Category: 112-63-0

Zhao, Guozhong; Gao, Qidou; Wang, Yifei; Gao, Jianbiao; Li, Shu; Chen, Zhenjia; Wang, Xiaowen; Yao, Yunping published the artcile< Characterisation of sugars as the typical taste compounds in soy sauce by silane derivatisation coupled with gas chromatography-mass spectrometry and electronic tongue>, Formula: C19H34O2, the main research area is soy sauce sugar taste compound silane derivatization GCMS.

Summary : A total of 214 taste compounds were identified in soy sauce by silane derivatisation coupled with gas chromatog.-mass spectrometry (SD-GC-MS), including 74 kinds of sugars. The proportion of total sugars is highest from 37.24-77.24% among all taste compounds In particular, rare sugars were detected and identified as the special compounds in soy sauce which come from the sugar metabolism Rare sugars identified in soy sauce by traditional fermented technol. were prominent than Japanese technol. Principal component anal. (PCA) investigation of these results showed that samples can be distinguished by sugars as the first principal component and the general evaluation index (GEI) of samples was consistent with the result of sensory evaluation. Meanwhile, sweetness had the maximum range (from -9.89 to 14.10) in all taste indexes by electronic tongue (E-tongue) anal.

International Journal of Food Science and Technology published new progress about Soy sauce. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Massarweh, Amir; Tschernichovsky, Roi; Stemmer, Amos; Benouaich-Amiel, Alexandra; Siegal, Tali; Eliakim-Raz, Noa; Stemmer, Salomon M.; Yust-Katz, Shlomit published the artcile< Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in patients with primary brain tumors: a prospective cohort study>, Application In Synthesis of 112-63-0, the main research area is primary brain tumor BNT162b2 19 vaccine immunogenicity; BNT162b2; Covid-19; Glioma; Vaccine; mRNA.

Immunogenicity of Covid-19 vaccines may be neg. impacted by anti-cancer treatment. The management of primary brain tumors (PBTs) routinely includes temozolomide and steroids, which are immune-suppressive. We aimed to determine the rate of seropositivity in PBT patients following receipt of two doses of the BNT162b2 vaccine. We prospectively evaluated IgG levels against SARS-CoV-2 spike protein in 17 PBT patients following two doses of the BNT162b2 vaccine. IgG levels were collected at two time points: T1-after a median of 44 days from the second vaccine dose and T2-after a median of 130 days from the second dose. Titers were compared against a group of healthy controls (HC) comprised of patients’ family members. At T1, 88.2% (15/17) of PBT patients achieved seroconversion, compared with 100% (12/12) of HCs. Median IgG titer was significantly lower in the PBT group (1908 AU/mL vs 8,198 AU/mL; p = 0.002). At T2, 80% (12/15) of PBT patients seroconverted, compared to 100% (10/10) of HCs. Median IgG titer remained significantly lower in the PBT group (410 AU/mLvs 1687 AU/mL; p = 0.002). During the peri-vaccination period, 15 patients received systemic treatment and 8 patients were treated with corticosteroids. All 3 patients who failed to seroconvert at T2 were treated with corticosteroids. In a univariate anal., steroid use was neg. associated with antibody titer. Most PBT patients successfully seroconvert following two doses of the BNT162b2 vaccine, albeit with lower antibody titer compared to HCs. Steroid use during the vaccination period is associated with lower titer.

Journal of Neuro-Oncology published new progress about Anaplastic astrocytoma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dong, Qiang; Wang, Degui; Li, Lanlan; Wang, Jie; Li, Qiao; Duan, Lei; Yin, Hang; Wang, Xiaoqing; Liu, Yang; Yuan, Guoqiang; Pan, Yawen published the artcile< Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy>, Category: esters-buliding-blocks, the main research area is biochanin temozolomide anticancer agent autophagy glioblastoma; AMPK; Autophagy; Biochanin A; Chemosensitivity; Glioblastoma; Molecular docking.

Resistance to temozolomide (TMZ) chemotherapy is the main reason for treatment failure in patients with glioblastoma (GBM). In the present study, we investigated biochanin A (BCA) a potent sensitizer of TMZ in GBM. We observed that BCA significantly enhanced cell sensitivity to TMZ in vitro and in vivo. Mechanistically, the specific chemosensitizing effect of BCA is mediated by autophagy inhibition. Moreover, by performing a mol. docking anal., we demonstrated that BCA interacts with AMPK residues and impairs autophagy by regulating the AMPK/ULK1 pathway. These results suggest that BCA is a potential therapeutic agent that sensitizes GBM to TMZ and provide new insight into its therapeutic potential in chemoresistant GBM.

Molecular Neurobiology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fang, Jing; Zhao, Huamei; Liu, Qinglei; Zhang, Wang; Gu, Jiajun; Su, Yishi; Abbas, Waseem; Su, Huilan; You, Zhengwei; Zhang, Di published the artcile< AgBr/diatomite for the efficient visible-light-driven photocatalytic degradation of Rhodamine B>, HPLC of Formula: 112-63-0, the main research area is silver bromide diatomite rhodamine photocatalytic degradation wastewater treatment.

The treatment of organic pollution via photocatalysis has been investigated for a few decades. However, earth-abundant, cheap, stable, and efficient substrates are still to be developed. Here, we prepare an efficient visible-light-driven photocatalyst via the deposition of Ag nanoparticles (< 60 nm) on diatomite and the conversion of Ag to AgBr nanoparticles (< 600 nm). Exptl. results show that 95% of Rhodamine B could be removed within 20 min, and the degradation rate constant (κ) is 0.11 min-1 under 100 mW/cm2 light intensity. For comparison, AgBr/SiO2 (κ = 0.04 min-1) and commerical AgBr nanoparticles (κ = 0.05 min-1) were measured as well. The exptl. results reveal that diatomite acted more than a substrate benefiting the dispersion of AgBr nanoparticles, as well as a cooperator to help harvest visible light and adsorb dye mols., leading to the efficient visible-light-driven photocatalytic performance of AgBr/diatomite. Considering the low cost ($10 per ton) and large-scale availability of diatomite, our study provides the possibility to prepare other types of diatomite-based efficient photocatalytic composites with low-cost but excellent photocatalytic performance. Journal of Nanoparticle Research published new progress about Absorbents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Helong; Song, Guoyong published the artcile< Ru-Catalyzed Hydrogenolysis of Lignin: Base-Dependent Tunability of Monomeric Phenols and Mechanistic Study>, Synthetic Route of 112-63-0, the main research area is ruthenium catalyst hydrogenolysis lignin mechanism monomeric phenol.

Substantial attention has been given to depolymerization of lignin into monomeric phenols in recent years because lignin is a renewable and CO2-natural aromatic resource. Recent results indicated that the base can shift the selectivity from C3-fragmented phenols to C2-fragmented phenols partially in transition metal-catalyzed lignin hydogenolysis, while reaction mechanisms have remained elusive. Using a series of dimeric, trimeric, and polymeric β-O-4 lignin mimics, as well as their deuterated analogs, we now report an in-depth exptl. study on the mechanism of Ru/C-catalyzed hydogenolysis lignin. Exptl. evidence based on substrate probes, reactivity examination of possible intermediates, and isotopic labeling experiments confirmed that the reported pathways, such as enol ether generated via α,β-dehydration reaction or Cα carbonyl compounds generated via dehydrogenation or consecutive Cβ-O and Cγ-OH bonds hydrogenolysis, are irrelevant to current reactions. For C3-fragmented phenols with Ru/C catalyst under neutral condition, we deduced that the monolignol such as coniferyl alc. is formed primarily through a concerted hydrogenolysis process, where Cα-O and Cβ-O bonds are ruptured synchronously. For C2-fragmented phenols generated by the combination of Ru/C and Cs2CO3, the reaction should start from quinone methide specie generated from the dehydration (or demethanolization) reaction between phenolic proton and Cα-OH (or Cα-OMe). The followed deprotonation of Cγ-OH and the coordination of oxygen with Ru results in a Ru specie, which undergoes Cβ-H, Cβ-O, and Cβ-Cγ bonds cleavage to release 4-vinylphenol. In the case of Ru/C-catalyzed hydrogenolysis of an enzymic mild acidolysis lignin (EMAL) derived from birch tree, the effects of some key parameters such as temperature, reaction time, as well as the type and dosage of base were also examined in terms of monomer yields and selectivity. We found the formation of C2-phenols is a base-dependent process, which is in line with the proposed mechanism. Under optimized conditions, a high proportion of C2-phenols (44%) could be obtained with 26.6 weight % total monomers yield.

ACS Catalysis published new progress about Acid hydrolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Djerassi, Carl; Scholz, Caesar R. published the artcile< Brominations with pyridine hydrobromide perbromide, C5H5N.HBr.Br2>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is PYRIDINE AND PYRIDINE COMPOUNDS.

Cholestanone (38 mg.) and 31 mg. C5H5N.HBr.Br2 (I) in 1 cc. AcOH at 40-60° give 81% of the 2-Br derivative; Me 3-ketoallo-etiocholanate and I give 75% of the 2-Br derivative; EtOH or a mixture of EtOH and CHCl3 could be used as the solvent. Me 3-keto-12-acetoxycholanate (110 mg.) and 75 mg. I in 5 cc. AcOH, warmed 1 min. to about 40°, give 61% of the 4-Br derivative; coprostanone gives the 4-Br derivative Me 3(α)-acetoxy-12-ketoetiocholanate (195 mg.) and 155 mg. I in 1.2 cc. AcOH, warmed until solution resulted and kept 2.5 hrs. at room temperature, give on saponification and rearrangement 74% 3(α),12-dihydroxy-11-ketoetiocholanic acid. Cholestanone (380 g.) and 640 mg. I give after 10 min. 73% of the 2,4-di-Br derivative 4-(1-Piperidyl)-2-butanone (65 mg.) in 1 cc. AcOH containing 41% HBr and 135 mg. I, warmed about 30 sec., give 55% 1-bromo-4-(1-piperidyl)-2-butanone-HBr, m. 157-8° (decomposition). C5H5N.Br2 proved disappointing as a brominating agent.

Journal of the American Chemical Society published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maier, M. E. published the artcile< Product class 6: lactones>, SDS of cas: 112-63-0, the main research area is review lactone preparation organic synthesis.

A review of methods to prepare lactones and their applications to organic synthesis.

Science of Synthesis published new progress about Lactones Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yan, Xue-Long; Chen, Bei-Ling; Yuan, Fang-Yu; Zhu, Qin-Feng; Zhang, Xu; Lin, Yan; Long, Qing-De; Liao, Shang-Gao published the artcile< Six new tigliane diterpenoids with anti-inflammatory activity from Euphorbia kansuensis>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tigliane diterpenoid isolation antiinflammatory.

Six new tigliane diterpenoids, euphkanoids A – F I [R1 = OH, [(2E,4E,6E)-8-oxoocta-2,4,6-trienoyl]oxy, [(2E,4E,6E,8E)-10-oxodeca-2,4,6,8-tetraenoyl]oxy; R2 = H, acetyl; R3 = H, acetyl, [(9Z,12Z)-octadeca-9,12-dienoyl]], along with 12 known diterpenoids II [R4 = isopropenyl, isopropyl], III [R5 = oxo, hydroxy], IV, V, and VI were isolated from the roots of Euphorbia kansuensis, a traditional Chinese medicinal plant. Their structures were elucidated by spectroscopic anal., ECD calculation and chem. methods. Compounds I [R1 = [(2E,4E,6E)-8-oxoocta-2,4,6-trienoyl]oxy, [(2E,4E,6E,8E)-10-oxodeca-2,4,6,8-tetraenoyl]oxy, 2,4,6,8,10-dodecapentaenoyl; R2 = acetyl; R3 = H] represent the unusual examples of tigliane diterpenoids with a conjugated olefinic aldehyde moiety. I-VI and two hydrolyzed analogs I [R1 = H, OH; R2 = H; R3 = H] were screened for the inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells. The results showed that I [R1 = [(2E,4E,6E)-8-oxoocta-2,4,6-trienoyl]oxy, [(2E,4E,6E,8E)-10-oxodeca-2,4,6,8-tetraenoyl]oxy, 2,4,6,8,10-dodecapentaenoyl; R2 = acetyl; R3 = H] and VII markedly inhibited NO production with IC50 values in the range of 4.8-11.3μM, which were more active than the pos. control quercetin (IC50 = 12.3μM).

Arabian Journal of Chemistry published new progress about Alcohols Role: PAC (Pharmacological Activity), PUR (Purification or Recovery), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mel’nikova, L. A.; Kozlova, I. A.; Peterson, O. P.; Zhdanov, V. M. published the artcile< Origin of a factor causing deproteinization of vaccinia virus nucleocapsid>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Chicken fibroblast cultures wese infected with inactivated (2.5-3 hrs. at 56°) vaccinia virus and after 2-2.5 hrs. the cells were washed with saline and treated with antivaccinia serum. Then, after 3-fold centrifugation at 3000 and twice at 2200 rpm., the sediment was homogenized, resuspended, and actinomycin D, 0.05 γ/ml., was added. The reactivation was realized by addition of active vaccinia virus with 20-80 γ/ml. pyrromycin. The title factor is probably an enzyme, evoked not by the virus, but by a cell genome. This factor is formed 2-2.5 hrs. after cell infection and makes possible the reactivation of inactivated virus.

Voprosy Virusologii published new progress about Viruses. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hermant, Paul; Bosc, Damien; Piveteau, Catherine; Gealageas, Ronan; Lam, BaoVy; Ronco, Cyril; Roignant, Matthieu; Tolojanahary, Hasina; Jean, Ludovic; Renard, Pierre-Yves; Lemdani, Mohamed; Bourotte, Marilyne; Herledan, Adrien; Bedart, Corentin; Biela, Alexandre; Leroux, Florence; Deprez, Benoit; Deprez-Poulain, Rebecca published the artcile< Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox>, Formula: C19H34O2, the main research area is hydroxamic acid plasma stability.

Hydroxamic acids are outstanding zinc chelating groups that can be used to design potent and selective metalloenzyme inhibitors in various therapeutic areas. Some hydroxamic acids display a high plasma clearance resulting in poor in vivo activity, though they may be very potent compounds in vitro. The authors designed a 57-member library of hydroxamic acids to explore the structure-plasma stability relationships in these series and to identify which enzyme(s) and which pharmacophores are critical for plasma stability. Arylesterases and carboxylesterases were identified as the main metabolic enzymes for hydroxamic acids. Finally, the authors suggest structural features to be introduced or removed to improve stability. This work thus provides the first medicinal chem. toolbox (exptl. procedures and structural guidance) to assess and control the plasma stability of hydroxamic acids and realize their full potential as in vivo pharmacol. probes and therapeutic agents. This study is particularly relevant to preclin. development as it allows obtaining compounds equally stable in human and rodent models.

Journal of Medicinal Chemistry published new progress about Blood plasma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics