Category: 112-63-0

Sun, Shaozu; Wang, Yangyang; Chen, Lianxi; Chu, Mei; Dong, Yulin; Liu, Dan; Liu, Peng; Qu, Deyu; Duan, Junxin; Li, Xi published the artcile< MOF(Ni)/CNT composites with layer structure for high capacitive performance>, Application In Synthesis of 112-63-0, the main research area is metal orgnice framework nickel carbon nanotube composite electrochem property.

Metal-organic frameworks (MOFs) with high porosity and multivalent metal ion is a kind of prospective material for supercapacitor. However, the poor conductivity and stability degrade the capacitive performance of MOFs. Herein, a corrugated-layered-structure MOF(Ni)/carbon nanotube composite (MOF(Ni)/CNT) was prepared by solvothermal method. The corrugated-layered-structure of MOF(Ni) offers a sufficient electrolyte storage space and a fast ion diffusion channel, and 1D nanotube structure of CNT offers a good elec. conductivity and stability, which makes MOF(Ni)/CNT have an excellent capacitive performance. Compare to MOF(Ni), MOF(Ni)/CNT(w%) have a better electrochem. performance. Especially, MOF(Ni)/CNT(10%) not only has the highest specific capacitance, but also possesses an outstanding rate capacity (88.6% retention at 10 A g-1). Moreover, the asym. supercapacitor MOF(Ni)/CNT(10%)//AC can reach 97 F g-1 at 0.5 A g-1 and has 83.2% retention after 5000 cycles. It′s also shows a high energy d. of 32.6 Wh kg-1 at a power d. of 476.5 W kg-1. This work illustrates that layered MOFs are prospective materials for supercapacitor and provides a facile and effective way to boost the capacitive performance.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about Anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bezzubets, M. K.; Rozina, V. S. published the artcile< Acidic derivatives of anthraquinone. I. Influence of substituents in the phenylamine radical of anthraquinone derivatives on their properties>, Category: esters-buliding-blocks, the main research area is .

Substitution of Br by PhNH in 1-amino-4-bromo-2-anthraquinonesulfonic acid (I) leads to a change of the orange color to blue (bathochromic effect); substitution within the PhNH group gives either a batho- or hypsochromic effect, insufficient, however, to change the visible color range, with Me giving the 1st effect and Cl giving the 2nd; their shift from the 4-position to the 2-position produces a hypsochromic effect. Stability of the dyes is improved by Me or Cl substitution in the PhNH group, with Cl giving the best effect; analogously, the solubility of Na salts drops. I (10 g., Na salt) in 200 ml. H2O and 16 ml. EtOH was heated 4 hrs. at 95° with 9.3 g. PhNH2, 5 g. Na2CO3, and 1 g. CuSO4, and, after steam distillation, the precipitated product was washed and recrystallized in the form of its Na salt, yielding 70% Na 1-amino-4-phenylamino-2-anthraquinonesulfonate, absorption maximum 605 mμ. o-Toluidine gave the corresponding 2′-Me derivative (75%), absorption maximum 610 mμ, while the 4′-analog had a maximum at 615 mμ. 2,4-Me2C6H3NH2 gave 65% of the 2′,4′-di-Me analog, maximum 620 mμ, while 2,4,5-Me3C6H2NH2 gave 73% of the 2′,4′,5′-tri-Me analog, maximum 630 mμ. 4-ClC6H4NH2 (9.6 g.) in 80 ml. H2O and 40 ml. EtOH was treated at 80-5° with 5 g. NaHCO3, 0.5 g. CuCl, and 10 g. I (Na salt) and refluxed 9 hrs.; after steam distillation the cooled filtrate yielded 64% Na 1-amino-4-(4-chlorophenylamino)-2-anthraquinonesulfonate (recrystallized from water), maximum 600 mμ; 2-ClC6H4NH2 gave 46% of the 2′-chloro analog, maximum 585 mμ; 2,5-Cl2C6H3NH2 gave 45% (after 25 hrs.’ reaction) of the 2,5′-di-Cl analog, maximum 580 mμ; the 3′,5′-di-Cl analog was similar; the 3,4,5-Cl3C6H2NH2 (I) gave 50% of the 3′,4′,5′-tri-Cl analog, maximum 575 mμ. Preparation of I: 50 g. p-nitroaniline in 300 ml. HCl and 150 ml. AcOH was chlorinated at 0°, yielding 78-80% 2,6,4-Cl2(O2N)C6H2NH2, m. 188.5-89° (from EtOH-AcOH); this (12 g.), diazotized, added at 90-5° to 300 ml. HCl and 30 g. CuCl paste, kept 1 hr. at 90°, and cooled, gave 3,4,5-trichloronitrobenzene (55%), m. 68-9° (from dilute AcOH); this (6.8 g.) added to hot 30 ml. H2O, 10 g. Fe shavings, and 1 ml. 40% AcOH, followed by steam distillation, gave I, m. 95-6°.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) published new progress about Dyes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chamaraux-Tran, Thien-Nga; Muller, Marie; Pottecher, Julien; Diemunsch, Pierre A.; Tomasetto, Catherine; Namer, Izzie-Jacques; Dali-Youcef, Nassim published the artcile< Metabolomic impact of lidocaine on a triple negative breast cancer cell line>, SDS of cas: 112-63-0, the main research area is lidocaine human triple neg breast cancer cell metabolomics; anesthesia; cancer progression; cancer surgery; lidocaine; metabolomics; onco-anesthesia; perioperative period.

Metabolomics and onco-anesthesia are two emerging research fields in oncol. Metabolomics (metabolites anal.) is a new diagnostic and prognostic tool that can also be used for predicting the therapeutic or toxic responses to anticancer treatments. Onco-anesthesia studies assess the impact of anesthesia on disease-free and overall survival after cancer surgery. It has been shown that local anesthetics (LA), particularly lidocaine (LIDO), exert antitumor properties both in vitro and in vivo and may alter the biol. fingerprints of cancer cells. As LA are known to impair mitochondrial bioenergetics and byproducts, the aim of the present study was to assess the impact of LIDO on metabolomic profile of a breast cancer cell line. Breast cancer MDA-MB-231 cells were exposed for 4 h to 0.5 mM LIDO or vehicle (n = 4). The metabolomic fingerprint was characterized by high resolution magic angle spinning NMR spectroscopy (HRMAS). The multivariate technique using the Algorithm to Determine Expected Metabolite Level Alteration (ADEMA) (Cicek et al., PLoS Comput. Biol., 2013, 9, e1002859), based on mutual information to identify expected metabolite level changes with respect to a specific condition, was used to determine the metabolites variations caused by LIDO. LIDO modulates cell metabolites levels. Several pathways, including glutaminolysis, choline, phosphocholine and total choline syntheses were significantly downregulated in the LIDO group. This is the first study assessing the impact of LIDO on metabolomic fingerprint of breast cancer cells. Among pathways downregulated by LIDO, many metabolites are reported to be associated with adverse prognosis when present at a high titer in breast cancer patients. These results fit with the antitumor properties of LIDO and suggest its impact on metabolomics profile of cancer cells. These effects of LIDO are of clin. significance because it is widely used for local anesthesia with cutaneous infiltration during percutaneous tumor biopsy. Future in vitro and preclin. studies are necessary to assess whether metabolomics anal. requires modification of local anesthetic techniques during tumor biopsy.

Frontiers in Pharmacology published new progress about Anesthesia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Na; Wang, Xinhui; Lang, Jinyan; Hu, Zhenhua; Zhang, Heng published the artcile< Synthesis and Characterization of Hyperbranched and Organosilicone Modified Waterborne Polyurethane Acrylates Photosensitive Resin>, HPLC of Formula: 112-63-0, the main research area is hyperbranched organosilicone waterborne polyurethane acrylate photosensitive resin preparation characterization; hyperbranched; organosilicone modified; photosensitive resin; polyurethane acrylates; waterborne.

A new type of waterborne polyurethane acrylate was synthesized for use as a UV curing coating. The N,N-dihydroxy Me ethyl-3-Me aminopropanoate monomer was first prepared via adding reactions of Me acrylate and diethanol amine with Me alc. as the solvent. Then, the hyperbranched prepolymer was obtained by addition of trimethylolpropane with toluenesulfonic acid as catalyst and N,N-DMF as solvent. The resulting hyperbranched and organosilicone modified waterborne polyurethane acrylates was synthesized through the mixed reaction of prepolymer and hydroxy silicone oil, polyethylene glycol-1000, toluene diisocyanate, dimethylolpropionic acid, 1,2-propylene glycol, hydroxyethyl acrylate, and triethylamine with dibutyltin dilaurate as the catalyst. The mol. structures were characterized by FT-IR and 1H NMR spectroscopy and GPC anal. and the thermal stability was studied by using TGA. Moreover, the influence of content of hydroxyl silicone oil, dimethylolpropionic acid, polyethylene glycol-1000, and prepolymer to various of properties such as glossiness, hardness, adhesive force, abrasion resistance, water absorption, elongation at break and tensile strength of films were analyzed. The temperature and catalyst dosage impact on percent conversion of isocyanate group (-NCO) were also studied. It was proven that the best dosage of hydroxyl silicone oil and dimethylolpropionic acid were 4.6%, the dosage of polyethylene glycol-1000 was 50%, and the amount of hyperbranched prepolymer was 0.5%, which could make the film achieve the optimum properties. The percent conversion of isocyanate group (-NCO) was maximum when reacting two hours at 80°C with 0.2% catalyst.

Polymers (Basel, Switzerland) published new progress about Abrasion resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Dan; Ryals, Renee C.; Huang, Samuel J.; Weller, Kyle K.; Titus, Hope E.; Robb, Bryan M.; Saad, Firas W.; Salam, Ribal A.; Hammad, Hytham; Yang, Paul; Marks, Daniel L.; Pennesi, Mark E. published the artcile< Monomethyl fumarate protects the retina from light-induced retinopathy>, Category: esters-buliding-blocks, the main research area is retinal injury monomethyl fumarate Hmox1 Nlrp3 NFKB Nrf2.

PURPOSE. We determine if monomethyl fumarate (MMF) can protect the retina in mice subjected to light-induced retinopathy (LIR). METHODS. Albino BALB/c mice were i.p. injected with 50 to 100 mg/kg MMF before or after exposure to bright white light (10,000 lx) for 1 h. Seven days after light exposure, retinal structure and function were evaluated by optical coherence tomog. (OCT) and electroretinog. (ERG), resp. Retinal histol. also was performed to evaluate photoreceptor loss. Expression levels of Hcar2 and markers of microglia activation were measured by quant. PCR (qPCR) in the neural retina with and without microglia depletion. At 24 h after light exposure, retinal sections and whole mount retinas were stained with Iba1 to evaluate microglia status. The effect of MMF on the nuclear factor kB subunit 1 (NF-kB) and Nrf2 pathways was measured by qPCR and Western blot. RESULTS. MMF administered before light exposure mediated dose-dependent neuroprotection in a mouse model of LIR. A single dose of 100 mg/kg MMF fully protected retinal structure and function without side effects. Expression of the Hcar2 receptor and the microglia marker Cd14 were upregulated by LIR, but suppressed by MMF. Depleting microglia reduced Hcar2 expression and its upregulation by LIR. Microglial activation, upregulation of proinflammatory genes (Nlrp3, Caspase1, Il-1 b, Tnf-α), and upregulation of antioxidative stress genes (Hmox1) associated with LIR were mitigated by MMF treatment. CONCLUSIONS. MMF can completely protect the retina from LIR in BALB/c mice. Expression of Hcar2, the receptor of MMF, is microglia-dependent in the neural retina. MMF-mediated neuroprotection was associated with attenuation of microglia activation, inflammation and oxidative stress in the retina.

Investigative Ophthalmology & Visual Science published new progress about Animal gene, TNFA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Grinberg, Valerij Y.; Burova, Tatiana V.; Grinberg, Natalia V.; Papkov, Vladimir S.; Khokhlov, Alexei R. published the artcile< Conformation-Dependent Affinity of Thermoresponsive Biodegradable Hydrogels for Multifunctional Ligands: A Differential Scanning Calorimetry Approach>, Product Details of C19H34O2, the main research area is cross linked polymethoxyethylaminophosphazene volume phase transition anionic ligand.

We investigated energetics of binding of multifunctional pyranine ligands to hydrogels of the cross-linked poly(methoxyethylaminophosphazene) (PMOEAP) from data on the thermotropic volume phase transition of the gels by means of high-sensitivity differential scanning calorimetry. Dependences of the transition temperature, enthalpy, and width on the concentration of pyranines were obtained, and the excess transition free energy as a function of the pyranine concentration was calculated We found that the affinity of the gels for the pyranine ligands increased very significantly upon the gel collapse. The intrinsic binding constants and free energies of binding of the ligands to the gels in the collapsed state were estimated from the DSC data. They revealed a significant increase in the hydrogel affinity for pyranines proportional to the number of anionic groups in the ligand structure. The affinity of the PMOEAP hydrogels for the multifunctional ligands was not affected by an increase in the crosslinking d. of the gels and only slightly reduced by physiol. salt concentrations

Langmuir published new progress about Biodegradable materials. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Hong; Lu, Jiantao; Feng, Pinzhen published the artcile< Synthesis and free radical polymerization of new spirocyclic monomer>, Reference of 112-63-0, the main research area is spirocyclic pentadecane derivative monomer preparation polymerization; radical polymerization spirocyclic pentadecane derivative monomer; ring opening polymerization spirocyclic pentadecane derivative.

A new type of monomer, 2-methylene-1,4-dioxo-dispiro[4.2.5.2]pentadecane was prepared through a series of organic reactions from simple com. materials. This spirocyclic monomer could undergo free radical ring-opening polymerization at 120° with dibenzoyl peroxide as initiator. The driving force for ring-opening was the relief of the strain at the central spiro atom as well as the formation of stable carbonyl group. However, it copolymerized with MMA (Me methacrylate) at the same condition without any ring opening. The structures of the monomer, resulting polymer and copolymer were determined by IR, NMR and MS. Mol. weight and its distribution of the polymers were estimated by GPC.

Gaofenzi Xuebao published new progress about Radical polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Yu; Shi, Xiao; Liu, Wei published the artcile< Transition-metal-free, chemoselective aerobic oxidations of sulfides and alcohols with potassium nitrate and pyridinium tribromide or bromine>, Electric Literature of 112-63-0, the main research area is sulfoxide preparation chemoselective aerobic oxidation sulfide; aldehyde preparation alc chemoselective aerobic oxidation; ketone preparation chemoselective aerobic oxidation alc.

An efficient oxidation of sulfides with air catalyzed by the combination of potassium nitrate with pyridinium tribromide under transition-metal-free conditions was reported. By replacing pyridinium tribromide with bromine, the reaction system was also useful in the oxidation of alcs. All reactions afforded the corresponding products in good to excellent yields with high chemoselectivities.

Synlett published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Franchino, Allegra; Marti, Alex; Nejrotti, Stefano; Echavarren, Antonio M. published the artcile< Silver-Free Au(I) Catalysis Enabled by Bifunctional Urea- and Squaramide-Phosphine Ligands via H-Bonding>, SDS of cas: 112-63-0, the main research area is gold phosphine thiourea urea squaramide substituted complex preparation; crystal mol structure gold phosphine thiourea urea squaramide complex; cyclization cycloisomerization catalyst gold phosphine thiourea urea squaramide complex; kinetics cyclization cycloisomerization gold phosphine thiourea urea squaramide catalyst; chloride abstraction; gold; hydrogen bond; kinetics; phosphine ligands.

A library of gold(I) chloride complexes I and II [R = H, CF3; Ar = Ph, 3,5-(CF3)2C6H3; X = CH2, (CH2)2, (CH2)3; Y = O, S] with phosphine ligands incorporating pendant (thio)urea and squaramide H-bond donors was prepared with the aim of promoting chloride abstraction from Au(I) via H-bonding. In the absence of silver additives, complexes bearing squaramides and trifluoromethylated aromatic ureas displayed good catalytic activity in the cyclization of N-propargyl benzamides, as well as in a 1,6-enyne cycloisomerization, a tandem cyclization-indole addition reaction and the hydrohydrazination of phenylacetylene. Kinetic studies and DFT calculations indicate that the energetic span of the reaction is accounted by both the chloride abstraction step, facilitated by the bidentate H-bond donor via an associative mechanism, and the subsequent cyclization step.

Chemistry – A European Journal published new progress about Abstraction reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mecwan, Marvin M.; Dong, Xia; Shi, Galen H.; Ratner, Buddy D. published the artcile< Plasma Polymerized HMDSO Coatings For Syringes To Minimize Protein Adsorption>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is coating hexamethyldisiloxane plasma polymerization syringe protein adsorption IgG; Glass vials; HMDSO; Hypodermic syringes; IgG; Protein adsorption; Protein retention; RFGD plasma polymerization; Silicone oil.

Current parenteral containers used for the storage and delivery of protein-based drugs, contain silicone oil which may seep into the protein solution and can result in adsorption, aggregation and denaturation of the protein. Tightly adherent surface coatings prepared by radio frequency glow-discharge (RFGD) plasma polymerization are described in this paper. Using this robust technique, methacrylic acid (MA) (hydrophilic), hexamethyldisiloxane (HMDSO) (hydrophobic), tetraglyme (TG) (hydrophilic) were plasma polymerized onto glass. In addition, HMDSO and MA were copolymerized to create a plasma polymerized HMDSO-MA (hydrophobic) surface. Untreated glass and glass dip-coated in PDMS were used as controls. TG and MA plasma coatings adsorbed the least amount of protein in all pH conditions. Interestingly HMDSO-MA retained significantly lesser protein compared to HMDSO and dip-coated PDMS samples. In the presence of Polysorbate 80 (PS80) all plasma polymerized coatings adsorbed and retained negligible amounts of protein, compared to controls. Furthermore, the peak glide force of plasma coated syringes did not significantly increase compared to syringes without plasma coating. Due to the versatility of RFGD plasma, this process is scalable and could potentially be used for the treatment of hypodermic syringes used for the storage and delivery of protein-based therapeutics.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Adsorption (of proteins). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics