Category: 112-63-0

Tsunoda, Takashi; Yamazaki, Atsuki; Mase, Toshiyasu; Sakamoto, Shuichi published the artcile< A Scalable Process for the Synthesis of 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine Monohydrate and 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic Acid: Two New Key Intermediates for the Synthesis of the AVP Antagonist Conivaptan Hydrochloride>, HPLC of Formula: 112-63-0, the main research area is safety methyltetrahydroimidazo benzazepine intermediate preparation scale up green chem; biphenylylcarbonyl aminobenzoic acid intermediate preparation vasopressin receptor antagonist.

A process for the multikilogram synthesis of the dual vasopressin-receptor antagonist, conivaptan hydrochloride, was developed. This method relies on the introduction of operationally simple chem. during the final stages of the process when two key intermediates, isolated by crystallization, are reacted to assemble the final mol. A three-stage sequence was developed for the synthesis of the first key amine hydrate intermediate, and modifications of the original process are described. Major strategic improvements were achieved in defining the final route to the side chain precursor mol., which is the second key intermediate. These advances revolve around the acylation of an unprotected amino benzoic acid and subsequent high-yield telescoped processes for the synthesis of 4-[(biphenyl-2-ylcarbonyl)amino]benzoic acid. This method leads to a 4-fold increase in the overall yield of the target materials, circumvents the restricted synthetic intermediates, and constitutes a safe, reliable, adaptable, environmentally friendly, and cost-effective approach with improved manipulability.

Organic Process Research & Development published new progress about Acid hydrolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Smith, Hilton A.; Fort, Tomlinson Jr. published the artcile< The kinetics of the base-catalyzed hydrolysis of the methyl esters of cyclohexanedicarboxylic acids>, Application of C19H34O2, the main research area is .

Saponifications involving the monomethyl esters and alkali are strictly 1st order with respect to alkali and 1st order with respect to ester. For the cis-1,2, trans-1,2, trans-1,3, and cis-1,4 forms of the dimethyl esters saponification of the 1st ester group was so much more rapid than for the 2nd that in the early stages of the reaction (up to some 20%) the kinetic behavior was 2nd order. For each ester there is a large decrease in the saponification rate of the 2nd ester group as compared with the 1st. On the basis of the ratios of the 1st- and 2nd-rate constants for saponification of the esters studied, the separation of the 2 ester groups shows the following order: trans-1,4 > cis-1,3 > cis-1,4 > trans-1,3 > trans-1,2 > cis-1,2. The relative entropies of activation for the saponification reactions based on the monomethyl ester of cis-1,2-cyclohexanedicarboxylic acid are given.

Journal of the American Chemical Society published new progress about Entropy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Miao-Miao; Li, Shi-Hong; Tu, Jia-Lin; Min, Qing-Qiang; Liu, Feng published the artcile< Metal-free iminyl radical-mediated C-C single bond cleavage/functionalization of redox-active oxime esters>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is distal cyano pyridine photochem preparation metal free; cycloketone oxime ester vinylpyridine radical mediated bond cleavage functionalization; cyano alkene distal photochem preparation metal free; allyl sulfone cycloketone oxime ester radical bond cleavage functionalization.

A visible-light-driven iminyl radical-mediated C-C bond cleavage and functionalization of cycloketone oxime esters have been accomplished to give distal cyano pyridines such as I [R1 = H, Me, Bn, etc.; R2 = H, Me, Ph, etc.; R3 = H, 4-Me, 5-Me; R4 = H, Ph, 4-ClC6H4; R5 = H, 4-MeC6H4; n = 1, 2, 3, etc.; X = O, CH(Ph), CH(OBn), etc.] and distal cyano alkenes such as II [R6 = COOEt, Ph, 2-naphthyl, etc.; R7 = H, Me, Bn, etc.; R8 = H, Me, Ph, etc.]. This protocol is simple and does not require expensive and toxic photoredox and/or transition-metal catalysis, providing a novel catalyst-free strategy for alkylation, allylation, vinylation and alkynylation through addition of C(sp3)-centered radicals to various unsaturated acceptors. The com. available and photoactive Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.

Organic Chemistry Frontiers published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation) (cyano). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Nan; Huang, Renxuan; Yang, Kunmeng; He, Yichun; Gao, Yufei; Dong, Delu published the artcile< Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioblastoma multiforme mitochondria oxidative phosphorylation temozolomide chemotherapy; AMPK; TP53; glioblastoma multiforme; mitochondrial dynamics; temozolomide.

Glioblastoma multiforme (GBM) is a primary tumor of the central nervous system (CNS) that exhibits the highest degree of malignancy. Radiotherapy and chemotherapy are essential to prolong the survival time of patients. However, clin. work has demonstrated that sensitivity of GBM to chemotherapy decreases with time. The phenomenon of multi-drug resistance (MDR) reminds us that there may exist some fundamental mechanisms in the process of chemo-resistance. We tried to explore the mechanism of GBM chemo-resistance from the perspective of energy metabolism First, we found that the oxidative phosphorylation (OXPHOS) level of SHG44 and U87 cells increased under TMZ treatment. In further studies, it was found that the expression of PINK1 and mitophagy flux downstream was downregulated in GBM cells, which were secondary to the upregulation of TP53 in tumor cells under TMZ treatment. At the same time, we examined the mitochondrial morphol. in tumor cells and found that the size of mitochondria in tumor cells increased under the treatment of TMZ, which originated from the regulation of AMPK on the subcellular localization of Drp1 under the condition of unbalanced energy supply and demand in tumor cells. The accumulation of mitochondrial mass and the optimization of mitochondrial quality accounted for the increased oxidative phosphorylation, and interruption of the mitochondrial fusion process downregulated the efficiency of oxidative phosphorylation and sensitized GBM cells to TMZ, which was also confirmed in the in vivo experiment What is more, interfering with this process is an innovative strategy to overcome the chemo-resistance of GBM cells.

Journal of Cellular and Molecular Medicine published new progress about Apoptosis-regulating proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sowers, Mark L.; Sowers, Lawrence C. published the artcile< Glioblastoma and Methionine Addiction>, Category: esters-buliding-blocks, the main research area is epigenetics; glioblastoma; metabolism; methionine; therapeutic development; tumor microenvironment.

Glioblastoma is a fatal brain tumor with a bleak prognosis. The use of chemotherapy, primarily the alkylating agent temozolomide, coupled with radiation and surgical resection, has provided some benefit. Despite this multipronged approach, average patient survival rarely extends beyond 18 mo. Challenges to glioblastoma treatment include the identification of functional pharmacol. targets as well as identifying drugs that can cross the blood-brain barrier. To address these challenges, current research efforts are examining metabolic differences between normal and tumor cells that could be targeted. Among the metabolic differences examined to date, the apparent addiction to exogenous methionine by glioblastoma tumors is a critical factor that is not well understood and may serve as an effective therapeutic target. Others have proposed this property could be exploited by methionine dietary restriction or other approaches to reduce methionine availability. However, methionine links the tumor microenvironment with cell metabolism, epigenetic regulation, and even mitosis. Therefore methionine depletion could result in complex and potentially undesirable responses, such as aneuploidy and the aberrant expression of genes that drive tumor progression. If methionine manipulation is to be a therapeutic strategy for glioblastoma patients, it is essential that we enhance our understanding of the role of methionine in the tumor microenvironment.

International Journal of Molecular Sciences published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hiscock, Jennifer R.; Gale, Philip A.; Hynes, Michael J. published the artcile< Tris-(2-aminoethyl)amine-based tripodal trisindolylureas: new receptors for sulphate>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is anion receptor urea amine preparation phosphate sulfate acetate benzoate.

Several TREN-based amide or urea linked tris-indole anion receptors have been synthesized and their anion complexation properties studied in DMSO-d6/water mixtures

Supramolecular Chemistry published new progress about Amidation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alayande, Abayomi Babatunde; Hong, Seungkwan published the artcile< Ultraviolet light-activated peroxymonosulfate (UV/PMS) system for humic acid mineralization: Effects of ionic matrix and feasible application in seawater reverse osmosis desalination>, Reference of 112-63-0, the main research area is peroxymonosulfate humic acid mineralization seawater reverse osmosis desalination; Disinfection byproducts; Halides; Humic acid; Reactive halogen species; UV/PMS oxidation; Water treatment.

The use of membrane-based technol. has evolved into an important strategy for supplying freshwater from seawater and wastewater to overcome the problems of water scarcity around the world. However, the presence of natural organic matter (NOM), including humic substances affects the performance of the process. Here, we present a systematic report on the mineralization of humic acid (HA), as a model for NOM, in high concentration of salts using the UV light-activated peroxymonosulfate (UV/PMS) system as a potential alternative for HA elimination during membrane-based seawater desalination and water treatment processes. Effects of various parameters such as PMS concentration, solution type, pH, anions, and anion-cation matrix on HA mineralization were assessed. The results show that 100%, 78% and 58% of HA (2 mg/L TOC) were mineralized with rate constants of 0.085 min-1, 0.0073 min-1, and 0.0041 min-1 after 180 min reaction time at pH 7 when 0.5 mM PMS was used in deionized water, sodium chloride solution (35,000 ppm) and synthetic seawater, resp. The reduced efficiency under saline conditions was attributed to the presence of anions in the system that acted as sulfate and hydroxyl radicals scavengers. Furthermore, the safety of the treated synthetic seawater was evaluated by analyzing the residual transformed products. Overall, pretreatment with the UV/PMS system mitigated fouling on the RO membrane.

Environmental Pollution (Oxford, United Kingdom) published new progress about Fouling. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beppu, Takaaki; Iwaya, Takeshi; Sato, Yuichi; Nomura, Jun-Ichi; Terasaki, Kazunori; Sasaki, Toshiaki; Yamada, Noriyuki; Fujiwara, Shunrou; Sugai, Tamotsu; Ogasawara, Kuniaki published the artcile< PET With 11C-Methyl-l-Methionine as a Predictor of Consequential Outcomes at the Time of Discontinuing Temozolomide-Adjuvant Chemotherapy in Patients With Residual IDH-Mutant Lower-Grade Glioma.>, Application of C19H34O2, the main research area is .

PURPOSE: The aim of this study was to clarify whether PET with 11C-methyl-l-methionine (11C-met PET) can predict consequential outcomes at the time of discontinuing temozolomide (TMZ)-adjuvant chemotherapy in patients with residual isocitrate dehydrogenase gene (IDH)-mutant lower-grade glioma. PATIENTS AND METHODS: Among 30 patients showing residual lesions of IDH-mutant lower-grade glioma, we compared the tumor-to-normal brain tissue ratio of standardized uptake values (SUVT/N) from 11C-met PET at the time of discontinuing TMZ-adjuvant chemotherapy with putative predictive factors including age, Karnofsky Performance Scale, number of courses of adjuvant therapy, residual tumor size, and promotor methylation status of O6-methylguanine-DNA methyl-transferase gene (MGMT). For each factor, progression-free survival (PFS) was compared between groups divided by cutoff values, determined to predict tumor relapse using receiver operating characteristic curves for each factor. Univariate and multivariate analyses were conducted using log-rank testing and Cox regression analysis, respectively. In addition, PFS was compared between patients grouped by combined findings from multiple predictors identified from univariate and multivariate analyses. RESULTS: Univariate and multivariate analyses identified SUVT/N from 11C-met PET and MGMT methylation status as independent predictors of outcomes after TMZ discontinuation. When comparing 3 groups assigned by the combination of MGMT and SUVT/N findings, PFS differed significantly among groups. CONCLUSIONS: The present study suggested that 11C-met PET at the time of discontinuing TMZ-adjuvant chemotherapy allows prediction of outcomes at least comparable to MGMT methylation status in patients with residual IDH-mutant lower-grade glioma. Further, 11C-met PET allows more precise prediction of outcomes by assessment in combination with MGMT findings.

Clinical nuclear medicine published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pan, Guihua; He, Changli; Chen, Min; Xiong, Qian; Cao, Weidi; Feng, Xiaoming published the artcile< Synthesis of dihydroisoquinoline and dihydropyridine derivatives via asymmetric dearomative three-component reaction>, Formula: C19H34O2, the main research area is dihydroisoquinoline dihydropyridine diastereoselective enantioselective; heteroarene allenoate methyleneindolinone asym dearomative three component reaction.

Authors report the first asym. three-component nucleophilic addition/dearomative [4+2] cycloaddition/isomerization cascade of transient dipoles generated from N-heteroarenes and allenoates with methyleneindolinones in the presence of chiral N,N’-dioxide/metal complexes. This tandem reaction enabled rapid access to versatile chiral polycyclic N-heterocycles with good to excellent enantioselectivities under mild reaction conditions in spite of the strong background reaction, including 1,2-dihydroisoquinoline, 1,2-dihydropyridine derivatives, and others. Meanwhile, a series of control experiments were conducted to elucidate the reaction mechanism and the roles of additives.

CCS Chemistry published new progress about [4+2] Cycloaddition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Becker, Jeffrey M.; Wilchek, Meir; Katchalski, Ephraim published the artcile< Irreversible inhibition of biotin transport in yeast by biotinyl-p-nitrophenyl ester>, Reference of 112-63-0, the main research area is biotin transport Saccharomyces inactivator; biotinylnitrophenyl yeast biotin transport.

Biotinyl-p-nitrophenyl ester (I) [33755-53-2] at .geq.10-7M irreversibly inactivated biotin [58-85-5] transport in Saccharomyces cerevisiae. The extent of inactivation increased with time, implying that I reacts with a transport component(s) to yield a covalently-bound biotinyl derivative I did not affect the transport of lysine [56-87-1], aspartic acid [56-84-8], or L-sorbose [87-79-6]. Inactivation of biotin transport by I was partially prevented in the presence of high concentrations of biotin (0.5mM). Biotinyl-p-nitroanilide [33755-54-3], (0.1mM) and acetyl-p-nitrophenyl ester (0.1mM) did not affect biotin transport when added to S. cerevisiae suspensions.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Saccharomyces cerevisiae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics