Category: 112-63-0

Dong, Jianyang; Yue, Fuyang; Liu, Jianhua; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published the artcile< Visible-light-mediated three-component Minisci reaction for heteroarylethyl alcohols synthesis>, HPLC of Formula: 112-63-0, the main research area is heteroarylethyl alc green diastereoselective preparation; heteroaryl alkene three component Minisci visible light iridium catalyst.

Herein, a mild, modular, practical Minisci reaction for catalytic synthesis of heteroarylethyl alcs. such as ArCH(R1)CHR2OH [Ar = quinol-2-yl, isoquinolin-1-yl, 2-benzothiazolyl, etc.; R1R2 = CH2(CH2)2CH2, CH2CH2CH2; R1 = On-Bu, Me; R2 = H, Me] via sequential addition of H2O and N-heteroarenes across olefinic double bonds was reported. This scalable protocol was used for direct hydroxy-heteroarylation of olefins with a wide range of N-heteroarenes and could be expected to permit rapid conversion of abundant feedstock materials into medically relevant mols.

Green Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation) (heteroarylethyl). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wei; Guo, Xiaoli; Ren, Jing; Chen, Yujiao; Wang, Jingyu; Gao, Ai published the artcile< GCN5-mediated PKM2 acetylation participates in benzene-induced hematotoxicity through regulating glycolysis and inflammation via p-Stat3/IL17A axis>, Reference of 112-63-0, the main research area is GCN5 PKM2 acetylation benzene hematotoxicity glycolysis inflammation Stat3 IL17A; Acetylation; Benzene; Glycolysis; Hematotoxicity; Inflammation; PKM2.

Benzene is a common environmental carcinogen that induces leukemia. Studies suggest that metabolic disorder has a relationship with the toxicity of benzene. Pyruvate kinase M2 (PKM2) is a key rate-limiting enzyme in glycolysis. However, the upstream and downstream regulatory mechanisms of PKM2 in benzene-induced hematotoxicity and the therapeutic effects of targeting PKM2 in vivo are unclear. This study aims to provide insights into the new mechanism of benzene-induced hematotoxicity and reveal the therapeutic significance of targeting PKM2. Herein, we demonstrated that PKM2-dependent glycolysis contributes to benzene-induced hematotoxicity by regulating inflammation reaction. Mechanistically, acetylated proteomics revealed that 1,4-benzoquinone (1,4-BQ) induced acetylation of PKM2 at position K66, and this modification contributed to the increase of PKM2 expression and can be inhibited by inhibition of acetyltransferase GCN5. Meanwhile, the elevated PKM2 was shown to prompt the activation of nuclear phosphorylated Stat3 (p-Stat3) and IL17A. Clin., pharmacol. inhibition of PKM2 alleviated the blood toxicity induced by benzene, which was mainly characterized by an increase in routine blood parameters and improvement of hematopoietic imbalance. Besides, elevated PKM2 is a promising biomarker in people occupationally exposed to benzene. Overall, we identified PKM2/p-Stat3/IL-17A axis participates in the hematotoxicity of benzene, and targeting PKM2 has certain therapeutic implications in hematol. diseases.

Environmental Pollution (Oxford, United Kingdom) published new progress about Acetylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gowrisankar, Saravanan; Neumann, Helfried; Beller, Matthias published the artcile< A convenient and practical synthesis of anisoles and deuterated anisoles by palladium-catalyzed coupling reactions of aryl bromides and chlorides>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is deuterated anisole preparation; aryl halide methanol coupling reaction palladium.

A palladium-catalyzed coupling reaction of aryl halides with methanol is described. A variety of substituted anisoles have been prepared in moderate to good yields from activated and nonactivated (hetero)aryl substrates. Meanwhile, deuterated anisoles could be obtained via coupling of aryl halides with CD3OD.

Chemistry – A European Journal published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Olaizola, Olatz; Iriarte, Igor; Zanella, Giovanna; Gomez-Bengoa, Enrique; Ganboa, Inaki; Oiarbide, Mikel; Palomo, Claudio published the artcile< Bronsted Base Catalyzed One-Pot Synthesis of Stereodefined Six-Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6-Addition>, Quality Control of 112-63-0, the main research area is substituted cyclohexene derivative enantioselective preparation; diene nitroalkene enantioselective addition cyclization Bronsted base catalyst; 1,6-conjugate additions; Brønsted bases; organocatalysis; synthetic methods; trienolates.

A catalyst-driven one-pot reaction sequence is developed for the enantio- and diastereoselective synthesis of tetrasubstituted cyclohexenes from simple unsaturated ketones or thioesters. The method involves a tertiary amine/squaramide-catalyzed α-selective addition of transiently generated trienolates to nitroolefins, subsequent base-catalyzed double bond isomerization, and an intramol. (vinylogous) 1,6-addition reaction, a rare key carbocyclization step that proceeded with essentially perfect stereocontrol.

Angewandte Chemie, International Edition published new progress about Addition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fialkov, Yu. A.; Sevast’yan, A. P.; Khranovskii, V. A.; Yagupol’skii, L. M. published the artcile< Study of the transfer of electron effects in conjugated perfluoropolyene systems. II. Asymmetric derivatives of α,β-difluorostilbene and 1,4-diphenyl-1,3-perfluorobutadiene>, Formula: C19H34O2, the main research area is conjugation aromatic butadiene stilbene; fluoro aromatic butadiene stilbene; NMR aromatic butadiene stilbene; UV aromatic butadiene stilbene.

UV and 19F NMR data for trans-4-RC6H4CF:CFC6H4R1-4 (R,R1 = H, Me; H, CO2H; H, CO2Et; H, NH2; H, NO2; NO2, NMe2; H, NMe2) and trans,trans-4-RC6H4CF:CFCF:CFC6H4R1-4 (R,R1 = H, NO2; NO2, NO2; NO2, NMe2; NMe2, NMe2; H, NMe2) showed that, although they were not coplanar, they transmitted conjugation effects.

Zhurnal Organicheskoi Khimii published new progress about Conjugation (bond). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Babu, Sukumaran Santhosh; Praveen, Vakayil K.; Kartha, Kalathil K.; Mahesh, Sankarapillai; Ajayaghosh, Ayyappanpillai published the artcile< Effect of the Bulkiness of the End Functional Amide Groups on the Optical, Gelation, and Morphological Properties of Oligo(p-phenylenevinylene) π-Gelators>, Formula: C19H34O2, the main research area is bulkiness amide group optical gelation morphol oligophenylenevinylene gelator; gels; hydrogen bonds; phenylenevinylenes; pi interactions; self-assembly.

Herein, we describe the role of end functional groups in the self-assembly of amide-functionalized oligo(p-phenylenevinylene) (OPV) gelators with different end-groups. The interplay between hydrogen-bonding and π-stacking interactions was controlled by the bulkiness of the end functional groups, thereby resulting in aggregates of different types, which led to the gelation of a wide range of solvents. The variable-temperature UV/Vis absorption and fluorescence spectroscopic features of gelators with small end-groups revealed the formation of 1D H-type aggregates in CHCl3. However, under fast cooling in toluene, 1D H-type aggregates were formed, whereas slow cooling resulted in 2D H-type aggregates. OPV amide with bulky dendritic end-group formed hydrogen-bonded random aggregates in toluene and a morphol. transition from vesicles into fibrous aggregates was observed in THF. Interestingly, the presence of bulky end-group enhanced fluorescence in the xerogel state and aggregation in polar solvents. The difference between the aggregation properties of OPV amides with small and bulky end-groups allowed the preparation of self-assembled structures with distinct morphol. and optical features.

Chemistry – An Asian Journal published new progress about Aggregation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Danyun; Li, Zhijun; Chen, Yue; Fan, Yan; Yu, Tao published the artcile< Paeoniflorin reduces the inflammatory response of THP-1 cells by up-regulating microRNA-124 - Paeoniflorin reduces the inflammatory response of THP-1 cells through microRNA-124>, Reference of 112-63-0, the main research area is paeoniflorin THP cell microRNA inflammatory response; Apoptosis; Paeoniflorin; Proliferation; THP-1 cells; miRNA-124.

The activation of macrophages and the release of inflammatory cytokines are the main reasons for the progress of systemic lupus erythematosus (SLE). MicroRNA (miRNA)-124 is involved in the regulation of macrophages and is a key regulator of inflammation and immunity. To explore whether paeoniflorin (PF) regulates the biol. functions of macrophages depends on miR-124. RT-PCR, WB, ELISA, CCK-8 and flow cytometry were used to evaluate that PF regulated the biol. functions of THP-1 cells through miR-124. PF significantly inhibited the proliferation while promotes the apoptosis of THP-1 cells, and inhibited the release of IL-6, TNF-α and IL-1β in THP-1 cells. RT-PCR results shown that PF up-regulated the expression of miR-124 in THP-1 cells. Functional recovery experiments showed that compared with the LPS + mimic-NC group, LPS + miR-124 mimic significantly inhibited the proliferation and the release of IL-6, TNF-α and IL-1β, but promoted the apoptosis of THP-1 cells. In addition, compared with the LPS + PF + inhibitor-NC group, LPS + PF + miR-124 inhibitor significantly promoted the proliferation and the release of IL-6, TNF-α and IL-1β, but inhibited the apoptosis of THP-1 cells. By down-regulating miR-124, PF inhibits the proliferation and inflammation of THP-1 cells, and promotes the apoptosis of THP-1 cells.

Genes & Genomics published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maimo-Barcelo, Albert; Martin-Saiz, Lucia; Fernandez, Jose A.; Perez-Romero, Karim; Garfias-Arjona, Santiago; Lara-Almunia, Monica; Pierola-Lopetegui, Javier; Bestard-Escalas, Joan; Barcelo-Coblijn, Gwendolyn published the artcile< Polyunsaturated Fatty Acid-Enriched Lipid Fingerprint of Glioblastoma Proliferative Regions Is Differentially Regulated According to Glioblastoma Molecular Subtype>, Quality Control of 112-63-0, the main research area is Glioblastoma proliferative region polyunsaturated fatty acid lipid fingerprint; MALDI-IMS lipidomics; glioblastoma; lipid metabolism; modular gene expression; molecular subtypes; temozolomide.

Glioblastoma (GBM) represents one of the deadliest tumors owing to a lack of effective treatments. The adverse outcomes are worsened by high rates of treatment discontinuation, caused by the severe side effects of temozolomide (TMZ), the reference treatment. Therefore, understanding TMZ′s effects on GBM and healthy brain tissue could reveal new approaches to address chemotherapy side effects. In this context, we have previously demonstrated the membrane lipidome is highly cell type-specific and very sensitive to pathophysiol. states. However, little remains known as to how membrane lipids participate in GBM onset and progression. Hence, we employed an ex vivo model to assess the impact of TMZ treatment on healthy and GBM lipidome, which was established through imaging mass spectrometry techniques. This approach revealed that bioactive lipid metabolic hubs (phosphatidylinositol and phosphatidylethanolamine plasmalogen species) were altered in healthy brain tissue treated with TMZ. To better understand these changes, we interrogated RNA expression and DNA methylation datasets of the Cancer Genome Atlas database. The results enabled GBM subtypes and patient survival to be linked with the expression of enzymes accounting for the observed lipidome, thus proving that exploring the lipid changes could reveal promising therapeutic approaches for GBM, and ways to ameliorate TMZ side effects.

International Journal of Molecular Sciences published new progress about 5-Lipoxygenase-activating protein inhibitors. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Yibing; Canturk, Belgin; Jo, Hyunil; Ma, Chunlong; Gianti, Eleonora; Klein, Michael L.; Pinto, Lawrence H.; Lamb, Robert A.; Fiorin, Giacomo; Wang, Jun; DeGrado, William F. published the artcile< Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel>, Electric Literature of 112-63-0, the main research area is amantadine antiviral influenza virus proton channel inhibitor.

Influenza virus infections lead to numerous deaths and millions of hospitalizations each year. One challenge facing anti-influenza drug development is the heterogeneity of the circulating influenza viruses, which comprise several strains with variable susceptibility to antiviral drugs. For example, the wild-type (WT) influenza A viruses, such as the seasonal H1N1, tend to be sensitive to antiviral drugs, amantadine and rimantadine, while the S31N mutant viruses, such as the pandemic 2009 H1N1 (H1N1pdm09) and seasonal H3N2, are resistant to this class of drugs. Thus, drugs targeting both WT and the S31N mutant are highly desired. The authors report the design of a novel class of dual inhibitors along with their ion channel blockage and antiviral activities. The potency of the most active compound 11 in inhibiting WT and the S31N mutant influenza viruses is comparable with that of amantadine in inhibiting WT influenza virus. Solution NMR studies and mol. dynamics (MD) simulations of drug-M2 interactions supported the design hypothesis: namely, the dual inhibitor binds in the WT M2 channel with an aromatic group facing down toward the C-terminus, while the same drug binds in the S31N M2 channel with its aromatic group facing up toward the N-terminus. The flip-flop mode of drug binding correlates with the structure-activity relationship (SAR) and has paved the way for the next round of rational design of broad-spectrum antiviral drugs.

Journal of the American Chemical Society published new progress about Antiviral agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Drakulic, Danijela; Schwirtlich, Marija; Petrovic, Isidora; Mojsin, Marija; Milivojevic, Milena; Kovacevic-Grujicic, Natasa; Stevanovic, Milena published the artcile< Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma>, Application In Synthesis of 112-63-0, the main research area is BMP signaling; GBM subtypes; Hippo signaling; Notch signaling; RA signaling; SHH signaling; TGFβ signaling; Wnt/β-catenin signaling; glioblastoma.

Glioblastoma (GBM) is the most common and highly lethal type of brain tumor, with poor survival despite advances in understanding its complexity. After current standard therapeutic treatment, including tumor resection, radiotherapy and concomitant chemotherapy with temozolomide, the median overall survival of patients with this type of tumor is less than 15 mo. Thus, there is an urgent need for new insights into GBM mol. characteristics and progress in targeted therapy in order to improve clin. outcomes. The literature data revealed that a number of different signaling pathways are dysregulated in GBM. In this review, we intended to summarize and discuss current literature data and therapeutic modalities focused on targeting dysregulated signaling pathways in GBM. A better understanding of opportunities for targeting signaling pathways that influences malignant behavior of GBM cells might open the way for the development of novel GBM-targeted therapies.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics