Category: 112-63-0

Qiu, Di; Mo, Fanyang; Zheng, Zhitong; Zhang, Yan; Wang, Jianbo published the artcile< Gold(III)-catalyzed halogenation of aromatic boronates with N-halosuccinimides>, Reference of 112-63-0, the main research area is halogenation arylboronate halosuccinimide gold trichloride catalyst; regioselective halogenation aryl boronate substituent directed preparation haloaryl boronate; chlorination bromination iodination arylboronate trichlorogold catalyst regioselective preparation haloarylboronate.

Halogenation of aryl boronates ArB(OCMe2)2 (ArBpin) was achieved by reaction with N-halosuccinimide in the presence of 2 mol% of AuCl3; in the same conditions, iron halides, BF3·OEt2 and other common catalysts were proven to be ineffective. Bromination of phenylboronate PhBpin was shown to be non-regioselective, yielding approx. 1:1:1 mixture of 2-Br-, 3-Br-, and 4-BrC6H4Bpin isomers, thus proving a weak ortho-para directing properties of the Bpin substituent. The directing effect of the boronate may be overridden in halogenation of differently substituted benzene derivatives XC6H4Bpin (X = 3-MeO, 2-MeO, 2-Me, 3-Me, 3-OH, 3-Cl, 3-Br, 3-F3CO, 4-Cl) or of disubstituted benzeneboronates X2C6H3Bpin (X2 = 3,5-Me2, 3,5-F2, 3,5-Cl2), which proceeds selectively and with good yields in o- or p-positions to the substituents X. 2- And 3-thiopheneboronates were also halogenated in 5- and 2,5-positions, resp.

Organic Letters published new progress about Aromatic compounds Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Songwen; Wang, Chunyang; Ji, Ming; Wu, Deyu; Lv, Yuanhao; Zhang, Kehui; Dong, Yi; Jin, Jing; Chen, Jiajing; Zhang, Jingbo; Sheng, Li; Li, Yan; Chen, Xiaoguang; Xu, Heng published the artcile< Discovery and Optimization of 2-Amino-4-methylquinazoline Derivatives as Highly Potent Phosphatidylinositol 3-Kinase Inhibitors for Cancer Treatment>, Synthetic Route of 112-63-0, the main research area is amino methyl quinazoline derivative preparation PI3K inhibitor cancer.

Increased phosphatidylinositol 3-kinase (PI3K) signaling is among the most common alterations in cancer, spurring intensive efforts to develop new cancer therapeutics that target this pathway. In this work, we discovered a series of novel 2-amino-4-methylquinazoline derivatives through a hybridization and subsequent scaffold hopping approach that were highly potent class I PI3K inhibitors. Lead optimization resulted in several promising compounds (e.g., 19, 20, 37, and 43) with nanomolar PI3K potencies, prominent antiproliferative activities, favorable PK profiles, and robust in vivo antitumor efficacies. More interestingly, compared with 19 and 20, 37 and 43 demonstrated improved brain penetration and in vivo efficacy in an orthotopic glioblastoma xenograft model. Furthermore, preliminary safety assessments including hERG channel inhibition, AMES, CYP450 inhibition, and single-dose toxicity were performed to characterize their toxicol. properties.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Batema, Guido D.; van de Westelaken, Koen T. L.; Guerra, Javier; Lutz, Martin; Spek, Anthony L.; van Walree, Cornelis A.; de Mello Donega, Celso; Meijerink, Andries; van Klink, Gerard P. M.; van Koten, Gerard published the artcile< Luminescent and electronic properties of stilbenoid NCN-pincer PtII compounds>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is platinum complex preparation crystal structure NMR UV spectra.

A series of 4,4′-disubstituted organic-organometallic stilbenes were synthesized, i.e., the 4′-substituted stilbenoid-NCN-pincer platinum(II) complexes [PtCl(NCN-R-4)] (NCN-R-4 = [C6H2(CH2NMe2)2-2,6-R-4]- in which R = C2H2C6H4-R’-4′ with R’ = NMe2, OMe, SiMe3, H, I, CN, NO2) (1-7). In these compounds the PtCl grouping can be considered to be present as a donor substituent. Their synthesis involved a Horner-Wadsworth-Emmons reaction of [PtCl(NCN-CHO-4)] (9) with the appropriate phosphonate ester derivatives (8a-g). Under these reaction conditions, the C-Pt bond in aldehyde 9 was not affected, and the platinated stilbene products were obtained in 53-90 % yield. The solid state structures of complexes 1, 2 and 5-7 were determined by single-crystal X-ray diffraction, which revealed interesting bent conformations for 2, 5 and 7. Linear correlations were found between both the 13C{1H} (C ipso to Pt) and the 195Pt{1H} NMR chem. shift and the Hammett σp value of the R’ substituent; therefore, these NMR shifts can be used as a qual. probe for the electronic properties of the delocalized π-system to which it is connected. The platinum-stilbene complexes were investigated for charge-transfer properties in solvents of different polarity. The luminescent properties, shown by donor-acceptor complexes 1, 6 and 7, were investigated by fluorescence spectroscopy, and the complexes showed pos. solvatochromism, which indicates dipolar character of the excited state. The excited state lifetimes, which were in the picosecond range, and the quantum yields (ranging from 0.002 to 0.2) were also determined for these complexes. It was established that the presence of the transition metal favors nonradiative decay from the excited state to the ground state.

European Journal of Inorganic Chemistry published new progress about Charge transfer complexes Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dhanusha, G.; Sujith, S.; Nisha, Ar; Aathira, Kk; Haima, Js published the artcile< Cytotoxic and antiproliferative potential of methanolic extracts of Asparagus racemosus in MDAMB231 cells>, SDS of cas: 112-63-0, the main research area is cytotoxic antiproliferative potential methanolic extract Asparagus racemosus.

The present study was carried out to evaluate the cytotoxic and antiproliferative activity of methanolic extract of Asparagus racemosus in MDAB-231 cells. The qual. phytochem. anal. of the extract revealed the presence of steroids, alkaloids, flavonoids, glycosides, saponins and diterpenes. MDAMB-231 cells were maintained in RPMI media containing 10 per cent serum and 1 per cent antibiotic and antimycotic solution The cells were harvested and seeded to 96 well plate at 5 x 103 cells/mL, incubated for 24 h at 37°C with 5 per cent CO2. The cells were treated with 160, 80, 40, 20 and 10μg/mL of the extract for 24 h and viability was accessed using MTT Assay. Also cells were plated in 6 well plates at concentrations 3 x 105 cells/mL and exposed to 80, 40, 20 and 10μg/mL of the extract of Asparagus racemosus for acridine orange ethidium bromide (AO/EB) staining. There was a dose dependent decrease in viability of cells exposed to methanolic extracts of Asparagus racemosus with a viability of 15.55 ± 0.193 per cent for cells treated with 160μg/mL. The IC50 was found to be 91.36 ± 0.87μg/mL. The AO/EB staining revealed that most of the cells were dead in extract treated with 80μg/mL where more than 90 per cent of cells were live when treated with 10μg/mL of the extract

Pharma Innovation published new progress about Alkaloids Role: ANT (Analyte), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Siping; Liu, Bo; Zhao, Dongbing; Wang, Zhen; Wu, Jie; Lan, Jingbo; You, Jingsong published the artcile< Pyrido[1,2-c][1,2,4]triazol-3-ylidene: Reactivity and its application in organocatalysis and organometallic catalysis>, Application of C19H34O2, the main research area is pyridotriazolylidene preparation reaction catalyst.

The reactivity and catalytic performance of 2-ethylpyrido[1,2-c][1,2,4]-triazol-3-ylidene (I) have been comprehensively investigated. I shows unusual properties owing to the effect of the pyrido-annulation. While formohydrazide and hydrazine are obtained via the destruction of the triazole skeleton of the carbene, 3-((1Z,3E)-4-(1H-pyrrol-1-yl)buta-1,3-dienyl)-1-ethyl-1H-1,2,4-triazole is achieved through the cleavage of the C-N bond of the pyridine ring. I is also a powerful catalyst in a variety of organocatalyzed and Pd(II)-catalyzed transformations.

Organic & Biomolecular Chemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liao, Hongdong; Wen, Xiangyu; Deng, Xuelei; Wu, Yonghong; Xu, Jianping; Li, Xin; Zhou, Shudong; Li, Xuefeng; Zhu, Chunhui; Luo, Feng; Ma, Yanqing; Zheng, Jingyuan published the artcile< Integrated proteomic and metabolomic analyses reveal significant changes in chloroplasts and mitochondria of pepper (Capsicum annuum L.) during Sclerotium rolfsii infection>, COA of Formula: C19H34O2, the main research area is pepper Capsicum annuum Sclerotium rolfsii infection chloroplast mitochondria analysis; Sclerotium rolfsii; chloroplasts; mitochondria; pepper; proteomics-metabonomics integrated analysis.

Infection by Sclerotium rolfsii will cause serious disease and lead to significant economic losses in chili pepper. In this study, the response of pepper during S. rolfsii infection was explored by electron microscopy, physiol. determination and integrated proteome and metabolome analyses. Our results showed that the stomata of pepper stems were important portals for S.rolfsii infection. The plant cell morphol. was significantly changed at the time of the fungal hyphae just contacting (T1) or surrounding (T2) the pepper. The chlorophyll, carotenoid, and MDA contents and the activities of POD, SOD, and CAT were markedly upregulated at T1 and T2. Approx. 4129 proteins and 823 metabolites were clearly identified in proteome and metabolome analyses, resp. A change in 396 proteins and 54 metabolites in pepper stem tissues was observed at T1 compared with 438 proteins and 53 metabolites at T2. The proteins and metabolites related to photosynthesis and antioxidant systems in chloroplasts and mitochondria were disproportionally affected by S. rolfsii infection, impacting carbohydrate and amino acid metabolism This study provided new insights into theresponse mechanism in pepper stems during S. rolfsii infection, which can guide future work on fungal disease resistance breeding in pepper.

Journal of Microbiology (Seoul, Republic of Korea) published new progress about Amino acid metabolism disorders. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Jiang; Zhao, Qunchao; Wilson, Thomas C.; Verhoog, Stefan; Lu, Long; Gouverneur, Veronique; Shen, Qilong published the artcile< Synthesis and Reactivity of α-Cumyl Bromodifluoromethanesulfenate: Application to the Radiosynthesis of [18F]ArylSCF3>, Product Details of C19H34O2, the main research area is aryl boronic pinacol ester cumyl bromodifluoromethanesulfenate copper bromodifluoromethylthiolation catalyst; bromodifluoromethylthiolated arene preparation fluorine18; fluorine18 labeled trifluoromethylthiolated arene preparation; PET; boron reagents; bromodifluoromethylthiolation; fluorine; radiolabeling.

A highly reactive electrophilic bromodifluoromethylthiolating reagent, α-cumyl bromodifluoro-methanesulfenate 1, was prepared to allow for direct bromodifluoromethylthiolation of aryl boron reagents. This coupling reaction takes place under copper catalysis, and affords a large range of bromodifluoromethylthiolated arenes. These compounds are amenable to various transformations including halogen exchange with [18F]KF/K222 , a process giving access to [18F]arylSCF3 in two steps from the corresponding aryl boronic pinacol esters.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation) (bromodifluoromethylthiolated). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xuan; Thummuri, Dinesh; Liu, Xingui; Hu, Wanyi; Zhang, Peiyi; Khan, Sajid; Yuan, Yaxia; Zhou, Daohong; Zheng, Guangrong published the artcile< Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity>, Electric Literature of 112-63-0, the main research area is preparation PROTAC apoptosis BCLxL degrader cancer platelet toxicity; Apoptosis; BCL-X(L); Degradation; PROTAC; Platelet.

Anti-apoptotic protein BCL-XL plays a key role in tumorigenesis and cancer chemotherapy resistance, rendering it an attractive target for cancer treatment. However, BCL-XL inhibitors such as ABT-263 cannot be safely used in the clinic because platelets solely depend on BCL-XL to maintain their viability. To reduce the on-target platelet toxicity associated with the inhibition of BCL-XL, we designed and synthesized PROTAC BCL-XL degraders that recruit CRBN or VHL E3 ligase because both of these enzymes are poorly expressed in human platelets compared to various cancer cell lines. We confirmed that platelet-toxic BCL-XL/2 dual inhibitor ABT-263 can be converted into platelet-sparing CRBN/VHL-based BCL-XL specific degraders. A number of BCL-XL degraders are more potent in killing cancer cells than their parent compound ABT-263. Specifically, XZ739, a CRBN-dependent BCL-XL degrader, is 20-fold more potent than ABT-263 against MOLT-4 T-ALL cells and has >100-fold selectivity for MOLT-4 cells over human platelets. Our findings further demonstrated the utility of PROTAC technol. to achieve tissue selectivity through recruiting differentially expressed E3 ligases.

European Journal of Medicinal Chemistry published new progress about Antitumor agents (low). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dupau, Philippe; Renouard, Thierry; Le Bozec, Hubert published the artcile< Straightforward synthesis of 4-formyl- and 4,4'-diformyl-2,2'-bipyridines: access to new dialkenyl substituted bipyridyl ligands>, Application of C19H34O2, the main research area is bipyridine formyl preparation; bipyridinecarboxaldehyde preparation; bipyridinedicarboxaldehyde preparation; Bredereck reagent formylation methylbipyridine.

4-Formyl-2,2′-bipyridines and 4,4′-diformyl-2,2′-bipyridines were prepared in two steps and in 52-71% overall yields via enamination of the corresponding 4-methyl-2,2′-bipyridines or 4,4′-dimethyl-2,2′-bipyridines. The synthesis of two 4,4′-dialkenyl-2,2′-bipyridyl ligands was also described. The treatment of 4,4′-dimethyl-2,2′-bipyridine with modified Bredereck’s reagent tert-butoxybis(dimethylamino)methane gave [2,2′-bipyridine]-4,4′-dicarboxaldehyde after oxidation of an intermediate [bipyridinedyl]propenamine.

Tetrahedron Letters published new progress about Formylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wijekoon, Champa; Netticadan, Thomas; Siow, Yaw L.; Sabra, Ali; Yu, Liping; Raj, Pema; Prashar, Suvira published the artcile< Potential Associations among Bioactive Molecules, Antioxidant Activity and Resveratrol Production in Vitis vinifera Fruits of North America>, Product Details of C19H34O2, the main research area is resveratrol Vitis vinifer bioactive mol antioxidant activity North America; antioxidant activity; bioactive molecules; grapes; resveratrol; stilbene synthase.

Grapes (Vitis vinifera L.) are rich in bioactive mols. contributing to health benefits. Consumption of grapes is linked to reduced incidence of cardiovascular diseases. Studies on table grape cultivars are limited although much attention in research was focused on the wine industry. Bioactive effects of grapes as anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective have also been reported. For example, resveratrol is a natural food ingredient present in grapes, with high antioxidant potential. Here we conducted an exploratory study to investigate bioactive mols., antioxidant activity and the association between constitutive stilbene synthase (STS) gene expression and the resveratrol biosynthesis in selected table grape varieties in North America. The phenolic compounds, fatty acid composition and antioxidant activity of four grape varieties were compared. Red Globe variety was rich in unsaturated fatty acids as well as phenolic compounds such as caffeic acid, quercetin and resveratrol. Meanwhile, the constitutive expression of grape stilbene synthase gene was higher in Flame and Autumn Royal where resveratrol content of these cultivars was relatively low compared to the Red Globe variety. This study shows the potential links in grape antioxidant activity and resveratrol production, but more studies are necessary to show the association

Molecules published new progress about Anthocyanins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics