Category: 112-63-0

Shakouri, Zahra; Nazockdast, Hossein; Sadeghi Ghari, Hedayatollah published the artcile< Effect of the geometry of cellulose nanocrystals on morphology and mechanical performance of dynamically vulcanized PLA/PU blend>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cellulose nanocrystal vulcanized PLA polyurethane elastomer blend mech property.

Effects of the addition of single but geometrically different cellulose nanocrystals (CNCs) namely cylindrical CNCs (ultrasonic treated), spherical CNCs (chem. treated) and rod-like CNCs (com.) on microstructural development and mech. performance of the thermoplastic vulcanizates (TPVs) based on polylactic acid/polyurethane prepolymer (80/20) were studied. It was shown that a fraction of PLA mols. reacted with PU mols. during the dynamic crosslinking process. This was confirmed by the results of gel content measurements which showed an appreciable amount of addnl. gel content. This phenomenon together with the dynamic vulcanization process facilitated the development of a dual-continuous morphol. in the TPV sample which was confirmed by the melt viscoelastic results and TEM micrographs. Interestingly, the addition of spherical CNCs to the TPV led to a remarkable enhancement in its toughness. A similar effect but to a lesser extent was observed in the TPV sample filled with cylindrical CNCs. These results could be explained in terms of a 3D percolated or interconnected network microstructure formed between finely dispersed CNCs localized in PLA and/or between CNCs and the PLA matrix. This fact was evidenced by observation of strong liquid-solid transition in the melt viscoelastic results, as well as TEM and AFM micrographs. On contrary to other counterparts, the rod-like CNCs had a weakening effect on toughness of the TPV which was attributed to their poor dispersion and/or formation of their aggregates which could act as stress concentrators. Moreover, DMTA results showed an almost similar reinforcing effect for the three CNCs on increasing the modulus of the TPV below Tg of the PU and partially compensated the PU reducing effect on modulus in the temperature range between the Tg of PU and PLA.

Cellulose (Dordrecht, Netherlands) published new progress about Elongation at break. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xiao-Le; Wang, Ya-Ting; Guo, Zhen-Yu; Zhang, Ning-Ning; Wang, Yuan-Yuan; Hu, Die; Wang, Zhen-Zhen; Zhang, Yi published the artcile< Efficacy of paeoniflorin on models of depression: A systematic review and meta-analysis of rodent studies>, Category: esters-buliding-blocks, the main research area is meta analysis Paeonia depression paeoniflorin human; Animal studies; Depression; Paeoniflorin; Systematic review; meta-Analysis.

Meta-anal. of paeoniflorin, a bioactive compound extracted from the traditional Chinese herb, Paeonia lactiflora Pall, has been demonstrated to possess efficient antidepressant activity in previous studies. Our systematic review and meta-anal. aimed to assess the effectiveness of paeoniflorin in relieving depressive-like behaviors in animal models. We searched for in vivo studies on the antidepressant effects of paeoniflorin in rodents using electronic databases from their inception to Apr. 2021. The measurements of animal behavioral tests, including the sucrose consumption, forced swimming, tail suspension, and open field tests, were regarded as the outcomes. Fourteen studies involving 416 animals met the inclusion criteria and were included in the meta-anal. Statistical anal. revealed remarkable differences between the paeoniflorin and control groups. Furthermore, the paeoniflorin group showed great efficiency in improving depressive-like symptoms of animals in the sucrose consumption, forced swimming, tail suspension, and open field tests. Our meta-anal. demonstrates that paeoniflorin can significantly improve depressive-like symptoms in animals and suggests that it can be a potential therapy for patients with depression in the future.

Journal of Ethnopharmacology published new progress about Depression. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hawkins, Joel M.; Meyer, Axel; Nambu, Mitch published the artcile< Asymmetric bisosmylation of fullerene C60: novel chiral π-systems>, HPLC of Formula: 112-63-0, the main research area is stereoselective regioselective bisosmylation fullerene; fullerene osmium complex chiral; cinchona alkaloid stereoselective biosmylation fullerene.

Two isomers of C60(OsO4py2)2 are chiral by virtue of the substitution pattern on the icosahedral carbon cluster. Treatment of C60 with two equiv of OsO4 and five equiv of cinchona alkaloid derivative, followed by exchange of the chiral ligands for pyridine, gives the chiral (C2) isomers of C60(OsO4py2)2 with optical rotations up to 3700° and CD spectra which reflect the novel chiral band-shaped π-systems of these compounds The regiochem. and stereochem. of the bisosmylation of C60 appear to be controlled by attractive electronic interactions between the arene components of the cinchona alkaloid ligands and the fullerene surface.

Journal of the American Chemical Society published new progress about Dihydroxylation, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rose, P. E.; Benoit, W. R.; Adams, M. C. published the artcile< Tracer testing at Dixie Valley, Nevada, using pyrene tetrasulfonate, amino G, and fluorescein>, Application In Synthesis of 112-63-0, the main research area is tracer study geothermal reservoir fluid flow injection well Nevada.

A series of four tracer tests was recently conducted at the Dixie Valley, Nevada, geothermal reservoir in order to determine fluid-flow processes and to evaluate candidate tracers for use in hydrothermal systems. These tests have resulted in the first successful use of the compounds amino G and pyrene tetrasulfonate as tracers in a geothermal reservoir. The tracer candidates were first subjected to simulated hydrothermal conditions in laboratory reactors at temperatures as high as 300°C in order to determine their thermal stabilities. They were next injected as pulses into the target injection wells. Fluids from the surrounding production wells were then sampled and analyzed in order to determine injectate flow patterns. The tracer data indicate that injected fluids flow only to a cluster of production wells in the south-central portion of the field; no tracer was produced in the producers located in the northeast section of the reservoir. Tracer returns from fluids injected into one of the wells indicate a much shorter residence time and a more heterogeneous flow pattern than tracer fluids from the other three injectors.

Transactions – Geothermal Resources Council published new progress about Flow. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh, Sangeeta; Syme, Colin A.; Singh, Ashvani K.; Devor, Daniel C.; Bridges, Robert J. published the artcile< Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease>, Synthetic Route of 112-63-0, the main research area is chloride channel benzimidazolone preparation cystic fibrosis; structure activity benzimidazolone lung disease cystic fibrosis.

The diseases of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are characterized by mucus-congested airways. Agents that stimulate the secretion of Cl- are anticipated to facilitate mucociliary clearance and thus be of benefit in the treatment of CF and COPD. Recently 1-EBIO (1-ethyl-2-benzimidazolinone or 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) was shown to stimulate chloride secretion albeit at relatively high concentrations (0.6-1 mM). The studies reported here were undertaken to develop a more potent benzimidazolone. Structure activity studies with 30 benzimidazolone derivatives revealed that Et and hydrogen groups at the 1 and 3 nitrogen positions, resp., were critical for the activation of hIK1 K+ channels and that other alkyl groups were not tolerated at these positions without some loss in potency. Substitutions at the 5 and 6 positions improved the potency of 1-EBIO. Compared with 1-EBIO, the most potent of these derivatives, DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) was severalfold better in a 86Rb+ uptake assay, 20-fold better in short circuit current measurements on T84 monolayers, and 100-fold better in patch-clamp assays of hIK1 activity. Short circuit current studies revealed DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance. The improved potency of DCEBIO strengthens the possibility that compounds in this class may be of therapeutic benefit in the treatment of CF and COPD.

Journal of Pharmacology and Experimental Therapeutics published new progress about Chloride channel openers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bao, Jiyin; Liu, Haichun; Zhi, Yanle; Yang, Wenqianzi; Zhang, Jiawei; Lu, Tao; Wang, Yue; Lu, Shuai published the artcile< Discovery of benzo[d]oxazole derivatives as the potent type-I FLT3-ITD inhibitors>, Application of C19H34O2, the main research area is phenylamino benzooxazole preparation antitumor activity tyrosine kinase inhibitor SAR; AML; Benzo[d]oxazole; FLT3 inhibitor.

A series of compounds I [R1 = H, Me, F, MeO; R2 = diethylamino, piperidinyl, piperazin-1-yl, etc.; R3 = Ph, pyridin-3-yl, pyridin-4-yl, etc.] were designed and synthesized based on benzo[d]oxazole-2-amine scaffold to discover new potent Fms-like tyrosine kinase 3 inhibitors. During the medicinal chem. works, flexible mol. docking was used to provide design rationale and study the binding modes of the target compounds Through the mixed SAR exploration based on the enzymic and cellular activities, compound I [R1 = MeO; R2 = piperazin-1-yl; R3 = 3-carbamoylphenyl] was identified with potent FLT3-ITD inhibitory (IC50: 0.41 nM) and anti-proliferative (IC50: 0.037μM against MV4-11 cells) activities. And the binding mode of I [R1 = MeO; R2 = piperazin-1-yl; R3 = 3-carbamoylphenyl] with ”DFG-in” FLT3 was simulated by a 20-ns mol. dynamics run, providing some insights into further medicinal chem. efforts toward novel FLT3 inhibitors in AML therapy.

Bioorganic Chemistry published new progress about Acute myeloid leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bickerton, Laura E.; Langton, Matthew J. published the artcile< Controlling transmembrane ion transport via photo-regulated carrier mobility>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is transmembrane ion transport photo regulated carrier.

Stimuli-responsive transmembrane ion carriers allow for targeted and controllable transport activity, with potential applications as therapeutics for channelopathies and cancer, and in fundamental studies into ion transport phenomena. These applications require OFF-ON activation from a fully inactive state which does not exhibit background activity, but this remains challenging to achieve with synthetic transport systems. Here we introduce a novel mechanism for photo-gating mobile ion carriers, which involves modulating the mobility of the carriers within the lipid bilayer membrane. By appending a membrane-targeting anchor to the carrier using a photo-cleavable linker, the carriers ion transport activity is fully switched off by suppressing its ability to shuttle between the two aqueous-membrane interfaces of the bilayer. The system can be reactivated rapidly in situ within the membrane by photo-triggered cleavage of the anchor to release the mobile ion carrier. This approach does not involve direct functionalization of the ion binding site of the carrier, and so does not require the de novo design of novel ion binding motifs to implement the photo-caging of activity. This work demonstrates that controlling the mobility of artificial transport systems enables precise control over activity, opening up new avenues for spatio-temporally targeted ionophores.

Chemical Science published new progress about Affinity (Binding). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Otevrel, Jan; Svestka, David; Bobal, Pavel published the artcile< Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones>, COA of Formula: C19H34O2, the main research area is alc preparation enantioselective; fluoroketone nitroalkane Henry reaction bianthryl catalyst; bianthryl organocatalyst preparation.

A catalytic system based on bianthrylbis(thiourea), e.g., I for the asym. Henry reaction of fluoroketones R1C(O)C(F2)R2 (R1 = Ph, thiophen-2-yl, 3-nitrophenyl, etc.; R2 = H, F) and nitroalkanes R3CH2NO2 (R3 = H, Me) that resulted from the screening of a library containing 31 chiral non-racemic organocatalysts has been developed. The corresponding adducts R1C(OH)(C(F2)R2)CH(NO2)R3 were isolated in up to 6 times shorter reaction time in comparison with the previously published organocatalysts. High levels of stereocontrol have been generally observed, with measured product enantiomeric excesses up to 97% and diastereomeric ratio 3 : 2 (anti/syn). The above-mentioned catalysts have been successfully applied to the total asym. synthesis of CF3-tethered (S)-halostachine, which has proved that this method constitutes an easy entry to similar enantiopure compounds

Organic & Biomolecular Chemistry published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cai, Qian; Li, Zhengqiu; Wei, Jiajia; Ha, Chengyong; Pei, Duanqing; Ding, Ke published the artcile< Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalyzed cascade process>, Computed Properties of 112-63-0, the main research area is indole carboxylic ester preparation; copper catalyzed condensation coupling deformylation halo aldehyde ketone isocyanoacetate.

A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalyzed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with Et isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-substrates under room temperature or mild conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (halo). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Suji; Sung, Dan-Bi; Kang, Seungyoon; Parameswaran, Saravanan; Choi, Jun-Ho; Lee, Jong Seok; Han, Min Su published the artcile< Development of human serum albumin selective fluorescent probe using thieno[3,2-b]pyridine-5(4H)-one fluorophore derivatives>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is human serum albumin thienopyridine one fluorophore fluorescent probe; fluorescent probe; human serum albumin; intramolecular charge transfer; microalbuminuria; thieno[3,2-b]pyridine-5(4H)-one.

The level of human serum albumin (HSA) in biol. fluids is a key health indicator and its quant. determination has great clin. importance. In this study, we developed a selective and sensitive fluorescent HSA probe by fluorescence-based high-throughput screening of a set of fluorescent thieno[3,2-b]pyridine-5(4H)-one derivatives against major plasma proteins: HSA, bovine serum albumin (BSA), globulin, fibrinogen, and transferrin. The fluorophore chosen finally (4) showed noticeable fluorescence enhancement in the presence of HSA (160-fold increase), and it exhibited rapid response, high sensitivity (detection limit 8 nM), and the ability to clearly distinguish HSA from BSA in pH 9 buffer condition. Moreover, the probe could be applicable to detect trace amounts of HSA in an artificial urine sample; further, it might be applied to the determination of the HSA concentration in complex biol. samples for pre-clin. diagnosis.

Sensors published new progress about Blood plasma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics