Category: 112-63-0

Curd, Matthew E.; Morrison, Neil F.; Smith, Michael J. A.; Gajjar, Parmesh; Yousaf, Zeshan; Parnell, William J. published the artcile< Geometrical and mechanical characterization of hollow thermoplastic microspheres for syntactic foam applications>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hollow thermoplastic microsphere syntactic foam property.

Recently, hollow thermoplastic microspheres, have emerged as an innovative filler material for use in polymer-matrix composites. The resulting all-polymer syntactic foam takes on excellent damage tolerance properties, strong recoverability under large strains, and favorable energy dissipation characteristics. Aside from syntactic foams, thermoplastic microspheres are finding increasing usage in a variety of applications and industries. Despite this, there is an absence of statistical geometrical and mech. data for certain classes of thermoplastic microspheres. In this work we characterize two classes of thermoplastic microsphere using X-ray computed tomog., focused ion beam and electron microscopy. We observe the spatial distribution of these microspheres within a polyurethane-matrix syntactic foam and show that the volume-weighted polydisperse shell diameters follow a normal distribution. Interestingly, polydispersity of the shell wall thickness is not observed and furthermore the wall thickness is not correlated to the shell diameter We utilize the geometrical information obtained in anal. micromech. techniques in the small strain regime to determine, for the first time, estimates of the Young’s modulus and Poisson’s ratio of the microsphere shell material itself. Our results contribute to potential future improvements in the design and fabrication of materials that employ thermoplastic microspheres, including syntactic foams.

Composites, Part B: Engineering published new progress about Bulk modulus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Scott, Nicholas A.; Lawson, Melissa A. E.; Hodgetts, Ryan James; Le Gall, Gwenaelle; Hall, Lindsay J.; Mann, Elizabeth R. published the artcile< Macrophage metabolism in the intestine is compartment specific and regulated by the microbiota>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is intestine macrophage metabolism microbiota; gut; macrophage; metabolism; microbiota.

Intestinal macrophages play a vital role in the maintenance of gut homeostasis through signals derived from the microbiota. We previously demonstrated that microbial-derived metabolites can shape the metabolic functions of macrophages. Here, we show that antibiotic-induced disruption of the intestinal microbiota dramatically alters both the local metabolite environment and the metabolic functions of macrophages in the colon. Broad-spectrum antibiotic administration in mice increased the expression of the large neutral amino acid transporter LAT1 and accordingly, amino acid uptake. Subsequently, antibiotic administration enhanced the metabolic functions of colonic macrophages, increasing phosphorylation of components of mammalian/mechanistic target of rapamycin signalling pathways, with increased expression of genes involved in glycolysis and oxidative phosphorylation (OXPHOS), increased mitochondrial function, increased rate of extracellular acidification (ECAR; measure of glycolysis) and increased rate of oxygen consumption (OCR; measure of OXPHOS). Small bowel macrophages were less metabolically active than their colonic counterparts, with macrophage metabolism in the small intestine being independent of the microbiota. Finally, we reveal tissue-resident Tim4+ CD4+ macrophages exhibit enhanced fatty acid uptake alongside reduced fatty acid synthesis compared to recruited macrophages. Thus, the microbiota shapes gut macrophage metabolism in a compartment-specific manner, with important implications for monocyte recruitment and macrophage differentiation.

Immunology published new progress about Acidification (extracellular). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Buker, Nicholas; Firestone, Kimberly A.; Haller, Marnie; Purvis, Lafe; Lao, David; Snoeberger, Robert; Jen, Alex K.-Y.; Dalton, Larry R. published the artcile< Functionalized guanidines for electro-optic materials>, Computed Properties of 112-63-0, the main research area is guanidine imidazole benzimidazole preparation nonlinear optical chromophore; UV visible absorption hyperpolarizability guanidine containing nonlinear optical chromophore; functionalized guanidine electrooptical material.

Guanidines derived from imidazoles or benzimidazoles such as I are prepared as potential nonlinear optical chromophores. Condensation of 4-nitrobenzaldehyde with 4,5,5-trimethyl-3-cyano-2,5-dihydrofuranylidenemalononitrile, reduction of the nitro group, and substitution of 1,3-dimethyl-2-chloroimidazolidinium chloride by the aromatic amine yields I. Olefination of 3,4-dibutyl-2-thiophenecarboxaldehyde with di-Et 4-nitrophenylphosphonate, formylation of the thiophene ring, condensation with 4,5,5-trimethyl-3-cyano-2,5-dihydrofuranylidenemalononitrile, reduction of the nitro group, and reaction with either 1,3-dimethyl-2-chloroimidazolidinium chloride or 1,3-dimethyl-2-chlorobenzimidazolium chloride provides the thiophene-containing chromophores. I has both a lower UV-visible absorption wavelength maximum and a higher hyperpolarizability than the comparable chromophore lacking the guanidine; guanidine-containing chromophores with a divinylthiophene linker have decreased hyperpolarizabilities compared to the chromophore lacking the guanidine. Guanidine-containing chromophores are more stable to heat than the related diethylamino chromophores.

Materials Research Society Symposium Proceedings published new progress about Chromophores. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Qihong; Dong, Shi; Shi, Yuanyuan; Lu, Tiangong published the artcile< Guizhi-Fuling formula inhibits ovarian cancer progression by targeting STAT3 signaling network>, Formula: C19H34O2, the main research area is guizhi fuling formula ovarian cancer progression STAT3 signal transduction.

Ovarian cancer (OC) is the most lethal gynecol. malignancy. Frequent peritoneal dissemination is the main cause of low survival rate. Guizhi-Fuling formula (GZFL) is a classical traditional Chinese herbal formula, and has been clin. used for treating ovarian cancer with good outcome. However, its therapeutic mechanism for treating OC has not been clearly elucidated. Network pharmacol. anal. was used to predict potential mol. mechanisms of GZFL in treating OC. In vitro and in vivo anal., including STAT3 KO/WT cells proliferation assay, scratch assay and antitumor efficacy study were performed to assess the biol. activity of GZFL on targeting STAT3 in OC cells. We generated a “”GZFL target – OC – STAT3″” gene interaction network, and predicted that GZFL is tightly associated with IL6/JAK/STAT3 signal pathway and cancer metastasis. Our preliminary data showed that GZFL inhibited OC cell proliferation in a STAT3 dependent manner. It suppressed cell migration and downregulated p-STAT3 expression. In a tumor bearing mouse model, GZFL displayed a safety profile. GZFL inhibits OC progression by targeting STAT3 signaling network. Our newly proposed pharmacol. mechanisms of Guizhi-Fuling formula will provide a new insight for its clin. use in treating OC.

TMR Modern Herbal Medicine published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ma, Mengying; Cai, Haoran; Xu, Chenlu; Huang, Renzhi; Wang, Shurong; Pan, Huilin; Hu, Yong-Sheng published the artcile< Engineering Solid Electrolyte Interface at Nano-Scale for High-Performance Hard Carbon in Sodium-Ion Batteries>, Reference of 112-63-0, the main research area is carbon engineering solid electrolyte interface nanoscale sodium ion battery.

Engineering the structure and chem. of solid electrolyte interface (SEI) on electrode materials is crucial for rechargeable batteries. Using hard carbon (HC) as a platform material, a correlation between Na+ storage performance, and the properties of SEI is comprehensively explored. It is found that a “”good”” SEI layer on HC may not be directly associated with certain kinds of SEI components, such as NaF and Na2O. Whereas, arranging nano SEI components with refined structures constructs the foundation of “”good”” SEI that enables fast Na+ storage and interface stability of HC in Na-ion batteries. A layer-by-layer SEI on HC with inorganic-rich inner layer and tolerant organic-rich outer flexible layer can facilitate excellent rate and cycling life. Besides, SEI layer as the gate for Na+ from electrolyte to HC electrode can modulate interfacial crystallog. structures of HC with pillar-solvent that function as “”pseudo-SEI”” for fast and stable Na+ storage in optimal 1 M NaPF6-TEGDME electrolytes. Such a layer-by-layer SEI combined with a “”pseudo-SEI”” layer for HC enables an outstanding rate of 192 mAh g-1 at 2 C and stable cycling over 1100 cycles at 0.5 C. This study provides valuable guidance to improve the electrochem. performance of electrode materials through regulation of SEI in optimal electrolytes.

Advanced Functional Materials published new progress about Correlation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Doebelin, Christelle; Patouret, Remi; Garcia-Ordonez, Ruben D.; Chang, Mi Ra; Dharmarajan, Venkatasubramanian; Novick, Scott; Ciesla, Anthony; Campbell, Sean; Solt, Laura A.; Griffin, Patrick R.; Kamenecka, Theodore M. published the artcile< Identification of potent RORβ modulators: Scaffold variation>, Application In Synthesis of 112-63-0, the main research area is aminothiophene preparation retinoid related orphan receptor RORbeta modulator; Aminothiophene; Nuclear receptor; RORβ; Selective ligand.

The authors sought to develop RORβ-selective probe mols. to investigate the function of the receptor in vitro and in vivo and its role in the pathophysiol. of disease. To accomplish this, the authors modified a potent dual RORβ/RORγ inverse agonist from the primary literature with the goal of improving selectivity for RORβ vs. RORγ. Truncation of the Western portion of the mol. ablated activity at RORγ and led to a potent series of RORβ modulators. Continued exploration of this series investigated alternate replacement cores for the aminothiazole ring. Numerous suitable replacements were found during the course of the authors’ SAR investigations and are reported herein.

Bioorganic & Medicinal Chemistry Letters published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pajak, Beata published the artcile< Looking for the Holy Grail-Drug Candidates for Glioblastoma Multiforme Chemotherapy>, Computed Properties of 112-63-0, the main research area is review glioblastoma multiforme chemotherapy; clinical trials; drug candidates; glioblastoma multiforme (GBM); glycolysis inhibitors; immunomodulatory action; kinases inhibitors.

A review. Glioblastoma multiforme (GBM) is the deadliest and the most heterogeneous brain cancer. The median survival time of GBM patients is approx. 8 to 15 mo after initial diagnosis. GBM development is determined by numerous signaling pathways and is considered one of the most challenging and complicated-to-treat cancer types. Standard GBM therapy consist of surgery followed by radiotherapy or chemotherapy, and combined treatment. Current standard of care (SOC) does not offer a significant chance for GBM patients to combat cancer, and the selection of available drugs is limited. For almost 20 years, there has been only one drug, Temozolomide (TMZ), approved as a first-line GBM treatment. Due to the limited efficacy of TMZ and the high rate of resistant patients, the implementation of new chemotherapeutics is highly desired. However, due to the unique properties of GBM, many challenges still need to be overcome before reaching a ‘breakthrough’. This review article describes the most recent compounds introduced into clin. trials as drug candidates for GBM chemotherapy.

Biomedicines published new progress about Chemotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Majumdar, K. C.; Muhuri, S. published the artcile< Regioselective synthesis of polyheterocyclic scaffolds by sequential [3,3] sigmatropic rearrangements and pyridine hydrotribromide mediated heterocyclization>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aryloxypropynyloxy methylpyranone preparation thionation Claisen rearrangement; aryloxymethyloxopyranothiopyran preparation sigmatropic rearrangement enolization pyridine hydrotribromide regioselective heterocyclization; tetracyclic polyhetero scaffold bromo methyltrihydropyranothiopyranobenzopyranone preparation.

A number of tetracyclic polyhetero scaffolds, e.g., I, have been regioselectively synthesized in 70-75% yield from 4-[(3-aryloxy-2-propynyl)oxy]-6-methyl-pyran-2-ones via thionation of the lactone carbonyl, sequential Claisen rearrangements and pyridine hydrotribromide mediated heterocyclization.

Journal of Heterocyclic Chemistry published new progress about [3,3]-Sigmatropic rearrangement. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parzuchowski, Pawel; Maminski, Mariusz L. published the artcile< Poly-(3-ethyl-3-hydroxymethyl)oxetanes-synthesis and adhesive interactions with polar substrates>, Application of C19H34O2, the main research area is ethyl hydroxymethyl oxetane ring opening polymerization polar substrate; adhesive interaction; adhesion; hot melt adhesive; polyoxetanes.

Hyperbranched polyoxetanes are a relatively new class of polymers. These are branched polyethers that are synthesized from oxetanes-four-member cyclic ethers bearing hydroxymethyl groups-via ring-opening polymerization Four series of polyoxetanes were synthesized from 3-ethyl-3-(hydroxymethyl)oxetane and 1,1,1-tris(hydroxymethyl)propane as a core mol. Reagents ratios ranged from 1:5 to 1:50, theor. molar mass ranged from 714 g/mol to 5942 g/mol, and dispersities ranged from 1.77 to 3.75. The morphol. of the macromols. was investigated by a matrix-assisted laser desorption/ionization time of flight technique. The polyoxetanes’ adhesive interactions with polar materials were analyzed and provided results as follows: the work of adhesion was 101-105 mJ/m2, the bond-line tensile shear strengths were 0.39-1.32 MPa, and there was a brittle fracture mode within the polymer. The findings confirmed a good adhesion to polar substrates, but further research on polyoxetane modifications toward a reduction of brittleness is necessary.

Polymers (Basel, Switzerland) published new progress about Adhesion, physical. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Tingting; Zhao, Min; Zhang, Yumeng; Qiu, Zhaozhao; Zhang, Yixin; Zhao, Chunjie; Wang, Miao published the artcile< Pharmacokinetic-pharmacodynamic modeling analysis and anti-inflammatory effect of Wangbi capsule in the treatment of adjuvant-induced arthritis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Wangbi Capsule anti inflammatory rheumatoid arthritis pharmacokinetic pharmacodynamic; Wangbi capsule; adjuvant-induced arthritis; pharmacokinetic-pharmacodynamic model; rheumatoid arthritis; traditional Chinese medicine.

Clin., Wangbi Capsule (WBC) is widely used in the treatment of Rheumatoid arthritis (RA) because of its remarkable therapeutic effect. To reveal the mechanism, a pharmacokinetic-pharmacodynamic (PK-PD) model was developed for the first time to assess the relationship between time-concentration (dose)-effect. Freund’s Complete Adjuvant was used to induce the adjuvant-induced arthritis model. Multi-indexes were used to evaluate the therapeutic effect and an S-Imax PK-PD model was established based on the concentrations of osthole, 5-O-methylvisamminoside, cimifugin, albiflorin, paeoniflorin and icariin and the levels of interleukin-1β and prostaglandin E2 using a two-compartment PK model together with a PD model with an effect-site compartment. The results suggest that WBC can treat RA by regulating the levels of prostaglandin E2 and interleukin-1β . For the PK-PD model, the parameters indicated that WBC had a large safety margin and all six bioactive ingredients of WBC have therapeutic effects on RA. Among them icariin, osthole and 5-O-methylvisamminoside may be the main effective substances. This study provided a scientific basis for further study of population pharmacokinetics / population pharmacodynamics (PPK/PPD), to develop a reasonable administration plan and improve individualized drug therapy.

Biomedical Chromatography published new progress about Arthritis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics