Category: 112-63-0

Rana, Qurrat Ul Ain; Irfan, Muhammad; Ahmed, Safia; Hasan, Fariha; Shah, Aamer Ali; Khan, Samiullah; Ur Rehman, Fazal; Khan, Haji; Ju, Meiting; Li, Weizun; Badshah, Malik published the artcile< Bio-catalytic transesterification of mustard oil for biodiesel production>, Electric Literature of 112-63-0, the main research area is biodiesel mustard oil fatty acid mathyl ester biocatalysis transesterification.

The depletion of non-renewable fossil fuels and a surge in their prices have led researchers to seek alternative, renewable energy sources; among them, biodiesel is a good option, especially in the ever-growing global transport sector. Mustard oil is a potential feedstock for biodiesel production, and because it is non-edible it avoids the food vs. fuel feud. Biocatalytic transesterification of mustard oil for biodiesel production makes this process cost efficient, environmentally friendly and sustainable. In the current study, Pseudomanas aeruginosa Q8 KX12304-mediated transesterification of mustard oil was carried out. The parameters for the transesterification reaction were statistically optimized using Plackett-Burman and central composite design. The highest biodiesel volumetric yield obtained was 100% at optimized conditions. The quality of biodiesel was confirmed using gas chromatog.-mass spectrometry (GCMS) and the produced biodiesel was found to meet the quality standards specified by American Society for Testing and Materials (ASTM) and EU-14103. The fatty acid Me ester contents of the biodiesel produced were erucic acid Me esters (48.2%), palmitic acid Me esters (11.8%), oleic acid Me esters (10.6%), linolenic acid Me esters (10.3%), linoleic acid Me esters (9.1%) and stearic acid Me esters (8%). To the best of our knowledge, this is the first study to report transesterification of mustard oil via biocatalysis.

Biofuels published new progress about Biocatalysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Asikainen, Sanja; Seppala, Jukka published the artcile< Photo-crosslinked anhydride-modified polyester and -ethers for pH-sensitive drug release>, Quality Control of 112-63-0, the main research area is photocrosslinked anhydride modified polyester polyether drug delivery system; Drug delivery; Lidocaine; Photo-crosslinking; Poly(ester anhydride); Poly(ether anhydride); Vitamin B(12).

Photo-crosslinkable polymers have a great potential for the delivery of sensitive drugs. They allow preparation of drug releasing devices by photo-crosslinking, thus avoiding high processing temperatures In this study, the hydrolysis behavior and drug release of three different photo-crosslinkable poly(ether anhydride)s and one poly(ester anhydride) were investigated. Three-arm poly(ethylene glycol) or polycaprolactone was reacted with succinic anhydride to obtain carboxylated macromers, and further functionalized with methacrylic anhydride to form methacrylated marcromers with anhydride linkages. The synthesized macromers were used to prepare photo-crosslinked matrixes with different hydrolytic degradation times for active agent release purposes. The hydrolysis was clearly pH-sensitive: polymer networks degraded slowly in acidic conditions, and degradation rate increased as the pH shifted towards basic conditions. Drug release was studied with two water-soluble model drugs lidocaine (234 mol/g) and vitamin B12 (1355 g/mol). Vitamin B12 was released mainly due to polymer network degradation, whereas smaller mol. lidocaine was released also through diffusion and swelling of polymer network. Only a small amount of vitamin B12 was released in acidic conditions (pH 1.3 and pH 2.1). These polymers have potential in colon targeted drug delivery as the polymer could protect sensitive drugs from acidic conditions in the stomach, and the drug would be released as the conditions change closer to neutral pH in the intestine.

European Journal of Pharmaceutics and Biopharmaceutics published new progress about Acrylic polymers, polyester- Role: PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), PREP (Preparation), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Xiaotong; Li, Shengnan; Wang, Limin; Huang, Sujuan; Liu, Zhongqiu; Liu, Yujing; Ying, Anguo published the artcile< Novel photic and magnetic double responsive Pickering interfacial solid catalysts for biodiesel production>, Formula: C19H34O2, the main research area is diazabicyclooctane spiropyran iron oxide silica transesterification catalyst nanocomposite.

The prime purpose of this work is to prepare a novel kind of Pickering interfacial solid catalysts for biodiesel production to meet the requirements of highly efficiency and environmental benign. To achieve this goal, the core-shell P[xSPA-yDABCO]@SiO2@Fe3O4 composite materials with a shell of photo-responsive and base catalytic sites were manufactured by means of layer-by-layer fabrication method. The modified materials, entirely characterized by transmission electron microscopy (TEM), scanning electron microscope (SEM), Fourier transform IR (FT-IR) spectra, X-ray powder diffraction (XRD) and magnetization vs. magnetic (VSM) techniques, demonstrated sufficient catalytic active sites and photo-responsive sites. Among all the so-prepared catalysts, P[3SPA-2DABCO]@Fe3O4 performs extremely well and can stabilize soybean oil-in-methanol Pickering emulsion for 24 h, achieving a biodiesel yield up to 98.2% at a catalyst dosage of 5 wt% after the reaction time of 5 h at 60 °C. Furthermore, the double responsive solid catalyst can be readily separated from the mixture of reaction by an external magnet and UV irradiation, and still presented superior catalytic activity after 6 cycles.

Fuel published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dajek, Maciej; Pruszczynska, Agnieszka; Konieczny, Krzysztof A.; Kowalczyk, Rafal published the artcile< Cinchona Squaramide-Catalyzed Intermolecular Desymmetrization of 1,3-Diketones Leading to Chiral 1,4-Dihydropyridines>, Category: esters-buliding-blocks, the main research area is cyclic diketone unsaturated ketoester ammonium acetate squaramide catalyst Michael; hexahydroquinoline carboxylate diastereoselective preparation.

Addition of prochiral cyclic 1,3-diketones to Michael acceptors applying bifunctional Cinchona-derived squaramides resulted in chiral adducts with stereoselectivities of up to 99% ee and allowed for desymmetrization of the nucleophile. These labile hemiacetal intermediates were transformed to new 1,4-dihydropyridines with high diastereoselectivities and no erosion of optical purity. Their further oxidation to pyridine followed by Fisher indolization provided chiral pyridine-indoles.

Advanced Synthesis & Catalysis published new progress about Benzopyrans Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yichang; Bao, Gang; Zhang, Miao; Xiang, Jianyang; Zhou, Haoyu; Wahafu, Alafate; Wu, Wei; Ma, Xudong; Huo, Longwei; Bai, Xiaobin; Xie, Wanfu; Liu, Peijun; Wang, Maode published the artcile< CRB2 enhances malignancy of glioblastoma via activation of the NF-κB pathway>, Reference of 112-63-0, the main research area is CRB2 NFkappaB signaling activation glioblastoma malignancy.

Glioblastoma (GBM) is one of the most lethal types of primary brain tumors in adults with a median survival of less than 15 mo. Although comprehensive clin. treatment strategies including surgical resection followed by radiotherapy and chemotherapy are widely applied, the prognosis for GBM patients remains dismal. The Nuclear Factor-κB (NF-κB) signaling pathway is a complex network linking extracellular stimuli to cell survival and proliferation, and aberrant activation of NF-κB signaling has been implicated in the propagation of a wide range of cancers. However, the underlying mechanism of NF-κB activation still requires further investigation. Here, we report that crumbs homolog 2 (CRB2) is markedly up-regulated in human GBM relative to non-tumor tissues or normal astrocytes. Clin., enriched CRB2 could be observed in high grade glioma with IDH IDH wild-type and 1p19q co-deletion and implied poor outcome in GBM. Consistent with this, malignant characteristics of GBM cells including proliferation, migration, invasion and tumorigenesis were significantly suppressed by lentivirus knock-down of CRB2. Furthermore, exogenous overexpression of CRB2 enhanced the malignant biol. signatures of GBM cells as well as therapy resistance to temozolomide (TMZ). To further investigate the mol. mechanisms responsible, bioinformatics anal. was performed using 3 public databases, with the result that CRB2 was found to correlate closely with tumor necrosis factor α (TNFα)-NF-κB signaling. Mechanistically, elevated CRB2 increased the phosphorylation of IκB-kinase α (IKKα), thus activating NF-κB via reduction of Ikβ protein. Taken together, these data suggest that CRB2 might be a reliable prognostic biomarker and potential therapeutic target for GBM.

Experimental Cell Research published new progress about Astrocyte. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ulmer, Anna; Brunner, Christoph; Arnold, Andreas M.; Poethig, Alexander; Gulder, Tanja published the artcile< A Fluorination/Aryl Migration/Cyclization Cascade for the Metal-Free Synthesis of Fluoro-Benzoxazepines>, Related Products of 112-63-0, the main research area is fluorobenzoxazepine preparation fluorination aryl migration cyclization cascade; regioselective chemoselective benzoxazepine preparation styrene fluoroiodane compound cascade; 1,2-aryl shift; benzoxazepines; fluorination; hypervalent iodine.

Fluorinated organic mols. are of high interest for many applications across chem. and medical disciplines. Efficient methods for the synthesis of such compounds are thus needed. Within this work, application of the bench-stable cyclic hypervalent iodine(III) fluoro reagent facilitated the development of an efficient, metal-free method for the preparation of the novel class of 4-fluoro-1,3-benzoxazepines starting from readily available styrenes. The efficacy and broad applicability of this concept is demonstrated by the synthesis of 20 structurally diverse congeners in high yields, regio-, and diastereoselectivities. The presented method provides complementary chemoselectivity when compared to the common, com. available electrophilic fluorination reagents, such as selectfluor. First mechanistic investigations with isotopically labeled substrates reveal a complex reaction mechanism, proceeding via an unusual fluorination/1,2-aryl migration/cyclization cascade.

Chemistry – A European Journal published new progress about Aryl alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (styrenes). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Shaowei; He, Jinrong; Chen, Yanping; Wang, Xiaojing; Li, Yanyang; Su, Yulin; Wen, Ruyan; Li, Xiuling; Yang, Guanghua; Luo, Shuang; Zhou, Lian; Luo, Xia published the artcile< Effect of Huangqin decoction on regulating intestinal flora in colitis mice characterized as inhibition of the NOD2-dependent pathway>, Related Products of 112-63-0, the main research area is colitis intestinal flora NOD2 signaling pathway Huangqin decoction; HQD; NF-κB; Ulcerative colitis; muramyl dipeptide; nucleotide binding oligomerization domain containing 2.

ContextChinese herb Huangqin decoction (HQD) can regulate intestinal flora in ulcerative colitis (UC) mice. Our study clarifies the mechanism of HQD in regulating the intestinal flora of UC mice. C57BL/6 mice were randomly divided into six groups: Control, Model (3% DSS), Sulfasalazine (500 mg/kg), HQD-L (250 mg/kg), HQD-M (500 mg/kg), and HQD-H (1000 mg/kg) groups. Measurement of body weight, colon length, DAI, and haematoxylin-eosin staining were conducted. FISH and 16S rDNA detected colonic bacterial infiltration and intestinal flora changes. The expression of RegIIIγ and PRRs (NOD2, TLR5, TLR4) were detected by FCM and WB, resp. In addition, WB, qPCR, or IHC were used to detect the expression of NOD2, MyD88, RIP2, and NF-κB p65 in the colon. ELISA was used to determine cytokines. Compared with the model group (DAI score, 2.38 ± 0.05; histol. score, 4.08 ± 0.54), HQD treatment significantly reduced the DAI score (L, 2.16 ± 0.09; M, 1.45 ± 0.05; H, 1.18 ± 0.05) and histol. score (L, 3.16 ± 0.82; M, 2.50 ± 0.81; H, 1.51 ± 0.76); restored the weight, the colonic length (p < 0.05). 16S rDNA identification showed HQD regulated the balance of intestinal flora. Moreover, HQD suppressed the expression of RegIIIγ (p < 0.05) and prevented colonic bacterial infiltration. Furthermore, WB results showed NOD2, and TLR4 were inhibited by HQD, especially NOD2 (p < 0.01). The data of WB, qPCR, and IHC demonstrated that the NOD2-dependent pathway was inhibited by HQD (p < 0.01). HQD (1000 mg/kg) regulates the intestinal flora of colitis mice, mainly characterized as inhibition of the NOD2-dependent pathway. These results indicate that HQD has potential. Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about Actinobacteria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

kacem, Yosra Hadj; Bougarech, Abdelkader; Quintard, Guilhem; Abid, Souhir; Abid, Majdi; Fleury, Etienne published the artcile< Sulfonated poly (Ester-Urethane) / ionic liquids systems: synthesis, characterization and properties>, Electric Literature of 112-63-0, the main research area is sulfonated polyester urethane ionic liquid system preparation property.

A new class of materials based on crosslinked poly (ester-urethane) containing low proportions of ionic liquid were synthesized using biobased sulfonated oligoester diol, trimethylol propane (TMP), 4,4′-methylene bis(cyclohexyle isocyanate) (HMDI) and 1-butyle-3-methylimidazolium acetate (BMIMAc). Sulfonated oligoester with a well-controlled molar mass was first obtained by melt polycondensation catalyzed by Ti(OBu)4. The resulting products were characterized by, 1HNMR, DSC and MALDI-TOF MS techniques. The systems of crosslinked poly (ester-urethane) and ionic liquid were obtained via a one-shot process. FTIR tech. was used for a more effective control of crosslinking reaction. The Thermomech. anal. of the resulting materials were performed by DSC and DMA technique. Furthermore, the hydrolytic and oxidative degradation study revealed that the degradation of systems mainly depends on the content in ionic liquid and the crosslinking degree of networks.

Journal of Polymer Research published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Jing; Peng, Li; Zeng, Jinhao; Zhang, Meiheng; Xu, Feng; Zhang, Xiaotong; Wei, Qin published the artcile< Paeoniflorin suppresses allergic and inflammatory responses by promoting autophagy in rats with urticaria>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is paeoniflorin antiinflammatory agent allergy inhibitor autophagy urticaria; allergy; autophagy; inflammation; paeoniflorin; urticaria.

Paeoniflorin (PF) has been reported to be effective against several skin disorders, such as allergic contact dermatitis and psoriasis; however, it remains unclear whether PF can protect against urticarial lesions. Herein, the effects of PF on rats with urticarial lesions and the possible underlying mechanism were investigated. The effects of PF administration on a rat model of ovalbumin-induced urticarial-like lesions were evaluated via pathol. anal. using hematoxylin-eosin staining. Toluidine blue staining was performed to detect mast cells and ELISA was performed to determine serum histamine levels. PF-induced regulatory effects on autophagic activity and the potential underlying mechanism of this were also investigated using transmission electron microscopy, immunohistochem. and reverse transcription-quant. PCR. It was demonstrated that PF suppressed allergic and inflammatory responses to improve urticarial lesions, as evidenced by the attenuation of pathol. abnormalities, mast cell infiltration and histamine secretion. Mechanistically, PF treatment was found to markedly limit the production and release of inflammatory cytokine interleukin (IL)-23, while the levels of IL-17 remained unchanged. PF intervention led to an increased number of autophagosomes, along with higher levels of light chain 3B (LC3B) and Beclin-1, and lower levels of P62, indicating that PF could augment autophagic activity in urticarial lesions. PF treatment increased the expression of liver kinase B1 (LKB1) and AMP-activated protein kinase-α (AMPK-α), contributing to the PF-enhanced autophagic activity. In conclusion, PF could effectively improve urticarial lesions by inhibiting inflammatory cytokine IL-23 and increasing the autophagic activity via the LKB1/AMPK-α pathway.

Experimental and Therapeutic Medicine published new progress about Allergy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Grotjahn, Sascha; Koenig, Burkhard published the artcile< Photosubstitution in Dicyanobenzene-based Photocatalysts>, Reference of 112-63-0, the main research area is photosubstitution cyano group dicyanobenzene photocatalysts; dicyanobenzene photocatalysts photosubstitution.

We report the photosubstitution of one cyano group in dicyanobenzene-based photocatalysts and thermally activated delayed fluorescence (TADF) emitters. The reaction is a general degradation pathway for some widely used organic photocatalysts such as 4CzIPN and suggests that the active photocatalyst in many reactions is likely different from 4CzIPN. On the contrary, photosubstitution is a facile route to diverse highly reducing photocatalysts and blue TADF emitters.

Organic Letters published new progress about Benzylation (decarboxylative). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics