102°, which was converted as above into 94% 2,4-Me2C6H3CH2CN, b18 138-41°. Bromination of p-xylene gave 80% 2,5-Me2C6H3Br, b10 80°, which was converted into a Grignard compound and treated with solid CO2 to yield 75% 2,5-Me2C6H3CO2H, m. 133°; the latter with SOCl2 gave 90% acid chloride, b14 108°. 2,6-Me2C6H3NH2 was converted successively into 44% bromide, b20 90-3° into 70% 2,6-Me2C6H3CO2H, m. 116°, into 95% Me ester, b12 98-100°, by reduction with LiAlH4 into 91% 2,6-Me2C6H3CH2OH, m. 91-2°, with SOCl2 into 94% chloride, b13 96-7°, m. 31°, with NaCN in EtOH into 93% nitrile, b11 125-7°, m. 36°, and hydrolyzed with 50% aqueous H2SO4 into 89% 2,6-Me2C6H3CH2CO2H, m. 130°. 3,4-Me2C6H3NH2 was converted successively into 57% bromide, b13 88-90°, into 90% 3,4-Me2C6H3CO2H, m. 163-5°, and then into 60% acid chloride, b17 119-22°. Chloromethylation of o-xylene with ClCH2OMe gave 7% 3,4-Me2C6H3CH2Cl, b16 105-15°, which was converted into 85% nitrile, b10 123-8°. 3,5-Me2C6H3Br (b14 84-7°) was converted via its Grignard compound and paraformaldehyde into 20% 3,5-Me2C6H3CH2OH, b2 83-5°, which was converted into 90% chloride, b15 100-10°, and then into 60% nitrile, b15 128-32°. Mesitylene was chloromethylated to 47% 2,4,6-Me3C6H2CH2Cl, b16 119-23°, which was converted into 84% nitrile, b18 147-56°, and hydrolyzed to 87% 2,4,6-Me3C6H2CH2CO2H, m. 167°. 2-EtC6H4NH2 was converted successively into 40% bromide, b16 79-80°, into 89% benzoic acid compound, m. 68°, into 96% Et ester, b16 114-16°, into 100% 2-EtC6H4CH2OH, into 94% chloride, b20 105°, and into 96% nitrile, b20 138-40°. Chloromethylation of PhEt gave 60% 4-EtC6H4CH2Cl, b16 100-2°, which was converted into 85% nitrile, b16 148-51°, n20D 1.5172. 2,6-Et2C6H3NH2 was converted successively into 52% bromide, b16 109-14°, into 86% 2,6-Et2C6H3CO2H, m. 85°, into 75% Me ester, b13 115-21°, into 90% 2,6-Et2C6H3CH2OH, m. 65°, into 98% chloride, b11 117°, and into 73% 2,6-Et2C6H3CH2CO2H, m. 72°. 2-Iso-PrC6H4NH2 was converted successively into 46% bromide, b15 90-3°, into 83% corresponding benzoic acid, m. 96°, into 95% Et ester, b15 119-20°, into 98% 2-iso-PrC6H4CH2OH, into 91% chloride, b20 109-11°, and into 94% nitrile, b16 133-9°. Chlorination of 4-iso-PrC6H4Me gave 92% 4-iso-PrC6H4CH2Cl, b17 112-14° which was converted into 92% nitrile, b10 130-3°. 2,6-Iso-Pr2C6H3NH2 was converted successively into 44% bromide, b15 128-30°, into 68% corresponding benzoic acid, into 81% Me ester, b20 136-8°, m. 31°, into 98% corresponding benzyl alc., b20 146-8°, m. 98°, into 92% chloride, b18 136-7°, and into 97% nitrile, b0.5 116-18°, m. 60°. 2-tert-BuC6H4Br (I) (b11 97°) (Crawford and Stewart, CA 48, 6398b) was converted successively into 80% corresponding benzoic acid, m. 68°, into 90% Me ester, b15 120-3°, into 100% corresponding benzyl alc., b16 130-3°, into 90% chloride (II), b16 116-21°, into 72% nitrile, b18 148-54°, n20D 1.5230, and into 99% 2-tert-BuC6H4CH2CO2H (III), m. 84°. The Grignard compound of II treated with CO2 gave 20% III and 50% (2-tert-BuC6H4CH2)2, b0.001 140-50°, m. 83-4°. The Grignard compound (IV) of I treated with CH2:CHCH2Br in C6H6 gave 57% 2-tert-BuC6H4CH2CH:CH2 (V), b13 102-5°. Treatment of IV with Ac2O at -20° gave 40% 2-tert-BuC6H4Ac (VI), b12 112-22°. Oxidation of V or carrying out a Willgerodt reaction with VI failed to give III. 4-tert-BuC6H4CO2H was converted successively into 93% Me ester, b16 136-8°, into 95% corresponding benzyl alc., into 80% chloride, b16 122-30°, into 90% nitrile, b16 149-53°, and into 95% 4-tert-BuC6H4CH2CO2H, m. 78-9°. Chloromethylation of naphthalene gave 65% 1-C10H7CH2Cl, b5 130-5°, which was converted into 83% nitrile, b2 155-65°. Naphthalene treated with AcCl gave 80% 2-C10H7Ac, b11 155-61°, m. 30°, which was converted with S and morpholine into 84% crude thiomorpholide (VII) of 2-C10H7CH2CO2H (VIII); hydrolysis of VII with AcOH-H2SO4 yielded 72% VIII, m. 140-3°. The above compounds [arylacetic acids (IX), arylacetonitriles (X), and arylcarboxylic acid chlorides (XI)] were converted into RCH2CO2Et (XII) by the following methods: (A) esterification of the IX by refluxing with EtOH and some H2SO4; (B) esterification of the X by refluxing with 3:1 EtOH-H2SO4; and (C) treatment of the XI with CH2N2 and rearrangement of the resulting diazoketones with EtOH and Ag2O (Arndt-Eistert reaction). The following XII were prepared (R, method, % yield, b.p./mm. given): 3-MeC6H4, B, 80, 115°/15; 2,3-Me2C6H3, C, 66, 132-45°/ 15; 2,4-Me2C6H3, B, 64, 138-40°/17; 2,5-Me2C6H3, C, 67, 118-29°/12; 2,6-Me2C6H3, A, 87, 93-5°/2; 3,4-Me2C6H3, C, 30, 120-30°/7; 3,4-Me2C6H3, B, 67, 123-8°/10; 3,5-Me2C6H3, B, 80, 130-4°/14; 2,4,6-Me3C6H2, A, 64, 115°/2; 2-EtC6H4, B, 87, 134°/20; 4-EtC6H4, B, 78, 152-4°/35; 2,6-Et2C6H3, A, 96, 135-6°/10; 2-iso-PrC6H4, C, 80, 135-6°/17; 4-iso-PrC6H4, C, 81, 139-41°/15; 2,6-iso-Pr2C6H3, C, 90, 108-9°/0.5; 2-tert-BuC6H4, A, 90, 153-4°/19; 4-tert-BuC6H4, A1, 88, 134-7°/8; 1-naphthyl, B, 72, 140-5°/3; 2-naphthyl, A, 90, 135-8°/2. Dry XII (0.37 mol) and 0.70 mol dry (EtO2C)2 added during 1 min. to 0.40 mol NaOEt (from which traces of EtOH had been removed by drying in vacuo) with stirring at 40-50° while simultaneously distilling any volatile products which formed, the mixture heated to 130° with constant stirring and distilling and then to 180°/10-20 mm., cooled, treated with 200 mL. H2O, 12-15 mL. concentrated H2SO4, and 500 mL. Et2O, the Et2O layer separated, the aqueous layer extracted 4 times with Et2O, the combined Et2O solutions washed with 2N Na2CO3 until acidification no longer produced any turbidity and then with H2O until neutral to litmus, concentrated, the residue dried azeotropically with C6H6, treated with porcelain powder, heated at 180° (bath temperature)/ 10-20 mm. until no more CO2 was generated, and distilled twice gave the following RCH(CO2Et)2 (XIIa) (R, % yield, and b.p./mm. given): 3-MeC6H4, 52, 125-32°/1; 2,3-Me2C6H3, 42, 127°/1; 2,4-Me2C6H3, 94, 151°/4; 2,5-Me2C6H3, 40,128°/1.5; 2,6-Me2C6H3, 57, 122-8°/1; 3,4-Me2C6H3, 49, 137°/2; 3,5-Me2C6H3, 52, 127°/1.5; 2,4,6-Me3C6H2, 65, 150-60°/2 (m. 46-7°); 2-EtC6H4, 63, 117-18°/1; 4-EtC6H4, 60, 122-4°/1; 2,6-Et2C6H3, 42, 132-3°/1; 2-iso-PrC6H4, 75, 121°/1; 4-iso-PrC6H4, 68, 130°/1; 2,6-iso-Pr2C6H3, 36, 137-9°/1; 2-tert-BuC6H4 (XIII), 17, 130°/1; 4-tert-BuC6H4, 57, 149-52°/1; 1-naphthyl, 68, 176-7°/1 (m. 62°); 2-naphthyl, 39, 180°/2 (m. 96-7°). Attempted synthesis of XIII by the method of Cope and Field (CA 44, 5861a) failed. IV was coupled to mesoxalic ester at -70° to give 57% tartronate, b0.05 158-62°, which was converted with SOCl2 into 55% chloride, b0.01 130°, but the latter could not be reduced catalytically. The following 2-RCH2CO2C6H4CO2Me (XIV) (where R is an aliphatic or aromatic group or H) (required as intermediates by another route) were prepared by treating the XI with 2-HOC6H4CO2Me (XV) (method D) or by treating the IX with XV (method E) [methods of Stahmann, et al., CA 38, 7417). The following XIV were prepared (R, method, % yield, m.p., b.p./mm. given): Ph, D, 50, 54-5°, 160°/0.8; H, E., 90, 47-9°, -; 2-MeC6H4, D, 74, 58-61°, 180-95°/0.1 (obtained by successively converting PhCH2Cl into 50% 2-MeC6H4CH2OH, b17 112°, into 85% chloride, b15 82-6°, into 93% nitrile, b15 115-28°, into 68% 2-MeC6H4CH2CO2H, m. 88-9°, into 85% acid chloride, b15 108-9°, and condensing with XV); 4-MeC6H4, D, 55, -, 175-200°/0.05 (obtained by chlorinating p-xylene to 79% p-MeC6H4CH2Cl, b8 70-4°, and successively converting the latter to 80% nitrile, b12 115°, 80% p-MeC6H4CH2CO2H, m. 90-1°, 90% acid chloride, b9 98-9°, and condensing with XV): 2,4,6-Me3C6H2, D, 61, 64-5°, 175-85°/0.03 (obtained by condensation of 2,4,6-Me3C6H2CH2COCl, b17 134-7 °, with XV). The 3-(R-substituted) 4-hydroxycoumarins (XVI) were prepared by 3 methods. (F) Na (0.2 g. atom) in 200 mL. paraffin oil heated to 250°, the mixture treated with 0.2 mol XIV with stirring at 250°, heated and stirred 1 h. at 250°, the paraffin oil decanted, the residue washed with petr. ether, dissolved in 600 mL. H2O, the solution acidified to pH 6-7, extracted with Et2O, and acidified to pH 1-2 gave the XVI. (G) XIIa (0.1 mol) and 0.1 mol PhOH distilled azeotropically with C6H6, the mixture heated 24-72 h. at 250-300° (the reaction was terminated when a drop of the mixture solidified on cooling), poured into 400 mL. 5% aqueous NaHCO3, boiled 1 h., filtered, the filtrate acidified to pH 6-7, extracted with C6H6 or Et2O, and acidified to pH 1-2 gave the XVI. (H) PhNH2 (0.03 mol) in 12 mL. 12N HCl and 18 mL. H2O diazotized with 3 g. NaNO2 at -5°, the diazonium solution added slowly to 5 g. 4-hydroxycoumarin in 20 mL. Me2CO containing 6 g. NaOAc at -5° with stirring, treated with 1 g. CuCl2, heated to 40-50°, stirred and heated 30 min., the Me2CO distilled, the residue acidified, the precipitate filtered off, dissolved in 5% aqueous NaHCO3, and the solution worked up as in B gave the XVI. The following XVI were prepared (R, method, yield, m.p. given): Ph, F and H, 28 and 15, 234°; 2-MeC6H4, F and H, 15 and 0, 146°; 3-MeC6H4, G, 40, 205°; 4-MeC6H4, F and H, 24 and 12, 226°; 2,3-Me2C6H3, G, 43, 203°; 2,4-Me2C6H3, G, 28, 207°; 2,5-Me2C6H3, G, 45, 206°; 2,6-Me2C6H3, G, 43, 190°; 3,4-Me2C6H3, G and H, 47 and 14, 244°; 3,5-Me2C6H3, G, 35, 216°; 2,4,6-Me3C6H2, G and F, 29 and 0, 196 °; 2-EtC6H4, G, 72, 135; 4-EtC5II4, G, 59, 175°; 2,6-Et2C6H3, G, 73, 176°; 2-iso-PrC6H4, G, 57, 107°; 4-iso-PrC6H4, G, 47, 146°; 2,6-iso-Pr2C6H3, G, 76, 212°; 4-tert-BuC6H4, G, 12, 212°; 3-O2NC6H4, H, 13, 267°; 4-O2NC6H4, H, 15, 311°; 1-naphthyl, G, 46,225°; 2-naphthyl, G, 22, 281°; H, F, 25,214°. Polarog. investigation of the XVI revealed that there was no conjugation between the 4-hydroxycoumarin skeleton and the 3-substituent. On the basis of this result and of model considerations it was concluded that the plane of the 3-substituent was perpendicular to the plane of the 4-hydroxycoumarin ring. The steric effect due to o-substitution in the 3-Ph ring could be calculated from the observations and correlated with the size of the o-substituent concerned. An attempt was also made to give a theor. interpretation of the waves observed upon polarog. reduction of the XVI prepared The anticoagulant activities of the XVI were found to differ widely. The most active XVI were those having an o-group on the 3-Ph substituent of the 4-hydroxycoumarin. The differences in activity observed were related to the spatial dimensions of the mol.

Sci. Communs. Research Dept., N. V. Koninkl. Pharm. Fabrieken v/h Brocades-Stheeman & Pharmacia published new progress about Grignard reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Naresh, P.; Shyam Sundar, P.; Girija, K.; Pradheesh, S. J.; Shanthoshivan, A. G.; Akashwaran, S.; Swaroop, A. K.; Jubie, S. published the artcile< Drug repurposing of Daclatasvir and Famciclovir as antivirals against dengue virus infection by in silico and in vitro techniques>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is daclatasvir famciclovir antiviral drug repurposing dengue virus.

Drug repurposing is a technique for reusing an existing drug to treat another ailment. It is common knowledge that nearly all medicines used in human therapy have more than one target impact in addition to their primary action. The present work is aimed to repurpose existing antiviral drugs for dengue disease. A mol. docking study is performed with the DENVE protein for the identification of the suitable drug candidate which acts in the fusion process. For all repurposed drugs at the active site of DENVE, mol. docking experiments were performed using CLC Drug Discovery Workbench Software (PDB ID: 1OKE). The relative binding modes and the affinities of all the selected drugs were predicted and compared with the co-crystallized n-octyl-beta-D-glucopyranoside (βOG). The Daclatasvir (Score-53.52) makes hydrogen bonds with ALA50 and THY48. According to the docking score evaluation, the entire drug candidates had docking result ranging from -32.15 to -53.52. Among the drugs tested the two drugs namely Daclatasvir and Famciclovir have been identified as HITS for combating DENVE protein.

Indian Journal of Biochemistry & Biophysics published new progress about Aedes aegypti. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guan, Ting; Guo, Jing-Yu; Zhang, Qing-Hong; Xu, Xin-Wen; Yu, Xiao-Yu; Zhang, Yu; Zhao, Kai published the artcile< Photoredox-catalyzed regio- & stereoselective C(sp2)-H cyanoalkylation of enamides with cycloketone oximes via selective C-C bond cleavage/radical addition cascade>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cyanoalkyl enamide preparation regioselective diastereoselective green chem; enamide cycloketone oxime Heck type cyanoalkylation photoredox catalyst.

A photoredox-catalyzed regio- and stereoselective Heck-type cyanoalkylation of synthetically prominent enamides R1C(=CH2)N(R2)(R3) (R1 = Ph, thiophen-3-yl, 2H-1,3-benzodioxol-5-yl, etc.; R2 = Ac, Bn; R3 = Bn, Me, cyclohexylmethyl, etc.) with cycloketone oximes I (Y = CH, N; R4 = H, n-C6H13, cyclohexylmethyl, Bn, etc.; R5 = H, Ph, CN, Boc, etc.; n = 1, 2) via selective β-C-C bond scission/selective radical addition cascade is developed, enabling the incorporation of synthetically versatile and pharmaceutically appealing distal cyanoalkyl moieties into enamide scaffolds R1C(N(R2)(R3))=CHCH(R4)Y(R5)(CH2)nCN under mild conditions. The synthetic importance of this methodol. was highlighted by the broad substrate scopes, satisfying functional group compatibilities, excellent regio- and stereoselectivities as well as the versatile and diverse synthetic applications of β-cyanoalkylated enamides.

Green Chemistry published new progress about Aliphatic nitriles Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Jiayi; Cui, Yahua; Yang, Yanling; Li, Huahua; Zhang, Yi; Yang, Haiju; Du, Shouying; Bai, Jie published the artcile< Optical Coherence Tomography and Microdialysis for Microneedle-Mediated Penetration Enhancement Study of Paeoniflorin-Loaded Ethosomes>, Reference of 112-63-0, the main research area is microneedle penetration paeoniflorin ethosome; Ethosome; Microdialysis; Microneedle; Optical coherence tomography; Pharmacokinetics.

This paper uses microdialysis to systematically study the percutaneous pharmacokinetics of paeoniflorin-loaded ethosomes. First, optical coherence tomog. (OCT) was used to study the effectiveness of microneedle puncture. Second, a microdialysis method and a UPLC-MS method for determining the amount of paeoniflorin (Pae) in dialyzate were established. Finally, the transdermal pharmacokinetics of TGP-E was studied using in vivo microdialysis in rats under the above MN-assisted conditions. The optimal MN-assisted conditions were obtained at a microneedle length of 500μm, a pressure of 3 N, and an action time of 3 min. The pharmacokinetic results demonstrated that the maximum drug concentration (Cmax) and the area under the curve (AUC) of the TGP-E gel were higher than the TGP-saline solution gel, and the mean retention time was lower. These indicated that microneedle can promote the entry of the ethosomes into the skin for in vivo experiments and greatly improve the possibility of deep penetration of the water-soluble Pae. Therefore, the microneedle-ethosomes delivery system is a more ideal means for promoting the deep penetration of Pae. These findings may provide a reference for the combination of multiple penetration-enhancement ways to promote drug absorption, and also provide a new insight to realize the development of novel, safe, and more effective dosage forms and administration routes of drugs.

Skin Pharmacology and Physiology published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hashemzadeh, Mehrnoosh; Movahed, Mohammad R.; Russu, Wade A.; Soroush, Ladan; Hill, Dine N. published the artcile< Novel design and synthesis of modified structure of carvedilol>, Reference of 112-63-0, the main research area is carvedilol analog synthesis beta blocker drug design heart failure.

β-Adrenergic blocking agents have been in use for nearly 40 years. β-Blockers have been more thoroughly studied in the past twenty years as they have become commonly prescribed to heart failure patients. The class of β-blockers has grown considerably and has many pharmaceutical applications in patients with heart failure. Carvedilol has been the most effective beta-blocker in the treatment of the systolic heart failure. Carvedilol is a non-selective β- and α-blocker enantiomer with antioxidant effects that are attributed to its carbazole moiety. Carvedilol is taken twice daily because it is extensively metabolized and therefore loses its effectiveness due to a short half-life. Recently a long acting carvedilol has become available, as Coreg CR. Coreg CR is available for once-a-day administration as controlled-release oral capsules containing 10, 20, 40, or 80 mg carvedilol phosphate. The subject of the current report is to design a new structural analog of carvedilol that incorporates a protecting group such as a fluorine atom at position 8 of the carbazole ring for the purpose of blocking a critical metabolic pathway thus increasing its half life. This will follow discussion regarding current carvedilol patents. We believe that carvedilol activity will remain unchanged. The synthesis of 8-Fluoro-1, 2, 3, 9- tetrahydro-4H-carbazol-4-one, a key synthetic intermediate of the designed carvedilol analog, was carried out and successfully characterized.

Recent Patents on Cardiovascular Drug Discovery published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kothandaraman, Shankaran; Donnely, Karla L.; Butora, Gabor; Jiao, Richard; Pasternak, Alexander; Morriello, Gregori J.; Goble, Stephen D.; Zhou, Changyou; Mills, Sander G.; MacCoss, Malcolm; Vicario, Pasquale P.; Ayala, Julia M.; DeMartino, Julie A.; Struthers, Mary; Cascieri, Margaret A.; Yang, Lihu published the artcile< Design, synthesis, and structure-activity relationship of novel CCR2 antagonists>, Reference of 112-63-0, the main research area is tetrahydropyranylaminocyclopentanecarboxamide preparation CCR2 antagonist.

A series of novel 1-aminocyclopentyl-3-carboxamides incorporating substituted tetrahydropyran moieties have been synthesized and evaluated for their antagonistic activity against the human CCR2 receptor. Among them analog I was found to posses potent antagonistic activity.

Bioorganic & Medicinal Chemistry Letters published new progress about CC chemokine receptor CCR2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics