Category: 112-63-0

Li, Sha; Xu, Jiayu; Luo, Xian; Yang, Wenhan; Yao, Changsheng published the artcile< Efficient N-heterocyclic carbene-catalyzed cascade synthesis of functionalized naphthopyranone>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is heterocyclic carbene catalyst naphthopyranone cascade reaction preparation.

An efficient N-heterocyclic carbene(NHC)-catalyzed “”Michael-Michael-Lactonization”” cascade process involving chalcone derivatives and α-bromoenals for the syntheses of functionalized naphthopyranones was disclosed. This approach was qualified with good yields, readily available starting materials and mild reaction conditions.

Youji Huaxue published new progress about Lactonization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Haoyang; Jin, Kangyu; Jiang, Chaonan; Pan, Fen; Wu, Jing; Luan, Honglin; Zhao, Zhiyong; Chen, Jingkai; Mou, Tingting; Wang, Zheng; Lu, Jing; Lu, Shaojia; Hu, Shaohua; Xu, Yi; Huang, Manli published the artcile< A pilot exploration of multi-omics research of gut microbiome in major depressive disorders>, Reference of 112-63-0, the main research area is major depressive disorder gut microbiome metabolism immunity brain.

The pathophysiol. of major depressive disorder (MDD) remains obscure. Recently, the microbiota-gut-brain (MGB) axiss role in MDD has an increasing attention. However, the specific mechanism of the multi-level effects of gut microbiota on host metabolism, immunity, and brain structure is unclear. Multi-omics approaches based on the anal. of different body fluids and tissues using a variety of anal. platforms have the potential to provide a deeper understanding of MGB axis disorders. Therefore, the data of metagenomics, metabolomic, inflammatory factors, and MRI scanning are collected from the two groups including 24 drug-naive MDD patients and 26 healthy controls (HCs). Then, the correlation anal. is performed in all omics. The results confirmed that there are many markedly altered differences, such as elevated Actinobacteria abundance, plasma IL-1β concentration, lipid, vitamin, and carbohydrate metabolism disorder, and diminished gray matter volume (GMV) of inferior frontal gyrus (IFG) in the MDD patients. Notably, three kinds of discriminative bacteria, Ruminococcus bromii, Lactococcus chungangensis, and Streptococcus gallolyticus have an extensive correlation with metabolome, immunol., GMV, and clin. symptoms. All three microbiota are closely related to IL-1β and lipids (as an example, phosphoethanolamine (PEA)). Besides, Lactococcus chungangensis is neg. related to the GMV of left IFG. Overall, this study demonstrate that the effects of gut microbiome exert in MDD is multifactorial.

Translational Psychiatry published new progress about Acrobacter (lekithochrous). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chenna, Bala C.; Li, Linfeng; Mellott, Drake M.; Zhai, Xiang; Siqueira-Neto, Jair L.; Calvet Alvarez, Claudia; Bernatchez, Jean A.; Desormeaux, Emily; Alvarez Hernandez, Elizabeth; Gomez, Jana; McKerrow, James H.; Cruz-Reyes, Jorge; Meek, Thomas D. published the artcile< Peptidomimetic vinyl heterocyclic inhibitors of cruzain effect antitrypanosomal activity>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is peptidomimetic vinyl heterocyclic inhibitor cruzain preparation antitrypanosomal structure activity; PVHI cruzain substrate dipeptide enzyme kinetic mol docking; drug design computer assisted; Wittig reaction Horner Wadsworth Emmons amino acid peptide coupling.

Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaffold appended to vinyl heterocycles meant to provide replacements for the irreversible reactive “”warheads”” of vinyl sulfone inactivators of cruzain. Peptidomimetic vinyl heterocyclic inhibitors (PVHIs) containing Cbz-Phe-Phe/homoPhe scaffolds with vinyl-2-pyrimidine, vinyl-2-pyridine, and vinyl-2-(N-methyl)-pyridine groups conferred reversible, time-dependent inhibition of cruzain (Ki* = 0.1-0.4μM). These cruzain inhibitors exhibited moderate to excellent selectivity vs. human cathepsins B, L, and S and showed no apparent toxicity to human cells but were effective in cell cultures of Trypanosoma brucei brucei (EC50 = 1-15μM) and eliminated T. cruzi in infected murine cardiomyoblasts (EC50 = 5-8μM). PVHIs represent a new class of cruzain inhibitors that could progress to viable candidate compounds to treat Chagas disease and human sleeping sickness.

Journal of Medicinal Chemistry published new progress about Chagas disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Derfuss, Tobias; Mehling, Matthias; Papadopoulou, Athina; Bar-Or, Amit; Cohen, Jeffrey A.; Kappos, Ludwig published the artcile< Advances in oral immunomodulating therapies in relapsing multiple sclerosis>, SDS of cas: 112-63-0, the main research area is review multiple sclerosis oral immunomodulating therapy.

A review. Although these immunomodulating therapies are all orally administered, and thus convenient for patients, they have different modes of action. These distinct mechanisms of action allow better adaptation of treatments according to individual comorbidities and offer different mechanisms of treatment such as inhibition of immune cell trafficking vs. immune cell depletion, thereby substantially expanding the available treatment options. Evobrutinib reduced MRI activity in a phase 2 trial, and a phase 3 trial is underway, in patients with relapsing multiple sclerosis. Diroximel fumarate is metabolised to monomethyl fumarate, the active metabolite of di-Me fumarate, reduces circulating lymphocytes and modifies the activation profile of monocytes, and is being tested in this disease with the aim to improve gastrointestinal tolerability. With new modes of action introduced to the treatment of multiple sclerosis, the question of how to select and sequence different treatments in individual patients arises. Balancing risks with the expected efficacy of disease-modifying therapies will still be key for treatment selection. This treatment scheme might lead to higher efficacy but also to new safety concerns. These sequential treatments were largely excluded in phase 2 and 3 trials; therefore, monitoring both short-term and long-term effects of sequential disease-modifying therapies in phase 4 studies, cohort studies, and registries will be necessary.

Lancet Neurology published new progress about Brain. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Min-Chen; Furukawa, Fumiya; Wang, Ching-Wei; Peng, Hui-Wen; Lin, Ching-Chun; Lin, Tzu-Hao; Tseng, Yung-Che published the artcile< Multigenerational inspections of environmental thermal perturbations promote metabolic trade-offs in developmental stages of tropical fish>, Related Products of 112-63-0, the main research area is Tilapia development citrate metabolite global warming environmental thermal perturbation; Dynamic visualization; Energy trade-off; Hypothermic experience; Multigeneration; Transgenerational plasticity.

Global warming both reduces global temperature variance and increases the frequency of extreme weather events. In response to these ambient perturbations, animals may be subject to trans- or intra-generational phenotype modifications that help to maintain homeostasis and fitness. Here, we show how temperature-associated transgenerational plasticity in tilapia affects metabolic trade-offs during developmental stages under a global warming scenario. Tropical tilapia reared at a stable temperature of 27°C for a decade were divided into two temperature-experience groups for four generations of breeding. Each generation of one group was exposed to a single 15°C cold-shock experience during its lifetime (cold-experienced CE group), and the other group was kept stably at 27°C throughout their lifetimes (cold-naive CN group). The offspring at early life stages from the CE and CN tilapia were then assessed by metabolomics-based profiling, and the results implied that parental cold-experience might affect energy provision during reproduction Furthermore, at early life stages, progeny may be endowed with metabolic traits that help the animals cope with ambient temperature perturbations. This study also applied the feature rescaling and Uniform Manifold Approximation and Projection (UMAP) to visualize metabolic dynamics, and the result could effectively decompose the complex omic-based datasets to represent the energy trade-off variability. For example, the carbohydrate to free amino acid conversion and enhanced compensatory features appeared to be hypothermic-responsive traits. These multigenerational metabolic effects suggest that the tropical ectothermic tilapia may exhibit transgenerational phenotype plasticity, which could optimize energy allocation under ambient temperature challenges. Knowledge about such metabolism-related transgenerational plasticity effects in ectothermic aquatic species may allow us to better predict how adaptive mechanisms will affect fish populations in a climate with narrow temperature variation and frequent extreme weather events.

Environmental Pollution (Oxford, United Kingdom) published new progress about Appetite. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tanaka, Kuniyoshi; Sugawa, Toshio; Nakamori, Ritsuo; Sanno, Yasushi; Ando, Yasuo; Imai, Kinichi published the artcile< Nucleic acid antagonists. VI. Synthesis of 1,4,6-triazaindenes (5H-pyrrolo[3,2-d]pyrimidines)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ANTIMETABOLITES; CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; HETEROCYCLIC COMPOUNDS; NUCLEIC ACIDS; PYRIMIDINES; PYRROLES.

Derivatives of 1,4,6-triazaindene, an isostere of purine and indole, were prepared by 2 methods. MeC(:NH)NH2.HCl (11.8 g.) treated with 4.2 g. Na in 85 cc. EtOH and the mixture filtered, treated with 23 g. AcCH(NHAc)CO2Et (I), and heated 4 hrs. on the water bath gave 13.5 g. 2,6-dimethyl-4-hydroxy-5-acetamidopyrimidine (II), m. 275-7° (EtOH). H2NC(:NH)NH2.H2CO3 (4.5 g.) and 1.15 g. Na in 20 cc. EtOH heated 0.5 hr., filtered, treated with 9.35 g. I in 20 cc. EtOH, and heated 8 hrs. on the water bath yielded 3.4 g. 2-NH2 analog of II, m. 295-8° (decomposition). H2NCSNH2 (720 mg.) and 0.5 cc. H2O treated with stirring with 700 mg. Me2SO4 and then with 500 mg. NaOH in 1 cc. H2O and 1.87 g. I and the mixture kept overnight and heated 1 hr. on the water bath gave 700 mg. 2-MeS analog of II, m. 248-52° (EtOH and H2O). II (5 g.) added to 1.9 g. Na in 40 cc. EtOH, the EtOH removed under N, and the residue heated 20 min. under N at 320-5° yielded 2.4 g. 5-Me derivative of III, needles, m. 336° (decomposition). 4-Hydroxy-5-acetamido-6-methylpyrimidine (5 g.) and 2.2 g. Na gave similarly 1.5 g. III, m. above 360°. 5-Benzamido-4-hydroxy-2,6-dimethylpyrimidine (IV) (3.4 g.) and 1.1 g. Na gave similarly during 15 min. at 310° 1.8 g. 2-phenyl-5-methyl-7-oxo-6,7-dihydro-1,4,6-triazaindene, crystal powder, m. 325° (decomposition) (EtOH); also obtained in 60% yield when using iso-PrOH instead of EtOH. 2,4-Diethoxy-6-methyl-5-nitropyrimidine (V) (9.1 g.), 6 g. (CO2Et)2, and 1 g. Na in 20 cc. EtOH heated 1 hr. on the water bath yielded 14 g. yellow precipitate, m. 305° (decomposition); a 13-g. portion, 50 cc. Me2CO, 10 cc. HCl, and 20 cc. H2O refluxed 0.5 hr. gave 1 g. 6-EtO2CCO derivative (VI) of V, m. 115° (decomposition). 2,4-Diallyloxy analog (10 g.) of V and 20 cc. (CO2Et)2 added in a small amount of CH2:CHCH2OH with cooling to 3.2 g. Na in 80 cc. CH2:CHCH2OH and kept at room temperature overnight, and the product dissolved in Me2CO and heated with 10% HCl yielded 12 g. 2,4-diallyloxy analog (VII) of VI, yellow, m. 45° (aqueous EtOH). (CO2Et)2 (5 cc.) and 2 g. 4-amino-2-ethoxy-6-methyl-5-nitropyrimidine in 100 cc. EtOH added to 800 mg. Na in 30 cc. EtOH and heated 3 hrs. on the water bath gave 2.5 g. 4-NH2 analog of VI, yellow, m. 220° (EtOH). VI (10 g.) in 100 cc. AcOEt hydrogenated over Pd-C gave 8 g. 2-carbethoxy-5,7-diethoxy-1,4,6-triazaindene (VIII), m. 141° (Me2CO). VII (3.5 g.) in 35 cc. AcOH treated at 70-80° with 7 g. Zn dust in small portions during 2 hrs., and the oily product (3.1 g.) treated with picric acid yielded the picrate of the 5,7-diallyloxy analog of VIII, yellow, m. 144° (aqueous EtOH). VII (4 g.) in 200 cc. EtOH hydrogenated over Pd-C, and the product heated 6 hrs. with HCl gave 5,7-dioxo-4,5,6,7-tetrahydro-1,4,6-triazaindene-2-carboxylic acid, m. above 360° (H2O). 4-NH2 analog (2 g.) of VI in 300 cc. EtOH hydrogenated over Pd-C gave the 7-NH2 analog of VIII, needles, m. 232° (EtOH).

Chemical & Pharmaceutical Bulletin published new progress about Nucleic acids Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kucuk, Asuman Celik; Yamanaka, Toshiro; Yokoyama, Yuko; Abe, Takeshi published the artcile< Low-cost fluoride source for organic liquid electrolyte-based fluoride shuttle battery>, Category: esters-buliding-blocks, the main research area is fluoride shuttle battery organic liquid electrolyte defluorination.

The effects of using low-cost inorganic fluoride salts (i.e., KF or NaF) as fluoride sources in fluoride shuttle batteries (FSBs) on the electrochem. compatibility of BiF3 electrodes are investigated herein. The preparation of electrolytes containing saturated KF or NaF and 0.5 M 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (DiOB-Py) in G4 is described. For Py/NaF/G4, the discharge and charge reactions of BiF3 were hindered because of the low solubility of NaF as well as the low ionic conductivity of the electrolyte. However, inductively coupled plasma mass spectrometry (ICP-MS) anal. revealed that the solubility of KF in Py/KF/G4 was moderate and the ionic conductivity of Py/KF/G4 was promising. Higher oxidation and reduction peaks observed in the cyclic voltammograms of Py/KF/G4 than those of Py/G4 and Py/NaF/G4 are attributed to the enhanced electrochem. activity of the former. Consequently, the BiF3/C nanocomposite electrode exhibits good cycling capability in Py/KF/G4, with initial discharge/charge capacities of 316/218 mAh g-1, resp. Moreover, the ICP-MS and Raman spectroscopy analyses revealed that defluorination reactions of BiF3 occur via a direct desorption mechanism. Py/KF/G4 is the first effective electrolyte based on a low-cost inorganic salt. FSBs exhibit improved performance in Py/KF/G4 compared with CsF salt systems, which warrants further investigation.

Journal of the Electrochemical Society published new progress about Ball milling. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Syahir, A. Z.; Zulkifli, N. W. M.; Masjuki, H. H.; Kalam, M. A.; Harith, M. H.; Yusoff, M. N. A. M.; Zulfattah, Z. M.; Jamshaid, M. published the artcile< Tribological Improvement Using Ionic Liquids as Additives in Synthetic and Bio-Based Lubricants for Steel-Steel Contacts>, HPLC of Formula: 112-63-0, the main research area is ionic liquid additive synthetic lubricant steel contact tribol.

This study investigates the performance of three ionic liquids (ILs), trihexyl(tetradecyl)phosphonium bis(2,4,4-trimethylpentyl)phosphinate, trihexyl(tetradecyl)phosphonium decanoate, and 1-butyl-3-methylimidazolium tetrafluoroborate, as lubricant additives in synthetic oil polyalphaolefin (PAO8) and bio-based oil trimethylolpropane trioleate (TMPTO). The ILs were added at 0.5, 1.0, and 1.5 wt% concentrations and evaluated in terms of their miscibility with base oils as well as friction- and wear-reducing abilities. Four-ball and high-frequency reciprocating rig (HFRR) tribotesters were employed to evaluate the tribol. performance under a boundary lubrication regime. Worn steel surfaces were characterized using optical microscopy, profilometry, SEM (SEM), and energy-dispersive X-ray (EDX) anal. The results suggested that the addition of trihexyl(tetradecyl)phosphonium bis(2,4,4-trimethylpentyl)phosphinate and trihexyl(tetradecyl)phosphonium decanoate improved the tribol. performance of both PAO8 and TMPTO at an optimum concentration of 1 wt%. They showed good friction reduction, lower overall surface wear, and improved surface finishing. 1-Butyl-3-methylimidazolium tetrafluoroborate managed to improve the tribol. performance of both base oils only at 0.5 wt%. A further increase in 1-butyl-3-methylimidazolium tetrafluoroborate concentration caused detrimental effects on the steel surface due to the formation of halogenic compounds

Tribology Transactions published new progress about Abrasive wear. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yuning; Mesa-Antunez, Pablo; Fortuin, Lisa; Andren, Oliver C. J.; Malkoch, Michael published the artcile< Degradable High Molecular Weight Monodisperse Dendritic Poly(ethylene glycols)>, Electric Literature of 112-63-0, the main research area is PEG dendrimer.

Poly(ethylene glycols) (PEGs) are extensively explored by the pharma industry as foundations for new therapeutic products. PEGs are typically used for their conjugation to active drugs, peptides, and proteins and the likeliness to increase the half-life and enhance the therapeutic outcome. Considering the necessity of batch-to-batch consistency for clin. products, monodisperse PEGs are highly attractive but are generally limited to 5 kDa as an upper mol. weight (Mw) and with an oligomer purity of 95%. By amalgamating short, monodisperse PEGs with dendritic frameworks based on 2,2-bis(methylol)propionic acid polyesters, we showcase a robust synthetic approach to monodisperse PEGs with Mw ranging from 2 to 65 kDa. The latter is, to our knowledge, the highest Mw structure of its kind ever reported. Importantly, the dendritic multifunctional connector facilitated degradability at pH 7.4 at 37°C, which is an important feature for the delivery of therapeutic agents.

Biomacromolecules published new progress about Biocompatibility. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cao, Wei; Shen, Delong published the artcile< Synthesis of Diclazuril>, Formula: C19H34O2, the main research area is diclazuril synthesis dichloronitroaniline anticoccidial drug.

Diclazuril was synthesized from 2,6-dichloro-p-nitroaniline through seven steps reaction. The yield of diclazuril was about 20%, and its m.p. was 291°. Based on the investigation of laboratory synthesis, the industrial investigation was completed.

Jingxi Huagong Zhongjianti published new progress about Coccidiostats. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics