Category: 112-63-0

Li, Danyi; Yuan, Li; Liang, Guozheng; Gu, Aijuan published the artcile< Self-Healable and Remoldable Transparent Polyurethane Film with High Dielectric Constant from the Synergistic Effect between Lithium Salt and Ionic Liquid>, Application of C19H34O2, the main research area is self healable remoldable transparent polyurethane dielec lithium ionic liquid.

The rapid development of new-generation flexible touch display panels puts forward more requirements on the overlays, not only including colorlessness and transparency but also having self-healing and remolding abilities as well as high dielec. constant Herein, new self-healable and remoldable polyurethane films (PULEx) with high dielec. constant were developed through building of reversible crosslinked networks with special synergistic effect between lithium salt and ionic liquid The integrated performance of PULEx was systematically investigated. Results show that as the loadings of lithium salt and ionic salt increase, films show increased dielec. constant and self-healing ability. The film with suitable composition (PULE7.5) has the best comprehensive performance; its dielec. constants (104-106 Hz) range from 9.6 to 6.1, which are comparable to those of glass (commonly used overlay for rigid capacitive touchscreen panels). The construction of reversible covalent crosslinking endows PULE7.5 with good mech. strength, high self-healing efficiency after complete fracture (92.7%), and high recovery of mech. properties after remolding (91.8%). In addition, the colorless PULE7.5 has high transparency (90.7% transmittance at 550 nm) and can freely convert among three shapes of bending, scrolling, and S-shape, showing great prospects in fabricating flexible display devices. The mechanism behind these outstanding integrated performances of PULE films is investigated through correlation with structures.

Industrial & Engineering Chemistry Research published new progress about Dielectric constant. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lange, Heiko; Bergander, Klaus; Froehlich, Roland; Kehr, Seda; Nakamura, Shuichi; Shibata, Norio; Toru, Takeshi; Hoppe, Dieter published the artcile< Highly enantioselective reactions of configurationally labile epimeric diamine complexes of lithiated S-benzyl thiocarbamates>, Product Details of C19H34O2, the main research area is enantioselective reaction configuration labile epimeric diamine complex lithiation benzylthiocarbamate.

Substitution reactions that employ primary-carbamoyl-protected arylmethanethiols are described. The enantio-determination step was found to occur in the post-deprotonation step as a dynamic thermodn. resolution with a chiral bis(oxazoline) ligand. The configurationally labile lithium complexes were trapped with various electrophiles to yield different substitution products in good to excellent yields and enantiomeric excesses. The absolute configurations of the substitution products were determined, and the stereochem. pathway of the substitution reaction was elucidated for different classes of electrophiles. The temperature-dependent epimerization process was monitored by 1H and 6Li NMR spectroscopy.

Chemistry – An Asian Journal published new progress about Absolute configuration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boyer, Paul L.; Rehm, Catherine A.; Sneller, Michael C.; Mican, JoAnn; Caplan, Margaret R.; Dewar, Robin; Ferris, Andrea L.; Clark, Patrick; Johnson, Adam; Maldarelli, Frank; Hughes, Stephen H. published the artcile< A combination of amino acid mutations leads to resistance to multiple nucleoside analogs in reverse transcriptases from HIV-1 subtypes B and C>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is abacavir azidothymidine zidovudine antiviral agent drug resistance HIV1 infection.

Resistance to anti-HIV drugs has been a problem from the beginning of antiviral drug treatments. The recent expansion of combination antiretroviral therapy worldwide has led to an increase in resistance to antiretrovirals; understanding the mechanisms of resistance is increasingly important. In this study, we analyzed reverse transcriptase (RT) variants based on sequences derived from an individual who had low-level rebound viremia while undergoing therapy with abacavir, azidothymidine (AZT) (zidovudine), and (-)-L-2,3-dideoxy-3-thiacytidine (3TC) (lamivudine). The RT had mutations at positions 64, 67, 70, 184, and 219 and a threonine insertion after amino acid 69 in RT. The virus remained partially susceptible to the nucleoside RT inhibitor (NRTI) regimen. We show how these mutations affect the ability of NRTIs to inhibit DNA synthesis by RT. The presence of the inserted threonine reduced the susceptibility of the RT mutant to inhibition by tenofovir.

Antimicrobial Agents and Chemotherapy published new progress about Anti-HIV agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wagner, Peter J.; Meador, Michael A.; Zhou, Boli; Park, Bong Ser published the artcile< Photocyclization of α-(o-tolyl)acetophenones: triplet and 1,5-biradical reactivity>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is photocyclization tolylacetophenone mechanism stereochem; biradical intermediate tolylacetophenone photocyclization; safety bromine addition DMF.

Several ring-substituted α-(o-tolyl)acetophenones undergo photocyclization to 2-indanol derivatives in high quantum efficiency in solution and in high chem. yield as solids. The mechanism for reaction involves triplet state δ-hydrogen atom abstraction that generates 1,5-biradicals. Quenching studies indicate that the n,π* excited triplets of these ketones react, with rate constants >108 s-1. Variations in triplet reactivity are ascribed to conformational equilibrium that populate reactive and unreactive geometries to different extents. The α-aryl ring eclipses the carbonyl in the lowest energy geometry, from which the most favorable geometry for reaction can be reached by small bond rotations. α-(2,4,6-Triisopropylphenyl)acetophenone forms the relatively long lived enol as well as indanol in solvent-dependent ratios; deuterium labeling indicates that the 1,5-biradical disproportionates to form enol. This does not happen with α-mesitylacetophenone, so its 54% cyclization quantum efficiency is ascribed to an internal triplet quenching that competes with hydrogen abstraction. This internal quenching is presumed to be of the charge-transfer type and does not appear to lead directly to 1,5-biradicals. 1-Methyl-2-phenyl-2-indanol is formed from α-(o-ethylphenyl)acetophenone with a Z/E ratio of 20:1 in benzene and 2:1 in methanol. The 1,5-biradical intermediates were characterized by flash spectroscopy; they have lifetimes between 15 and 45 ns, with those derived from α-(o-isopropylphenyl) ketones being twice as long-lived as those derived from α-(o-methylphenyl) ketones, and show only a small solvent dependence. Biradical lifetimes and the diastereoselectivity of cyclization are interpreted in terms of biradical intersystem crossing occurring preferentially along the reaction coordinate for cyclization, such that the two processes effectively occur concurrently. The applicability of this concept to other biradicals is discussed. Authors counsel caution in addition of Br2 to DMF.

Journal of the American Chemical Society published new progress about Abstraction reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

de la Osa, Clara; Perez-Lopez, Jesus; Feria, Ana-Belen; Baena, Guillermo; Marino, Daniel; Coleto, Inmaculada; Perez-Montano, Francisco; Gandullo, Jacinto; Echevarria, Cristina; Garcia-Maurino, Sofia; Monreal, Jose A. published the artcile< Knock-down of phosphoenolpyruvate carboxylase 3 negatively impacts growth, productivity, and responses to salt stress in sorghum (Sorghum bicolor L.)>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Sorghum root leaf growth nitrate reductase citrate synthase; Sorghum bicolor ; RNA interference; central metabolism; phosphoenolpyruvate carboxylase; productivity; salt stress; stomata.

Phosphoenolpyruvate carboxylase (PEPC) is a carboxylating enzyme with important roles in plant metabolism Most studies in C4 plants have focused on photosynthetic PEPC, but less is known about non-photosynthetic PEPC isoenzymes, especially with respect to their physiol. functions. In this work, we analyzed the precise roles of the sorghum (Sorghum bicolor) PPC3 isoenzyme by the use of knock-down lines with the SbPPC3 gene silenced (Ppc3 lines). Ppc3 plants showed reduced stomatal conductance and plant size, a delay in flowering time, and reduced seed production In addition, silenced plants accumulated stress indicators such as Asn, citrate, malate, and sucrose in roots and showed higher citrate synthase activity, even in control conditions. Salinity further affected stomatal conductance and yield and had a deeper impact on central metabolism in silenced plants compared to wild type, more notably in roots, with Ppc3 plants showing higher nitrate reductase and NADH-glutamate synthase activity in roots and the accumulation of mols. with a higher N/C ratio. Taken together, our results show that although SbPPC3 is predominantly a root protein, its absence causes deep changes in plant physiol. and metabolism in roots and leaves, neg. affecting maximal stomatal opening, growth, productivity, and stress responses in sorghum plants. The consequences of SbPPC3 silencing suggest that this protein, and maybe orthologs in other plants, could be an important target to improve plant growth, productivity, and resistance to salt stress and other stresses where non-photosynthetic PEPCs may be implicated.

Plant Journal published new progress about Biomass. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yu; Xi, Hui; Fu, Yingjie; Li, Peng; Sun, Shihao; Zong, Yongli published the artcile< Effects of Organic Acids on the Release of Fruity Esters in Water: An Insight at the Molecular Level>, Computed Properties of 112-63-0, the main research area is ester organic acid mol interaction hydrogen bond; aroma release; density functional theory; esters; intermolecular interaction; odour detection threshold; organic acids.

It is well known that organic acids (OAs) could affect the flavor of fruit juices and beverages. However, the mol. mechanism of aroma release is still unclear. In this study, the effects of citric acid (CA), L-(-)-malic acid (MA) and L-lactic acid (LA) on the release of six selected esters and their sensory perception were investigated by means of HS-GC-MS analyses and odor detection threshold determination, resp. Meanwhile, the d. functional theory (DFT) calculation was employed to explore the interaction modes between esters and OAs. HS-GC-MS analyses showed that the concentration and the type of OAs regulated the release of esters. The results were basically consistent with the detection threshold change of those esters. The DFT calculation suggested that the main intermol. interaction was hydrogen bonds, and several esters could form a ternary ring structure with OAs through hydrogen bonds. The interactions can induce the different release behaviors of esters in OAs water solution The number of carboxyl functional groups in OAs and the spatial conformation of esters appeared to influence the magnitude of the interaction. The above results demonstrated the mechanism of OAs affecting the release of esters and indicated a possible flavor control way by using different OAs and OA concentrations

Molecules published new progress about Esters Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cai, Yuanhong; Tan, Donghang; Zhang, Qiqi; Lv, Wenxin; Li, Qingjiang; Wang, Honggen published the artcile< Synthesis of difluoromethylated benzylborons via rhodium(I)-catalyzed fluorine-retainable hydroboration of gem-difluoroalkenes>, Related Products of 112-63-0, the main research area is rhodium catalyzed fluorine retainable hydroboration gem fluoroalkene; fluoromethylated benzylborane preparation.

The synthesis of borylated organofluorines is of great interest due to their potential values as synthons in modular construction of F-containing mols. Reported herein is a Rh-catalyzed hydroboration of aryl gem-difluoroalkenes leading to α-difluoromethylated benzylborons. The use of cationic Rh catalyst and a biphosphine ligand with large bite angle was crucial for reactivity by offering good regioselectivity and diminishing the undesired β-F elimination. Preliminary derivatizations of the products were conducted to showcase the utility of this protocol.

Chinese Chemical Letters published new progress about Boranes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (difluoromethylated benzylborons). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghaffari, Behnaz; Preshlock, Sean M.; Plattner, Donald L.; Staples, Richard J.; Maligres, Peter E.; Krska, Shane W.; Maleczka, Robert E.; Smith, Milton R. published the artcile< Silyl Phosphorus and Nitrogen Donor Chelates for Homogeneous Ortho Borylation Catalysis>, Related Products of 112-63-0, the main research area is ortho silylphosphinylbenzene tethered iridium cyclooctadiene preparation catalyst orthoborylation; crystal structure ortho silylphosphinylbenzene tethered iridium cyclooctadiene; mol structure ortho silylphosphinylbenzene tethered iridium cyclooctadiene.

Ir catalysts supported by ortho-(diisopropylsilyl)(di-p-tolylphosphino)benzene bidentate ligand that contains P- or N-donors, effects ortho-borylations for a range of substituted aromatics E.g., reaction of C6H5CO2Me with bis(pinacolato)diboron (B2pin2) in the presence of 1.25 mol% [Ir(OMe)(cod)]2/ 2.5 mol% (p-tol)2PC6H4-2-(SiHiPr2) in THF at 80° to give 72% yield of Me 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate. The substrate scope is broad, and the modular ligand synthesis allows for flexible catalyst design.

Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (benzamides). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamaguchi, Akihiro; Okazaki, Mitsuo published the artcile< Modified wittig reaction. II. Preparation of α-bromo-4-nitrostilbenes and diphenylacetylenes>, Application In Synthesis of 112-63-0, the main research area is stilbene halo nitro; halonitrostilbene preparation Wittig; nitrohalostilbene preparation Wittig; Wittig aldehyde halobenzylphosphonate; aromatic aldehyde Wittig reaction; phosphonate haloenzyl Wittig reaction; arylnitrophenylacetylene preparation Wittig.

α-Bromo-4-nitrostilbenes and diphenylacetylenes were prepared by a modified Wittig reaction. Diethyl α-bromo-p-nitrobenzylphosphonate (I) was obtained quant. by bromination of diethyl p-nitrobenzylphosphonate. Treatment of I with aromatic aldehydes in the presence of an equivalent amount of Na alkoxide in alc. at room temperature gave the corresponding α-bromo-4-nitrostilbenes in good yield. The use of two equivalent base gave diphenylacetylenes. Similarly, the reaction of α-iodo-p-nitrobenzylphosphonate with aromatic aldehydes was investigated.

Nippon Kagaku Kaishi published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramchandani, Shanaya; Mohan, Chakrabhavi Dhananjaya; Mistry, Jenaifer Rustom; Su, Qi; Naz, Irum; Rangappa, Kanchugarakoppal S.; Ahn, Kwang Seok published the artcile< The multifaceted antineoplastic role of pyrimethamine against human malignancies>, SDS of cas: 112-63-0, the main research area is review cancer chronic lymphocytic leukemia pyrimethamine anticancer drug; MAPK; STAT3; apoptosis; cancer; drug repurposing; pyrimethamine.

A review. Cancer accounted for nearly 10 million deaths in 2020 and is the second leading cause of death worldwide. The chemotherapeutic agents that are in clin. practice possess a broad range of severe adverse effects towards vital organs which emphasizes the importance of the discovery of new therapeutic agents or repurposing of existing drugs for the treatment of human cancers. Pyrimethamine is an antiparasitic drug used for the treatment of malaria and toxoplasmosis with a well-documented excellent safety profile. In the last 5 years, numerous efforts have been made to explore the anticancer potential of pyrimethamine in in vitro and in vivo preclin. models and to repurpose it as an anticancer agent. The studies have demonstrated that pyrimethamine inhibits oncogenic proteins such as STAT3, NF-κB, DX2, MAPK, DHFR, thymidine phosphorylase, telomerase, and many more in a different types of cancer models. Moreover, pyrimethamine has been reported to work in synergy with other anticancer agents, such as temozolomide, to induce apoptosis of tumor cells. Recently, the results of phase-1/2 clin. trials demonstrated that pyrimethamine administration reduces the expression of STAT3 signature genes in tumor tissues of chronic lymphocytic leukemia patients with a good therapeutic response. In the present article, we have reviewed most of the published articles related to the antitumor effects of pyrimethamine in malignancies of breast, liver, lung, skin, ovary, prostate, pituitary, and leukemia in in vitro and in vivo settings. We have also discussed the pharmacokinetic profile and results of clin. trials obtained after pyrimethamine treatment. From these studies, we believe that pyrimethamine has the potential to be repurposed as an anticancer drug.

IUBMB Life published new progress about Animal gene, DHFR Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics