Category: 112-63-0

Hyodo, Isao; Tobisu, Mamoru; Chatani, Naoto published the artcile< Catalytic Arylation of a C-H Bond in Pyridine and Related Six-Membered N-Heteroarenes Using Organozinc Reagents>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nitrogen heteroarene diphenylzinc direct arylation nickel; aryl nitrogen heteroarene preparation; nickel direct arylation catalyst.

Despite significant advances in the catalytic direct arylation of heteroarenes, the application of this reaction to pyridines has been met with limited success. An oxidative nucleophilic arylation strategy has been developed to overcome this problem. Pyridine, pyrazine, quinolone, and related electron-deficient N-heteroarenes can be arylated at the most electrophilic site using the developed nickel-catalyzed reaction. This protocol serves as a complementary method to catalytic direct arylation reactions.

Chemistry – An Asian Journal published new progress about Arylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Jia-Shu; Clarke, Ross; Haddad, Alexander F.; Wang, Elaina J.; Lacroix, Michel; Sarkar, Indra Neil; Zand, Ramin; Chen, Elizabeth S.; Toms, Steven A. published the artcile< The effect of levetiracetam treatment on survival in patients with glioblastoma: a systematic review and meta-analysis>, HPLC of Formula: 112-63-0, the main research area is human glioblastoma levetiracetam treatment meta analysis; Anti-epileptic; Glioblastoma; Levetiracetam; Survival; Temozolomide.

Levetiracetam (LEV) is an anti-epileptic drug (AED) that sensitizes glioblastoma (GBM) to temozolomide (TMZ) chemotherapy by inhibiting O6-methylguanine-DNA methyltransferase (MGMT) expression. Adding LEV to the standard of care (SOC) for GBM may improve TMZ efficacy. This study aimed to pool the existing evidence in the literature to quantify LEV’s effect on GBM survival and characterize its safety profile to determine whether incorporating LEV into the SOC is warranted. A search of CINAHL, Embase, PubMed, and Web of Science from inception to May 2021 was performed to identify relevant articles. Hazard ratios (HR), median overall survival, and adverse events were pooled using random-effect models. Meta-regression, funnel plots, and the Newcastle-Ottawa Scale were utilized to identify sources of heterogeneity, bias, and statistical influence. From 20 included studies, 5804 GBM patients underwent meta-anal., of which 1923 (33%) were treated with LEV. Administration of LEV did not significantly improve survival in the entire patient population (HR 0.89, p = 0.094). Significant heterogeneity was observed during pooling of HRs (I2 = 75%, p < 0.01). Meta-regression determined that LEV treatment effect decreased with greater rates of MGMT methylation (RC = 0.03, p = 0.02) and increased with greater proportions of female patients (RC = - 0.05, p = 0.002). Concurrent LEV with the SOC for GBM did not increase odds of adverse events relative to other AEDs. Levetiracetam treatment may not be effective for all GBM patients. Instead, LEV may be better suited for treating specific mol. profiles of GBM. Further studies are necessary to identify optimal GBM candidates for LEV. Journal of Neuro-Oncology published new progress about Anticonvulsants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Kedong; Zhang, Yingbo; Li, Libo; Zhang, Jingyan; Rong, Hua; Liu, Deshui; Wang, Junping; Jin, Ming; Luo, Nan; Zhang, Xiaojie published the artcile< Neuroprotective effect of paeoniflorin in the mouse model of Parkinson′s disease through α-synuclein/protein kinase C δ subtype signaling pathway>, Category: esters-buliding-blocks, the main research area is Parkinsons disease alpha synuclein protein kinase C paeoniflorin neuroprotective.

Paeoniflorin, an active component of Radix Paeoniae Alba, has a neuroprotective effect in Parkinson′s animal models. However, its mechanism of action remains to be determined In this study, we hypothesized that the neuroprotective effect of paeoniflorin occurs through the α-synuclein/protein kinase C δ subtype (PKC-δ) signaling pathway. We tested our hypothesis in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson′s disease. We evaluated the effects of paeoniflorin on the expression levels of signal components of the α-synuclein/PKC-δ pathway, cellular apoptosis and motor performance. Our results demonstrated that paeoniflorin restored the motor performance impairment caused by MPTP, inhibited apoptosis, and protected the ultrastructure of neurons. Paeoniflorin treatment also resulted in the dose-dependent upregulation of an antiapoptotic protein, B-cell lymphoma-2, at the mRNA and protein levels, similar to the effects of the pos. control, selegiline. In contrast, paeoniflorin treatment downregulated the expression of pro-apoptotic proteins BCL2-Associated X2, α-synuclein, and PKC-δ at the mRNA and protein levels, as well as the level of the activated form of nuclear factor kappa B (p-NF-κB p65). Thus, our results showed that paeoniflorin exerts its neuroprotective effect by regulating the α-synuclein/PKC-δ signaling pathway to reduce neuronal apoptosis.

NeuroReport published new progress about Antiapoptotic proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cao, Xiyue; Xu, Hui; Li, Fosheng; Zou, Yijun; Ran, Yulu; Ma, Xiaorui; Cao, Yu; Xu, Qingrui; Qiao, Dairong; Cao, Yi published the artcile< One-step direct transesterification of wet yeast for biodiesel production catalyzed by magnetic nanoparticle-immobilized lipase>, Related Products of 112-63-0, the main research area is lipase wet yeast biodiesel magnetic nanoparticle transesterification.

To develop a method for direct transesterification of wet yeast using immobilized lipase, the oleaginous yeast Saitozyma podzolica Zwy-2-3 and the lipase producing Burkholderia pyrrolica WZ10-3 were used as materials for production of biodiesel. Fe3O4@SiO2-CHO prepared by modifying Fe3O4 with TEOS, APTES and glutaraldehyde. The biocatalysts covalently cross-linked with WZ10-3 lipase by Fe3O4@SiO2-CHO were characterized by FTIR, XRD and TEM. When the enzyme dosage, glutaraldehyde concentration, temperature and time were 30.22 mL, 2.0%, 40°C and 4 h, the immobilized lipase activity and immobilization rate reached 10038.0 U/g and 96.9%, resp. The optimum temperatures for immobilized and free lipase were 60 degrees and 40 degrees. The immobilized enzyme still had 80% enzymic activity after 48 d storage at 4°C. The optimized conditions for the direct conversion of immobilized lipase to esterified wet yeast (one-step) were: enzyme dosage 2.5 g, reaction temperature 35°C; water content 15%; and molar ratio of n-hexane to methanol 3: 1. The transesterification rates of one-step method for oil and biomass were 98.12% and 56.11%, resp. In contrast, the two-step method was only 88.75% and 51.21%. The immobilized enzyme had 90% enzyme activity after 10 times of reuse.

Renewable Energy published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mayer, Nicole; Schweiger, Martina; Fuchs, Elisabeth; Migglautsch, Anna K.; Doler, Carina; Grabner, Gernot F.; Romauch, Matthias; Melcher, Michaela-Christina; Zechner, Rudolf; Zimmermann, Robert; Breinbauer, Rolf published the artcile< Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)>, Application of C19H34O2, the main research area is PNPLA2 lipolysis NAFLD atglistatin murine ATGL inhibitors SAR; Atglistatin; Lipolysis; NAFLD; PNPLA2; Small molecule inhibitor.

High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alc. fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure-activity relationship (SAR) studies of small mol. inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target.

Bioorganic & Medicinal Chemistry published new progress about Drug targets. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bai, Lei; Huo, Shuhui; Chen, Jing; Lu, Xiaoquan published the artcile< Squaramide fluorescence probe for chiral recognition of α-amino acids>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is squaramide fluorescence probe chiral recognition alpha amino acid fluorometry.

Four squaramide fluorescence probes were synthesized using natural amino acids as chiral sources, which featured concise synthetic route, simple work-up and purification without column chromatog. The chiral recognition effects of these squaramide probes for phenylalanine, valine and proline were tested using fluorescence spectrum, which indicated that probe 5 could effectively discriminate two enantiomers of phenylalanine. The fluorescence intensity of probe 5 was remarkably enhanced after adding L-phenylalanine. On the contrary, it was observably reduced when D-phenylalanine was added, and the fluorescence intensity ratio of two enantiomers (IL/ID) was up to 2.4.

Gaodeng Xuexiao Huaxue Xuebao published new progress about Chiral recognition. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meng, Xianglong; Yan, Jingning; Ma, Junnan; Kang, An Na; Kang, Seok Yong; Zhang, Qi; Lyu, Chenzi; Park, Yong-Ki; Jung, Hyo Won; Zhang, Shuosheng published the artcile< Effects of Jowiseungki-tang on high fat diet-induced obesity in mice and functional analysis on network pharmacology and metabolomics analysis>, Electric Literature of 112-63-0, the main research area is diabetes mellitus obesity Jowiseungki tang metabolomics pharmacol; Diabetes mellitus; High fat diet; Jowiseungki-tang; Metabolomics; Network pharmacology.

In traditional Chinese and Korean medicine, Jowiseungki-tang (JST) is a prescription for diabetes mellitus (DM) treatment. However, little scientific evidence is known of its effect in diabetic condition. We assessed the effects of JST on high-fat diet (HFD)-induced obesity with inflammatory condition in mice and to analyze the therapeutic function of JST on network pharmacol. as well as targeted metabolomics. JST administration at 100 mg/kg and 500 mg/kg for a period of 4 wk in HFD-induced obese mice, body weight gain, energy utility, calorie intake, and levels of glucose, insulin, total cholesterol, triglyceride, LDL-cholesterol as well as interleukin-6 were measured. Measurements of HDL-cholesterol (HDL-C) were performed and compared to those of the control group. Moreover, the therapeutic function of JST on obesity was analyzed furtherly based on network pharmacol. and targeted metabolomics methods. Administration of JST at 100 mg/kg and 500 mg/kg for a period of 4 wk in HFD-induced obesity mice significantly decreased the body weight gain, energy utility, calorie intake, and levels of insulin, total cholesterol, LDL-cholesterol, triglyceride, and interleukin-6. However, HDL-cholesterol (HDL-C) levels showed marked elevation relative to control groups. JST administration strongly inhibited expressions of inducible nitric oxide synthase, inflammatory proteins, and cyclooxygenase-2 in the pancreas, stomach, and liver tissues, and reduced hepatic steatosis and pancreatic hyperplasia. In network pharmacol. anal., the putative functional targets of JST are underlie on modulation of cofactor-, coenzyme-, and fatty acid-bonding, insulin resistance, and inflammatory response, fine-tuned the phosphatase binding and signal pathway activation, such as mitogen activated protein kinases, phosphatidylinositol 3-kinases/protein kinase B, protein kinase C, and receptor of glycation end products as well-advanced glycation end products. According to the metabolomics anal., the contents and energy metabolites, and medium and long chain fatty acids was significantly changed in mice pancreases. JST is a valuable prescription for treatment of patients with DM in traditional clinics through inhibition of obesity, inflammatory condition and metabolism

Journal of Ethnopharmacology published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rout, Deeptimayee; Dash, Umesh Chandra; Kanhar, Satish; Swain, Sandeep Kumar; Sahoo, Atish Kumar published the artcile< Homalium zeylanicum attenuates streptozotocin-induced hyperglycemia and cellular stress in experimental rats via attenuation of oxidative stress imparts inflammation>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Homalium hyperglycemia leaf oxidative stress inflammation; 8-OHdG; CRP; Homalium zeylanicum; TNF-α; α-amylase; α-glucosidase.

Homalium zeylanicum (Gardner) Benth (Salicaceae) leaves are being used as folklore medicine to treat diabetes by the local folk of Andhra Pradesh, India. The medicinal claim of this plant with hypoglycemic effects was initially studied by the authors. Antioxidant activities of the hydroalc. fraction of leaves of H. zeylanicum leaves (HAHZL) were pos. correlated with phenols and flavonoids contents. Based on the previous findings, addnl. research is needed to examine the efficacy of using HAHZL to treat hyperglycemia. We therefore investigated in vitro and in vivo glycemic response of HAHZL, and evaluation of possible mechanism of bioactive mols. in mitigating streptozotocin-induced cellular stress in exptl. rats via attenuation of oxidative stress imparts inflammation. GC-MS/MS anal. of HAHZL was carried out to identify bioactive constituents. In vitro antidiabetic (α-glucosidase, α-amylase) and anti-inflammatory activities were investigated. HFD/low-STZ-prompted diabetic Wistar rats were administered with HAHZL (300 and 400 mg/kg; oral) for 28 days. Blood serum, oxidative stress, inflammation, DNA damage, and antidiabetic markers of pancreas and liver were determined Histopathol. studies of liver and pancreas were performed to assess the protective role of HAHZL. GC-MS/MS study revealed 7 bioactive compounds e.g., Phenol, 4-ethenyl-, acetate (28.68%), hydroquinone (9.10%), n-hexadecanoic acid (0.55%), phytol (0.57%), arbutin (17.65%), Vitamin E (1.04%), β-Sitosterol (1.54%) which possess antioxidant, anti-inflammatory and anti-diabetic activities. HAHZL showed significant in vitro glycemic response as evidenced by the inhibition of α-amylase, and α-glucosidase activities. Lineweaver-Burk plot revealed that HAHZL exhibited competitive and mixed competitive inhibition towards α-amylase and α-glucosidase, resp. HAHZL at 400 mg/kg modulated the pathophysiol. associated with HFD/STZ-induced type2 diabetes mellitus and significantly (p < 0.001) improved antihyperglycemic (SG, SI, HOMA-IR, and HbA1C), antidyslipidemic (TC, HDL-C, LDL-C, and TG), antioxidative (MDA, SOD, CAT, GSH, and 8-OHdG) and anti-inflammatory (TNF-α, and CRP) markers in serum, pancreas and liver. In vitro and in vivo test results were corroborated by the improvement of pancreatic and hepatic tissue architecture in diabetic rats. HAHZL bearing bioactive components phenol, 4-ethenyl-,acetate, hydroquinone, n-hexadecanoic acid, arbutin, phytol, vitamin E and β-sitosterol balanced glycemic level by normalizing the levels of glycemic indexes, lipid profile, pancreas and liver functional markers in STZ-induced T2DM rats. Journal of Ethnopharmacology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diaz-Navarro, Marta; Bolivar, Paula; Andres, Maria Fe; Gomez-Munoz, Maria Teresa; Martinez-Diaz, Rafael A.; Valcarcel, Felix; Garcia-Paris, Mario; Bautista, Luis M.; Gonzalez-Coloma, Azucena published the artcile< Antiparasitic Effects of Potentially Toxic Beetles (Tenebrionidae and Meloidae) from Steppe Zones>, COA of Formula: C19H34O2, the main research area is Blaps Mylabris Aspergillus Hyalomma myristic acid methyl linoleate antiparasitic; GCMS; Meloidae; Tenebrionidae; antiprotozoal; cantharidin; ethyl oleate; nematicide; otididae.

Arthropods and specifically beetles can synthesize and/or sequester metabolites from dietary sources. In beetle families such as Tenebrionidae and Meloidae, a few studies have reported species with toxic defensive substances and antiparasitic properties that are consumed by birds. Here we have studied the antiparasitic activity of extracts from beetle species present in the habitat of the Great Bustard (Otis tarda) against four pathogen models (Aspergillus niger, Meloidogyne javanica, Hyalomma lusitanicum, and Trichomonas gallinae). The insect species extracted were Tentyria peiroleri, Scaurus uncinus, Blaps lethifera (Tenebrionidae), and Mylabris quadripunctata (Meloidae). M. quadripunctata exhibited potent activity against M. javanica and T. gallinae, while T. peiroleri exhibited moderate antiprotozoal activity. The chem. composition of the insect extracts was studied by gas chromatog. coupled with mass spectrometry (GC-MS) anal. The most abundant compounds in the four beetle extracts were hydrocarbons and fatty acids such as palmitic acid, myristic acid and Me linoleate, which are characteristic of insect cuticles. The presence of cantharidin (CTD) in the M. quadripunctata meloid and Et oleate (EO) in T. peiroleri accounted for the bioactivity of their extracts

Toxins published new progress about Aspergillus niger. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chevenier, Emmanuel; Lucatelli, Christophe; Pandya, Urvish; Wang, Wei; Gimbert, Yves; Greene, Andrew E. published the artcile< An anionic polycondensation strategy for the synthesis of dibenzoxanthenones: Progress toward the synthesis of hypoxyxylerone>, Reference of 112-63-0, the main research area is anionic polycondensation dibenzoxanthenone hypoxyxylerone synthesis.

An anionic polycondensation has been used as the key step in a highly convergent strategy for the preparation of hypoxyxylerone derivatives, e.g. I.

Synlett published new progress about Condensation reaction (polycondensation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics