Category: 112-63-0

Nakamatsu, Seiken; Toyota, Shinji; Jones, William; Toda, Fumio published the artcile< The important role of solvent vapor in an organic solid state reaction>, Category: esters-buliding-blocks, the main research area is solvent vapor important role organic solid state reaction.

Some organic reactions in the solid state proceeded very efficiently and selectively in the presence of a small amount of solvent vapor.

Chemical Communications (Cambridge, United Kingdom) published new progress about Addition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ishola, Ahmed Adebayo; Adewole, Kayode Ezekiel published the artcile< Phytosterols and triterpenes from Morinda lucida Benth. exhibit binding tendency against class I HDAC and HDAC7 isoforms>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Morinda phytosterol triterpene HDAC isoform; Anticancer; HDACs; Morinda lucida; Phytosterols; Triterpenes.

The important role of histone deacetylases (HDACs) in the development of cancer has been demonstrated by various studies. Thus targeting HDACs with inhibitors is a major focus in anticancer drug research. Although few synthetic HDAC inhibitors (HDIs) have been approved for cancer treatment, they have significant undesirable side effects. Therefore emphases have been placed on natural HDIs as substitutes for the synthetic ones. In a bid to identify more HDIs, this study evaluated the binding tendency of compounds derived from Morinda lucida Benth. towards selected HDACs for the discovery of potent HDIs as potential candidates for anticancer therapeutics, based on the report of anticancer potentials of Morinda lucida-derived extracts and compounds Druglikeness and Absorption-Distribution-Metabolism-Excretion (ADME) parameters of the top 7 compounds were evaluated using the Swiss online ADME web tool. The results revealed that out of the 49 compounds, 3 phytosterols (campesterol, cycloartenol, and stigmasterol) and 2 triterpenes (oleanolic acid and ursolic acid) exhibited high HDAC inhibitory activity compared to givinostat. These 5 compounds also fulfill oral drugability of Lipinski rule of five. Morinda lucida-derived phytosterols and triterpenes show high binding tendency towards the selected HDACs and exhibited good drugability characteristics and are therefore good candidates for further studies in the search for therapies against abnormalities linked with over-activity of HDACs.

Molecular Biology Reports published new progress about Morinda lucida. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Linnenkugel, Sebastian; Paterson, Anthony H. J.; Huffman, Lee M.; Bronlund, John E. published the artcile< Prediction of the effect of water on the glass transition temperature of low molecular weight and polysaccharide mixtures>, COA of Formula: C19H34O2, the main research area is polysaccharide mixture water glass transition temperature low mol weight.

The right storage conditions for food powders containing amorphous carbohydrates are crucial to avoid structural changes. By combining the sorption isotherm and the glass transition temperature (Tg) data for these food powders enables the determination of appropriate moisture and temperature conditions for their storage. In this study, the modified Flory-Huggins free volume theory was utilized to predict the stability diagrams purely from the composition of the powders. The validation of the approach using the literature data of blends of grapefruit, mango and acai powders with various blends of maltodextrin (MD) and gum Arabic. The blends of fructose, glucose individual and in combination with citric acids as well as blackcurrant juice concentrate with MD DE 9-13 were also investigated. The alignment of exptl. and predicted data of fruit powders demonstrates that it was possible to predict the relation of the Tg well as a function of the water activity for carbohydrate mixtures

Food Hydrocolloids published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Holland, Herbert L.; Kindermann, Maik; Kumaresan, Sudalaiyandi; Stefanac, Tomislav published the artcile< Side chain hydroxylation of aromatic compounds by fungi. Part 5. Exploring the benzylic hydroxylase of Mortierella isabellina>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hydroxylation stereochem aromatic compound fungi; Mortierella isabellina hydroxylation aromatic compound; active site model benzylic hydroxylase enzyme.

The active site topog. of the hydroxylase enzyme of Mortierella isabellina ATCC 42613, which carries out the benzylic hydroxylation of toluene, ethylbenzene, and related compounds, has been explored. Operating in a whole cell biotransformation mode, this enzyme shows selectivity in substrate processing based on the nature, position and size of substituent side chains close to the site of hydroxylation. The results of determination of the yield and stereochem. of hydroxylation of over twenty substrates and potential substrates, together with previously reported data, have been used to propose an active site model for the benzylic hydroxylase enzyme.

Tetrahedron: Asymmetry published new progress about Hydroxylation, enzymic. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Krapcho, A. Paul; Jahngen, Edwin G. E. Jr.; Kashdan, David S. published the artcile< α-Carbalkoxylations of carboxylic acids. General synthetic route to monoesters of malonic acids>, Formula: C19H34O2, the main research area is carboxylation carboxylic acid; malonic acid monoester.

Treatment of α-anions of acyclic and alicyclic carboxylic acids, prepared by reaction of the acid with LiN(CHMe2)2, with either ClCO2Et or (RO)2CO (R = Me, Et) gave 46-88% of monoesters of malonic acids. Thus, Me2CHCO2H reacted with ClCO2Et in the presence of LiN(CHMe2)2 to give 85% Me2C(CO2H)CO2Et.

Tetrahedron Letters published new progress about Carboxylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xing; Chen, Honglin; Xie, Shuting; Wang, Ning; Wu, Sujuan; Duan, Yuyou; Zhang, Minmin; Shui, Lingling published the artcile< Fabrication of photo-crosslinkable poly (trimethylene carbonate)/polycaprolactone nanofibrous scaffolds for tendon regeneration>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is polyester polycarbonate scaffold youngs modulus yield strain; composite scaffolds; creep resistance; photo-crosslinking; poly(trimethylene carbonate); tissue engineering.

The treatment of tendon injuries remains a challenging problem in clin. due to their slow and insufficient natural healing process. Scaffold-based tissue engineering provides a promising strategy to facilitate tendon healing and regeneration. However, many tissue engineering scaffolds have failed due to their poor and unstable mech. properties. To address this, we fabricated nanofibrous polycaprolactone/methacrylated poly(trimethylene carbonate) (PCL/PTMC-MA) composite scaffolds via electrospinning. PTMC-MA was characterized by NMR. Fiber morphol. of composite scaffolds was evaluated using SEM. The monotonic tensile test was performed for determining the mech. properties of composite scaffolds. Cell viability and collagen deposition were assessed via PrestoBlue assay and ELISA, resp. These PCL/PTMC-MA composite scaffolds had an increase in mech. properties as PTMC-MA content increase. After photo-crosslinking, they showed further enhanced mech. properties including creep resistance, which was superior to pure PCL scaffolds. It is worth noting that photo-crosslinked PCL/PTMC-MA (1:3) composite scaffolds had a Young’s modulus of 31.13 ± 1.30 MPa and Max stress at break of 23.80 ± 3.44 MPa that were comparable with the mech. properties of native tendon (Young’s modulus 20-1200 MPa, max stress at break 5-100 MPa). In addition, biol. experiments demonstrated that PCL/PTMC-MA composite scaffolds were biocompatible for cell adhesion, proliferation, and differentiation.

International Journal of Nanomedicine published new progress about Electrospinning. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Konstandaras, Nicholas; Dunn, Michelle H.; Guerry, Max S.; Barnett, Christopher D.; Cole, Marcus L.; Harper, Jason B. published the artcile< The impact of cation structure upon the acidity of triazolium salts in dimethyl sulfoxide>, Product Details of C19H34O2, the main research area is triazolium salt acidity DMSO.

A series of triazolium salts, selected for their varying electronic and steric properties, were prepared and their pKa values were determined in DMSO at 25 °C using the bracketing indicator method. The effect of each systematic structural variation upon the acidity of the triazolium cation has been considered, in particular examining the effects of systematically altering electronic properties, quantified through the use of Hammett σ parameters. The first pKa value for an azolium salt that generates a mesionic carbene is also reported. These new data allow for the selection of appropriate bases for the deprotonation of such triazolium salts and the potential to correlate the pKa values determined herein with the nucleophilicity of the corresponding carbenes.

Organic & Biomolecular Chemistry published new progress about Bronsted acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kariofillis, Stavros K.; Jiang, Shutian; Zuranski, Andrzej M.; Gandhi, Shivaani S.; Martinez Alvarado, Jesus I.; Doyle, Abigail G. published the artcile< Using Data Science To Guide Aryl Bromide Substrate Scope Analysis in a Ni/Photoredox-Catalyzed Cross-Coupling with Acetals as Alcohol-Derived Radical Sources>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is arene preparation; aryl halide dialkyl acetal photochem cross coupling nickel catalyst.

Ni/photoredox-catalyzed (deutero)methylation and alkylation of aryl halides RX (R = Ph, Ac, t-Bu, etc.; X = Br, Cl) and benzaldehyde di(alkyl) acetals R1CH(OR2)2 (R1 = Ph, 4-(1H-imidazol-4-yl)benzen-1-yl, 5-tert-butyl-2-chlorophenyl, etc.; R2 = Me, Et, Bn, etc.) that serve as alc.-derived radical sources were reported. Reaction development, mechanistic studies, and late-stage derivatization of a biol. relevant aryl chloride, fenofibrate, are presented. Then, the integration of data science techniques, including DFT featurization, dimensionality reduction, and hierarchical clustering, to delineate a diverse and succinct collection of aryl bromides that is representative of the chem. space of the substrate class was described. By superimposing scope examples from published Ni/photoredox methods on this same chem. space, areas of sparse coverage and high vs. low average yields were identified, enabling comparisons between prior art and this new method. Addnl., it was demonstrated that the systematically selected scope of aryl bromides RBr can be used to quantify population-wide reactivity trends and reveal sources of possible functional group incompatibility with supervised machine learning.

Journal of the American Chemical Society published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Guoqiang; Zong, Xianqing; Sun, Meiling; Sun, Jie; Li, Xuebo published the artcile< Research and development of synthetic process of brominated SBS>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is synthetic process brominated SBS.

Styrene butadiene rubber SBS-4303 was selected as the reaction raw material, and the volume ratio of dichloromethane and methanol was 3.5% in the reactor In a mixed solvent of 5:1; Tetra-Et ammonium tribromide solid was prepared by adding bromine and tetra-Et ammonium bromide with a mass ratio of bromine: tetra-Et ammonium bromide: styrene butadiene rubber of 8:6:3 into water. Dissolve tetra-Et ammonium tribromide into a mixed solvent prepared by dichloromethane and methanol in proportion; The temperature of the reactor is controlled at 10°C, and the above mixed solution of tetra-Et ammonium tribromide is added to the reactor to slowly react with SBS-4303. After dropping, the heat preservation reaction is completed for 3 h, then tin tetrachloride with 2% mass of styrene butadiene rubber is added for catalytic reaction, and the temperature is slowly raised to 39°C, and the heat preservation reaction is continued for 10 h. After the reaction, add sufficient water into the distillation kettle, add TXP-10 dispersed emulsifier according to 3% of the water mass to completely dissolve it, and raise the temperature of the kettle to 90°C. Slowly add the solution after the reaction to the extraction kettle under stirring. While the product is precipitated during the dropping process, the reaction solvent is evaporated from the kettle at the same time, cooled and recycled. After centrifugation, drying and laboratory test, the precipitated products shall be tested according to 1 Dibutyltin maleate was added in the proportion of 5% to improve the thermal stability of the product. Finally, the product was packaged. Circulation and application of centrifugal liquid

Shandong Huagong published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maimulyanti, Askal; Prihadi, Anton Restu published the artcile< Integrated extraction by percolation, distillation, and soxhlet extraction to separate bioactive and bioenergy compounds from spent coffee ground>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is coffee ground caffeine chlorogenic acid percolation distillation soxhlet extraction.

The spent coffee ground has potential compounds applied in food and bioenergy. In this study, an integrated extraction to sep. chem. compounds from the spent coffee ground was designed. Furthermore, the extraction apparatus was combined for percolation, distillation, and Soxhlet extraction The distillation technique produces flavored coffee, Soxhlet extraction separates coffee oil; while percolation produces the coffee extract Anal. of coffee aroma using distillation techniques obtained alpha furfuryl alc. (52.16%), Me pyrazine (15.63%), and 2.6-di-Me paradiazine (9.62%). Anal. of coffee extract using the percolation technique obtained antioxidant compounds with IC50 (56.61μg/mL), polyphenols (1.25 mg/g), caffeine (7.88%), chlorogenic acid (1.25%), and tannins (21.22%). Anal. of coffee oil using the Soxhlet extraction technique obtained Me ester compounds that have the potential for biodiesel such as linoleic acid Me ester (39.90%), palmitic acid Me ester (34.30%), oleic acid Me ester (8.74%), and stearic acid Me ester (8.66%). The integrated extraction has successfully separated many chem. components from spent coffee ground dan it has added value to be applied in food, beverage, pharmaceutical, and bioenergy.

Rasayan Journal of Chemistry published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics