Category: 112-63-0

Hay, Duncan A.; Rogers, Catherine M.; Fedorov, Oleg; Tallant, Cynthia; Martin, Sarah; Monteiro, Octovia P.; Muller, Susanne; Knapp, Stefan; Schofield, Christopher J.; Brennan, Paul E. published the artcile< Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is BRD7 BRD9 inhibitor anticancer agent drug design cancer.

Emerging evidence suggests bromodomain-containing proteins 7 and 9 (BRD7 and BRD9) have roles in the regulation of human transcription and disease including cancer. We describe potent and selective inhibitors of the BRD7 and BRD9 bromodomains intended for use as tools to elucidate the biol. roles of BRD7 and BRD9 in healthy and diseased cells.

MedChemComm published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Coogan, Michael P.; Harger, Martin J. P. published the artcile< Nucleophilic substitution in benzylic thiophosphinyl and thiophosphonyl chlorides: the contribution of elimination-addition pathways with methylenethioxophosphorane (thiophosphene) intermediates>, Category: esters-buliding-blocks, the main research area is thiophosphinyl thiophosphonyl chloride benzylic nucleophilic substitution; methylenethioxophosphorane intermediate elimination addition pathway; thiophosphene intermediate elimination addition pathway.

For the reactions of ArCH2P(S)(Ph)Cl and ArCH2P(S)(NMe2)Cl with Et2NH, changing ArCH2 from benzyl to 4-nitrobenzyl increases the rates of substitution by factors of 80 and >103, resp., and reduces markedly the ability to discriminate between competing Et2NH and Me2NH nucleophiles. With Et2ND, the nitrobenzyl substrates give products that contain D in the benzylic methylene group. These observations point to substitution by elimination-addition, with a 3-coordinate methylenethioxophosphorane (thiophosphene) intermediate, for the nitrobenzyl compounds

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about Elimination reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Muramoto, Yokichi; Fujita, Masaki; Ichimoto, Itsuo; Ueda, Hiroo published the artcile< Ethyl 3-oxoglutarate derivatives. III. Synthesis of long chain oxodicarboxylic esters from ethyl 3-oxoglutarate>, Computed Properties of 112-63-0, the main research area is glutarate oxo alkylation haloester; alkylation oxoglutarate haloester; oxoalkanedioate dialkyl; carboxylic diester aliphatic oxo.

The monoanion of the Mg chelate prepared from Et 3-oxoglutarate (I) and Mg(OEt)2 was alkylated with a haloester to give a monoalkylated derivative A second alkylation with a different haloester in the presence of NaOEt followed by decarboxylative hydrolysis and esterification gave an unsymmetrical long chain oxodicarboxylic ester, such as di-Et 5-oxoheptadecanedioate, di-Me 6-methyl-8-oxopentadecanedioate di-Et 6-methyl-4-oxopentadecanedioate, or di-Et 2-methyl-4-oxopentadecanedioate. Moreover, di-Et 8-oxopentadecanedioate was obtained by the alkylation of I with Et 6-bromohexanoate in the presence of NaOEt alone as a catalyst. These esters appear suitable for cyclization to macrocyclic ketones.

Agricultural and Biological Chemistry published new progress about Esters. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gevorgyan, Ashot; Mkrtchyan, Satenik; Grigoryan, Tatevik; Iaroshenko, Viktor O. published the artcile< Application of Silicon-Initiated Water Splitting for the Reduction of Organic Substrates>, Application of C19H34O2, the main research area is nitro compound amine oxide sulfoxide alkene alkyne reduction; aryl halide hydrodehalogenation silicon initiated water splitting; catalysis; silicon; substrate scope; transfer hydrogenation; water splitting.

The use of water as a donor for hydrogen suitable for the reduction of several important classes of organic compounds is described. It is found that the reductive water splitting can be promoted by several metalloids among which silicon shows the best efficiency. The developed methodologies were applied for the reduction of nitro compounds, N-oxides, sulfoxides, alkenes, alkynes, hydrodehalogenation as well as for the gram-scale synthesis of several substrates of industrial importance.

ChemPlusChem published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Ge; Tao, Xiang; Ji, Baowei; Gong, Jie published the artcile< Hypoxia-Driven M2-Polarized Macrophages Facilitate Cancer Aggressiveness and Temozolomide Resistance in Glioblastoma.>, Category: esters-buliding-blocks, the main research area is .

Hypoxia-induced M2 phenotypes of tumor associated macrophages (TAMs) promote the development and chemoresistance of multiple types of cancers, including glioblastoma (GBM). However, the detailed molecular mechanisms have not been fully understood. In this study, we firstly reported that hypoxic pressure promoted M2 macrophage generation, which further promoted cancer progression and temozolomide (TMZ) resistance in GBM through secreting vascular endothelial growth factor (VEGF). Specifically, the clinical data suggested that M2 macrophages were significantly enriched in GBM tissues compared with the adjacent normal tissues, and the following in vitro experiments validated that hypoxic pressure promoted M2-polarized macrophages through upregulating hypoxia-inducible factor-1α (HIF-1α). In addition, hypoxic M2 macrophages VEGF-dependently promoted cell proliferation, epithelial-mesenchymal transition (EMT), glioblastoma stem cell (GSC) properties, and TMZ resistance in GBM cells through activating the PI3K/Akt/Nrf2 pathway. Also, M2 macrophages secreted VEGF to accelerate angiogenesis in human umbilical vein endothelial cells (HUVECs) through interacting with its receptor VEGFR. In general, we concluded that hypoxic M2 macrophages contributed to cancer progression, stemness, drug resistance, and angiogenesis in GBM through secreting VEGF, and our data supported the notion that targeting hypoxia-associated M2 macrophages might be an effective treatment strategy for GBM in clinical practices.

Oxidative medicine and cellular longevity published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Guiqiao; Liu, Xiaowei; Cai, Shaokang; Zhang, Shurong; Cui, Jinzhi; Gao, Canzhu; Cheng, Zhongfa published the artcile< A Pyrene Fluorescent Probe for Rapid Detection of Ferric Ions>, Application In Synthesis of 112-63-0, the main research area is ferric ion pyrene fluorescent probe detection; Ferric ions; Fluorescence quenching; Fluorescent material; PTSA.

The 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt (PTSA) is a pyrene derivative with high fluorescence characteristics and is widely used in fluorescence tracer. This study aims at investigating a simple and fast fluorescence detection method for determining the concentration of ferric ion by using PTSA, which the principle is that the fluorescence quenching of PTSA by ferric ions. Theor. and exptl. methods were adopted to deeply analyze its detection performance and characteristics. The fluorescence quenching phenomena under different pH conditions and the effect of the different interfering metal ions on PTSA/Fe3+ system was studied. The results showed that the PTSA was quite promising for the fluorescence detection of trace ferric ions, and the limit of detection is 9μg/L. This study is envisioned to provide inspirational insights on trace detection of iron ions, opening new routes for water monitoring use fluorescence properties.

Journal of Fluorescence published new progress about Fluorescence. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karapanayiotis, Thanasis; Bowen, Richard D. published the artcile< Differentiation of ionized benzimidazole from its isomeric α-distonic ion by collision-induced dissociation and neutralization-reionization mass spectrometry>, Computed Properties of 112-63-0, the main research area is benzimidazole radical cation distonic tautomer CID NR mass spectra.

Ionized benzimidazole and its isomeric α-distonic ion (or ionized ylide) have been examined by recording their metastable ion, collision-induced dissociation and neutralization-reionization mass spectra. These tautomers may be distinguished by careful consideration of key features of the collision-induced dissociation spectra, with or without prior neutralization and reionization. Formation of doubly-charged ions by charge stripping occurs preferentially when the α-distonic ion is subjected to collision. This α-distonic ion survives neutralization and reionization, thus establishing that the corresponding ylide is stable on the microsecond time frame. The effects of benzannulation on the ease of differentiation of classical and distonic radical cations derived from biol. important heterocycles are considered.

European Journal of Mass Spectrometry published new progress about Collision-induced dissociation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ozen, Tevfik; Demirtas, Ibrahim published the artcile< Comparison of the chemical composition and bioactive properties of extracts prepared from the mature Turkish and Brazilian banana peels>, Application In Synthesis of 112-63-0, the main research area is Brazilian Turkish banana peel extract chem composition bioactive property.

The banana (Musa sp.) plant grows in tropical and subtropical regions. The fruit of the banana is eaten and the peel of the banana is discarded. In this study, chem. analyzes (HPLCTOF/MS ve GC-MS) and biochem. activities (antioxidant and antimicrobial) of Et acetate (Ea) and methanol/chloroform (Me/Ch) extracts prepared from banana peel (Bbp) grown in Brazil and banana peel (Tbp) grown in Turkey were investigated. Cetene, 4-hydroxybenzoic, palmitic, linoleic, stearic, gentisic and syringic acid are the most abundant compounds in the extracts The total antioxidant activity of Tbp-Ea (A0.5: 36.84 μg/mL), inhibition of lipid peroxidation of Bbp-Ea (IC50: 3.22 μg/mL), reducing power of Tbp-Me/Ch (A0.5: 4.96 μg/mL), DPPH• scavenging activity of Bbp-Ea (IC50: 8.54 μg/mL), metal chelating activity of Tbp-Ea (IC50: 16.54 μg/mL) and H2O2 scavenging activity of Tbp-Me/Ch (IC50: 0.36 μg/mL) were found the most effective. It was exhibited that extracts were effective against gramneg. and gram-pos. bacteria. In conclusion, the phytochem. and biochem. results of the TbP and Bbp extracts will contribute further pharmacol., biochem. and pharmacol. investigations.

International Journal of Chemistry and Technology (Kilis, Turkey) published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Al-Ani, Mena; Elemam, Noha Mousaad; Hundt, Jennifer Elisabeth; Maghazachi, Azzam A. published the artcile< Drugs for multiple sclerosis activate natural killer cells: do they protect against COVID-19 infection?>, COA of Formula: C19H34O2, the main research area is review human covid19 virus natural killer cell; COVID-19; NK cells; multiple sclerosis.

A review. COVID-19 infection caused by the newly discovered coronavirus severe acute respiratory distress syndrome virus-19 (SARS-CoV-2) has become a pandemic issue across the globe. There are currently many investigations taking place to look for specific, safe and potent anti-viral agents. Upon transmission and entry into the human body, SARS-CoV-2 triggers multiple immune players to be involved in the fight against the viral infection. Amongst these immune cells are NK cells that possess robust antiviral activity, and which do not require prior sensitization. However, NK cell count and activity were found to be impaired in COVID-19 patients and hence, could become a potential therapeutic target for COVID-19. Several drugs, including glatiramer acetate (GA), vitamin D3, di-Me fumarate (DMF), monomethyl fumarate (MMF), natalizumab, ocrelizumab, and IFN-β, among others have been previously described to increase the biol. activities of NK cells especially their cytolytic potential as reported by upregulation of CD107a, and the release of perforin and granzymes. In this review, we propose that such drugs could potentially restore NK cell activity allowing individuals to be more protective against COVID-19 infection and its complications.

Infection and Drug Resistance published new progress about COVID-19. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Almoshari, Yosif; Iqbal, Haroon; Razzaq, Anam; Ali Ahmad, Khalil; Khan, Muhammad Khalid; Saeed Alqahtani, Saad; Hadi Sultan, Muhammad; Ali Khan, Barkat published the artcile< Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective Colon cancer therapy>, Computed Properties of 112-63-0, the main research area is curcumin temozolomide anticancer agent colon cancer; Nanocubosomes; colon cancer; curcumin; temozolomide; therapy.

Current research aimed to develop nanocubosomes co-loaded with dual anticancer drugs curcumin and temozolomide for effective colon cancer therapy. Drugs co-loaded nanocubosomal dispersion was prepared by modified emulsification method using glyceryl monooleate (GMO), pluronic F127 and bovine serum albumin (BSA) as a lipid phase, surfactant, and stabilizer, resp. The resulting nanocubosomes were characterized by measuring hydrodynamic particle size, particle size distribution (PSD), drug loading capacity (DL), encapsulation efficiency (EE), colloidal stability and drug release profile. We also physiochem. characterized the nanocubosomes by transmission electron microscopy (TEM), Fourier transform IR (FTIR), and x-rays diffraction (XRD) for their morphol., polymer drug interaction and its nature, resp. Further, the in-vitro cell-uptake, mechanism of cell-uptake, in-vitro anti-tumor efficacy and apoptosis level were evaluated using HCT-116 colon cancer cells. The prepared nanocubosomes exhibited a small hydrodynamic particle size (PS of 150 ± 10 nm in diameter) with nearly cubic shape and appropriate polydispersity index (PDI), enhanced drug loading capacity LC of 6.82 ± 2.03% (Cur) and 9.65 ± 1.53% (TMZ), high entrapment efficiency EE of 67.43 ± 2.16% (Cur) and 75.55 ± 3.25% (TMZ), pH-triggered drug release profile and higher colloidal stability in various physiol. medium. Moreover, the nanocubosomes showed higher cellular uptake, in-vitro cytotoxicity and apoptosis compared to free drugs, curcumin and temozolomide, most likely because its small particle size. In addition, BSA-stabilized nanocubosomes were actively taken by aggressive colon cancer cells that over-expressed the albumin receptors and utilized BSA as nutrient source for their growth. In short, this study provides a new and simple strategy to improve the efficacy and simultaneously overawed the adaptive treatment tolerance in colon cancer.

Drug Delivery published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics