Category: 112-63-0

Versluis, Frank; Tomatsu, Itsuro; Kehr, Seda; Fregonese, Carlo; Tepper, Armand W. J. W.; Stuart, Marc C. A.; Ravoo, Bart Jan; Koning, Roman I.; Kros, Alexander published the artcile< Shape and Release Control of a Peptide Decorated Vesicle through pH Sensitive Orthogonal Supramolecular Interactions>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is protein peptide decorated vesicle cyclodextrin encapsulation.

A pH sensitive carrier is obtained by coating a cyclodextrin vesicle with an adamantane-terminated octapeptide through the formation of an inclusion complex. Upon lowering the pH from 7.4 to 5.0, the formation of peptide β-sheets on the vesicle surface induces a transition of the bilayer from a sphere to a fiber. This transition is fully reversible and repeatable. The vesicles release their cargo upon fiber formation.

Journal of the American Chemical Society published new progress about Conformational transition. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Barros, Jessica A. S.; Cavalcanti, Joao Henrique F.; Pimentel, Karla G.; Medeiros, David B.; Silva, Jose C. F.; Condori-Apfata, Jorge A.; Lapidot-Cohen, Taly; Brotman, Yariv; Nunes-Nesi, Adriano; Fernie, Alisdair R.; Avin-Wittenberg, Tamar; Araujo, Wagner L. published the artcile< The significance of WRKY45 transcription factor in metabolic adjustments during dark-induced leaf senescence>, COA of Formula: C19H34O2, the main research area is WRKY transcription factor metabolic adjustment dark leaf senescence; Arabidopsis thaliana; alternative pathways; energy depletion; mitochondria; transcription factor.

Plants are constantly exposed to environmental changes that affect their performance. Metabolic adjustments are crucial to controlling energy homoeostasis and plant survival, particularly during stress. Under carbon starvation, coordinated reprogramming is initiated to adjust metabolic processes, which culminate in premature senescence. Notwithstanding, the regulatory networks that modulate transcriptional control during low energy remain poorly understood. Here, we show that the WRKY45 transcription factor is highly induced during both developmental and dark-induced senescence. The overexpression of Arabidopsis WRKY45 resulted in an early senescence phenotype characterized by a reduction of maximum photochem. efficiency of photosystem II and chlorophyll levels in the later stages of darkness. The detailed metabolic characterization showed significant changes in amino acids coupled with the accumulation of organic acids in WRKY45 overexpression lines during dark-induced senescence. Furthermore, the markedly upregulation of alternative oxidase (AOX1a, AOX1d) and electron transfer flavoprotein/ubiquinone oxidoreductase (ETFQO) genes suggested that WRKY45 is associated with a dysregulation of mitochondrial signalling and the activation of alternative respiration rather than amino acids catabolism regulation. Collectively our results provided evidence that WRKY45 is involved in the plant metabolic reprogramming following carbon starvation and highlight the potential role of WRKY45 in the modulation of mitochondrial signalling pathways.

Plant, Cell & Environment published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mishra, Jigni; Khan, Washim; Ahmad, Sayeed; Misra, Kshipra published the artcile< Supercritical carbon dioxide extracts of Cordyceps sinensis: chromatography-based metabolite profiling and protective efficacy against hypobaric hypoxia>, Product Details of C19H34O2, the main research area is Cordyceps sinensis hypobaric hypoxia carbon dioxide chromatog metabolite profiling; Cordyceps sinensis (Berk) Sacc.; GC-MS; HPTLC; hypobaric hypoxia (HH); metabolomics; supercritical fluid extract.

The toxicity and disposal concerns of organic solvents used in conventional extraction purposes has entailed the need for greener alternatives. Among such techniques, supercritical fluid extraction (SFE) has gained popularity by yielding extracts of high purity in a much faster manner. Carbon dioxide (CO2) is generally preferred as a supercritical solvent because of its lower temperature requirements, better diffusivity and easy removal. The present study describes the characterization of supercritical CO2 extracts of Indian variety of Cordyceps sinensis (CS)- a high-altitude medicinal mushroom widely revered in traditional medicine for its extensive anti-hypercholesterolemic, anti-inflammatory, anti-proliferative and energy-enhancing properties. Exptl. parameters viz. 300 and 350 bar of extraction pressure, 60°C of temperature, 0.4°L/h CO2 of flow rate and use of 1% (volume/volume) of ethanol as entrainer were optimized to prepare three different extracts namely, CSF1, CSF2 and CSF3. High-performance thin-layer chromatog. (HPTLC) was used for assessing the quality of all the extracts in terms of cordycepin, the pivot biomarker compound in CS. Characterization by HPTLC and GC-MS confirmed the presence of flavonoids and nucleobases and, volatile organic compounds (VOCs), resp. The chromatog. data acquired from metabolite profiling were subjected to chemometric anal. in an open source R studio which illustrated interrelatedness between CSF1 and CSF2 in terms of two major principal components. i.e. Dim 1 and Dim 2 whose values were 40.33 and 30.52% in variables factor map plotted using the HPTLC-generated retardation factor values. The factor maps based on retention times of the VOCs exhibited a variance of Dim 1 = 43.95% and Dim 2 = 24.85%. Furthermore, the extracts demonstrated appreciable antibacterial activity against Escherichia coli and Salmonella typhi by generation of reactive oxygen species (ROS), protein leakage and efflux pump inhibition within bacterial pathogens. CSFs were elucidated to be significantly cytoprotective (p < 0.05) in a simulated hypobaric hypoxia milieu (0.5% oxygen). CSF2 showed the best results by effectively improving the viability of human embryonic kidney (HEK 293) cells to 82.36 ± 1.76% at an optimum dose of 100 μg/mL. Levels of hypoxia inducible factor-1 alpha (HIF-1α) were modulated four-fold upon supplementation with CSF2. The results collectively evinced that the CSF extracts are substantially bioactive and could be effectively utilized as mycotherapeutics for multiple bioeffects. Frontiers in Pharmacology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kisel, V. M.; Kovtunenko, V. A.; Tyltin, A. K.; Babichev, F. S. published the artcile< Imino(amino) derivatives of isoquino[2,3-a]quinazoline and dibenz[b,f]azocine>, Related Products of 112-63-0, the main research area is condensation bromomethylphenylacetonitrile anthranilonitrile solvent effect; benzeneacetonitrile bromomethyl condensation anthranilonitrile; isoquinoquinazoline; dibenzazocine.

o-BrCH2C6H4CH2CN condensed with o-H2NC6H4CN to give 49% isoquinoquinazolinimine I (Z = NH2+ Br-) (II) in refluxing MeNO2, 40% o-NCCH2C6H4CH2NRC6H4CN-o (III, R = H) (IV) in refluxing Me2CHOH containing NaOAc, and 34% isoquinolinium salt V in Me2CHOH at 70-75°. Refluxing II with 40% H2SO4 in EtOH gave 40.5% I (Z = O). Acetylating IV with AcCl in dioxane containing NaOAc gave 78% III (R = Ac), which underwent intramol. cycloaddition in refluxing Me3COH containing KOCMe3 to give 52% dibenzazocine VI.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about Condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Daff, Simon; Manson, Forbes D. C.; Reid, Graeme A.; Chapman, Stephen K. published the artcile< Strategic manipulation of the substrate specificity of Saccharomyces cerevisiae flavocytochrome b2>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cytochrome b5 lactate dehydrogenase substrate specificity; Saccharomyces cytochrome b5 lactate dehydrogenase specificity.

Flavocytochrome b2 from Saccharomyces cerevisiae acts physiol. as an L-lactate dehydrogenase. Although L-lactate is its primary substrate, the enzyme is also able to utilize a variety of other (S)-2-hydroxy acids. Structural studies and sequence comparisons with several related flavoenzymes have identified the key active-site residues required for catalysis. However, the residues Ala-198 and Leu-230, found in the X-ray-crystal structure to be in contact with the substrate Me group, are not well conserved. The authors propose that the interaction between these residues and a prospective substrate mol. has a significant effect on the substrate specificity of the enzyme. In an attempt to modify the specificity in favor of larger substrates, three mutant enzymes have been produced: A198G, L230A and the double mutant A198G/L230A. As a means of quantifying the overall kinetic effect of a mutation, substrate-specificity profiles were produced from steady-state experiments with (S)-2-hydroxy acids of increasing chain length, through which the catalytic efficiency of each mutant enzyme with each substrate could be compared with the corresponding wild-type efficiency. The Ala-198 → Gly mutation had little influence on substrate specificity and caused a general decrease in enzyme efficiency. However, the Leu-230 → Ala mutation caused the selectivity for 2-hydroxyoctanoate over lactate to increase by a factor of 80.

Biochemical Journal published new progress about Enzyme kinetics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Zhuang; An, Zhenzhen; Guo, Yongyang; Zhang, Kangning; Chen, Xiaoling; Zhang, Dongxia; Xue, Zhonghua; Zhou, Xibin; Lu, Xiaoquan published the artcile< Au-Pt bimetallic nanoparticles supported on functionalized nitrogen-doped graphene for sensitive detection of nitrite>, Product Details of C19H34O2, the main research area is gold platinum bimetallic nanoparticle nitrogen doped graphene detection nitrite; Electrocatalytic oxidation; Gold-platinum bimetallic nanoparticles; Nitrite; Nitrogen-doped graphene; Sensor.

In this work, we report a novel Au-Pt bimetallic nanoparticles (Au-PtNPs) decorated on the surface of nitrogen-doped graphene (NG) functionalized with 1,3,6,8-pyrenetetrasulfonic acid sodium salt (PyTS) by direct electrodeposition method. The results of SEM, energy dispersive X-ray spectroscopy (EDS) and electrochem. impedance spectrum (EIS) reveal that the Au-PtNPs were successfully anchored on the surface of NG sheets with a diameter of 20-40 nm. Further, the prepared Au-PtNPs/PyTS-NG nanocomposite exhibits superior catalytic activity for the oxidation of nitrite. Under optimal exptl. conditions, an amperometric sensor with a linear range of 0.5-1621 μM and a detection limit of 0.19 μM (S/N=3) for the detection of nitrite was set up and applied to real samples.

Talanta published new progress about Amperometric sensors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Goldinger, Simone M.; Buder-Bakhaya, Kristina; Lo, Serigne N.; Forschner, Andrea; McKean, Meredith; Zimmer, Lisa; Khoo, Chloe; Dummer, Reinhard; Eroglu, Zeynep; Buchbinder, Elizabeth I.; Ascierto, Paolo A.; Gutzmer, Ralf; Rozeman, Elisa A.; Hoeller, Christoph; Johnson, Douglas B.; Gesierich, Anja; Kolblinger, Peter; Bennannoune, Naima; Cohen, Justine V.; Kahler, Katharina C.; Wilson, Melissa A.; Cebon, Jonathan; Atkinson, Victoria; Smith, Jessica L.; Michielin, Olivier; Long, Georgina V.; Hassel, Jessica C.; Weide, Benjamin; Haydu, Lauren E.; Schadendorf, Dirk; McArthur, Grant; Ott, Patrick A.; Blank, Christian; Robert, Caroline; Sullivan, Ryan; Hauschild, Axel; Carlino, Matteo S.; Garbe, Claus; Davies, Michael A.; Menzies, Alexander M. published the artcile< Chemotherapy after immune checkpoint inhibitor failure in metastatic melanoma: a retrospective multicentre analysis>, SDS of cas: 112-63-0, the main research area is human metastatic melanoma immune checkpoint inhibitor chemotherapy; Anti-PD-1 antibodies; Cancer; Checkpoint inhibitors; Chemotherapy; Immunotherapy; Melanoma.

Despite remarkably improved outcomes with immune checkpoint inhibition, many patients with metastatic melanoma will eventually require further therapy. Chemotherapy has limited activity when used first-line but can alter the tumor microenvironment and does improve efficacy when used in combination with immunotherapy in lung cancer. Whether chemotherapy after checkpoint inhibitor failure has relevant activity in patients with metastatic melanoma is unknown.Patients with metastatic melanoma treated with chemotherapy after progression on immunotherapy with checkpoint inhibitors were identified retrospectively from 24 melanoma centers. Objective response rate (ORR), progression-free survival (PFS), overall survival (OS) and safety were examinedIn total, 463 patients were treated between 2007 and 2017. Fifty-six per cent had received PD-1-based therapy before chemotherapy. Chemotherapy regimens included carboplatin + paclitaxel (32%), dacarbazine (25%), temozolomide (15%), taxanes (9%, nab-paclitaxel 4%), fotemustine (6%) and others (13%). Median duration of therapy was 7.9 wk (0-108). Responses included 0.4% complete response (CR), 12% partial response (PR), 21% stable disease (SD) and 67% progressive disease (PD). Median PFS was 2.6 mo (2.2, 3.0), and median PFS in responders was 8.7 mo (6.3, 16.3), resp. Twelve-month PFS was 12% (95% CI 2-15%). In patients who had received anti-PD-1 before chemotherapy, the ORR was 11%, and median PFS was 2.5 mo (2.1, 2.8). The highest activity was achieved with single-agent taxanes (N = 40), with ORR 25% and median PFS 3.9 mo (2.1, 6.2). Median OS from chemotherapy start was 7.1 mo (6.5, 8.0). Subsequent treatment with checkpoint inhibitors achieved a response rate of 16% with a median PFS of 19.1 mo (2.0-43.1 mo). No unexpected toxicities were observedChemotherapy has a low response rate and short PFS in patients with metastatic melanoma who have failed checkpoint inhibitor therapy, although activity varied between regimens. Chemotherapy has a limited role in the management of metastatic melanoma.

European Journal of Cancer published new progress about Antibodies and Immunoglobulins Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses) (Anti-PD-1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dowling, Sally D.; Mullin, Jerry L.; Seitz, W. Rudolf published the artcile< Binding of sulfonated fluorophors by metal-polyethylenimine complexes>, Computed Properties of 112-63-0, the main research area is pyrenesulfonate binding polyethylenimine metal complex; anilinonaphthalenesufonate binding polyethylenimine metal complex; copper polyethylenimine complex binding sulfonate; zinc polyethylenimine complex binding sulfonate; silver polyethylenimine complex binding sulfonate; fluorescence polyethylenimine complex binding sulfonate.

The binding of Na 1-pyrenesulfonate (I) [59323-54-5], tetra-Na 1,3,6,8-pyrenetetrasulfonate (II) [59572-10-0] and magnesium 1,8-anilinonaphthalenesulfonate (III) [18108-68-4] to the Cu(II), Zn(II), and Ag(I) complexes of poly(ethylenimine) (IV) was studied by measuring fluorescence intensities and excitation and emission spectra at various metal-to-pyrene ratios in the presence of IV. I reacts to form ground-state dimers when bound to Cu(II)- and Zn(II)-IV: on Cu(II)- and Zn(II)-IV and to a lesser extent on Ag(I)-IV the amounts of bound I exceed that required for electroneutrality under certain conditions: II binds more strongly to Ag(I)-IV than to Cu(II)-IV. I forms excimers to only a very small extent when bound to protonated IV. III emits at shorter wavelength when bound to Zn(II)-IV than when bound to protonated IV. The results are interpreted as indicating that binding to Cu(II)- and Zn(II)-IV is predominantly hydrophobic and territorial because the IV shields the bound counterion from the charge on the metal ion. On Ag(I)-IV and particularly on protonated IV the charge on the polyelectrolyte is more acceptable to bound counterions, causing electrostatic interactions to be more important and binding to be more site specific.

Macromolecules published new progress about Excimer. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Yunjeong; Weerawongwiwat, Veeraya; Kim, Jong-Hwa; Yoon, Jung-Hoon; Suh, Min Kuk; Kim, Han Sol; Lee, Jung-Sook; Sukhoom, Ampaitip; Kim, Wonyong published the artcile< Sneathiella sedimenti sp. nov., isolated from marine sediment>, Related Products of 112-63-0, the main research area is sequence Sneathiella marine sediment menaquinone10 phosphatidylethanolamine fatty acids phylogeny; 16S rRNA gene sequence; Alphaproteobacteria; Sneathiella sedimenti; Sneathiellaceae; genome sequencing; marine sediment.

A novel bacterium, designated CAU 1612T, was isolated from coastal sediment sampled in the Republic of Korea. Cells of the strain were Gram-stain-neg., rod-shaped and motile. Optimum growth occurred at 30 °C, at pH 7.0 and with 1.0 % (w/v) NaCl. Based on 16S rRNA gene sequences, phylogenetic anal. revealed that strain CAU 1612T belonged to the genus Sneathiella and showed highest similarity to ′Sneathiella litorea′ JCM 33810T (98.5 %), followed by Sneathiella chungangensis KCTC 32476T (97.7 %), Sneathiella aquimaris KCTC 12842T (96.0 %), Sneathiella chinensis LMG 23452T (95.5 %), Sneathiella limimaris KCTC 52846T (95.5 %) and Sneathiella glossodoripedis KCTC 12842T (95.4 %). The average nucleotide identity and digital DNA-DNA hybridization values of strain CAU 1612T were estimated to be 68.5-81.7 % and ≤23.7 %, resp., to members of the genus Sneathiella. The DNA G + C content was 54.1 mol%. The major cellular fatty acids (>10 %) were C16 : 0, C19 : 0 cyclo ω8c and summed feature 8 (C18 : 1 ω7c and/or C18 : 1 ω6c). The major menaquinone was Q-10 and the predominant polar lipids were phosphatidylmethylethanolamine, phosphatidylethanolamine and phosphatidylglycerol. On the basis of taxonomic evidence, strain CAU 1612T represents a novel species, for which the name Sneathiella sedimenti sp. nov. is proposed. The type strain is CAU 1612T (= KCTC 82427T = MCCC 1K06082T). The 16S rRNA gene and the whole-genome sequences of strain CAU 1612T have been deposited in GenBank/EMBL/DDBJ with the accession numbers MW192779 and JAFLNC000000000, resp.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Fang-Fang; Ma, Jian-Fang; Yang, Jin; Jia, Heng-Qing; Hu, Ning-Hai published the artcile< Syntheses, structures and luminescence of silver(I) sulfonate complexes with PPh3 ligand>, Computed Properties of 112-63-0, the main research area is silver sulfonate phosphine preparation structure luminescence; crystal structure silver arylsulfonato phosphine complex.

Four new luminescent silver(I) sulfonate complexes with PPh3, Ag(L1)(PPh3)2 (1), Ag(L2)(PPh3)3 (2), [Ag2(L3)(PPh3)4(H2O)]·1.5CH3CN·0.5H2O (3) and [Ag4(L4)(PPh3)10]·8H2O (4), where L1 = p-toluenesulfonate, L2 = 1-naphthalenesulfonate, L3 = 3-carboxylate-4-hydroxybenzenesulfonate, L4 = 1,3,6,8-pyrenetetrasulfonate and PPh3 = triphenylphosphine, were synthesized and characterized. The crystal structures were determined by single-crystal x-ray diffraction method. Compounds 1, 2, 3 and 4 adopt discrete structures rather than polymeric structures. Compounds 1 and 2 show mononuclear structures while 3 and 4 are dinuclear and tetranuclear mols., resp. Also the numbers of PPh3 mols. coordinating to one silver center are two or three. The photoluminescent properties of 1, 2 and 3 are discussed.

Journal of Molecular Structure published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics