Category: 112-63-0

Zhang, Zhen-Hua; Wang, Xing; Wang, Xiao-Jun; Li, Yuesheng; Hong, Miao published the artcile< Tris(2,4-difluorophenyl)borane/Triisobutylphosphine Lewis Pair: A Thermostable and Air/Moisture-Tolerant Organic Catalyst for the Living Polymerization of Acrylates>, HPLC of Formula: 112-63-0, the main research area is difluorophenylborane triisobutylphosphine Lewis pair thermostable catalyst living polymerization acrylate.

Lewis pair polymerization (LPP) has emerged as a powerful tool for the efficient polymerization of polar vinyl monomers. However, air/moisture, highly sensitive metal-based catalysts, and low reaction temperatures are necessary for achieving highly active LPP with a high degree of control. In this contribution, we report the development of a robust Lewis pair (LP) organic catalyst based on tris(2,4-difluorophenyl)borane and triisobutylphosphine, which not only renders efficient and living LPP of acrylates for the first time at ambient or even industrially relevant temperature (60-80°C) but also allows the polymerization under an open-air condition. Accordingly, well-defined multiblock acrylic copolymers have been synthesized successfully over a broad reaction temperature range. Good thermal stability, appreciable air/moisture tolerance, high efficiency, and precise controllability of this LP organic catalyst thus establish LPP as a truly green/sustainable and practical polymerization methodol.

Macromolecules (Washington, DC, United States) published new progress about Chain extension polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vinogradova, Ekaterina V.; Mueller, Peter; Buchwald, Stephen L. published the artcile< Structural Reevaluation of the Electrophilic Hypervalent Iodine Reagent for Trifluoromethylthiolation Supported by the Crystalline Sponge Method for X-ray Analysis>, SDS of cas: 112-63-0, the main research area is structural reevaluation electrophilic hypervalent iodine reagent trifluoromethylthiolation; crystalline sponge X ray analysis.

Hypervalent iodine λ3-benziodoxoles are common electrophilic transfer reagents known for their enhanced stability compared to their non-cyclic analogs. Herein we present data showing that chlorobenziodoxole reacts with two different thiolate nucleophiles (thiocyanate and trifluoromethylthiolate), resulting in the formation of stable thioperoxy complexes rather than the expected benziodoxole derivatives We further report a revised structure for the earlier described electrophilic trifluoromethylthiolation reagent (1), which was previously believed to contain the benziodoxole framework. Our findings, which are based on a combination of anal. techniques, including the recently introduced crystalline sponge method for X-ray anal., unambiguously demonstrate that 1 is a thioperoxy compound both in solution and the solid state.

Angewandte Chemie, International Edition published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Poulsen, Thomas B.; Alemparte, Carlos; Saaby, Steen; Bella, Marco; Jorgensen, Karl Anker published the artcile< Direct organocatalytic and highly enantio- and diastereoselective Mannich reactions of α-substituted α-cyanoacetates>, Synthetic Route of 112-63-0, the main research area is Mannich stereoselective cyanoacetate imino ester quinidine catalyst.

Highly functionalized mols. with two contiguous stereocenters are easily accessed in high yield with high enantio- and diastereoselectivity by using the com. available organocatalyst (DHQD)2PYR. The easily removed Boc protecting group in the product is an added value to this method as an important tool in asym. synthesis.

Angewandte Chemie, International Edition published new progress about Mannich reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Choi, Chulho; Tian, Shi-Kai; Deng, Li published the artcile< A formal catalytic asymmetric synthesis of (+)-biotin with modified cinchona alkaloids>, SDS of cas: 112-63-0, the main research area is biotin formal catalytic asym synthesis desymmetrization meso cyclic anhydride; vitamin B7 formal catalytic asym synthesis; cinchona alkaloid catalyst desymmetrization meso cyclic anhydride solvolysis; chemoselective reduction hemiester biotin formal catalytic asym synthesis; lactone preparation hemiester chemoselective reduction cyclization.

A formal catalytic asym. synthesis of (+)-biotin (I) was realized. The key steps involve a catalytic, highly enantioselective and quant. desymmetrization of a meso cyclic anhydride followed by a one-pot chemoselective reduction to form the optically active lactone intermediate in the Goldberg-Sternbach (+)-biotin synthesis.

Synthesis published new progress about Lactones Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mohammed, Eman H. M.; Mandal, Dindyal; Mozaffari, Saghar; Abdel-Hamied Zahran, Magdy; Osman, Amany Mostafa; Tiwari, Rakesh Kumar; Parang, Keykavous published the artcile< Comparative molecular transporter properties of cyclic peptides containing tryptophan and arginine residues formed through disulfide cyclization>, SDS of cas: 112-63-0, the main research area is lamivudine disulfide peptide arginine HIV infection breast gastric cancer; cancer; cell-penetrating peptide; cellular uptake; cytotoxicity; disulfide bridge; drug delivery; phosphopeptide.

We have previously reported cyclic cell-penetrating peptides [WR]5 and [WR]4 as mol. transporters. To optimize further the utility of our developed peptides for targeted therapy in cancer cells using the redox condition, we designed a new generation of peptides and evaluated their cytotoxicity as well as uptake behavior against different cancer cell lines. Thus, cyclic [C(WR)xC] and linear counterparts (C(WR)xC), where x = 4-5, were synthesized using Fmoc/tBu solid-phase peptide synthesis, purified, and characterized. The compounds did not show any significant cytotoxicity (at 25 μM) against ovarian (SK-OV-3), leukemia (CCRF-CEM), gastric adenocarcinoma (CRL-1739), breast carcinoma (MDA-MB-231), and normal kidney (LLCPK) cells after 24 and 72 h incubation. Both cyclic [C(WR)5C] and linear (C(WR)5C) demonstrated comparable mol. transporter properties vs. [WR]5 in the delivery of a phosphopeptide (F′-GpYEEI) in CCRF-CEM cells. The uptake of F′-GpYEEI in the presence of 1,4-dithiothreitol (DTT) as the reducing agent was significantly improved in case of l(C(WR)5C), while it was not changed by [C(WR)5C]. Fluorescence microscopy also demonstrated a significant uptake of F′-GpYEEI in the presence of l(C(WR)5C). Cyclic [C(WR)5C] improved the uptake of the fluorescent-labeled anti-HIV drugs F′-d4T, F′-3TC, and F′-FTC by 3.0-4.9-fold. These data indicate that both [C(WR)5C] and linear (C(WR)5C) peptides can act as mol. transporters.

Molecules published new progress about Cell proliferation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bagriantsev, Sviatoslav N.; Ang, Kean-Hooi; Gallardo-Godoy, Alejandra; Clark, Kimberly A.; Arkin, Michelle R.; Renslo, Adam R.; Minor, Daniel L. published the artcile< A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels>, Category: esters-buliding-blocks, the main research area is screening small mol temperature K2P potassium channel yeast.

K2P (KCNK) potassium channels generate “”leak”” potassium currents that strongly influence cellular excitability and contribute to pain, somatosensation, anesthesia, and mood. Despite their physiol. importance, K2Ps lack specific pharmacol. Addressing this issue has been complicated by the challenges that the leak nature of K2P currents poses for electrophysiol.-based high-throughput screening strategies. Here, we present a yeast-based high-throughput screening assay that avoids this problem. Using a simple growth-based functional readout, we screened a library of 106,281 small mols. and identified two new inhibitors and three new activators of the mammalian K2P channel K2P2.1 (KCNK2, TREK-1). By combining biophys., structure-activity, and mechanistic anal., we developed a dihydroacridine analog, ML67-33, that acts as a low micromolar, selective activator of temperature- and mechano-sensitive K2P channels. Biophys. studies show that ML67-33 reversibly increases channel currents by activating the extracellular selectivity filter-based C-type gate that forms the core gating apparatus on which a variety of diverse modulatory inputs converge. The new K2P modulators presented here, together with the yeast-based assay, should enable both mechanistic and physiol. studies of K2P activity and facilitate the discovery and development of other K2P small mol. modulators.

ACS Chemical Biology published new progress about Biological ion transport, potassium. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enuh, Blaise Manga; Aytar Celik, Pinar published the artcile< Insight into the biotechnology potential of Alicyclobacillus tolerans from whole genome sequence analysis and genome-scale metabolic network modeling.>, HPLC of Formula: 112-63-0, the main research area is Alicyclobacillus carbohydrates bioinformatics biotechnol network modeling; Acidophiles; Alicyclobacillus tolerans; Extreme environment; Genome-scale metabolic network model; Iron oxidation; Whole-genome sequence.

Extremophilic bacteria have numerous uncovered biotechnol. potentials. Acidophilic bacteria are important iron oxidizers that are valuable in bioleaching and in studying extreme environments on earth and in space. Despite their obvious potential, little is known about the genetic traits that underpin their metabolic functions, which are equally poorly understood from a mechanistic perspective. Novel bioinformatics and computational biol. pipelines can be used to analyze whole genomes to obtain insights into the phenotypic potential of organisms as well as develop a math. model representation of metabolism Whole-genome sequence anal. and a genome-scale metabolic network model was curated for an iron-oxidizing bacterium initially isolated from an acid mine drainage in Turkey, previously identified as Alicyclobacillus tolerans. The genome contained a high proportion of genes for energy generation from carbohydrates, amino acids synthesis and conversion, nucleic acid metabolism and repair which contribute to robust adaptation to their extreme environments. Several candidate genes for pyrite metabolism, iron uptake, regulation and storage, as well as genes for resistance to important heavy metals were annotated. A curated genome-scale metabolic network anal. accurately predicted facultative anaerobic growth, heterotrophic characteristics, and growth on a wide variety of carbon sources. This is the first in-depth in silico anal. of A. tolerans to the best of our knowledge which is expected to lay the groundwork for future research and drive innovations in environmental microbiol. and biotechnol. applications. The genomic data and mechanistic framework will have applications in biomining, synthetic geomicrobiol. on earth, as well as for space exploration and settlement.

Journal of Microbiological Methods published new progress about Alicyclobacillus tolerans. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Isaacs-Ten, Anna; Moreno-Gonzalez, Mar; Bone, Caitlin; Martens, Andre; Bernuzzi, Federico; Ludwig, Tobias; Hellmich, Charlotte; Hiller, Karsten; Rushworth, Stuart A.; Beraza, Naiara published the artcile< Metabolic Regulation of Macrophages by SIRT1 Determines Activation During Cholestatic Liver Disease in Mice>, COA of Formula: C19H34O2, the main research area is cholestatic liver disease autophagy SIRT1 macrophage metabolic regulation; Cholestasis; Inflammasome; Macrophages; Metabolism; SIRT1.

Inflammation is the hallmark of chronic liver disease. Metabolism is a key determinant to regulate the activation of immune cells. Here, we define the role of sirtuin 1 (SIRT1), a main metabolic regulator, in controlling the activation of macrophages during cholestatic liver disease and in response to endotoxin. We have used mice overexpressing SIRT1, which we treated with i.p. lipopolysaccharides or induced cholestasis by bile duct ligation. Bone marrow-derived macrophages were used for mechanistic in vitro studies. Finally, PEPC-Boy mice were used for adoptive transfer experiments to elucidate the impact of SIRT1-overexpressing macrophages in contributing to cholestatic liver disease. We found that SIRT1 overexpression promotes increased liver inflammation and liver injury after lipopolysaccharide/GalN and bile duct ligation; this was associated with an increased activation of the inflammasome in macrophages. Mechanistically, SIRT1 overexpression associated with the activation of the mammalian target of rapamycin (mTOR) pathway that led to increased activation of macrophages, which showed metabolic rewiring with increased glycolysis and broken tricarboxylic acid cycle in response to endotoxin in vitro. Activation of the SIRT1/mTOR axis in macrophages associated with the activation of the inflammasome and the attenuation of autophagy. Ultimately, in an in vivo model of cholestatic disease, the transplantation of SIRT1-overexpressing myeloid cells contributed to liver injury and fibrosis. Our study provides novel mechanistic insights into the regulation of macrophages during cholestatic disease and the response to endotoxin, in which the SIRT1/mTOR crosstalk regulates macrophage activation controlling the inflammasome, autophagy and metabolic rewiring.

Cellular and Molecular Gastroenterology and Hepatology published new progress about Adhesion G protein-coupled receptor E1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Jeongmin; Savoie, Brett M.; Miller, Thomas F. III published the artcile< Interfacial Electron Transfer and Ion Solvation in the Solid Electrolyte Interphase>, Electric Literature of 112-63-0, the main research area is interfacial electron transfer ion solvation battery solid electrolyte interphase; atomic resolution simulation solid polymer liquid electrolyte solvation.

As a chem. and structurally well-defined model for redox processes in the solid electrolyte interphase of battery electrodes, we investigate electron transfer (ET) to lithium ions at the interface between a platinum metal anode and a solid polymer electrolyte. Studied electrolytes include LiTFSI (lithium bis(trifluoromethane)sulfonimide) salts in polyethylene oxide and poly(diethylene oxide-alt-oxymethylene), as well as in the associated liquid electrolytes 1,2-dimethoxyethane and tetraglyme. Atomic-resolution simulations are performed with constant-potential polarizable electrodes to characterize interfacial ET kinetics, including lithium-ion solvation structures and solvent reorganization effects as a function of applied electrode potential. The linear-response assumptions of the Marcus theory for ET are found to be robust in these systems, yet ion-solvation behavior at the anode interface is strikingly dependent on chain connectivity, solvation environment, and the magnitude of the applied electrode potential, resulting in very different ET kinetics for lithium electroreduction

Journal of Physical Chemistry C published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Khan, N. M.; Mazuki, N. F.; Samsudin, A. S. published the artcile< Contribution of Li+ Ions to a Gel Polymer Electrolyte Based on Polymethyl Methacrylate and Polylactic Acid Doped with Lithium Bis(oxalato) Borate>, COA of Formula: C19H34O2, the main research area is polymethyl methacrylate polylactic acid lithium bisoxalato borate doping electrolyte.

In this work, gel polymer electrolyte systems based on a polymethyl methacrylate (PMMA) and polylactic acid (PLA) blend that was doped with various compositions of lithium bis(oxalato) borate (LiBOB) were successfully prepared Several characterizations, which included Fourier transform IR (FTIR) spectroscopy, X-ray diffraction (XRD), and elec. impedance spectroscopy, were carried out to determine their structural and ionic conduction properties. FTIR anal. revealed that mol. interactions had occurred via Li+ ions in several regions, representing the functional groups of C-O, C=O and C-H stretching of the PMMA-PLA. Moreover, an increase in the amorphous phase upon the incorporation of LiBOB was revealed through XRD anal. A sample containing 20 weight% of LiBOB (PPLi20) was found to be the most amorphous sample in this study. This result is in alignment with the ionic conduction properties, showing an increase of ionic conductivity up to the PPLi20 sample, which exhibited the highest ionic conductivity with a value of 1.37 x 10-3 S cm-1. The contribution of Li+ ions towards the enhancement of ionic conductivity was determined through the transport parameter anal. It was proven that upon the addition of LiBOB, the value of η, μ, and D increased, which signified the high dissociation of ions. Beyond 20 weight%, the transport parameters decreased due to the overcrowding of ions.

Journal of Electronic Materials published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics