Category: 112-63-0

Bates, Gareth W.; Triyanti; Light, Mark E.; Albrecht, Markus; Gale, Philip A. published the artcile< 2,7-Functionalized Indoles as Receptors for Anions>, Product Details of C19H34O2, the main research area is indole carboxamide amido ureido thioureido preparation structure anion complexation; stability constant phosphate carboxylate chloride amido ureido thioureido indolecarboxamide; titration NMR anion complexation indolecarboxamide amido ureido thioureido derivative; hydrogen bond phosphate carboxylate indolecarboxamide amido ureido thioureido derivative; crystal structure indolecarboxamide amido ureido thioureido derivative; mol structure indolecarboxamide amido ureido thioureido derivative.

A series of 7-amido- and 7-ureido- and 7-thioureido-1H-indole-2-carboxamide derivatives were prepared by reduction and acylation of the corresponding 7-nitro-1H-indolecarboxamides; the compounds exhibit binding properties towards dihydrophosphate, acetate, benzoate and chloride ions. Amidation of 7-nitro-1H-indole-2-carboxylic acid by amines RNH2 gave N-R-7-nitro-1H-indole-2-carboxamides (8a,b; R = Bu, Ph), which were reduced to the corresponding N-R-7-amino-1H-indole-2-carboxamides (9a,b). Reaction of 9a,b with BuCOCl, PhCOCl, PhCH2COCl, BuNCO, PhNCO and PhNCS gave N-R-7-R1NH-1H-indole-2-carboxamides (1 R = Bu, R1 = BuCO; 2 R = Ph, R1 = PhCO; 3 R = Ph, R1 = PhCH2CO; 4 R = Bu, R1 = BuNHCO; 5 R = Ph, R1 = PhNHCO, 6 R = Ph, R1 = PhNHCS). Stability constants were measured in aqueous solution for complexation of 1-6 with H2PO4-, MeCO2-, PhCO2- and Cl- anions. Anion complexation studies show a marked difference in the mode of interaction of carboxylates with indole-ureas vs. indole-amides.

Journal of Organic Chemistry published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zhaoyan; Tian, Fangyuan; Chen, Xi published the artcile< Cost-Effectiveness Analysis of a Three-Drug Regimen Containing Bevacizumab for the Treatment of Recurrent Pediatric Medulloblastoma in China: Based on a COG Randomized Phase II Screening Trial.>, Application of C19H34O2, the main research area is bevacizumab; cost-effectiveness; irinotecan; recurrent pediatric medulloblastoma; temozolomide.

Background: Medulloblastoma is the most common malignant brain tumor of childhood, accounting for 6 to 7 percent of all childhood CNS tumors. The purpose of this study was to evaluate the economic efficacy of a bevacizumab combined with temozolomide + irinotecan regimen for the treatment of recurrent pediatric medulloblastoma in China. Methods: The data analyzed were from a randomized phase II screening trial that showed an improved survival benefit in child patients with recurrent medulloblastoma treated with a T+I+B combination regimen. A Markov model is constructed to estimate the incremental cost-effectiveness ratio (ICER) from the perspective of Chinese society. The uncertainty in the model is solved by one-way certainty and probabilistic sensitivity analysis. Results: Our base case analysis showed that the total costs of treatment increased from $8,786.403 to $27,603.420 with the combination bevacizumab vs. the two-agent chemotherapy regimen. Treatment with T+I+B combination therapy was associated with an increase in effectiveness of 0.280 QALYs from 0.867 to 1.147 QALYs T+I regimen. The incremental cost-effectiveness ratio was $67,203.632/QALY, which exceeded our pre-specified willingness-to-pay threshold ($38,136.26/QALY). Cost changes associated with grade 3-4 AE management, tests used, or hospitalization costs had little effect on the ICER values predicted by sensitivity analysis. Conclusions: Taken together, the results of this study suggest that the combination of bevacizumab with temozolomide and irinotecan is not a cost-effective option from the perspective of Chinese payers as a first-line treatment option for children with recurrent medulloblastoma in China.

Frontiers in public health published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jonsson, Erlendur; Ellison, James H. J.; Wang, Evelyna; Kunz, Vera; Liu, Tao; Temprano, Israel; Grey, Clare P. published the artcile< On the solvation of redox mediators and implications for their reactivity in Li-air batteries>, Reference of 112-63-0, the main research area is triethylphosphine oxide tetraglyme solvation lithium air battery.

Lithium-air batteries are a promising energy storage technol. for transport applications, given their exceptionally high energy d. However, their development is significantly hampered by high overpotentials, which lead to poor efficiency and short lifetimes. Redox mediators provide a solution to this problem by shuttling electrons from the electrode to the active species at just above the redox potential of the mediator. Thus, knowing the redox potential and having the ability to tune it are critical to electrochem. performance. We focus on LiI as a model mediator-given its addnl. role in controlling LiOH vs Li2O2 chem.-and use cyclic voltammetry (CV), NMR, UV/Vis spectrometry, and mol. dynamics (MD) simulations to monitor the effects of electrolyte composition on solvation. Li+ and I- solvation in common Li-air solvents, the electrochem. implications, and the applicability of each technique to probe the nature of the solvation shell and its effect on the electrochem. properties are explored. Starting with a simple thermodn. model, we then used UV/Vis spectrometry to probe I- solvation, 1H NMR spectroscopy to study water solvation and 31P of the probe mol. triethylphosphine oxide (TEPO) to explore Li+ solvation; we find that no single descriptor can provide an accurate description of the solvation environment. Instead, we use all these methods in combination with the MD results to help rationalize the CV data. We find that the I- solvation improves significantly in tetraglyme (G4), with increasing salt and water concentration, but minimal effects on changing salt/water concentrations are seen in DMSO. In contrast, increasing salt concentration increases the Li+ activity in DMSO but not in G4. Furthermore, a simple model considering the equilibrium between the different species was used to explain the 1H NMR data.

Journal of the Electrochemical Society published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Serafim, Rodolfo Bortolozo; Cardoso, Cibele; Arfelli, Vanessa Cristina; Valente, Valeria; Archangelo, Leticia Frohlich published the artcile< PIMREG expression level predicts glioblastoma patient survival and affects temozolomide resistance and DNA damage response>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is GLI1 PIMERG DNA damage glioblastoma; ATM; ATR; DNA damage response; GBM; Gliomas; Temozolomide resistance.

PIMREG expression strongly correlates with cellular proliferation in both malignant and normal cells. Throughout embryo development, PIMREG expression is prominent in the central nervous system. Recent studies have described elevated PIMREG expression in different types of tumors, which correlates with patient survival and tumor aggressiveness. Given the emerging significance of PIMREG in carcinogenesis and its putative role in the context of the nervous system, we investigated the expression and function of PIMREG in gliomas, the most common primary brain tumors. We performed an extensive anal. of PIMREG expression in tumors samples from glioma patients. We then assessed the effects of PIMREG silencing and overexpression on the sensitivity of glioblastoma cell lines treated with genotoxic agents commonly used for treating patients and assessed for treatment response, proliferation and migration. Our anal. shows that glioblastoma exhibits the highest levels of PIMREG expression among all cancers analyzed and that elevated PIMREG expression is a biomarker for glioma progression and patient outcome. Moreover, PIMREG is induced by genotoxic agents, and its silencing renders glioblastoma cells sensitive to temozolomide treatment and affects ATR- and ATM-dependent signaling. Our data demonstrate that PIMREG is involved in DNA damage response and temozolomide resistance of glioblastoma cells and further supports a role for PIMREG in tumorigenesis.

Biochimica et Biophysica Acta, Molecular Basis of Disease published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khatua, Hillol; Das, Sandip Kumar; Roy, Satyajit; Chattopadhyay, Buddhadeb published the artcile< Dual Reactivity of 1,2,3,4-Tetrazole: Manganese-Catalyzed Click Reaction and Denitrogenative Annulation>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is manganese catalyst tetrazole click denitrogenative annulation; nitrogen heterocycle disubstituted triazole triazolopyridine preparation; 1,3-cycloaddition; catalysis; click chemistry; denitrogenative annulation; manganese.

A general catalytic method using a Mn-porphyrin-based catalytic system is reported that enables two different reactions (click reaction and denitrogenative annulation) and affords two different classes of nitrogen heterocycles, 1,5-disubstituted 1,2,3-triazoles (with a pyridyl motif) and 1,2,4-triazolo-pyridines. Mechanistic studies suggest that although the click reaction likely proceeds through an ionic mechanism, which is different from the traditional click reaction, the denitrogenative annulation reaction likely proceeds via an electrophilic metallonitrene intermediate rather than a metalloradical intermediate. Collectively, this method is highly efficient and offers several advantages over other methods. For example, this method excludes a multi-step synthesis of the N-heterocyclic mols. described and produces only environmentally benign N2 gas a byproduct.

Angewandte Chemie, International Edition published new progress about Click chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Iwashima, Makoto; Kinsho, Takeshi; Smith, Amos B. III published the artcile< A caveat on the Sharpless asymmetric dihydroxylation>, Application of C19H34O2, the main research area is vinyl C glycoside stereoselective dihydroxylation; alditol; Sharpless stereoselective hydroxylation olefin sugar.

Sharpless asym. dihydroxylation (AD) of the homochiral synthetic intermediates 2a-c gave anomalous results: pairs of pseudoenantiomeric reagents, expected to generate complementary diastereomer ratios characteristic of double diastereoselection, instead generally furnished indistinguishable product mixtures AD reactions of related monosubstituted olefins failed to pinpoint the structural features responsible for the unexpected behavior.

Tetrahedron Letters published new progress about Alditols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liang, Chun-Ling; Lu, Weihui; Qiu, Feifei; Li, Dan; Liu, Huazhen; Zheng, Fang; Zhang, Qunfang; Chen, Yuchao; Lu, Chuanjian; Li, Bin; Dai, Zhenhua published the artcile< Paeoniflorin ameliorates murine lupus nephritis by increasing CD4+Foxp3+ Treg cells via enhancing mTNFα-TNFR2 pathway>, Reference of 112-63-0, the main research area is paeoniflorin immunosuppressant antiinflammatory agent TNF alpha TNFR2 lupus nephritis; Lupus nephritis; Macrophage; Paeoniflorin; TNF-α /TNFR2; Treg.

Treg cells are essential for re-establishing self-tolerance in lupus. However, given that direct Treg therapies may be inadequate to control autoimmunity and inflammation, a strategy of inducing or expanding endogenous Treg cells in vivo may be a good option. Macrophages are main tissue-infiltrating cells and play a role in promoting Treg differentiation while paeoniflorin (PF), a monoterpene glycoside, exhibits anti-inflammatory and immunoregulatory effects. Here, we studied the effects of PF on CD4+FoxP3+ Treg frequency and the potential mechanisms involving M2 macrophages. We demonstrated that PF ameliorated lupus nephritis in lupus-prone B6/gld mice by reducing urinary protein, serum creatinine and anti-dsDNA levels, diminishing renal cellular infiltration, improving renal immunopathol. and downregulating renal gene and protein expressions of key cytokines, including IFN-γ, IL-6, IL-12 and IL-23. PF also lowered the percentage of CD44highCD62Llow effector T cells while augmenting CD4+FoxP3+ Treg frequency in B6/gld mice. Importantly, PF increased TNFR2 expression on CD4+FoxP3+ Tregs, but not CD4+FoxP3- T cells, in vivo and in vitro. Furthermore, we found that CD206+ subset of F4/80+CD11b+ macrophages expressed a higher level of mTNF-α than their CD206- counterparts while PF increased mTNF-α expression on CD206+ macrophages in vitro and in vivo. In vitro studies showed that mTNF-α+ M2 macrophages were more potent in inducing Treg differentiation and proliferation than their mTNF-α- counterparts, whereas the effects of mTNF-α+ M2 macrophages were largely reversed by separation of M2 macrophages using a transwell or TNFR2-blocking Ab in the culture. Finally, PF also promoted in vitro Treg generation induced by M2 macrophages. Thus, we demonstrated that mTNFα-TNFR2 interaction is a new mechanism responsible for Treg differentiation mediated by M2 macrophages. We provided the first evidence that PF may be used to treat lupus nephritis.

Biochemical Pharmacology (Amsterdam, Netherlands) published new progress about Antinuclear antibodies Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Min; Zhang, Haifeng; Zhang, Yameng; Fan, Jinting; Zhu, Jinhao; Gu, Xinyue; Li, Zhonghui; Zhang, Chengyang; Liu, Zhen; Li, Yuebai; Zang, Mingxi; Jin, Ge; Li, Guoping; Mi, Yang published the artcile< Berberine modulates macrophage activation by inducing glycolysis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is TNFalpha berberine macrophage activation glycolysis endotoxic shock.

Classical activation of macrophage and monocyte differentiation induced by β-glucan is accompanied with metabolic change in glucose. However, the role of the metabolic rewiring in monocyte/macrophage activation remains elusive. In this study, we show that berberine induces aerobic glycolysis by blocking the tricarboxylic acid cycle and modulates cytokine responses in bone marrow-derived macrophages (BMDMs) from mice and human PBMC. 13-Methyberberine had activities on glucose metabolism and BMDM activation similar to those of berberine, whereas other tested derivatives lost both activities. Glucose transporter (GLUT)1 expression and total cellular hexokinase activity increased gradually in BMDMs in the presence of berberine. In the contrast, LPS upregulated GLUT1 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) levels in 6 h. Extracellular glucose levels and replacing glucose with galactose in culture medium affected the cytokine secretion of BMDMs. Berberine alleviated enteritis of Salmonella typhimurium infection and protected mice against endotoxic shock. In mice i.p. injected with LPS, the increase of serum TNF-α and the drop of blood glucose were attenuated by berberine treatment. These data together demonstrated that macrophage activation was closely related with glucose metabolism

Journal of Immunology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Al-Azawi, Anas; Cenev, Zoran; Tupasela, Topi; Peng, Bo; Ikkala, Olli; Zhou, Quan; Jokinen, Ville; Franssila, Sami; Ras, Robin H. A. published the artcile< Tunable and Magnetic Thiol-ene Micropillar Arrays>, Electric Literature of 112-63-0, the main research area is superhydrophobic micopillar thiol; microdroplet transport; micromanipulation; self-assembly; superhydrophobicity; thiol-ene elastomers.

Tunable and responsive surfaces offer routes to multiple functionalities ranging from superhydrophobic surfaces to controlled adhesion. Inspired by cilia structure in the respiratory pathway, magnetically responsive periodic arrays of flexible and magnetic thiol-ene micropillars are fabricated. Omnidirectional collective bending of the pillar array in magnetic field is shown. Local non-contact actuation of a single pillar is achieved using an electromagnetic needle to probe the responsiveness and the elastic properties of the pillars by comparing the effect of thiol-ene crosslinking d. to pillar bending. The suitable thiol-ene components for flexible and stiff magnetic micropillars and the workable range of thiol-to-allyl ratio are identified. The wettability of the magnetic pillars can be tailored by chem. and topog. modification of the pillar surface. Low-surface-energy self-assembled monolayers are grafted by UV-assisted surface activation, which is also used for surface topog. modification by covalent bonding of micro- and nanoparticles to the pillar surface. The modified thiol-ene micopillars are resistant to capillarity-driven collapse and they exhibit low contact angle hysteresis, allowing water droplet motion driven by repeated bending and recovery of the magnetic pillars in an external magnetic field. Transport of polyethylene microspheres is also demonstrated.

Macromolecular Rapid Communications published new progress about Contact angle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Van Wyk, Hedwig M.; Schoeman, Dewald; Kwembeya, Ezekeil; Hans, Renate H.; Pool, Edmund J.; Louw, Stefan published the artcile< In vitro acetylcholinesterase inhibitory activity and chemical composition of the dichloromethane extracts of the leaves and inflorescences of the tumbleweed, Trachyandra laxa (N.E.Br.) Oberm. var. rigida (Suesseng.) Roessl>, Reference of 112-63-0, the main research area is Trachyandra laxa acetylcholinesterase inhibitor chem composition dichloromethane leaf tumbleweed.

Trachyandra laxa, which belongs to the family Asphodelaceae, is a poisonous geophyte, often consumed by livestock, particularly when pastures are poor. Ingestion of T. laxa by livestock causes paresis and paralysis of the animals. However, the chem. composition of this plant has never been studied before and its toxic components are still unknown. In this study, an acetylcholinesterase (AChE) inhibition assay of different extracts of the parts of Trachyandra laxa (N.E.Br.) Oberm. var. rigida (Suesseng.) Roessl. revealed that the DCM extracts possess the highest AChE inhibitory activity. In addition, using qual. phytochem. tests, it was determined that all the plant parts contain polyphenols and tannins, while only the leaves contain flavonoids. Saponins were detected in all plant parts, except in the flowers and anthraquinones were detected in all plant parts expect the roots. Using GC-MS anal., 13 volatile constituents were identified in the DCM extracts of the leaves and inflorescences, including α,β-unsaturated lactones, carboxylic acids and esters, a diterpenoid, phytol, and a phytosterol, β-sitosterol. Of particular interest are the α,β-unsaturated lactones, which were identified as dihydroactinidiolide (DHA) and its hydroxylated analog, hydroxy-DHA, as well as phytol, a diterpenoid. DHA and phytol have been reported to possess potent AChE inhibition activity. It is therefore plausible that these compounds and potentially also hydroxy-DHA could contribute to the AChE inhibitory activity of the DCM extracts, and thus the neurotoxicity of T. laxa var. rigida.

South African Journal of Botany published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics