Category: 112-63-0

Rachwalak, Marta; Rozniewska, Malgorzata; Golebiewska, Justyna; Jakubowski, Tomasz; Sobkowski, Michal; Romanowska, Joanna published the artcile< A practical synthesis of nucleoside 5'-diphosphates from nucleoside 5'-H-phosphonate monoesters>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is nucleotide nucleoside phosphate phosphonate synthesis pyridinium oxidation deoxyribonucleoside.

A simple and convenient synthetic protocols based on H-phosphonate chem. have been developed for the preparation of nucleoside 5′-diphosphates. It consists of oxidation of the silylated H-phosphonate monoesters in pyridine with iodine to produce the corresponding N-pyridinium phosphonate intermediates, followed by their reactions with orthophosphoric acid used as a nucleophile. The added value of the method is that substrates for the reaction, H-phosphonate monoesters, can be prepared in situ from the corresponding nucleosides and used for the next step without isolation. The procedure is simple and applicable to the preparation of various diphosphates of ribo- and deoxyribonucleosides, and their analogs.

Synthetic Communications published new progress about Deoxyribonucleosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ding, Weijie; Sheng, Jie; Li, Jin; Cheng, Xu published the artcile< Electroreductive 4-pyridylation of unsaturated compounds using gaseous ammonia as a hydrogen source>, Formula: C19H34O2, the main research area is unsaturated compound cyanopyridine electrochem reductive pyridinylation; alkylpyridine preparation.

Electrochem. radical-cross-coupling with ammonia as a terminal reductant was reported in the reactions of α-Keto esters, β-keto esters, α,β-unsaturated esters, and α,β-unsaturated ketones with 4-CN pyridine. More than 50 corresponding pyridylation products were synthesized under constant current conditions using thiourea as an essential promoter to activate the intermediate derived from 4-CN pyridine.

Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Bin; Ge, Junyue; Liu, Wei; Hu, Dejun; Li, Ping published the artcile< Unveiling spatial metabolome of Paeonia suffruticosa and Paeonia lactiflora roots using MALDI MS imaging>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is metabolome Paeonia root MALDI mass spectrometry; Moutan Cortex; Paeoniae Radix Alba; mass spectrometry imaging; monoterpenes; spatial distribution; tannins.

Summary : Paeonia suffruticosa (PS) and Paeonia lactiflora (PL) belong to the only genus in the family Paeoniaceae. Comparative anal. of the spatial metabolomes of PS and PL has rarely been performed. In this work, combined with multiple matrixes and dual-polarity detection, high mass resolution matrix-assisted laser desorption/ionization MS imaging (MALDI MSI) and MALDI tandem MSI were performed on the root sections of the two Paeonia species. The spatial distributions of many metabolites including monoterpene and paeonol glycosides, tannins, flavonoids, saccharides and lipids were systematically characterized. The ambiguous tissue distribution of the two isomers paeoniflorin and albiflorin were distinguished by tandem MSI using lithium salt doped 2,5-dihydroxybenzoate matrix. In addition, the major intermediates involved in the biosynthetic pathway of gallotannins were successfully localized and visualized in the root sections. High-mass resolution MALDI full-scan MSI provides comprehensive and accurate spatial distribution of metabolites. The anal. power of the technique was further tested in the tandem MSI of two isomers. The ion images of individual metabolites provide chem. and microscopic characteristics beyond morphol. identification, and the detailed spatiochem. information could not only improve our understanding of the biosynthetic pathway of hydrolyzable tannins, but also ensure the safety and effectiveness of their medicinal use.

New Phytologist published new progress about Gallotannins Role: ANT (Analyte), BSU (Biological Study, Unclassified), PUR (Purification or Recovery), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Zhenfeng; Lu, Yu; Chen, Pingping; Zeng, Qinghui; Wen, Xin; Wen, Wen; Liu, Yu; Chen, Anqi; Li, Zengxi; Wang, Zhixiang; Zhang, Liaoyun published the artcile< Suppressing shuttle effect by large oxygen-containing crosslinked hyperbranched polyurethane as cathode encapsulated layer for high-performance lithium-sulfur batteries>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is polyurethane lithium sulfur cathode battery encapsulation.

Lithium-sulfur (Li-S) batteries have attracted a lot of attention because of their high energy d., low cost, and environmental friendliness. However, shuttle effect is one of the most obstacles to make the poor cycling performance and inhibit the development of Li-S batteries. Herein, a kind of large oxygen-containing polymer coated cathode, named polyurethane coated carbon-nanotube/sulfur composites (PU@S-CNT), is prepared from sulfur capsulated by the reaction of hyper branched polyether and diisocyanate via a simple “”one-pot”” strategy to impede the shuttle effect. This PU@S-CNT cathode can not only inhibit the dissolution of lithium polysulfides by phys. barrier, but also can absorb the lithium polysulfides by the chem. effect. Especially, the cell with PU@S-CNT electrode shows an excellent initial cycling capacity of 892 mAh g-1 at 2C and remarkable capacity retention (a low decay rate of 0.051% per cycle at 2C after 450 cycles). More importantly, this coated cathode (PU@S-CNT) demonstrates a good inhibition of shuttle effect, high transmission speed of lithium ion and good cycle reversibility. This work exhibits the cross-linked hyper branched polyurethane is used as coatings of the sulfur cathode for the first time, which can reveal a potential prospect of high-level heteroatom doped coated cathodes for high-performance lithium-sulfur batteries.

Electrochimica Acta published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yayik, Nihan; Perez, Maria; Molins, Elies; Bosch, Joan; Amat, Mercedes published the artcile< Studies on the enantioselective synthesis of E-ethylidene-bearing spiro[indolizidine-1,3'-oxindole] alkaloids>, Quality Control of 112-63-0, the main research area is ethylidene bearing spiro indolizidine oxindole alkaloid enantioselective preparation; alkaloids; ethylidene; oxindoles; spiro compounds.

A synthetic route for the enantioselective construction of the tetracyclic spiro[indolizidine-1,3′-oxindole] framework present in a large number of oxindole alkaloids, with a cis H-3/H-15 stereochem., a functionalized two-carbon substituent at C-15, and an E-ethylidene substituent at C-20, was reported. The key steps of the synthesis were the generation of the tetracyclic spirooxindole ring system by stereoselective spirocyclization from a tryptophanol-derived oxazolopiperidone lactam, the removal of the hydroxymethyl group, and the stereoselective introduction of the E-ethylidene substituent by acetylation at the α-position of the lactam carbonyl, followed by hydride reduction and elimination. Following this route, the 21-oxo derivative of the enantiomer of the alkaloid 7(S)-geissoschizol oxindole was prepared

Molecules published new progress about Diastereoselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saadatian, Mohammad; Mohammad, Rizgar Hassan; Jumaah, Amjad Ahmad; Oagaz, Jeger Ali published the artcile< Evaluation of nutritional value, fatty acids and polyphenols profiles of Pyrus amygdaliformis L. grown in north-east Kurdistan regional government, Iraq>, Related Products of 112-63-0, the main research area is Pyrus fatty acid polyphenol nutritional value Iraq; Pyrus; chlorogenic acid; natural resource; phenolic compounds; tricosanoic acid.

The present research evaluated some chem. composition in tissues from the leaves, seed, and fruits P. amygdaliformis. In leaf samples, phenolics compounds are predominated, whereas, in fruit samples, sugars, organic acid predominated. Among phenolic compounds, chlorogenic acid and fumaric acid were found in the highest amount in leaf tissue. In addition, the amounts of minerals in the fruit tissue had high values. In the P. amigdaliformis seed oil, oleic and linoleic acid were the primary fatty acids. This study shows that these wild pears have beneficial natural compounds and can also be used as a new source of natural oil.

Journal of Oleo Science published new progress about Edible oils Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Swiha, Mina M.; Sutherland, Duncan E. K.; Sistani, Golmehr; Khatami, Alireza; Abazid, Rami M.; Mujoomdar, Amol; Wiseman, Daniele P.; Romsa, Jonathan G.; Reid, Robert H.; Laidley, David T. published the artcile< Survival predictors of 177Lu-Dotatate peptide receptor radionuclide therapy (PRRT) in patients with progressive well-differentiated neuroendocrine tumors (NETS)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is peptide receptor radionuclide therapy progressive neuroendocrine tumor; Lu-Dotatate; Neuroendocrine; PRRT; Prognostic factors; Survival predictors.

177Lu-Dotatate is an emerging treatment modality for patients with unresectable or metastatic well-differentiated NETs. This study examines survival predictors in patients who received 177Lu-Dotatate. A retrospective single-center review was conducted, examining 47 individuals with progressive well-differentiated NETs treated with 177Lu-Dotatate (four induction cycles of 5.5 GBq at 10-wk intervals followed by eight maintenance cycles of 3.7 GBq at 6-mo intervals). Median follow-up was 63.1 mo with a median progression-free survival (PFS) of 34.1 mo. However, median overall survival (OS) was not reached at the time of anal. The presence of ≥ 5 bone metastases (hazard ratio HR 4.33; p = 0.015), non-gastroenteropancreatic (non-GEP) NETs (HR 3.22; p = 0.025) and development of interim ascites (HR 3.15; p = 0.047) independently predicted a worse OS. Patients with chromogranin A of 1774 × upper limit of normal (ULN) had shorter OS (p < 0.001) and PFS (p = 0.004). Similarly, those with pre-existing ascites demonstrated a worse OS (p = 0.009) and PFS (p = 0.026). Liver metastases involving greater than 50% liver volume and the existence of unusual metastatic locations had a neg. impact on OS (p = 0.033) and PFS (p = 0.026), resp. High burden of skeletal and hepatic metastases, non-GEP-NETs, chromogranin A of ≥ 4 × ULN, unusual metastatic sites, pre-existing and interim ascites are predictors of poor outcomes in patients treated with 177Lu-Dotatate. These common indicators can be used for the risk stratification and identification of patients most likely to benefit from PRRT. Journal of Cancer Research and Clinical Oncology published new progress about Alpers-Huttenlocher syndrome. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ozgiray, Erkin; Sogutlu, Fatma; Biray Avci, Cigir published the artcile< Chk1/2 inhibitor AZD7762 enhances the susceptibility of IDH-mutant brain cancer cells to temozolomide>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is AZD7762; DNA damage response; IDH-mutant glioma; Polploidy; Temozolomide.

Abstract: The IDH mutation initially exhibits chemosensitive properties, progression-free survival cannot be achieved in the later grades, and malignant transformation occurs as a result of TMZ-induced hypermutation profile and adaptation to this profile. In this study, we evaluated the potential of the combination of TMZ and AZD7762 at mol. level, to increase the anticancer activity of TMZ in IDH-mutant U87-mg cells. We used the WST-1 test to evaluate cytotoxic effect of TMZ and AZD7762 combination with dose-effect and isobologram curves. The effects of the inhibitory and effective concentrations of the combination on apoptosis, cell cycle and γ-H2AX phosphorylation were analyzed with flow cytometry. The expression of genes responsible for the DNA damage response was analyzed with qRT-PCR. The combination showed a synergistic effect with high dose reduction index. Single and combined administrations of TMZ and AZD7762 increased in G2/M arrest from 24 to 48 h, and cells in the G2/M phase shifted towards octaploidy at 72 h. While no double-strand breaks were detected after TMZ treatment, AZD7762 and combination treatments caused a significant increase in γ-H2AX phosphorylation and increased apoptotic stimulation towards 72 h although TMZ did not cause apoptotic effect in IDH-mutant U87-mg cells. The genes controlling the apoptosis were determined to be upregulated in all three groups, and genes regarding cell cycle checkpoints were downregulated. Targeting Chk1/2 with AZD7762 simultaneously with TMZ may be a potential therapeutic strategy for both increasing the sensitivity of IDH-mutant glioma cells to TMZ and reducing the dose of TMZ. Graphical abstract: In IDH-mutant glioma cells, AZD7762, the Chk1/2 inhibitor, can increase the efficacy of Temozolomide by (i) increasing mitotic chaos, and (ii) inhibiting double-strand break repair, (iii) thereby inducing cell death. [graphic not available: see fulltext]

Medical Oncology (New York, NY, United States) published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anilkumar, Parambath; Lawson, Taylor B.; Abbina, Srinivas; Makela, Janne T. A.; Sabatelle, Robert C.; Takeuchi, Lily E.; Snyder, Brian D.; Grinstaff, Mark W.; Kizhakkedathu, Jayachandran N. published the artcile< Mega macromolecules as single molecule lubricants for hard and soft surfaces>, Category: esters-buliding-blocks, the main research area is mega hyperbranched polyglycerol mol lubricant hard soft surface.

A longstanding goal in science and engineering is to mimic the size, structure, and functionality present in biol. with synthetic analogs. Today, synthetic globular polymers of several million mol. weight are unknown, and, yet, these structures are expected to exhibit unanticipated properties due to their size, compactness, and low inter-chain interactions. Here we report the gram-scale synthesis of dendritic polymers, mega hyperbranched polyglycerols (mega HPGs), in million daltons. The mega HPGs are highly water soluble, soft, nanometer-scale single polymer particles that exhibit low intrinsic viscosities. Further, the mega HPGs are lubricants acting as interposed single mol. ball bearings to reduce the coefficient of friction between both hard and soft natural surfaces in a size dependent manner. We attribute this result to their globular and single particle nature together with its exceptional hydration. Collectively, these results set the stage for new opportunities in the design, synthesis, and evaluation of mega polymers.

Nature Communications published new progress about Anionic ring-opening polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Press, Loren P.; Kosanovich, Alex J.; McCulloch, Billy J.; Ozerov, Oleg V. published the artcile< High-Turnover Aromatic C-H Borylation Catalyzed by POCOP-Type Pincer Complexes of Iridium>, HPLC of Formula: 112-63-0, the main research area is borylation arene pinacolate iridium pincer complex catalyst mechanism; crystal structure mol iridium pincer complex preparation borylation catalyst.

The catalytic C-H borylation of arenes with HBpin (pin = pinacolate) using POCOP-type pincer complexes of Ir has been demonstrated, with turnover numbers exceeding 10,000 in some cases. The selectivity of C-H activation was based on steric preferences and largely mirrored that found in other Ir borylation catalysts. Catalysis in the (POCOP)Ir system depends on the presence of stoichiometric quantities of sacrificial olefin, which is hydrogenated to consume the H2 equivalents generated in the borylation of C-H bonds with HBpin. Smaller olefins such as ethylene or 1-hexene were more advantageous to catalysis than sterically encumbered tert-butylethylene (TBE). Olefin hydroboration is a competing side reaction. The synthesis and isolation of multiple complexes potentially relevant to catalysis permitted examination of several key elementary reactions. These experiments indicate that the C-H activation step in catalysis ostensibly involves oxidative addition of an aromatic C-H bond to the three-coordinate (POCOP)Ir species. The olefin is mechanistically critical to gain access to this 14-electron, monovalent Ir intermediate. C-H activation at Ir(I) here is in contrast to the olefin-free catalysis with state-of-the-art Ir complexes supported by neutral bidentate ligands, where the C-H activating step is understood to involve trivalent Ir-boryl intermediates.

Journal of the American Chemical Society published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics