Category: 112-63-0

Vidomanova, Eva; Majercikova, Zuzana; Dibdiakova, Katarina; Pilchova, Ivana; Racay, Peter; Hatok, Jozef published the artcile< The effect of temozolomide on apoptosis-related gene expression changes in glioblastoma cells.>, Synthetic Route of 112-63-0, the main research area is apoptosis; glioblastoma; temozolomide gene expression..

BACKGROUND: Glioblastoma (GB) is the most common and biologically the most aggressive primary brain tumor of the central nervous system (CNS) in adults. Standard treatment for newly diagnosed GB consists of surgical resection, radiotherapy, and chemotherapy with temozolomide (TMZ). Despite numbers of studies, a resistance to chemotherapy is the major obstacle to successful GB treatment. OBJECTIVES: The aim of our study was to detect the sensitivity of glioblastoma T98G cells to TMZ treatment and subsequently to determine the expression changes of apoptosis-associated genes in glioblastoma cells. MATERIAL AND METHODS: The human glioblastoma cell line (T98G) was treated with specified concentrations of TMZ during different time periods. Their viability was measured by colorimetric MTT assay and the activation of the apoptotic pathway was determined by measuring the caspase 3/7 activity. Commercial pre-designed microfluidic array was used to quantify expression of human apoptosis-associated genes. RESULTS: The untreated control of T98G cell line against human brain total RNA standards reported significant changes in several apoptotic genes expression levels. We identified also a deregulation in geneexpression levels between the TMZ treated and untreated T98G cells associated with apoptotic pathways. After 48 hours of exposure of T98G cells to TMZ, we observed a significant deregulation ofseven genes: BBC3, BCL2L1, RIPK1, CASP3, BIRC2, CARD6 and DAPK1. These results can contribute to the importance of apoptosis in glioblastoma cells metabolism and effect of TMZ treatment. CONCLUSIONS: Identification of apoptotic gene panel in T98G cell line could help to improve understanding of brain tumor cells metabolism. Recognizing of the pro-apoptotic and anti-apoptotic genes expression changes could contribute to clarify the sensitivity to TMZ therapy and molecular base in healthy and tumor cells (Tab. 1, Fig. 2, Reference 48).

Bratislavske lekarske listy published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Copcu, Burcu; Sayin, Koray; Karakas, Duran published the artcile< Investigations substituent effect on structural, spectral and optical properties of phenylboronic acids>, Related Products of 112-63-0, the main research area is phenylboronic acid substituent effect spectral optical property.

Ortho- and para-substituent arylboronic acid are investigated. Geometric structure and structural properties of these compounds are done. IR and NMR spectrum are calculated for the spectral characterizations. Contour diagram of frontier MOs which are HOMO and LUMO is calculated and mol. electrostatic potential (MEP) map of them are obtained to evaluate the electronic properties and to determine the active site on the mols. Non-linear optical (NLO) properties are investigated. UV-VIS spectrum of studied compounds is calculated and the wavelength of main band is examined Then, some quantum chem. parameters which are total static dipole moment, the average linear polarizability, the anisotropy of the polarizability and first hyperpolarizability are calculated and it was found that B3 is the best NLO material for applications.

Journal of Molecular Structure published new progress about Anisotropy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Le; Ma, Yong; Gu, Yuting; Yuan, Xuzhou; He, Ying; Li, Xinjian; Zhao, Liang; Peng, Yang; Deng, Zhao published the artcile< Ru-Embedded Highly Porous Carbon Nanocubes Derived from Metal-Organic Frameworks for Catalyzing Reversible Li2O2 Formation>, Category: esters-buliding-blocks, the main research area is ruthenium porous carbon nanocube catalyst lithium oxygen battery; Li−O2 batteries; metal−organic frameworks; oxygen catalyst; porous carbon; ruthenium nanoparticles.

Rechargeable lithium-oxygen batteries (LOBs) have attracted increasing attention due to their high energy d. but highly rely on the development of efficient oxygen catalysts for reversible Li2O2 deposition/decomposition Herein, highly porous carbon nanocubes with a sp. surface area up to 1600 m2 g-1 are synthesized and utilized to tightly anchor Ru nanoparticles for using as the oxygen-cathode catalyst in LOBs, achieving a low charge/discharge potential gap of only 0.75 V, a high total discharge capacity of 17,632 mA h g-1, and a superb cycling performance of 550 cycles at 1000 mA g-1. Comprehensive ex situ and operando characterizations unravel that the outstanding LOB performance is ascribed to the highly porous catalyst structure embedding rich active sites that synergistically function in reducing overpotentials, suppressing parasitic reactions, accommodating reaction products, and promoting mass and charge transportation.

ACS Applied Materials & Interfaces published new progress about Adsorption (isotherm). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xing; Xu, Wenqing; Yuan, Wenhua; Liu, Kangkang; Zhou, Jian; Shan, Guorong; Bao, Yongzhong; Pan, Pengju published the artcile< Separate crystallization and melting of polymer blocks and hydrogen bonding units in double-crystalline supramolecular polymers>, Application In Synthesis of 112-63-0, the main research area is crystallization melting polymer block supramol.

End functionalization of oligomers by the multiple H-bonding units is a feasible way to prepare the supramol. polymers (SMPs). The crystallization of oligomer blocks and H-bonding units can lead to form the complicated double crystalline structure in SMPs; such double crystalline behavior and its correlation with the phys. properties are of fundamental importance for the processing and applications of SMPs. Herein, we choose the oligomeric polycaprolactone (PCL) end-functionalized by the self-complementary quadruple H-bonding 2-ureido-4-pyrimidinone (UPy) units (named as U-PCL) as the model double crystalline SMPs and investigate their crystalline structure, crystallization kinetics, thermally induced structural evolution, and structure-property relationships. The U-PCLs display the similar composition-dependent crystallization and melting behavior as the double crystalline block copolymers. The U-PCLs with short, medium-length, and long PCL blocks crystallize in the UPy crystals, UPy/PCL mixed crystals, and PCL crystals, resp. Melting temperature of UPy crystals decreases and their melting peak disappears as the UPy content of U-PCLs decreases. UPy units and PCL blocks are microphase-separated in the U-PCLs, despite the absence of long-range ordered phase structure. Dual shape memory effects capable of switching at the body temperature were realized based on the double crystalline nature of U-PCLs by using UPy crystals as the phys. crosslinkers and PCL blocks as the switching segments.

Polymer published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hafner, Andreas; Filipponi, Paolo; Piccioni, Lorenzo; Meisenbach, Mark; Schenkel, Berthold; Venturoni, Francesco; Sedelmeier, Joerg published the artcile< A Simple Scale-up Strategy for Organolithium Chemistry in Flow Mode: From Feasibility to Kilogram Quantities>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is scale strategy organolithium chem feasibility kilogram.

A platform for conducting organolithium chem. in continuous flow mode, covering the scales from medicinal chem. to later phase process development, is described. The use of this flow setup, which mimics the concept of flash chem. on scale, was demonstrated by the exemplary, large-scale preparation of (4-fluoro-2-(trifluoromethyl)phenyl)boronic acid following a reaction sequence of halogen/lithium exchange, borylation, and semibatch workup. Also, the key factors and corresponding practical assessments required for the streamlined and seamless scale-up from laboratory environment to higher productivity are highlighted.

Organic Process Research & Development published new progress about Apparatus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pongmuksuwan, Pornlada; Harnnarongchai, Wanlop published the artcile< Synthesis and characterization of soft polyurethane for pressure ulcer prevention>, Quality Control of 112-63-0, the main research area is pressure ulcer prevention polyurethane preparation.

A series of super-soft polyurethanes was prepared by synthesizing lightly crosslinked polyurethane with low isocyanate:hydroxyl ([NCO]:[OH]) molar ratios. The starting materials were polymeric isocyanate (pMDI), polypropylene glycol (PPG), and 1,1,1-tris(hydroxymethyl)propane (TMP). The effects of the [NCO]:[OH] molar ratio and concentrations of the crosslinking agent TMP on the crosslink d. and the thermal, dynamic-mech., and mech. properties of the polyurethanes were determined In addition, TMP generates chem. and phys. crosslinks within polyurethane; therefore, data calculated using the Flory-Rehner equation and the rubber elasticity were compared. The success of the reaction between pMDI and PPG was confirmed using Fourier-transform IR spectroscopy. The synthesized polyurethanes exhibited a mixing phase between soft and hard segments. The addition of TMP increased the crosslinking d., resulting in increased glass transition temperature, tensile properties, and hardness; however, the pressure distribution was suppressed. The synthesized polyurethane showed effective properties for pressure ulcer relief applications.

Polymer Testing published new progress about Crosslinking agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Mengyan; Liu, Peirong; Lu, Shuxian; Wang, Zhihao; Lyu, Zhaojie; Liu, Hongkai; Sun, Yuhong; Liu, Feng; Tian, Jing published the artcile< Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is naoxintong cardiomyopathy zebrafish transcriptome profile; Cardiomyopathy; HEG1; Naoxintong (NXT); Transcriptome; Zebrafish.

Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure. Naoxintong (NXT), as a traditional Chinese Medicine (TCM) preparation, is widely used in the treatment of cardiovascular diseases, including cardiomyopathy, while its underlying mechanism has not been fully elucidated. The purpose of this study is to investigate the therapeutic effect of NXT on cardiomyopathy and its mol. mechanism in zebrafish model. The zebrafish cardiomyopathy model was established using terfenadine (TFD) and treated with NXT. The therapeutic effect of NXT on cardiomyopathy was evaluated by measuring the heart rate, the distance between the sinus venosus and bulbus arteriosus (SV-BA), the pericardial area, and the blood flow velocity of zebrafish. Then, the zebrafish hearts were isolated and collected; transcriptome anal. of NXT on cardiomyopathy was investigated. Moreover, the heg1 mutant of zebrafish congenital cardiomyopathy model was used to further validate the therapeutic effect of NXT on cardiomyopathy. Addnl., UPLC anal. combined with the zebrafish model investigation was performed to identify the bioactive components of NXT. In the TFD-induced zebrafish cardiomyopathy model, NXT treatment could significantly restore the cardiovascular malformations caused by cardiac dysfunction. Transcriptome and bioinformatics analyses of the TFD and TFD + NXT treated zebrafish developing hearts revealed that the differentially expressed genes were highly enriched in biol. processes such as cardiac muscle contraction and heart development. As a cardiac development protein associated with cardiomyopathy, HEG1 had been identified as one of the important targets of NXT in the treatment of cardiomyopathy. The cardiovascular abnormalities of zebrafish heg1 mutant could be recovered significantly from NXT treatment, including the expanded atrial cavity and blood stagnation. qRT-PCR anal. further showed that NXT could restore cardiomyopathy phenotype in zebrafish through HEG1-CCM signaling. Among the seven components identified in NXT, paeoniflorin (PF) and salvianolic acid B (Sal B) were considered to be the main bioactive ones with myocardial protection. NXT presented myocardial protective effect and could restore myocardial injury and cardiac dysfunction in zebrafish; the action mechanism was involved in HEG1-CCM signaling.

Chinese Medicine (London, United Kingdom) published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (NEXN). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Karolak, Aleksandra; Levatic, Jurica; Supek, Fran published the artcile< A framework for mutational signature analysis based on DNA shape parameters>, Synthetic Route of 112-63-0, the main research area is DNA sequence mutational signature oligonucleotides mutagenesis.

The mutation risk of a DNA locus depends on its oligonucleotide context. In turn, mutability of oligonucleotides varies across individuals, due to exposure to mutagenic agents or due to variable efficiency and/or accuracy of DNA repair. Such variability is captured by mutational signatures, a math. construct obtained by a deconvolution of mutation frequency spectra across individuals. There is a need to enhance methods for inferring mutational signatures to make better use of sparse mutation data (e.g., resulting from exome sequencing of cancers), to facilitate insight into underlying biol. mechanisms, and to provide more accurate mutation rate baselines for inferring pos. and neg. selection. We propose a conceptualization of mutational signatures that represents oligonucleotides via descriptors of DNA conformation: base pair, base pair step, and minor groove width parameters. We demonstrate how such DNA structural parameters can accurately predict mutation occurrence due to DNA repair failures or due to exposure to diverse mutagens such as radiation, chem. exposure, and the APOBEC cytosine deaminase enzymes. Furthermore, the mutation frequency of DNA oligomers classed by structural features can accurately capture systematic variability in mutagenesis of >1,000 tumors originating from diverse human tissues. A nonneg. matrix factorization was applied to mutation spectra stratified by DNA structural features, thereby extracting novel mutational signatures. Moreover, many of the known trinucleotide signatures were associated with an addnl. spectrum in the DNA structural descriptor space, which may aid interpretation and provide mechanistic insight. Overall, we suggest that the power of DNA sequence motif-based mutational signature anal. can be enhanced by drawing on DNA shape features.

PLoS One published new progress about B-cell lymphoma. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sekeroglu, Zulal Atli; Sekeroglu, Vedat; Kucuk, Nihan published the artcile< Effects of Reverse Transcriptase Inhibitors on Proliferation, Apoptosis, and Migration in Breast Carcinoma Cells>, Product Details of C19H34O2, the main research area is breast carcinoma proliferation apoptosis migration reverse transcriptase inhibitor; apoptosis; breast cancer; migration; proliferation; reverse transcriptase inhibitors.

High telomerase activity in human breast cancer is associated with aggressive tumors resulting in decreased survival. In the present study, we examined the effects of 4 reverse transcriptase inhibitors (RTIs), used for the treatment of HIV; Abacavir (AC), Lamivudine (LV), Stavudine (SV), and Tenofovir (TF) on proliferation, apoptosis, and migration in the normal human mammary epithelial cell line, hTERT-HME1, and the human breast cancer cell line, MCF-7. Cells were treated with AC, LV, SV, or TF alone or in combination with paclitaxel (PAC), a known drug used to treat breast cancer. Conduct of the thiazolyl blue tetrazolium bromide assay demonstrated that AC, SV, and TF had stronger cytotoxic effects on MCF-7 cells than in hTERT-HME1 cells. The combined treatment of RTIs and PAC caused high rates of cell death in MCF-7 and low rates of cell death in HTERT-HME1 by apoptosis. The percentages of apoptotic cells in the treatment of AC and SV in combination with PAC for 48 and 72 h were higher than PAC. Significantly increased apoptosis and decreased migration levels were found in MCF-7 cells treated with AC and co-treatment of AC+PAC or SV+PAC than HME1 cells. These treatments can also prevent migration capacity more than PAC. Therefore, a combination strategy based on telomerase inhibitors such as AC or SV and anticancer drugs may be more effective in the treatment of certain breast cancers.

International Journal of Toxicology published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Giordano, Claudio; Coppi, Laura published the artcile< Br3- vs Br2: opposite diastereoselectivity in the bromination of enantiomerically pure ketals>, HPLC of Formula: 112-63-0, the main research area is stereochem bromination ketal bromine onium tribromide.

For the first time it has been shown that different halogenating species (Br3- vs. Br2, SO2Cl2 and ICl) provide opposite high diastereofacial selectivity in the functionalization of chiral auxiliary bound alkenes. The stereochem. outcome of the bromination of ketal I (n = 1; R = H), precursor of a single geometry constrained enol ether I (n = 0), with Br3- in different solvents is reported and compared with that with Br2. Thus, up to 99% of I (R = Br) was obtained in the bromination of I (R = H) with tetraalkylammonium tribromides, while the diastereomeric product was formed in up to 99% yield, when I (R = H) was brominated with Br2 in THF.

Journal of Organic Chemistry published new progress about Bromination, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics