Category: 112-63-0

Serbanovic, Ana; Branco, Luis C.; Nunes da Ponte, Manuel; Afonso, Carlos A. M. published the artcile< Osmium catalyzed asymmetric dihydroxylation of methyl trans-cinnamate in ionic liquids, followed by supercritical CO2 product recovery>, Related Products of 112-63-0, the main research area is osmium asym dihydroxylation cinnamate ionic liquid supercritical carbon dioxide; taxol side chain osmium dihydroxylation catalyst recycling.

In this work, osmium-catalyzed asym. dihydroxylation (AD) of Me trans-cinnamate was studied. Osmium and chiral ligand catalysts were immobilized in ionic liquid only, without any other reaction solvents, while the recovery of the product was performed by extraction with supercritical CO2, and compared with results obtained by extractions with organic solvents such as hexane and di-Et ether. In supercritical CO2 extraction experiments, optimal extraction pressure was found and ionic liquid chosen, so that the highest reaction yields coupled with lowest osmium content in the crude product can be achieved. Finally, recycle experiments of the same (ionic liquid + catalytic system) mixture were successfully conducted. Application of ionic liquids and supercritical CO2 in osmium catalyzed AD allows for the isolation of the diol basically without contamination with osmium, in high yield and enantiomeric excess, and it makes possible the efficient reuse of ionic liquid solvent and the catalytic system. The stereoselective dihydroxylation of trans-cinnamate gave (αR,βS)-α,β-di(hydroxy)benzenepropanoic acid Me ester.

Journal of Organometallic Chemistry published new progress about Dihydroxylation, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nagumo, Ryo; Omori, Kohei; Muraki, Yukihiro; Iwata, Shuichi; Mori, Hideki; Yamada, Hidetaka published the artcile< Correlation between Macroscopic Diffusion Rates and Microscopic Interactions in Ethylene Glycol-Based Solvents>, Computed Properties of 112-63-0, the main research area is diffusion residence time ethylene glycol based solvent MD simulation.

An evaluation of mol. interactions is important for estimating macroscopic properties, such as solubility and diffusivity. In this study, for several types of ethylene glycol-based absorbents, we discuss the correlation between a macroscopic property (mol. diffusivity) and a microscopic criterion (residence time) using mol. dynamics simulations for pure solvent systems and CO2-loaded solvent systems. The neg. correlations between the diffusivity and the residence time can be divided into categories, depending on the number of constituent hydroxy groups of the solvent mols. The disparity between the categories arises from whether hydrogen bonding can be formed between the solvent mols. This study leads to the systematic estimation of the mol. diffusivity from the theor. prediction of the residence time. We believe that the residence time is suitable as a criterion to evaluate macroscopic properties.

Industrial & Engineering Chemistry Research published new progress about Absorbents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zlatic, Nenad; Mihailovic, Vladimir; Ljesevic, Marija; Beskoski, Vladimir; Stankovic, Milan published the artcile< Geological substrate-related variability of Teucrium montanum L. (Lamiaceae) essential oil>, Formula: C19H34O2, the main research area is Teucrium montanum essential oil geol substrate related variability.

This study aimed to determine the qual. variability of essential oils of mountain germander – Teucrium montanum L. (Lamiaceae) at the population level, depending on the type of geol. substrate. Ten samples of essential oils originated from aerial plant parts of populations from calcareous and ten from serpentinite were tested by GCxGC-MS method. The obtained results showed that the serpentinite populations have more than 3 times higher essential oil yield than calcareous populations. Based on the average values for the relative percentage amounts of T. montanum essential oils, it was shown that the sesquiterpenes (34.89%) are the main compounds in analyzed essential oils. Population from calcareous habitats synthesize twice as many aliphatic hydrocarbons than populations from serpentinite habitats, while populations from serpentinite habitats synthesize twice as much mono- and sesquiterpenes. The compounds with highest relative percentage amounts in calcareous populations was the hydrocarbon tetracosane (9.02%), while in serpentinite populations it was oxygenated sesquiterpene, limonen-10-ol (4.81%). Compounds which were only detected for calcareous populations are: dodecane and isophytol, while for serpentinite populations are: 3-caren-2-ol, carvone oxide and pyronene. The obtained results indicate a significant influence of the habitat geol. substrate on the qual. characteristics of the T. montanum essential oil. Differentiation of calcareous and serpentinite populations into two distinct groups based on the essential oil composition indicate the significant presence of specific chemotypes developed by the influence of various edaphic characteristics.

Biochemical Systematics and Ecology published new progress about Cell differentiation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Becker, Patrick; Dohmann, Annemieke; Wohlbrand, Lars; Thies, Daniela; Hinrichs, Christina; Buschen, Ramona; Wuensch, Daniel; Neumann-Schaal, Meina; Schomburg, Dietmar; Winklhofer, Michael; Reinhardt, Richard; Rabus, Ralf published the artcile< Complex and flexible catabolism in Aromatoleum aromaticum pCyN1>, Product Details of C19H34O2, the main research area is Aromatoleum aromaticum growth catabolism pathway.

Large quantities of organic matter are continuously deposited, and (a)biotic gradients intersect in the soil-rhizosphere, where biodegradation contributes to the global cycles of elements. The betaproteobacterial genus Aromatoleum comprises cosmopolitan, facultative denitrifying degradation specialists. Aromatoleum aromaticum. pCyN1 stands out for anaerobically decomposing plant-derived monoterpenes in addition to monoarom. hydrocarbons, polar aromatics and aliphatics. The catabolic network’s structure and flexibility in A. aromaticum pCyN1 were studied across 34 growth conditions by superimposing proteome profiles onto the manually annotated 4.37 Mbp genome. Strain pCyN1 employs three fundamentally different enzymes for C-H-bond cleavage at the Me groups of p-cymene/4-ethyltoluene, toluene and p-cresol resp. Regulation of degradation modules displayed substrate specificities ranging from narrow (toluene and cyclohexane carboxylate) via medium-wide (one module shared by p-cymene, 4-ethyltoluene, α-phellandrene, α-terpinene, γ-terpinene and limonene) to broad (central benzoyl-CoA pathway serving 16 aromatic substrates). Remarkably, three variants of ATP-dependent (class I) benzoyl-CoA reductase and four different β-oxidation routes establish a degradation hub that accommodates the substrate diversity. The respiratory system displayed several conspicuous profiles, e.g. the presence of nitrous oxide reductase under oxic and of low-affinity oxidase under anoxic conditions. Overall, nutritional versatility in conjunction with network regulation endow A. aromaticum pCyN1 with broad adaptability.

Environmental Microbiology published new progress about Aliphatic compounds Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Chengbin; Zhang, Xi; Wang, Yi; Yang, Yongtai; Liu, Xiaofeng; Deng, Mingli; Jia, Yu; Ling, Yun; Meng, Ling-hua; Zhou, Yaming published the artcile< Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is azaindole phosphoinositide kinase inhibitor; 1H-pyrrolo[2,3-b] pyridine; PI3K; PI3K/mTOR; cancer therapy; oncology.

The phosphoinositide 3-kinase (PI3K) inhibitors potently inhibit the signaling pathway of PI3K/AKT/mTOR, which provides a promising new approach for the molecularly targeted cancer therapy. In this work, a novel series of 7-azaindole scaffold derivatives was discovered by the fragment-based growing strategy. The structure-activity relationship profiles identified that the 7-azaindole scaffold derivatives exhibit potent activity against PI3K at mol. and cellular levels as well as cell proliferation in a panel of human tumor cells.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Betti, Matteo; Castagnoli, Giulio; Panico, Alessandro; Sanna-Coccone, Salvatore; Wiedenau, Paul published the artcile< Development of a Scalable Route to the SMO Receptor Antagonist SEN794>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is scalable route Smoothened receptor antagonist SEN794.

A practical and scalable route to the SMO receptor antagonist SEN794 1 is described herein. A new and efficient access to the key intermediate 7 via the Kroehnke reaction was developed, significantly simplifying the synthesis and reducing costs. The optimized route consists of six chem. steps plus a palladium scavenging step. The intermediates are solids and were isolated by filtrations, except for ester 9, which was telescoped as the crude oil into the subsequent step. In the final amide formation step, target compound 1 was conveniently crystallized from the reaction mixture in high purity.

Organic Process Research & Development published new progress about Krohnke pyridine synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Bolin; Liu, Ning; Kang, Kui; Zhang, Renbo; Hao, Meilin; Song, Peiyong; Wang, Qingrong; Xie, Yuxiao; Li, Chuntao published the artcile< Dietary guanidineacetic acid supplementation ameliorated meat quality and regulated muscle metabolism of broilers subjected to pre-slaughter transport stress by metabolomics analysis>, HPLC of Formula: 112-63-0, the main research area is guanidineacetic acid dietary supplementation broiler meat muscle metabolism metabolomics; Qiandongnan Xiaoxiang chicken; gas chromatography−mass spectrometry; guanidine acetic acid; muscle metabolomics; pre-slaughter transport stress.

Pre-slaughter transport stress could induce multiple comprehensive variations in physiol. and metabolic parameters of broilers. However, the entire metabolomics of pre-slaughter transport stress and supplementation of exogenous energy regulatory substances on broilers is still poorly understood. The metabolome characteristics of broilers subjected to 3 h pre-slaughter transport stress combined with 1,200 mg/kg guanidinoacetic acid (GAA1,200) supplementation were analyzed using gas chromatog.-mass spectrometry (GC-MS) in this study. The results showed that, compared to the control group (no transport), 3 h pre-slaughter transport stress (T3h) decreased creatine (Cr), phosphocreatine (PCr) and ATP (ATP), and increased ADP (ADP), adenosine monophosphate (AMP) and the ratio of AMP to ATP in pectoralis muscle (PM) of broilers by high performance liquid chromatog. (HPLC) anal. However, GAA1,200 supplementation reversed the neg. effects induced by 3 h pre-slaughter transport stress. Besides, GAA1,200 supplementation elevated mRNA expression of creatine transporter in PM. Our metabolomics approaches demonstrated that 38 and 48 significant metabolites were sep. identified between the control group and T3h group, and T3h group and 3 h pre-slaughter transport stress combined with GAA1,200 supplementation group using the standard of variable importance in the projection values >1 and P < 0.05. Among these, the metabolites involved in amino acid metabolism (alanine, glycine, serine, threonine, cysteine , methionine, phenylalanine, tyrosine, and tryptophan), oxidative stress (3-methylhistidine, 1-methylhistidine and glutathione), non-protein amino acid (citrulline) metabolism, and energy metabolism (Cr, PCr, sarcosine, and glycocyamine) were confirmed through pathway enrichment anal., which could be chosen as suitable candidate targets for further anal. of the effects of exogenous energy substances on broilers subjected to transport stress. Poultry Science published new progress about Amino acids Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Szentirmai, Eva; Kapas, Levente published the artcile< Nicotinic acid promotes sleep through prostaglandin synthesis in mice>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nicotinic acid prostaglandin sleep mice.

Nicotinic acid has been used for decades for its antiatherogenic properties in humans. Its actions on lipid metabolism intersect with multiple sleep regulatory mechanisms, but its effects on sleep have never been documented. For the first time, we investigated the effects of acute systemic administration of nicotinic acid on sleep in mice. I.p. and oral gavage administration of nicotinic acid elicited robust increases in non-rapid-eye movement sleep (NREMS) and decreases in body temperature, energy expenditure and food intake. Preventing hypothermia did not affect its sleep-inducing actions suggesting that altered sleep is not secondary to decreased body temperature Systemic administration of nicotinamide, a conversion product of nicotinic acid, did not affect sleep amounts and body temperature, indicating that it is not nicotinamide that underlies these actions. Systemic administration of monomethyl fumarate, another agonist of the nicotinic acid receptor GPR109A, fully recapitulated the somnogenic and thermoregulatory effects of nicotinic acid suggesting that they are mediated by the GPR109A receptor. The cyclooxygenase inhibitor indomethacin completely abolished the effects of nicotinic acid indicating that prostaglandins play a key role in mediating the sleep and thermoregulatory responses of nicotinic acid.

Scientific Reports published new progress about Electroencephalogram. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Yeongsu; Yun, Jonghyeok; Shin, Hyun-Seop; Jung, Kyu-Nam; Lee, Jong-Won published the artcile< Synergistic nanoarchitecture of mesoporous carbon and carbon nanotubes for lithium-oxygen batteries>, Quality Control of 112-63-0, the main research area is mesoporous carbon lithium oxygen battery elec conductivity; Carbon nanotube; Electrochemistry; Lithium–oxygen battery; Mesoporous carbon.

A rechargeable lithium-oxygen battery (LOB) operates via the electrochem. formation and decomposition of solid-state Li2O2 on the cathode. The rational design of the cathode nanoarchitectures is thus required to realize high-energy-d. and long-cycling LOBs. Here, we propose a cathode nanoarchitecture for LOBs, which is composed of mesoporous carbon (MPC) integrated with carbon nanotubes (CNTs). The proposed design has the advantages of the two components. MPC provides sufficient active sites for the electrochem. reactions and free space for Li2O2storage, while CNT forests serve as conductive pathways for electron and offer addnl. reaction sites. Results show that the synergistic architecture of MPC and CNTs leads to improvements in the capacity ( ~18,400 mAh g- 1), rate capability, and cyclability (~200 cycles) of the CNT-integrated MPC cathode in comparison with MPC.

Nano Convergence published new progress about Current density. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Niu, K.; Wu, X. P.; Fu, Q.; Lang, K. P.; Zou, S. P.; Hu, Z. C.; Liu, Z. Q.; Zheng, Y. G. published the artcile< Effects of lipids and surfactants on the fermentation production of echinocandin B by Aspergillus nidulans>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Aspergillus echinocandin B fermentation lipid; Echinocandin B; lipids; methyl oleate; surfactant; tween 80.

Echinocandin B (ECB) is a kind of lipopeptide antifungal antibiotic, as well as the key precursor of antifungal drug Anidulafungin. Its efficient bioprodn. plays an important role in promoting the industrial production of Anidulafungin. Methods and Results : In this study, Me oleate and Tween 80 were firstly used to enhance the ECB fermentation by Aspergillus nidulans, the results showed that the ECB titer was significantly enhanced with the addition of Me oleate and Tween 80. Among the lipids, Me oleate was found to play a pivotal role in increasing the ECB titer to 2123 mg l-1, which was more than five times higher than that of the control. The addition of Tween 80 in the medium resulted in ECB titer increased to 2584 mg l-1. The scanning electron microscope (SEM) and N-phenyl-1-naphthylamine (NPN) assay indicated that Tween 80 could influence the cell membrane permeability of A. nidulans, and enhance the intracellular and extracellular substance exchange, therefore lead to the increasing of ECB titer. Me oleate and Tween 80 are optimal carbon sources and surfactants for efficient ECB biosynthesis resp. Significance and Impact of the Study : Surfactant was used in ECB fermentation for the first time, which provided feasible ideas for optimizing the fermentation process of other fungi.

Journal of Applied Microbiology published new progress about Aspergillus nidulans. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics