Category: 112-63-0

Zhang, Di; Wang, Qin; Yang, Jing; Zhang, Qing; Le, Yi; Liu, Li; Yan, Longjia published the artcile< Synthesis and biological evaluation of new pyrimidine derivatives as FAK inhibitors for development of antitumor agents>, Category: esters-buliding-blocks, the main research area is FAK inhibitor antitumor agent development pyrimidine derivative biol evaluation.

In this paper, a set of new pyrimidine derivatives was designed and synthesized. Subsequently, all the final targets were evaluated for antitumor activities in vitro on four human cancer cell lines including U-87 MG, MDA-MB-231, PC-3, and MCF-7, which were high expressed with focal adhesion kinase (FAK). The results were shown that these compounds performed well antitumor activities. Especially 2-((2-((4-((2-((2-acrylamidoethyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N-methylbenzamide (7b) exhibited the highest antitumor activities with 2.16 μM, 2.03 μM, 6.19 μM, and 21.31 μM, resp. In addition, all the compounds were tested activities against FAK and compound 7b was also the best candidate with IC50 value of 5.9 nM.

Heterocycles published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bruce, S. O.; Nwafor, O. I.; Omoirri, M. A.; Adione, N. M.; Onyeka, I. P.; Ezeoru, V. C. published the artcile< GC-MS, FTIR and antiulcer screening of aqueous seed extract and oil of Nigella sativa in wistar rats>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Nigella seed extract antiulcer agent phytochem peptic ulcer.

Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. This study was aimed at evaluating the antiulcer activity of the aqueous extract of Nigella sativa (black seed) and its constitutents. The pharmacognostic properties of the dry seeds were determined The seeds were extracted using two methods digestion and hydro-distillation The acute toxicity, phytochem. constituents and the antiulcer evaluation were performed on ethanol-induced ulcer in wistar rats using a standard method. FTIR and GC-MS anal. of the aqueous seed extract was also determined using standard methods. Nigella sativa seed shows the presence of starch grains, lignified tissues, tannins, cellulose, protein and oil globules. The aqueous extract has a high safety margin. The phytochem. studies revealed the presence of saponins, flavonoids, alkaloids, tannins, glycosides, fats and oil. The black seed aqueous and oil extract at 500 mg/kg significantly reduced the acidity, total acidity, and ulcer index, and pH of gastric content when compared with the pos. control (Famotidine). The FTIR anal. identified the presence of the following functional groups chloro, ether, amine, carboxylic acid, nitriles, methylene, alc., while the GC-MS identified five compounds such as glycerin, n-Hexadecanoic acid, 9, 12-octadecadienoic acid-Me ester, 9, 12-octadecadienoic acid and 9, 12-octadecadienoyl chloride. The pharmacognostic properties can act as a reliable tool for the standardization of the plant part. This study suggests that aqueous and oil extract possess antiulcer properties. Thus the aqueous and oil extract of black seed can be considered as antiulcer medication traditionally.

Journal of Drug Delivery and Therapeutics published new progress about Alkaloids Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tomassoli, Isabelle; Gundisch, Daniela published the artcile< The twin drug approach for novel nicotinic acetylcholine receptor ligands>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nicotinic acetylcholine receptor ligand; 3D QSAR pharmacophore; Nicotinic acetylcholine receptor; Structure–activity relationship; Twin drugs; nAChR.

The association of two pharmacophoric entities generates so-called ‘twin drugs’ or dimer derivatives The authors applied this approach for the design of a small compound library for the interaction with α4β2* nicotinic acetylcholine receptors (nAChRs). In this compound series, the nAChR ligand N,N-dimethyl-2-(pyridin-3-yloxy)ethan-1-amine served as one pharmacol. entity and it was initially kept constant as one part of the ‘twin’ compound ‘Twin’ compounds with identical or nonidentical entities using the ‘no linker mode’ or ‘overlap’ mode were synthesized and evaluated for their nAChR affinities. Compound I showed the highest affinity for the α4β2* nAChR subtype (Ki = 0.188 nM) and its (di)fluoro analogs could retain nanomolar affinities, when replacing pyridine as the hydrogen bond acceptor system by mono- or difluoro-phenyls. The ‘twin drug’ approach proved to provide compounds with high affinity and subtype selectivity for α4β2* nAChRs.

Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Toyodome, Hisaya; Higo, Yuhei; Sasai, Ryo; Kurawaki, Junichi; Kaneko, Yoshiro published the artcile< Behavior of chiral induction from polysilsesquioxanes bearing chiral and ammonium groups to anionic pyrene derivatives>, Category: esters-buliding-blocks, the main research area is chiral ammonium side chain polysilsesquioxane chiral induction.

The behavior of chiral induction from ladder-like polysilsesquioxanes (R60- and S60-PSQs) bearing chiral and ammonium side-chain groups (compositional ratio = ca. 60:40) to the anionic pyrene derivative, 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt (PTSNa4), was investigated. The CD spectra of PTSNa4/(R60- and S60-PSQs) mixtures in methanol exhibited reverse peaks at 230-250, 280-290, and 310-370 nm, which were assigned to PTSNa4 and indicated that the achiral PTSNa4 mol. had chirality induced from the chiral PSQs. In addition, it was found that an excimer of PTSNa4 was formed by hybridization with the chiral PSQs, i.e., the emission peaks not only due to a monomer state at 385 and 408 nm but also due to an eximer at 460-520 nm were observed in the fluorescence spectrum excited at 377 nm. This result suggests that the neg. charged PTSNa4 formed an eximer along the pos. charged side-chain ammonium groups of PSQs. To investigate the influence of the structures of the pyrene derivatives on chiral induction behavior, the CD measurements of the mixtures of R60- and S60-PSQs in methanol with different pyrene derivative, 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (pyranine), were also performed. It was found that the intensities of the absorptions for the pyanine solutions were lower than those for PTSNa4 solutions These results suggest that the point-symmetry of the pyrene derivatives influences the level of chiral induction. Therefore, the point-symmetry of pyrene derivatives is an important factor for determining the behavior of chiral induction from chiral PSQs to these compounds

Journal of Nanoscience and Nanotechnology published new progress about Chiral induction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pinarbasi-Degirmenci, Nareg; Sur-Erdem, Ilknur; Akcay, Vuslat; Bolukbasi, Yasemin; Selek, Ugur; Solaroglu, Ihsan; Bagci-Onder, Tugba published the artcile< Chronically Radiation-Exposed Survivor Glioblastoma Cells Display Poor Response to Chk1 Inhibition under Hypoxia>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is radiation glioblastoma cell Chk1 inhibition hypoxia radiotherapy DNA damage; Chk1; DNA damage response; glioblastoma; hypoxia; radioresistance; radiotherapy.

Glioblastoma is the most malignant primary brain tumor, and a cornerstone in its treatment is radiotherapy. However, tumor cells surviving after irradiation indicates treatment failure; therefore, better understanding of the mechanisms regulating radiotherapy response is of utmost importance. In this study, we generated clin. relevant irradiation-exposed models by applying fractionated radiotherapy over a long time and selecting irradiation-survivor (IR-Surv) glioblastoma cells. We examined the transcriptomic alterations, cell cycle and growth rate changes and responses to secondary radiotherapy and DNA damage response (DDR) modulators. Accordingly, IR-Surv cells exhibited slower growth and partly retained their ability to resist secondary irradiation Concomitantly, IR-Surv cells upregulated the expression of DDR-related genes, such as CHK1, ATM, ATR, and MGMT, and had better DNA repair capacity. IR-Surv cells displayed downregulation of hypoxic signature and lower induction of hypoxia target genes, compared to naÏve glioblastoma cells. Moreover, Chk1 inhibition alone or in combination with irradiation significantly reduced cell viability in both naÏve and IR-Surv cells. However, IR-Surv cells′ response to Chk1 inhibition markedly decreased under hypoxic conditions. Taken together, we demonstrate the utility of combining DDR inhibitors and irradiation as a successful approach for both naÏve and IR-Surv glioblastoma cells as long as cells are refrained from hypoxic conditions.

International Journal of Molecular Sciences published new progress about Adhesion G protein-coupled receptor L2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wagner, Annette; Dussling, Stefan; Scansani, Stefano; Bach, Peter; Ludwig, Michael; Steingass, Christof B.; Will, Frank; Schweiggert, Ralf published the artcile< Comparative Evaluation of Juices from Red-Fleshed Apples after Production with Different Dejuicing Systems and Subsequent Storage>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ascorbic acid anthocyanin polyphenol red fleshed apple juice storage; UHPLC-DAD-ESI-QTOF-HR-MS/MS; red-fleshed ‘Weirouge’ apples; reductive juice processing; spiral filter press; vacuum dejuicing.

In this work, two vintages (2019 and 2020) of red-fleshed ′Weirouge′ apples were processed with the innovative spiral filter press technol. to investigate juice production in an oxygen-reduced atm. After pressing, a more brilliant red color and appreciably higher amounts of oxidation-sensitive constituents (ascorbic acid, anthocyanins, and colorless (poly)phenols) were seen in spiral filter pressed juices compared to those produced with conventional systems (horizontal filter press and decanter). In a subsequent stability study (24 wk storage at 4, 20, and 37 °C), the color and phenolic compounds were monitored and differences in the juices produced with the different pressing-systems were widely maintained during the storage period. The analyses of the anthocyanins and colorless (poly)phenols were conducted by UHPLC-DAD-ESI-QTOF-HR-MS/MS and UHPLC-DAD. The spiral filter press emerged as a promising technol. for the production of juices with a more attractive color and a better retention of oxidation-sensitive constituents during processing and storage compared to conventional juices.

Molecules published new progress about Apple (red-fleshed). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lakouraj, Moslem M.; Ghodrati, Keivan published the artcile< Carboxy pyridinium bromide perbromide reagents. Part I. Selective oxidation of thiols and sulfides>, Electric Literature of 112-63-0, the main research area is thiol selective oxidation pyridinium hydrobromide perbromide oxidant; sulfide selective oxidation pyridinium hydrobromide perbromide oxidant; disulfide preparation; sulfoxide preparation.

Efficient and convenient oxidation of aliphatic and aromatic thiols to disulfides and of sulfides to sulfoxides with pyridinium hydrobromide perbromide (PHBP), nicotinic acid hydrobromide perbromide (NAHBP), and 2,6-dicarboxy pyridinium hydrobromide perbromide (DCPHBP) in a solvent or under solvent free conditions and at ambient temperature is introduced.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Disulfides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fregeau-Proulx, Lilianne; Lacouture, Aurelie; Berthiaume, Line; Weidmann, Cindy; Harvey, Mario; Gonthier, Kevin; Pelletier, Jean-Francois; Neveu, Bertrand; Jobin, Cynthia; Bastien, Dominic; Bergeron, Alain; Fradet, Yves; Lacombe, Louis; Laverdiere, Isabelle; Atallah, Chantal; Pouliot, Frederic; Audet-Walsh, Etienne published the artcile< Multiple metabolic pathways fuel the truncated tricarboxylic acid cycle of the prostate to sustain constant citrate production and secretion>, Quality Control of 112-63-0, the main research area is citrate anticancer agent tricarboxylic acid cycle secretion prostate cancer; Androgen; Fertility; Organoids; Prostate cancer; TCA cycle.

The prostate is metabolically unique: it produces high levels of citrate for secretion via a truncated tricarboxylic acid (TCA) cycle to maintain male fertility. In prostate cancer (PCa), this phenotype is reprogrammed, making it an interesting therapeutic target. However, how the truncated prostate TCA cycle works is still not completely understood.We optimized targeted metabolomics in mouse and human organoid models in ex vivo primary culture. We then used stable isotope tracer analyses to identify the pathways that fuel citrate synthesis.First, mouse and human organoids were shown to recapitulate the unique citrate-secretory program of the prostate, thus representing a novel model that reproduces this unusual metabolic profile. Using stable isotope tracer anal., several key nutrients were shown to allow the completion of the prostate TCA cycle, revealing a much more complex metabolic profile than originally anticipated. Indeed, along with the known pathway of aspartate replenishing oxaloacetate, glutamine was shown to fuel citrate synthesis through both glutaminolysis and reductive carboxylation in a GLS1-dependent manner. In human organoids, aspartate entered the TCA cycle at the malate entry point, upstream of oxaloacetate. Our results demonstrate that the citrate-secretory phenotype of prostate organoids is supported by the known aspartate-oxaloacetate-citrate pathway, but also by at least three addnl. pathways: glutaminolysis, reductive carboxylation, and aspartate-malate conversion.Our results add a significant new dimension to the prostate citrate-secretory phenotype, with at least four distinct pathways being involved in citrate synthesis. Better understanding this distinctive citrate metabolic program will have applications in both male fertility as well as in the development of novel targeted anti-metabolic therapies for PCa.

Molecular Metabolism published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zeng, Tengchao; He, Guiping; Li, Xinxiang; Wang, Chaoxia published the artcile< Synthesis of reactive self-adhesive branched polyurethane dispersant for textile pigment printing>, Application In Synthesis of 112-63-0, the main research area is cotton fabric printing polyurethane dispersant.

A series of reactive branched polyurethane dispersants (BPUs) were successfully synthesized based on epoxy as reactive group and nitrogen-containing heterocycles as anchoring group. The branched polyurethane was adopted an ”A2 + B3” approach with diisocyanate prepolymer and trimethylolpropane. The structure, mol. weight, and thermodn. property of BPUs were characterized. The pigment dispersions were prepared with BPUs as the dispersant by ball milling, and then the characteristic parameters such as pigment particle size, viscosity, stability, color properties, and fastness were evaluated. Excellent dispersing performances were observed that the particle size of five dispersions were below 200 nm, with the viscosity as low as 6-9 mPa·s. It is worth noting that the pigment dispersion prepared by BPU exhibited excellent stability and self-adhesive performance. These dispersions were printed on cotton fabrics without adhesives, their water washing fastness was approx. grade 4. And the dry rubbing and wet rubbing fastnesses were 3 and 2-3, resp.

Journal of Applied Polymer Science published new progress about Cotton textiles. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peeters, Emiel; Van Hal, Paul A.; Meskers, Stefan C. J.; Janssen, Rene A. J.; Meijer, E. W. published the artcile< Photoinduced electron transfer in a mesogenic donor-acceptor-donor system>, COA of Formula: C19H34O2, the main research area is photoinduced electron transfer mesogenic oligophenylenevinylene; liquid crystalline mesogenic oligophenylenevinylene photoinduced electron transfer.

A novel donor-acceptor-donor mol. consisting of two oligo(p-phenylene vinylene) (OPV4) units attached to a central perylene bisimide (PERY) core is described. This OPV4-PERY-OPV4 is the first mesogenic mol. that incorporates both p- and n-type semiconducting properties and possesses a liquid-crystalline mesophase, in which donor and acceptor functionalities self-assemble into an ordered material. Upon photoexcitation of the donor, a subpicosecond electron-transfer reaction occurs in OPV4-PERY-OPV4, both in solution and in (ordered) thin solid films. The lifetime of the charge-separated state is significantly longer in (ordered) thin films than in solution as a result of a reduction of geminate recombination by migration and spatial separation of charges in the film.

Chemistry – A European Journal published new progress about Electrooptical effect. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics