Category: 112-63-0

Ohkubo, Mitsuru; Kuno, Atsushi; Nakanishi, Isao; Takasugi, Hisashi published the artcile< Studies on cerebral protective agents. VIII. Synthesis of 2-aminothiazoles and 2-thiazolecarboxamides with anti-anoxic activity>, Application of C19H34O2, the main research area is antianoxic aminothiazole thiazolecarboxamide structure cerebral protection; aminothiazole preparation antianoxic cerebral protection structure; thiazolecarboxamide preparation antianoxic cerebral protection structure.

Various 2-aminothiazoles and 2-thiazolecarboxamides, possessing a nitrogenous basic moiety at the C-2 position of the thiazole ring, were prepared and tested for anti-anoxic (AA) activity in mice. Among them, N-[2-(4-morpholinyl)ethyl]-4-(3-trifluoromethylphenyl)-2-thiazolecarboxyamide hydrochloride (FR108143) (min. EDs of 3.2 mg/kg i.p. and 10 mg/kg p.o., resp.) exhibited more potent AA activity than either FK360 or FR75039, each of which has a nitrogenous basic moiety at the C-5 position. The structure-activity relationships with regard to AA activity of this series of compounds are discussed, and the three-dimensional electrostatic potentials (3D-MEP) around the basic nitrogen atom of FK360 and the thiazole derivative (FR108143) are compared.

Chemical & Pharmaceutical Bulletin published new progress about Electrostatic potential. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Du, Zheng-Cai; Xia, Zhong-Shang; Huang, Yan-Feng; Peng, Yi; Cao, Bing-Bing; Li, Chun-Qi; Liang, Yun-Fei; Zhao, Fang-Hui; Zhang, Ming-Zhe; Chen, Zhang-Mei; Hou, Xiao-Tao; Hao, Er-Wei; Deng, Jia-Gang published the artcile< Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish>, Synthetic Route of 112-63-0, the main research area is zebrafish cardiotoxicity cochinchina momordica seed extract; CMSE; apoptosis; cardiotoxicity; inflammation; oxidative stress; zebrafish.

Momordica cochinchinensis (Lour.) Spreng is an indigenous South Asian edible fruit, and seeds of Momordica cochinchinensis have been used therapeutically in traditional Chinese medicine. Previous studies have shown that M. cochinchinensis seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant and anti-ulcer effects as well as contains secondary metabolites with potential anticancer activities such as triterpenoids and saponins. Recent studies reported that water extract and ethanol extract of M. cochinchinensi seed were tested on mammals using an acute toxic classic method as OECD guidelines 420. No matter injected i.v. or i.m., animals died within several days. In this study, zebrafish embryos were exposed to various doses of Cochinchina momordica seed extract (CMSE) from 2 dpf (days post fertilization, dpf) to 3 dpf. CMSE-induced cardiotoxicity such as pericardial edema, cardiac apoptosis, increased ROS production, cardiac neutrophil infiltration, decreased blood flow velocity, and reduced expression of three marker genes of cardiac functions were found in zebrafish roughly in a dose-dependent manner. These results suggest that CMSE may induce cardiotoxicity through pathways involved in inflammation, oxidative stress, and apoptosis.

Journal of Applied Toxicology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Demarchi, Gianina; Valla, Sofía; Perrone, Sofía; Chimento, Agustina; Bonadeo, Nadia; Vitale, Daiana Luján; Spinelli, Fiorella Mercedes; Cervio, Andrés; Sevlever, Gustavo; Alaniz, Laura; Berner, Silvia; Cristina, Carolina published the artcile< β-Catenin is reduced in membranes of human prolactinoma cells and it is inhibited by temozolomide in prolactin secreting tumor models.>, Electric Literature of 112-63-0, the main research area is Prolactinomas; Wnt; pituitary tumors; temozolomide; β-Catenin.

INTRODUCTION: Prolactinomas are the most frequent pituitary tumor subtype. Despite most of them respond to medical treatment, a proportion are resistant and become a challenge in clinical management. Wnt/β-Catenin pathway has been implicated in several cancers including pituitary tumors and other sellar region malignancies. Interestingly, Wnt/β-Catenin inhibition augments the cytotoxicity of the chemotherapeutic agent Temozolomide (TMZ) in different cancers. TMZ is now being implemented as rescue therapy for aggressive pituitary adenoma treatment. However, the molecular mechanisms associated with TMZ action in pituitary tumors remain unclear. OBJECTIVES: Our aims in the present study were to evaluate differential β-Catenin expression in human resistant prolactinomas and Wnt/β-Catenin signaling activation and involvement in Prolactin (PRL) secreting experimental models treated with TMZ. RESULTS: We first evaluated by immunohistochemistry β-Catenin localization in human resistant prolactinomas in which we demonstrated reduced membrane β-Catenin in prolactinoma cells compared to normal pituitaries, independently of the Ki-67 proliferation indexes. In turn, in vivo 15 mg/kg of orally administered TMZ markedly reduced PRL production and increased prolactinoma cell apoptosis in mice bearing xenografted prolactinomas. Intratumoral β-Catenin strongly correlated with Prl and Cyclin D1, and importantly, TMZ downregulated both β-Catenin and Cyclin D1, supporting their significance in prolactinoma growth and as candidates of therapeutic targets. When tested in vitro, TMZ directly reduced MMQ cell viability, increased apoptosis and produced G2/M cell cycle arrest. Remarkably, β-Catenin activation and VEGF secretion were inhibited by TMZ in vitro. CONCLUSIONS: We concluded that dopamine resistant prolactinomas undergo a β-Catenin relocalization in relation to normal pituitaries and that TMZ restrains experimental prolactinoma tumorigenicity by reducing PRL production and β-Catenin activation. Together, our findings contribute to the understanding of Wnt/β-Catenin implication in prolactinoma maintenance and TMZ therapy, opening the opportunity of new treatment strategies for aggressive and resistant pituitary tumors.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gadekar, Santosh C.; Dhayalan, Vasudevan; Nandi, Ashim; Zak, Inbal L.; Mizrachi, Meital Shema; Kozuch, Sebastian; Milo, Anat published the artcile< Rerouting the Organocatalytic Benzoin Reaction toward Aldehyde Deuteration>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aldehyde deuteration rerouting organocatalytic benzoin reaction.

Herein, studies aimed at stabilizing reactive intermediates in the N-heterocyclic carbene (NHC) catalytic cycle was described, which enabled the full shutdown of the known benzoin coupling pathway, while rerouting its intermediates toward deuteration. The reversible nature of NHC catalysis and the selective stabilization of reaction intermediates facilitated clean hydrogen-deuterium exchange reactions of aromatic aldehydes by D2O, even for challenging electron-withdrawing substrates. In several cases, the addition of catalytic amounts of Ph boronic acid was used to further stabilize highly reactive intermediates and mitigate the formation of benzoin coupling byproducts. The mechanistic understanding at the foundation of this work resulted in unprecedented mild conditions with base and catalyst loadings as low as 0.1 mol %, and a scalable deuteration reaction applicable to a broad substrate scope with outstanding functional group tolerance. More importantly, adopting this approach enabled the construction of a guideline for identifying the appropriate catalyst and conditions for different substrates. Exptl. studies combined with machine learning and computational methods shed light on the nontrivial mechanistic underpinnings of this reaction.

ACS Catalysis published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thio, Joanne P.; Liang, Christopher; Bajwa, Alisha K.; Wooten, Dustin W.; Christian, Bradley T.; Mukherjee, Jogeshwar published the artcile< Synthesis and evaluation of mefway analogs as ligands for serotonin 5HT1A receptors>, Reference of 112-63-0, the main research area is mefway analog preparation serotonin 5HT1A receptor ligand; Mefway; PET imaging; Serotonin.

18F-Mefway (N-{2-[4-(2′-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4′-18F-fluoro-methylcyclohexane)carboxamide) (I) was developed and evaluated for use as a PET ligand for imaging 5-HT1A receptors. Ongoing studies of 18F-Mefway have shown it to be an effective PET radiotracer. We have synthesized isomers of Mefway by changing the position of the Me group in attempts to evaluate stability for imaging purposes. 2-Methyl-, 3-methyl-, and 4-methyl-cyclohexane-1-carboxylic acids and 3-carbomethoxy-, 4-carbomethoxycyclohexane-1-carboxylic acids were coupled with WAY-100634 to provide the methylcyclohexyl derivatives (2-, 3-, and 4-methyl). Mefway and 3-Mefway analogs were prepared by reduction of carbomethoxy- derivatives followed by fluorination. In vitro binding affinities for the methylated derivatives in rat brain homogenates were found to be 10.4 nM (2-methyl), 77 nM (3-methyl), and 21.5 nM (4-methyl). Binding affinity of 3-Mefway and 4-Mefway was found to be 17.4 nM and 6.26 nM, resp. Our results suggest that 3-methyl/3-fluoromethyl substituent has approx. threefold lower affinities compared to the 4-methyl/4-fluoromethyl substituent.

Medicinal Chemistry Research published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Dan; Cheng, Shiping; Zou, Guoming; Ding, Xiongfei published the artcile< Paeoniflorin inhibits proliferation and migration of psoriatic keratinocytes via the lncRNA NEAT1/miR-3194-5p/Galectin-7 axis>, COA of Formula: C19H34O2, the main research area is keratinocyte proliferation migration paeoniflorin lncRNA NEAT1 microRNA3194 5p Galectin7.

To investigate the mechanism underlying the effect of paeoniflorin (PF) on the proliferation and migration of psoriatic keratinocytes. The expressions of long noncoding RNA NEAT1, miR-3194-5p and Galectin-7 in skin tissues from psoriatic patients and healthy controls were detected. Psoriatic HaCat cells were used to investigate the function of NEAT1 and Galectin-7 as well as the effect and mechanism of PF in psoriasis. MTT, colony formation and scratch assays were used to assess the proliferation and migration of psoriatic HaCat cells. Dual-luciferase reporter assay was used to validate the interactions among NEAT1, miR-3194-5p and Galectin-7. NEAT1 and Galectin-7 were lowly expressed and miR-3194-5p was highly expressed in psoriatic patients. PF suppressed the proliferation and migration of psoriatic HaCat cells by elevating the expressions of NEAT1 and Galectin-7. NEAT1 pos. mediated the expression of Galectin-7 by targeting miR-3194-5p. PF controls the proliferation and migration of psoriatic HaCat cells via the NEAT1/miR-3194-5p/Galectin-7 axis.

Anti-Cancer Drugs published new progress about Cell migration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meng, Fan-Bing; Zhou, Li; Li, Jia-Jia; Li, Yun-Cheng; Wang, Meng; Zou, Long-Hua; Liu, Da-Yu; Chen, Wei-Jun published the artcile< The combined effect of protein hydrolysis and Lactobacillus plantarum fermentation on antioxidant activity and metabolomic profiles of quinoa beverage>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Lactobacillus plantarum fermentation antioxidant activity metabolomic profiles quinoa beverage; Antioxidant activity; Lactobacillus plantarum fermentation; Nontargeted metabolomics; Protein hydrolysis; Quinoa beverage.

Lactic acid bacteria fermentation is a commonly applied technique to produce nutritional, functional, and organoleptic enhanced foods. In the present study, protein hydrolysis and Lactobacillus plantarum fermentation were coupled to develop quinoa beverages. Protein hydrolysis effectively promoted the growth and fermentation of L. plantarum. Fermentation alone did not significantly improve antioxidant activity, but the combined use of protein hydrolysis and L. plantarum fermentation significantly improved the antioxidant activity of the quinoa beverage. Nontargeted metabolomics based on UHPLC-Q Exactive HF-X/MS and multivariate statistical anal. were performed to reveal the metabolite profile alterations of the quinoa beverage by different processing methods. A total of 756 metabolites were identified and annotated, which could be categorized into 12 different classes. The significant differentially abundant metabolites were mainly involved in primary metabolite metabolism and secondary metabolite biosynthesis. Many of these metabolites were proven to be vitally important to the function and taste formation of the quinoa beverage. Most importantly, the coupled use of protein hydrolysis and L. plantarum fermentation significantly increased some functional ingredients compared with protein hydrolysis and L. plantarum fermentation alone. The above results indicate that protein hydrolysis coupled with L. plantarum fermentation is an effective strategy to develop functional quinoa beverages.

Food Research International published new progress about Amino acids Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bila, Jose L.; Pijeat, Joffrey; Ramorini, Andrea; Fadaei-Tirani, Farzaneh; Scopelliti, Rosario; Baudat, Emilie; Severin, Kay published the artcile< Porous networks based on iron(II) clathrochelate complexes>, Related Products of 112-63-0, the main research area is iron boronate ester clathrochelate polymer preparation microporosity; crystal structure iron boronate ester clathrochelate.

Microporous networks based on boronate ester-capped iron(II) clathrochelate complexes are described. The networks were obtained by covalent crosslinking of tetrabrominated clathrochelate complexes via Suzuki-Miyaura polycross-coupling reactions with diboronic acids, or by Sonogashira-Hagihara polycross-coupling of clathrochelate complexes with terminal alkyne functions and 1,3,5-tribromobenzene. The networks display permanent porosity with apparent Brunauer-Emmett-Teller surface areas of up to SABET = 593 m2 g-1. A clathrochelate complex based on an enantiopure dioximato ligand was used to prepare chiral networks. One of these networks was shown to preferentially absorb D-tryptophan over L-tryptophan.

Dalton Transactions published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Jia-Sheng; Liu, Yuan; Shi, Rong; Lu, Xiong; Ma, Yue-Ming; Cheng, Neng-Neng published the artcile< Effects of combinations of Xiexin decoction constituents on diabetic nephropathy in rats>, Synthetic Route of 112-63-0, the main research area is xiexin decoction constituent diabetic nephropathy effect renoprotectant natural pharmaceutical; Baicalein (PubChem CID: 5281605); Baicalin (PubChem CID: 64982); Berberine (PubChem CID: 2353); Coptisine (PubChem CID: 72322); Diabetic nephropathy; Jatrorrhizine (PubChem CID: 72323); Palmatine (PubChem CID: 19009); Rats; Xiexin decoction.

Xiexin decoction (XXD) has been used as a treatment for diabetes mellitus for more than 1300 years. XXD constituents with protective effects against diabetic nephropathy (DN) include Rhizoma Coptidis alkaloids (RA), Radix et Rhizoma Rhei polysaccharides (RP), and Radix Scutellaria flavones (RF). The aim of the study is to investigate the effects of combinations of RA, RP, and RF on DN and their mechanisms of action. In vitro, high glucose-induced rat mesangial cells were treated with RA, RP, RF, and combinations thereof. Cell proliferation and levels of inflammatory factors were measured. In vivo, high-fat diet and streptozotocin-induced diabetic rats were treated with different combinations of RA, RP, and RF once per day for 12 wk. Blood and urine biochem. parameters, renal tissue morphol., and inflammation were investigated. In vitro, the combination of the three groups of components inhibited mesangial cell proliferation and reduced the levels of monocyte chemotactic protein-1 (MCP-1) and collagen IV. The effects of the three constituent groups in combination were stronger than those of each group alone or combinations of two groups. In diabetic rats, combinations of the three groups of herb components ameliorated blood glucose, urinary albumin excretion and decreased renal mesangial matrix expansion and basement membrane thickening. In addition, the combinations reduced renal tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) protein levels, down-regulated the expression of nuclear factor κB (NF-κB) and transforming growth factor beta 1 (TGF-β1), and up-regulated the expression of inhibitor of nuclear factor κB (IκB) protein. Among the three groups of herb components, RA produced the strongest effects, followed by RP, and then by RF. The combination of the three groups of herb components produced anti-DN effects through inhibition of inflammation mediated by NF-κB. Among the three groups of herb components, RA produced the strongest effect while RP and RF produced weaker effects.

Journal of Ethnopharmacology published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Weber, Simone Schneider; de Souza, Alessandra Carla Sampaio; Soares, Denise Caroline Luiz; Lima, Caroline Carvalho; de Moraes, Ana Carolina Rabello; Gkionis, Stephanie Viegas; Arenhart, Tanara; Rodrigues, Luiz Gustavo Goncalves; Ferreira, Sandra Regina Salvador; Pedrosa, Rozangela Curi; Silva, Denise Brentan; Paredes-Gamero, Edgar Julian; Perdomo, Renata Trentin; Parisotto, Eduardo Benedetti published the artcile< Chemical profile, antimicrobial potential, and antiaggregant activity of supercritical fluid extract from Agaricus bisporus>, COA of Formula: C19H34O2, the main research area is Agaricus chem profile antimicrobial antiaggregant anticoagulant.

Mushrooms are known for their medicinal value and health benefits, particularly the species Agaricus bisporus, which is rich in bioactive components. However, there are difficulties in determining bioactive compounds, as different extraction methods are rarely investigated and may yield extracts with different chem. profiles. For food and pharmaceutical applications, the toxicity of residual solvents must also be considered. This study aimed to (i) prepare A. bisporus extracts by supercritical fluid extraction (40 °C and 20 MPa-SFE1 or 30 MPa-SFE2) and conventional organic solvent extraction (COSE) with ethanol, (ii) compare the yield and chem. profile of extracts, and (iii) evaluate their antimicrobial, antiaggregant, and anticoagulant activities. The major compounds identified were two fatty acid Me esters (relative content greater than 40%): Me (E,E)-9,12-octadecadienoate (Me linoleate) and Me (Z)-9-octadecenoate (Me oleate). Me hexadecanoate and Me octadecanoate, two esters derived from palmitic acid, were also present in the extracts but at lower concentrations in terms of peak area percentage. Extracts obtained by SFE had low min. inhibitory concentrations (MIC) (75-500 μg/mL) against bacteria, being classified as strong inhibitors. On the other hand, MIC values of the extract obtained by COSE against Staphylococcus aureus and Staphylococcus epidermidis were higher than 2,000 μg/mL (weak inhibitor). COSE extract was not active against Gram-neg. bacteria. The antiplatelet aggregation effect of SFE extracts was higher than that of COSE extract In the face of ADP (ADP), COSE, SFE1, and SFE2 resulted in a 7%, 18%, and 12% decrease in platelet aggregation, resp. In the aggregation triggered by epinephrine, platelet aggregation decreased by 10%, 15%, and 18%, resp. Overall, A. bisporus extracts obtained by SFE showed the best performance in bioactive screening assays compared with the conventional ethanolic extract

Chemical Papers published new progress about Agaricus bisporus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics