Category: 112-63-0

Hao, Lin; Chen, Shaojin; Xu, Jianfeng; Tiwari, Bhoopendra; Fu, Zhenqian; Li, Tong; Lim, Jieyan; Chi, Yonggui Robin published the artcile< Organocatalytic Activation of Alkylacetic Esters as Enolate Precursors to React with α,β-Unsaturated Imines>, HPLC of Formula: 112-63-0, the main research area is enantioselective organocatalytic NHC catalyzed cycloaddition unsaturated imine alkanoate enolate.

Asym. functionalization of alkylacetic esters and their derivatives is traditionally achieved via preformed enolates with chiral auxiliaries. Catalytic versions of such transformations are attractive but challenging. A direct catalytic activation of simple alkylacetic esters via N-heterocyclic carbene organocatalysts to generate chiral enolate intermediates for highly enantioselective reactions is reported. E.g., chiral NHC-catalyzed cycloaddition of PhCH:CHC(:NTs)Ph with 4-nitrophenyl butanoate in presence of DBU afforded trans-lactam I as the major diastereomer in 99% ee.

Organic Letters published new progress about Carboxylic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamamoto, Shuhei; Yoshikawa, Yutaka; Ueda, Eriko; Yamashita, Tetushi; Kajiwara, Naemi; Sakurai, Hiromu; Kojima, Yoshitane published the artcile< Insulinomimetic activity of zinc (II) complexes with halogenated picolinic acids>, Synthetic Route of 112-63-0, the main research area is antidiabetic zinc complex halogenated picolinic acid.

We prepared six new zinc(II) complexes of halogenated picolinic acids with a Zn(N2O2) coordination mode and evaluated for their insulinomimetic activities by in vitro study. By introducing an electron withdrawing halogen groups into the picolinic acid, we prepared bis(4- or 6-chloro picolinato), bis(4-, 5- or 6-iodo picolinato), and bis(6-bromo picolinato)/zinc(II) complexes (Zn(4cpa)2, Zn(6cpa)2, Zn(4ipa)2, Zn(5ipa)2, Zn(6ipa)2, and Zn(6bpa)2, resp.). By in vitro evaluation of the inhibition of free fatty acid (FFA) release from isolated rat adipocytes in the presence of epinephrine, the insulinomimetic activities of Zn(4cpa)2, Zn(6cpa)2, Zn(4ipa)2, Zn(6ipa)2, and Zn(6bpa)2 (IC50 = 0.64, 0.60, 0.77, 0.85, and 0.50 mM, resp.) were higher than that of bis(picolinato)/zinc(II) complex (Zn(pic)2) (IC50 = 1.00 mM) in terms of IC50 value, the 50% inhibition concentrations for the FFA release from rat adipocytes.

Biomedical Research on Trace Elements published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Agnihotri, Harsha; Paramasivam, Mahalingavelar; Palakollu, Veerabhadraiah; Kanvah, Sriram published the artcile< Photoisomerization of Trans Ortho-, Meta-, Para-Nitro Diarylbutadienes: A Case of Regioselectivity>, Electric Literature of 112-63-0, the main research area is nitro diarylbutadiene preparation regioselective photoisomerization fluoroscence crystal structure.

A series of ortho-, meta- and para-substituted trans-nitro aryl (Ph and pyridyl) butadienes have been synthesized and characterized. The effect of substitution and positional selectivity on their fluorescence and photoisomerization were systematically investigated. Among all dienes, meta- and para-nitro phenyl-substituted derivatives exhibit remarkable solvatochromic emission shifts due to intramol. charge transfer. On the other hand, ortho derivatives undergo regioselective isomerization upon photoexcitation in contrast to inefficient isomerization of para and meta nitro-substituted dienes. Single crystal X-ray anal. revealed existence of intramol. hydrogen bonding between the nitro group and the hydrogen of the proximal double bond. This restricts the rotation of the proximal double bond thereby allowing regioselective isomerization. The observations were also supported by NMR spectroscopic studies.

Photochemistry and Photobiology published new progress about Alkadienes Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jary, Walther G.; Baumgartner, Judith published the artcile< Asymmetric dihydroxylation reactions leading to novel chiral ferrocene derivatives>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Sharpless asym dihydroxylation ferrocenyl alkene; ferrocene chiral dihydroxyalkyl derivative asym preparation; osmium catalyzed asym dihydroxylation ferrocenyl alkene.

Several ferrocenyl alkenes were used as starting materials for asym. dihydroxylation reactions. Although they turned out to be unreactive employing Sharpless’ standard conditions, by systematic variation of the reaction conditions the desired novel ferrocenyl diols could be obtained in good yields and in enantiomeric excesses up to >99%. E.g., (1-propenyl)ferrocene was added to a homogeneous MeCN/H2O solution of K3Fe(CN)6, K2CO3, K2OsO2(OH)4 and (DHQD)2PYR ligand to give 1-[((1S,2R)-cis-1,2-dihydroxy)propyl]ferrocene in 99% yield (97% e.e.).

Tetrahedron: Asymmetry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Scinto, Samuel L.; Ekanayake, Oshini; Seneviratne, Uthpala; Pigga, Jessica E.; Boyd, Samantha J.; Taylor, Michael T.; Liu, Jun; am Ende, Christopher W.; Rozovsky, Sharon; Fox, Joseph M. published the artcile< Dual-Reactivity trans-Cyclooctenol Probes for Sulfenylation in Live Cells Enable Temporal Control via Bioorthogonal Quenching>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tran cyclooctenol sulfenylation live cell.

Sulfenylation (RSH → RSOH) is a posttranslational protein modification associated with cellular mechanisms for signal transduction and the regulation of reactive oxygen species. Protein sulfenic acids are challenging to identify and study due to their electrophilic and transient nature. Described here are sulfenic acid modifying trans-cycloocten-5-ol (SAM-TCO) probes for labeling sulfenic acid functionality in live cells. These probes enable a new mode of capturing sulfenic acids via transannular thioetherification, whereas “”ordinary”” trans-cyclooctenes react only slowly with sulfenic acids. SAM-TCOs combine with sulfenic acid forms of a model peptide and proteins to form stable adducts. Analogously, SAM-TCO with the selenenic acid form of a model protein leads to a selenoetherification product. Control experiments illustrate the need for the transannulation process coupled with the activated trans-cycloalkene functionality. Bioorthogonal quenching of excess unreacted SAM-TCOs with tetrazines in live cells provides both temporal control and a means of preventing artifacts caused by cellular-lysis. A SAM-TCO biotin conjugate was used to label protein sulfenic acids in live cells, and subsequent quenching by tetrazine prevented further labeling even under harshly oxidizing conditions. A cell-based proteomic study validates the ability of SAM-TCO probes to identify and quantify known sulfenic acid redox proteins as well as targets not captured by dimedone-based probes.

Journal of the American Chemical Society published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Ai; Lian, Qianwen; An, Zhenzhen; Li, Zhuang; Guo, Yongyang; Zhang, Dongxia; Xue, Zhonghua; Zhou, Xibin; Lu, Xiaoquan published the artcile< Simultaneous determination of uric acid, xanthine and hypoxanthine based on sulfonic groups functionalized nitrogen-doped graphene>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is uric acid xanthine hypoxanthine simultaneous determination differential pulse voltammetry; pyrenetetrasulfonate functionalized nitrogen doped graphene modified electrode.

A highly sensitive and selective method was developed for simultaneous detection of uric acid (UA), xanthine (XA) and hypoxanthine (HX) based on a 1,3,6,8-pyrene tetra sulfonic acid sodium salt functionalized nitrogen-doped graphene (PyTS-NG) composite. The material was synthesized by using a facile ultrasonic method via π-π conjugate action between 1,3,6,8-pyrene tetra sulfonic acid sodium salt (PyTS) and nitrogen-doped graphene (NG) mol. Compared with pristine NG, the material had better dispersivity and conductivity, which might be attributed to a large number of edge-plane-like defective sites on the surface of PyTS-NG that would accelerate electron transfer between electrode and species in solution The surface morphol. was characterized by SEM and TEM. The electrochem. behaviors of UA, XA and HX on the surface of PyTS-NG were studied by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under the optimized condition, the linear ranges for the determination of UA, XA and HX were 9-1000, 8-800 and 8-200 μM, with the detection limits (S/N = 3) of 0.331, 0.0838 and 0.231 μM, resp. Also, the practical application of the present method was evidenced by determining UA, XA and HX in human blood serum and urine samples.

Journal of Electroanalytical Chemistry published new progress about Annealing. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chhanda, Sadia Afrin; Itsuno, Shinichi published the artcile< Synthesis of cinchona squaramide polymers by Yamamoto coupling polymerization and their application in asymmetric Michael reaction>, SDS of cas: 112-63-0, the main research area is cinchona squaramide polymer catalyst preparation Yamamoto coupling; styrene anthrone copolymer catalyst enantioselective Michael addition reaction; phenylethyl anthracenone preparation.

Yamamoto coupling polymerization was used for the synthesis of polymeric chiral organocatalysts. Cinchona squaramide derivatives with dibromophenyl moiety were polymerized under the Yamamoto coupling conditions to afford the corresponding chiral polymers in good yields. Using this technique, novel cinchona alkaloid polymers containing the squaramide moiety were designed and successfully synthesized. In addition to the homopolymerization of cinchona squaramide monomers with a dibromophenyl group, achiral comonomers such as dibromobenzene were copolymerized with the cinchona monomers to yield chiral co-polymers. These chiral polymers were successfully utilized as polymeric catalysts in asym. Michael addition reactions. Good to excellent enantioselectivities were observed for different types of asym. Michael reactions. Using the chiral homopolymer catalyst I, almost perfect diastereoselectivity (>100:1) with 99% ee were obtained for the reaction between Me 2-oxocyclopentanecarboxylate and trans-β-nitrostyrene. The polymer catalysts developed in this study have robust structures and can be reused several times without a loss in their catalytic activities.

Reactive & Functional Polymers published new progress about Anthracenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Xiaoxiao; Ma, Wentao; Fan, Baofeng; Li, Peng; Gao, Jing; Liu, Qiuhong; Hu, Chunling; Li, Yong; Yao, Mengying; Ning, Hanbing; Xing, Lihua published the artcile< Integrating network pharmacology, transcriptome and artificial intelligence for investigating into the effect and mechanism of Ning Fei Ping Xue decoction against the acute respiratory distress syndrome>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is acute respiratory distress syndrome NFPX decoction; integrating network pharmacol transcriptome artificial intelligence; Ning Fei Ping Xue decoction; acute respiratory distress syndrome; artificial intelligence analysis; inflammatory responses; network pharmacology; transcriptome analysis.

Acute respiratory distress syndrome (ARDS) is a high-mortality disease and lacks effective pharmacotherapy. A traditional Chinese medicine (TCM) formula, Ning Fei Ping Xue (NFPX) decoction, was demonstrated to play a critical role in alleviating inflammatory responses of the lung. However, its therapeutic effectiveness in ARDS and active compounds, targets, and mol. mechanisms remain to be elucidated. The present study investigates the effects of NFPX decoction on ARDS mice induced by lipopolysaccharides (LPS). The results revealed that NFPX alleviated lung edema evaluated by lung ultrasound, decreased lung wet/Dry ratio, the total cell numbers of bronchoalveolar lavage fluid (BALF), and IL-1β, IL-6, and TNF-α levels in BALF and serum, and ameliorated lung pathol. in a dose-dependent manner. Subsequently, UPLC-HRMS was performed to establish the compounds of NFPX. A total of 150 compounds in NFPX were characterized. Moreover, integrating network pharmacol. approach and transcriptional profiling of lung tissues were performed to predict the underlying mechanism. 37 active components and 77 targets were screened out, and a herbs-compounds-targets network was constructed. Differentially expressed genes (DEGs) were identified from LPS-treated mice compared with LPS combined with NFPX mice. GO, KEGG, and artificial intelligence anal. indicated that NFPX might act on various drug targets. At last, potential targets, HRAS, SMAD4, and AMPK, were validated by qRT-PCR in ARDS murine model. In conclusion, we prove the efficacy of NFPX decoction in the treatment of ARDS. Furthermore, integrating network pharmacol., transcriptome, and artificial intelligence anal. contributes to illustrating the mol. mechanism of NFPX decoction on ARDS.

Frontiers in Pharmacology published new progress about AMP-activated protein kinase activators. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shogren-Knaak, Michael A.; Imperiali, Barbara published the artcile< A reversible affinity tag for the purification of N-glycolyl capped peptides>, Formula: C19H34O2, the main research area is affinity tag reversible biotin based purification N glycolyl peptide.

A reversible biotin affinity tag, 2-[6-(biotinylamino)caproyloxy]acetic acid (I), has been generated for the efficient purification of peptides requiring N-terminal derivatization. This methodol. is compatible with solid phase peptide synthesis techniques. For example, HOCH2CO-FSRSDELAKLLRLHAG-NH2 was obtained via the following steps: solid-phase synthesis in an automated peptide synthesizer, capping with reagent I, isolation by avidin-based affinity column chromatog. and cleavage of I’s ester bond under mildly basic conditions to give the the final N-glycolyl peptide.

Tetrahedron Letters published new progress about Affinity purification. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Jun; Ma, Chunlong; Balannik, Victoria; Pinto, Lawrence H.; Lamb, Robert A.; DeGrado, William F. published the artcile< Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in Inhibitors of M2 from Influenza A Virus>, SDS of cas: 112-63-0, the main research area is hydrophobicity polar amine influenza A virus M2 inhibitor.

Inhibitors targeting the influenza A virus M2 (A/M2) proton channel have lost their effectiveness due to widespread resistance. As a first step in the development of new inhibitors that address this problem, we have screened several focused collections of small mols. using two-electrode voltage patch clamp assays (TEVC) on Xenopus laevis oocytes. Diverse head groups and scaffolds of A/M2 inhibitors have been explored. It has been found that not only amine but also hydroxyl, aminooxyl, guanidine, and amidine compounds are active against the A/M2 proton channel. Moreover, the channel is able to accommodate a wide range of structural variation in the apolar scaffold. This study offers information to guide the next generation of A/M2 proton channel inhibitor design.

ACS Medicinal Chemistry Letters published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics