Category: 112-63-0

Xiang, Jing; Ma, Lin; Gu, Zheng; Jin, Hongjun; Zhai, Hongbin; Tong, Jianfei; Liang, Tianjiao; Li, Juan; Ren, Qiushi; Liu, Qi published the artcile< A Boronated Derivative of Temozolomide Showing Enhanced Efficacy in Boron Neutron Capture Therapy of Glioblastoma>, Application In Synthesis of 112-63-0, the main research area is binary radiation therapy; boron delivery agents; boron neutron capture therapy; glioblastoma.

There is an incontestable need for improved treatment modality for glioblastoma due to its extraordinary resistance to traditional chemoradiation therapy. Boron neutron capture therapy (BNCT) may play a role in the future. We designed and synthesized a 10B-boronated derivative of temozolomide, TMZB. BNCT was carried out with a total neutron radiation fluence of 2.4 ± 0.3 x 1011 n/cm2. The effects of TMZB in BNCT were measured with a clonogenic cell survival assay in vitro and PET/CT imaging in vivo. Then, 10B-boronated phenylalanine (BPA) was tested in parallel with TMZB for comparison. The IC50 of TMZB for the cytotoxicity of clonogenic cells in HS683 was 0.208 mM, which is comparable to the IC50 of temozolomide at 0.213 mM. In BNCT treatment, 0.243 mM TMZB caused 91.2% ± 6.4% of clonogenic cell death, while 0.239 mM BPA eliminated 63.7% ± 6.3% of clonogenic cells. TMZB had a tumor-to-normal brain ratio of 2.9 ± 1.1 and a tumor-to-blood ratio of 3.8 ± 0.2 in a mouse glioblastoma model. BNCT with TMZB in this model caused 58.2% tumor shrinkage at 31 days after neutron irradiation, while the number for BPA was 35.2%. Therefore, by combining the effects of chemotherapy from temozolomide and radiotherapy with heavy charged particles from BNCT, TMZB-based BNCT exhibited promising potential for therapeutic applications in glioblastoma treatment.

Cells published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Huadi; Li, Hui; Lu, Shenyi; Shan, Shuangshuang; Guo, Yong published the artcile< Fuzheng Jiedu decoction induces apoptosis and enhances cisplatin efficacy in ovarian cancer cells in vitro and in vivo through inhibiting the PI3K/AKT/mTOR/NF-κB signaling pathway>, SDS of cas: 112-63-0, the main research area is ovarian cancer Fuzheng Jiedu decoction apoptosis cisplatin; PI3K AKT mTOR NFkB signaling pathway.

This study is aimed at investigating the anticancer activity of Fuzheng Jiedu decoction (FJD) alone or in combination with cisplatin in ovarian cancer (OC) models, as well as its underlying mechanisms of action. The anticancer activities of FJD, cisplatin, and the combination of the PI3K inhibitor (LY294002, LY) or activator (IGF-1) were evaluated in OC cell lines in vitro and in a SKOV3 xenograft mouse model in vivo. The cell proliferation and invasion ability were measured using MTT, EdU, and transwell assays, resp. The cell apoptosis was examined by flow cytometry and JC-1 assays. The expression levels of the Bcl-2 family and the PI3K/AKT/mTOR/NF-κB pathway-related proteins were analyzed by Western blot. The in vivo and in vitro studies showed that FJD administration could significantly inhibit cell proliferation and promote cell apoptosis in two OC cell lines SKOV3 and 3AO and partially decreased the tumor volumes and weights In addition, FJD could significantly downregulate the protein levels of p-PI3K/PI3K, p-AKT/AKT, p-mTOR/mTOR, NF-κB, p38, and Bcl-2 and upregulate the Bax, Cyt-C, and cleaved caspase-3 in OC tumor tissues and cells. FJD cotreatment increased the efficacy of cisplatin, including inhibiting OC cell proliferation and invasion, promoting cell apoptosis, and inhibiting the PI3K/AKT/ mTOR signaling pathway, while this enhancement was suppressed by IGF-1. Similarly, LY also enhanced the anticancer efficacy of cisplatin. This study indicated that FJD could improve the efficacy of cisplatin by inhibiting the PI3K/ AKT/mTOR/NF-κB signaling pathway. It is suggested that FJD may be a valuable adjuvant drug for the treatment of OC.

BioMed Research International published new progress about Acids Role: ANT (Analyte), BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Hanyuan; Ma, Biao; Liu, Qi-Sheng; Wang, Mei-Ling; Wang, Zhen-Yu; Xu, Hui; Li, Ling-Jun; Wang, Xing; Dai, Hui-Xiong published the artcile< Transformations of Aryl Ketones via Ligand-Promoted C-C Bond Activation>, Computed Properties of 112-63-0, the main research area is aryl borate preparation ketoarene ligand promoted bond activation; C−C bond activation; Pd catalysis; aryl ketones; borylation.

The coupling of aromatic electrophiles (aryl halides, aryl ethers, aryl acids, aryl nitriles etc.) with nucleophiles is a core methodol. for the synthesis of aryl compounds Transformations of aryl ketones in an analogous manner via carbon-carbon bond activation could greatly expand the toolbox for the synthesis of aryl compounds due to the abundance of aryl ketones. An exploratory study of this approach is typically based on carbon-carbon cleavage triggered by ring-strain release and chelation assistance, and the products are also limited to a specific structural motif. Here we report a ligand-promoted β-carbon elimination strategy to activate the carbon-carbon bonds, which results in a range of transformations of aryl ketones, leading to useful aryl borates, and also to biaryls, aryl nitriles, and aryl alkenes. The use of a pyridine-oxazoline ligand is crucial for this catalytic transformation. A gram-scale borylation reaction of an aryl ketone via a simple one-pot operation is reported. The potential utility of this strategy is also demonstrated by the late-stage diversification of drug mols. probenecid, adapalene, and desoxyestrone, the fragrance tonalid as well as the natural product apocynin.

Angewandte Chemie, International Edition published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yan; Song, Shuang; Li, Haitao; Wang, Xinyan; Song, Lianlian; Xue, Jianfei published the artcile< Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion by regulating CD4+CD25+Foxp3+ regulatory T cells>, Application In Synthesis of 112-63-0, the main research area is Ganoderma cognitive impairment chronic CD4 CD25 Foxp3 regulatoryT cell.

Ganoderma lucidum (G. lucidum) is a kind of edible and medicinal mushroom. G. lucidum polysaccharide-1 (GLP-1) is one of the polysaccharides purified from crude GLP. Chronic cerebral hypoperfusion (CCH) as the common pathol. basis of various forms of dementia is an important cause of cognitive impairment. In this study, a step-down test was used to evaluate the cognitive ability of CCH mice. Flow cytometry was used to detect the proportion of CD4+CD25+Foxp3+ regulatory T (Foxp3+Treg) cells. ELISA anal. and western blot anal. were used to detect the transforming growth factor-β1 (TGF-β1) and Interleukin-10 (IL-10) levels that Foxp3+Treg cells secreted. Metabolomic anal. based on gas chromatog.-mass spectrometry (GC-MS) was used to evaluate the effect of GLP-1 on dysfunctional metabolism caused by inflammation. GLP-1 exhibited an alleviating cognitive impairment effect on CCH mice. The mechanism was related to GLP-1 by increasing Foxp3+Treg cell levels to increase levels of IL-10 and TGF-β1 and regulate abnormal energy metabolism These findings could provide preliminary results to exploit G. lucidum as a health care product or functional food for the adjuvant therapy of cognitive impairment of CCH.

Food & Function published new progress about Brain corpus callosum. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Halder, Mita; Bhanja, Piyali; Islam, Mominul Md.; Chatterjee, Sauvik; Khan, Aslam; Bhaumik, Asim; Islam, Sk. Manirul published the artcile< Porous organic polymer as an efficient organocatalyst for the synthesis of biofuel ethyl levulinate>, Quality Control of 112-63-0, the main research area is organocatalyst biofuel ethyl levulinate synthesis porous organic polymer.

Levulinic acid (LA), a lignocellulosic biomass-derived compound has been recognized as one of the versatile building blocks for the synthesis of commodity chems. having biofuel properties together with potential as precursor for the synthesis of several value-added pharmaceuticals and polymers. Herein, we report the synthesis of catalytically active functionalized porous organic polymer and its utilization as heterogeneous organocatalyst for the synthesis of EL from LA in very high yield. Here, sulfonic acid functionalized porous organic polymer SBZ@POP have been prepared via simple Friedel-Crafts alkylation of benzene with dimethoxymethane followed by sulfonation of the aromatic rings. The structure and properties of the material was examined through PXRD, N2 sorption, HR TEM, 13C CP-MAS NMR, NH3-TPD, TG-DTA and FTIR anal. Our characterization data suggested nanoscale porosity with high surface acidity in SBZ@POP. The effects of reaction time, catalyst loading, molar ratio of levulinic acid to ethanol and reaction temperature were studied thoroughly to optimize the catalytic activity of SBZ@POP. Under optimized reaction conditions EL yield of 88 % has been achieved with 1:15 molar ratio of LA to ethanol under refluxing conditions in 10 h. This porous organic polymer based organocatalyst displayed good recyclability for consecutive five reaction cycles suggesting the sustainable application potential of this acidic organocatalyst.

Molecular Catalysis published new progress about Density functional theory. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lanaya, Salaheddine; El Jemli, Yousra; Khallouk, Khadija; Abdelouahdi, Karima; Hannioui, Abdellah; Solhy, Abderrahim; Barakat, Abdellatif published the artcile< Sulfated Well-Defined Mesoporous Nanostructured Zirconia for Levulinic Acid Esterification>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is sulfated zirconia mesoporous nanostructure catalyst levulinic acid esterification.

Well-organized zirconia (ZrO2) nanoparticles forming mesoporous materials were successfully synthesized via a facile micelle-templating method using cetyltrimethylammonium bromide as a structure-directing template to control the nucleation/growth process and porosity. The systematic use of such a surfactant in combination with a microwave-assisted solvothermal (cyclohexane/water) reaction enabled the control of pore size in a narrow-size distribution range (3-17 nm). The effect of solvent mixture ratio on the porosity of the synthesized oxide was determined, and the controlled growth of zirconia nanoparticles was confirmed by means of powder X-ray diffraction, small-angle X-ray scattering, transmission electron microscopy, selected area electron diffraction, high-resolution transmission electron microscopy, XPS, thermogravimetric anal., and Fourier transform IR spectroscopy as well as N2 physisorption isotherm anal. Then, the as- prepared nanostructured zirconia oxides were treated with sulfuric acid to have sulfated samples. The catalytic performances of these mesoporous zirconia nanoparticles and their sulfated samples were tested for levulinic acid (LA) esterification by ethanol, with quant. conversions of LA to Et levulinate after 8 h of reaction.

ACS Omega published new progress about Binding energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Qiao-zhen; Xiao, Dong-guang published the artcile< Comparisons of different extraction fibers for analysis of aroma compounds in Litchi wine>, HPLC of Formula: 112-63-0, the main research area is extraction fiber aroma compound Litchi wine.

The aroma compounds of Litchi wine were analyzed by head space solid-phase micro-extraction (HS-SPME) coupled to gas chromatog.-mass spectrometry (GC-MS). Extraction characteristics of three different coating of extraction fibers were compared. The results indicated that the 65 μm PDMS/DVB was the best in the same exptl. conditions.

Tianjin Keji Daxue Xuebao published new progress about Fibers Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Bo; Zhang, Hongye; Zhao, Yanfei; Chen, Sha; Xu, Jilei; Hao, Leiduan; Liu, Zhimin published the artcile< DBU-Based Ionic-Liquid-Catalyzed Carbonylation of o-Phenylenediamines with CO2 to 2-Benzimidazolones under Solvent-Free Conditions>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is DBU acetate ionic liquid catalyst carbonylation phenylenediamine carbon dioxide; benzimidazolone preparation.

2-Benzimidazolones were prepared via carbonylation of o-phenylenediamines with CO2 catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-based ionic liquids under solvent-free conditions. DBU acetate ([DBUH][OAc]) displayed high efficiency for catalyzing the reactions of CO2 with o-phenylenediamines, and a series of benzimidazolones were obtained in high yields. It was demonstrated that [DBUH][OAc] could serve as a bifunctional catalyst for these reactions with the cation activating CO2 and the anion activating o-phenylenediamines. This protocol provides an effective and environmentally friendly alternative route for production of benzimidazolones, and extends the chem. utilization of CO2 in organic synthesis as well.

ACS Catalysis published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Majkutewicz, Irena published the artcile< Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review dimethyl fumarate preclin efficacy neurodegenerative disease; Alzheimer’s disease; Amyotrophic lateral sclerosis; Dimethyl fumarate; Huntington’s disease; Neurodegenerative diseases; Parkinson’s disease.

A review. Di-Me fumarate (DMF) is an antioxidative and anti-inflammatory drug approved for treatment of multiple sclerosis and psoriasis; however, beneficial effects of DMF have also been found in other inflammatory diseases and cancers. DMF is a prodrug that is immediately hydrolyzed to monomethyl fumarate (MMF) in vivo. Both fumarates activate the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, and Nrf2 is a key transcription factor of the antioxidant response. The immunosuppressive and anti-inflammatory actions of DMF occur through several mechanisms: via inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway and by downregulation of aerobic glycolysis and pyroptosis in activated myeloid and lymphoid cells. MMF is also an agonist of hydroxycarboxylic acid receptor 2 (HCAR2). Differences in the strength of effects and mechanisms of action of both fumarates are discussed. The aim of this review was to analyze and compare the neuroprotective, antioxidative and anti-inflammatory effects of DMF and its active metabolite, MMF, in cellular (in vitro) and animal models of neurodegenerative diseases (NDs), other than multiple sclerosis. There are more than twenty studies that currently represent this field. Most of the studies are concerned with cellular or animal models of Alzheimer ‘s disease (AD) and Parkinson ‘s disease (PD), one utilized a mouse model of Huntington ‘s disease (HD) and one clin. trial was carried out with amyotrophic lateral sclerosis (ALS) patients. The discrepancies in the results of the various studies are discussed, and issues requiring further research have been identified.

European Journal of Pharmacology published new progress about Alzheimer disease. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhiyong; Lan, Qing; Yu, Yao; Zhou, Jungang; Lu, Hong published the artcile< Comparative metabolome and transcriptome analyses of the properties of Kluyveromyces marxianus and Saccharomyces yeasts in apple cider fermentation>, Quality Control of 112-63-0, the main research area is Kluyveromyces marxianus Saccharomyces apple cider fermentation metabolome transcriptome analysis; Apple cider; Aroma; Kluyveromyces marxianus; Nonvolatile; Saccharomyces yeasts; Transcriptome.

This study explored the application of Kluyveromyces marxianus and Saccharomyces cerevisiae (com. and wild type) in the alc. fermentation of Fuji apple juice under static conditions. Metabolome analyses revealed that Et esters, including Et hexanoate, Et decanoate, Et octanoate, octanoic acid and decanoic acid, were the dominant components in ciders fermented by the Saccharomyces yeasts. In the K. marxianus ciders, Et acetate, hexyl acetate, Pr acetate and acetic acid were the most abundant volatiles, suggesting that the cider fermented by K. marxianus might have a fruitier smell. Transcriptome analyses were adapted to gain insight into the differential metabolite patterns between K. marxianus and S. cerevisiae during cider fermentation GO and KEGG enrichments revealed that the metabolic pathways of glucose, organic acids and amino acids during cider fermentation were quite different between these two yeasts. The K. marxianus strain exhibited a higher rate of glycolysis and ethanol fermentation than did Saccharomyces yeasts under oxygen-limited conditions. It also reduced the metabolic flux of acetate into acetyl-CoA and then into the TCA cycle, increasing the syntheses of Et acetate and relevant esters, which may affect its cell growth under anaerobic conditions but enriched the taste and variety of aromas in apple cider.

Food Chemistry: Molecular Sciences published new progress about Acids Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics