Category: 112-63-0

Chmielewski, Piotr J.; Latos-Grazynski, Lechoslaw published the artcile< EPR and 2H NMR studies on the oxidation of nickel(II) tetraphenylcarbaporphyrin to form novel organometallic Ni(III) complexes>, Synthetic Route of 112-63-0, the main research area is EPR oxidation nickel 2 tetraphenylcarbaporphyrin complex; NMR oxidation nickel 2 tetraphenylcarbaporphyrin complex; electrochem oxidation nickel 2 tetraphenylcarbaporphyrin complex.

One-electron oxidation of nickel(II) 5,10,15,20-tetraaryl-2-aza-21-carbaporphyrin ((CTPP)NiII) and nickel(II) 2-methyl-5,10,15,20-tetraaryl-2-aza-21-carbaporphyrin ((MeCTPP)NiII) gave rare organonickel(III) derivatives The half-wave potential for the 1st oxidation of (CTPP)NiII and (MeCTPP)NiII is 0.66 V and 0.72 V, resp. (vs. SCE, CH2Cl2 solution, TBAP). The EPR spectral patterns of the 1-electron-oxidized species were determined at 293 and 77 K. In both temperatures the spectral parameters markedly depend on the axial ligand introduced by oxidants or in metathesis. In each case the spin-Hamiltonian parameters (gav > 2.1 (77 K) or giso > 2.1 (293 K)) reveal a metal-centered oxidation rather than a cation radical formation (giso ≈ 2.002). The localization of the 1-electron oxidation on the nickel ion was supported by the observation of 61Ni hyperfine splitting. The 2H NMR studies, carried out for pyrrole deuterated derivatives: (CTPP-d7)NiIIIBr, (CTPP-d7)NiIII(NO3), and (MeCTPP-d3)NiIIIOH, confirmed independently by the nickel(III) electronic structure.

Inorganic Chemistry published new progress about Electrochemical oxidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Das, Srabani; Ghosal, Pradyot K.; Ray, Bimalendu published the artcile< Structural studies of a polysaccharide from the seeds of Salmalia malabarica>, Related Products of 112-63-0, the main research area is Salmalia seed polysaccharide.

The polysaccharides isolated from the defatted seeds of Salmalia malabarica (Bombacaceae) were fractionated into Fractions I (48%), II (30%), III (14%), and IV (8%) using a column of Sephadex G-100 in pyridine-acetate buffer. The principal polysaccharide fraction, Fraction I (carbohydrate content 98%), was found to be electrophoretically homogeneous. Hydrolysis (M sulfuric acid, 16 h, 100°) of Fraction I revealed galactose and arabinose by paper chromatog. in a relative ratio of 7:3 as determined by gas-liquid chromatog. of their alditol acetates using myo-inositol as the internal standard The configuration of the galactose and arabinose were determined as D and L, resp., from their optical rotation measurements. Complete methylation of Fraction I by the Hakomori method (1964) and hydrolysis of the methylated polysaccharide yielded 2,3,5-tri-O-methyl-L-arabinofuranose (4.1 mol. equivalent), 2,3,4-tri-O-methyl-L-arabinopyranose (11 mol. equivalent), 2,3,4,6-tetra-O-methyl-D-galactose (0.85 mol. equivalent), 2,3,6-tri-O-methyl-D-galactopyranose (10.8 mol. equivalent), 2,4,6-tri-O-methyl-D-galactopyranose (2.2 mol. equivalent), 3,6-di-O-methyl-D-galactose (12.4 mol. equivalent), and 3,4-di-O-methyl-D-galactose (7.0 mol. equivalent). These products reveal that both L-arabinopyranose and L-arabinofuranose are present at the nonreducing ends. A small number of the nonreducing termini are occupied by D-galactose. Appearance of a large molar proportion of the tri-O-Me pentoses shows that the polysaccharide is highly branched. The major portion of the interior part consists of D-galactose residues linked (1→2,6) and (1→2,4). A portion of the chain was made by D-galactose linked principally (1→4). There was a small portion of D-galactose residues linked (1→3). The polysaccharide Fraction I consumed about 0.9 mol. equivalent of periodate per mol of hexosyl residue as was monitored spectrophotometrically. Only D-galactose was detected in the paper chromatogram when the periodate-oxidized, borohydride-reduced material was hydrolyzed with sulfuric acid (0.5 M). This observation was in fair agreement with the linkage pattern as suggested from the methylation anal.

Carbohydrate Research published new progress about Bombax ceiba. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Varn, Frederick S.; Johnson, Kevin C.; Martinek, Jan; Huse, Jason T.; Nasrallah, MacLean P.; Wesseling, Pieter; Cooper, Lee A. D.; Malta, Tathiane M.; Wade, Taylor E.; Sabedot, Thais S.; Brat, Daniel; Gould, Peter V.; Woehrer, Adelheid; Aldape, Kenneth; Ismail, Azzam; Sivajothi, Santhosh K.; Barthel, Floris P.; Kim, Hoon; Kocakavuk, Emre; Ahmed, Nazia; White, Kieron; Datta, Indrani; Moon, Hyo-Eun; Pollock, Steven; Goldfarb, Christine; Lee, Ga-Hyun; Garofano, Luciano; Anderson, Kevin J.; Nehar-Belaid, Djamel; Barnholtz-Sloan, Jill S.; Bakas, Spyridon; Byrne, Annette T.; D’Angelo, Fulvio; Gan, Hui K.; Khasraw, Mustafa; Migliozzi, Simona; Ormond, D. Ryan; Paek, Sun Ha; Van Meir, Erwin G.; Walenkamp, Annemiek M. E.; Watts, Colin; Weiss, Tobias; Weller, Michael; Palucka, Karolina; Stead, Lucy F.; Poisson, Laila M.; Noushmehr, Houtan; Iavarone, Antonio; Verhaak, Roel G. W. published the artcile< Glioma progression is shaped by genetic evolution and microenvironment interactions>, Category: esters-buliding-blocks, the main research area is transcriptome CDKN2A IDH mutation neoplastic signaling prognosis glioma; genomics; glioblastoma; glioma; hypermutation; macrophages; microenvironment; neurons; single-cell; spatial imaging; treatment resistance.

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histol. feature composition, somatic alterations, and microenvironment interactions. Hypermutation and acquired CDKN2A deletions were associated with an increase in proliferating neoplastic cells at recurrence in both glioma subtypes, reflecting active tumor growth. IDH-wild-type tumors were more invasive at recurrence, and their neoplastic cells exhibited increased expression of neuronal signaling programs that reflected a possible role for neuronal interactions in promoting glioma progression. Mesenchymal transition was associated with the presence of a myeloid cell state defined by specific ligand-receptor interactions with neoplastic cells. Collectively, these recurrence-associated phenotypes represent potential targets to alter disease progression.

Cell (Cambridge, MA, United States) published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (CCND2). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

van Rijssel, Erwin R.; Goumans, Theodorus P. M.; Lodder, Gerrit; Overkleeft, Herman S.; van der Marel, Gijsbert A.; Codee, Jeroen D. C. published the artcile< Chiral Pyrroline-Based Ugi-Three-Component Reactions Are under Kinetic Control>, Application of C19H34O2, the main research area is chiral pyrroline Ugi kinetic control.

Although it is often assumed that the stereochem. in Ugi multicomponent reactions is determined in the final Mumm rearrangement step, exptl. and computational evidence that Ugi reactions on hydroxylated pyrrolines proceed under kinetic control is reported. The stereochem. of the reaction is established with the addition of the isocyanide to the intermediate iminium ion, whose conformation is determined by its substitution pattern.

Organic Letters published new progress about Addition reaction, stereoselective (isocyanide). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ried, Walter; Stahlhofen, Paul published the artcile< Heterocyclic seven-membered ring systems. VII. The course of the reaction between ο-phenylenediamine and alkylidenepyruvic acids>, Category: esters-buliding-blocks, the main research area is .

The product from the condensation of ο-C6H4(NH2)2 (I) and PhCH:CHCOCO2H (II) is 2-hydroxy-3-styrylquinoxaline (III) and not 7-phenyl-2,3-benzo-1,4-diazacyclohepta-2,7-dien-5-one (IV) which is excluded since III was also obtained from I and II Me ester when the presence of O was carefully avoided. IV was obtained from I and BzCH2CO2Et (V). Analogs of III were also prepared I (2.1 g.) in 20 cc. alc. treated at 40-50° with an equimolar amount of RCH:CHCOCO2H gave 3-alkylidenemethyl-2-hydroxyquinoxalines (R, % yield, m.p., and crystallization solvent given): Ph (III), 57, 256°, dioxane; p-MeOC6H4, 61, 257°, dioxane; 2-furyl, 76, 262°, xylene; 3,4-(CH2O2)C6H3, 59, 300°, dioxane. 2-Hydroxy-3-methylquinoxaline (3.2 g.), 75 cc. xylene, 2.1 g. BzH, and 5-10 drops piperidine refluxed 5 hrs., 30 cc. solvent distilled, and the residue let stand several days precipitated III. III (1 g.) in 800 cc. EtOAc hydrogenated over Raney Ni, filtered, the EtOAc distilled, the oil in HOAc treated dropwise with a saturated aqueous solution of 2 g. NaNO2, kept 2 hrs., and filtered gave 1,4-dinitroso-2-hydroxy-3-(β-phenylethyl)-1,2,3,4-tetrahydroquinoxaline, m. 131° (decomposition) (alc. H2O). V (12.8 g.) in 50 cc. xylene added dropwise during 0.5 hr. to a boiling solution of 7.2 g. I in 50 cc. xylene, 30 cc. solvent distilled during 0.5 hr., and the mixture cooled gave 11 g. IV, m. 206° (dioxane); picrate, m. 168° (alc.). IV (3.3 g.) in 300 cc. EtOAc hydrogenated over Raney Ni and the filtered solution concentrated to 20 cc. gave 7-phenyl-2,3-benzo-1,4-diazacyclohept-2-en-5-one (VI), m. 167° (EtOAc); 1-NO derivative, m. 181° (decomposition) (MeOH). Similarly prepared were the 7-(2-furyl) analog of IV, m. 250° (dioxane) [pic-rate, m. 195° (decomposition) (alc.)], and the 7-(2-furyl) analog of VI, m. 169° (C6H6).

Chemische Berichte published new progress about Heterocyclic compounds, oxygen. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Rodrigues-Junior, Dorival Mendes; Liu, Sijia; Webb, Anna Taylor; Gomez-Puerto, Maria Catalina; ten Dijke, Peter; Heldin, Carl-Henrik; Moustakas, Aristidis published the artcile< The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma>, Application of C19H34O2, the main research area is protein kinase LKB1 self renewal invasiveness glioblastoma; LKB1; cancer stem cells; glioblastoma; invasion; metformin.

The role of liver kinase B1 (LKB1) in glioblastoma (GBM) development remains poorly understood. LKB1 may regulate GBM cell metabolism and has been suggested to promote glioma invasiveness. After analyzing LKB1 expression in GBM patient mRNA databases and in tumor tissue via multiparametric immunohistochem., we observed that LKB1 was localized and enriched in GBM tumor cells that co-expressed SOX2 and NESTIN stemness markers. Thus, LKB1-specific immunohistochem. can potentially reveal subpopulations of stem-like cells, advancing GBM patient mol. pathol. We further analyzed the functions of LKB1 in patient-derived GBM cultures under defined serum-free conditions. Silencing of endogenous LKB1 impaired 3D-gliomasphere frequency and promoted GBM cell invasion in vitro and in the zebrafish collagenous tail after extravasation of circulating GBM cells. Moreover, loss of LKB1 function revealed mitochondrial dysfunction resulting in decreased ATP levels. Treatment with the clin. used drug metformin impaired 3D-gliomasphere formation and enhanced cytotoxicity induced by temozolomide, the primary chemotherapeutic drug against GBM. The IC50 of temozolomide in the GBM cultures was significantly decreased in the presence of metformin. This combinatorial effect was further enhanced after LKB1 silencing, which at least partially, was due to increased apoptosis. The expression of genes involved in the maintenance of tumor stemness, such as growth factors and their receptors, including members of the platelet-derived growth factor (PDGF) family, was suppressed after LKB1 silencing. The defect in gliomasphere growth caused by LKB1 silencing was bypassed after supplementing the cells with exogenous PFDGF-BB. Our data support the parallel roles of LKB1 in maintaining mitochondrial homeostasis, 3D-gliomasphere survival, and hindering migration in GBM. Thus, the natural loss of, or pharmacol. interference with LKB1 function, may be associated with benefits in patient survival but could result in tumor spread.

Journal of Cellular Physiology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russo, Vincenzo; Rossano, Carmelina; Salucci, Emiliano; Tesser, Riccardo; Salmi, Tapio; Di Serio, Martino published the artcile< Intraparticle diffusion model to determine the intrinsic kinetics of ethyl levulinate synthesis promoted by Amberlyst-15>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Levulinic acid esterification kinetics Amberlyst catalyst intraparticle diffusion model.

Levulinic acid and its esters are considered very versatile chem. compounds used for a wide range of derivatives Traditionally Et levulinate is synthesized in batch reactors, using homogeneous catalysts (H2SO4, H3PO4). Several investigations were reported on solid acid catalysts, as zeolites, sulfated oxides, sulfonic ion-exchange resins. Amberlyst-15 showed high potentials: to design a continuous reactor, it is necessary to investigate the stability of the catalyst and the kinetics of the reaction. In the present work, we demonstrated that the resin is stable for more than 5 days. Kinetic and mass transfer phenomena were studied, evaluating the partition and take-up of the used resin when put in contact with reactants and products. Two different samples of Amberlyst-15 were used, characterized by different size, demonstrating that bigger particles lead to higher intraparticle diffusion limitations.

Chemical Engineering Science published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Yifan; Li, Chao; Zhang, Shu; Li, Qiaoling; Gholizadeh, Mortaza; Wang, Yi; Hu, Song; Xiang, Jun; Hu, Xun published the artcile< Pyrolysis of soybean residue: Understanding characteristics of the products>, Formula: C19H34O2, the main research area is soybean residue pyrolysis product.

Soybean residue (SR) is a main solid waste produced during the extraction of soybean oil with bulk volume In addition to the use as vegetable protein feed, SR could also be used as feedstock for producing biofuels and carbon materials via pyrolysis. In this study, the pyrolysis behaviors of SR at varied temperatures and heating rates were investigated. The results show that the pyrolysis of the organic components in SR could reach completion even at 500°C, due to the lower thermal stability of the organic component than that in the typical biomass. This also leads to the bio-oil with little heavy organics and also low carbon content of the resulting biochar, as the organic components decomposed to a significant extent while the charring reactions were insignificant. This leads to the biochar with low heating value and low energy yield when compared with that in the pyrolysis of typical biomass. In addition, the high content of proteins, amino acids and other nitrogen-containing nutrients make the SR derived bio-oil nitrogen-rich and a significant portion of nitrogen could also be retained in the biochar. These specialties have to be considered during their applications as either biofuels or functional carbon materials.

Renewable Energy published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Jinmeng; Liu, Yuhang; Liu, Lei; He, Song; Du, Zhuzhu; Wang, Ke; Xie, Linghai; Du, Hongfang; Ai, Wei published the artcile< Expediting Sulfur Reduction/Evolution Reactions with Integrated Electrocatalytic Network: A Comprehensive Kinetic Map>, COA of Formula: C19H34O2, the main research area is lithium sulfur battery reduction evolution reaction electrocatalytic kinetics; Electrocatalytic network; Li−S batteries; kinetic evolution map; practical conditions; versatile catalytic capability.

Electrocatalysts are considered the most promising candidates in ameliorating the slow kinetics of Li-S batteries (LSBs), however, the issue of insufficient catalytic capability remains to be addressed. Herein, we report an integrated catalytic network comprising graphitic carbon-encapsulated/bridged ultrafine NiCoP embedded in N, P-codoped carbon (GC-uNiCoP@NPC) as a highly competent catalyst for sulfur-based species conversions. By profiling the evolution map of Li-S chem. via operando kinetic analyses, GC-uNiCoP@NPC is demonstrated to possess versatile yet efficient catalytic activity for sulfur reduction/evolution reactions, especially the rate-determining heterogeneous phase transitions. As a result, GC-uNiCoP@NPC enables high capacity and stable cycling of sulfur cathode under high areal loading and lean electrolyte. Moreover, pouch cells assembled under practical conditions present promising performance with a specific energy of 302 Wh kg-1. This work not only conceptually expands the catalyst design for LSBs but also provides a comprehensive insight into the catalyst performance for Li-S chem.

Nano Letters published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Muqun; Liang, Shaofeng; Gao, Wei; Qin, Yuxuan published the artcile< The effect of promoting hydrogen bond aggregation based on PEMTC on the mechanical properties and shape memory function of polyurethane elastomers>, COA of Formula: C19H34O2, the main research area is polyurethane elastomer carbamate hydrogen bond aggregation shape memory property; hydrogen bond elastomer; polyurethane; shape memory; toughness.

In this work, small mol. diols named PEMTC were synthesized from isophorone diisocyanate, N-(2-hydroxyethyl) acrylamide and trimethylolpropane by a semi-directional method. PEMTC (2-(prop-2-enamido)ethyl N-{3-[({[2-ethyl-3-hydroxy-2(hydroxymethyl)propoxy]carbonyl}amino)methyl]-3, 5,5-trimethylcyclohexyl}carbamate) contains hydrogen bond active site and light-initiated C=C. We introduced it as a branch chain block into poly(ε-caprolactone) (PCL). By feeding and monitoring the reaction process, we synthesized a large number of polyurethane elastomers, hydrogen bonds PCL-based elastomer (HPE), which contain a large number of dynamic hydrogen bonds. Under UV irradiation, PEMTC can make HPE mols. aggregate and crosslink, improve the degree of internal hydrogen bonding interaction of HPE materials and endow HPE materials with good elasticity, toughness, heat resistance and shape memory ability. After 270 nm UV irradiation, the elongation at break of HPE materials decreased from 607.14-1463.95% to 426.60-610.36%, but the strength at break of HPE materials increased from 3.36-13.52 to 10.28-41.52 MPa, and the toughness increased from 16.36-129.71 to 40.48-172.22 MJ m-3. In addition, the highest shape fixation rate of HPE after UV irradiation was 98.0%, and the recovery rate was 93.7%.

Royal Society Open Science published new progress about Breaking strength. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics