Category: 112-63-0

Frkic, Rebecca L.; He, Yuanjun; Rodriguez, Beatriz B.; Chang, Mi Ra; Kuruvilla, Dana; Ciesla, Anthony; Abell, Andrew D.; Kamenecka, Theodore M.; Griffin, Patrick R.; Bruning, John B. published the artcile< Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics>, Product Details of C19H34O2, the main research area is dichlorodichloroquinolinyloxyphenylbenzenesulfonamide INT131 analog preparation PPARgamma agonist antidiabetic target.

Peroxisome Proliferator-Activated Receptor γ (PPARγ) is a nuclear receptor central to fatty acid and glucose homeostasis. PPARγ is the mol. target for type 2 diabetes mellitus (T2DM) therapeutics TZDs (thiazolidinediones), full agonists of PPARγ with robust antidiabetic properties, which are confounded with significant side effects. Partial agonists of PPARγ such as INT131 (1), have displayed similar insulin-sensitizing efficacy as TZDs, but lack many side-effects. To probe the structure-activity relationship (SAR) of the scaffold (1), the authors synthesized 14 analogs of compound (1) which revealed compounds with higher transcriptional potency for PPARγ and identification of moieties of the scaffold (1) key to high transcriptional potency. The sulfonamide linker is critical to activity, substitutions at position 4 of the benzene ring A were associated with higher transcriptional activity, substitutions at position 2 aided in tighter packing and activity, and the ring type and size of ring A affected the degree of activity.

Journal of Medicinal Chemistry published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vesely, David L. published the artcile< Biotin enhances guanylate cyclase activity>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is biotin organ guanylate cyclase.

biotin  [58-85-5] And its analog, (+)-biotin-p-nitrophenyl ester  [33755-53-2] enhanced guanylate cyclase  [9054-75-5] activity 2-3-fold in rat liver, kidney, colon, cerebellum, and heart. Dose-response relationships revealed that at concentrations as low as 1 μM, both biotin and its analog caused maximal augmentation of guanylate cyclase activity. These data suggest a role for the activation of guanylate cyclase in the mechanism of action of this vitamin.

Science (Washington, DC, United States) published new progress about Cerebellum. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Janne, Kjell; Ahlberg, Per published the artcile< Synthetic routes to a new bicyclic amidine, 1,2,3,4,4a,5,6,7-octahydro-1,8-naphthyridine (2,10-diazabicyclo[4.4.0]dec-1-ene)>, Quality Control of 112-63-0, the main research area is naphthyridine hydrogenation; diazabicyclodecene.

Treatment of 1,8-naphthyridine I with N-chlorosuccinimide in C6H6 followed by KOH gave 55% amidine II, which was also prepared in 18% yield by treatment of I with Hg(OAc)2 in AcOH followed by H2S. I was prepared in 70% yield by hydrogenation of 1,8-naphthyridine.

Synthesis published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Shicong; Liu, Xiaoyan; He, Jingyu; Liu, Menghua published the artcile< Insight into Seasonal Change of Phytochemicals, Antioxidant, and Anti-Aging Activities of Root Bark of Paeonia suffruticosa (Cortex Moutan) Combined with Multivariate Statistical Analysis>, Reference of 112-63-0, the main research area is Paeonia suffruticosa root bark phytochem antioxidant antiaging activity; root bark phytochem seasonal change multivariate statistical analysis; Cortex Moutan; anti-aging; antioxidant; collection period; composition; multivariate statistical analysis.

Chem. compositions, antioxidants, and anti-aging activities of Cortex Moutan (CM), from different collection periods and different producing areas, were measured and compared in order to obtain excellent CM extracts The bioactivities of CM extracts were examined by an in vitro antioxidant method and a UVB irradiated human dermal fibroblast (HDF) model. Phytochem. properties were obtained from ultra-fast liquid chromatog. quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF-MS) prior to the multivariate statistical anal. As for the results, the extracts of Heze CM (HZCM) and Luoyang CM (LYCM) collected in June had better in vitro antioxidant activities, significantly increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and reduced the content of malondialdehyde (MDA), compared to other CM extracts HZCM and LYCM extracts could upregulate the relative expression of SOD and GSH-Px mRNA. The extract of HZCM collected in June could significantly repress the production of matrix metalloproteinase 1 (MMP-1) and improve the production of procollagen type I (PCOL)-I in UVB irradiated HDF. In total, 50 compounds, including 17 monoterpenoids, 19 flavonoids, 13 phenols, and 1 amino acid were identified or tentatively identified in the CM extracts Gallic acid, p-hydroxybenzoic acid, oxypaeoniflorin, paeoniflorin, 1,2,3,4,6-O-pentagalloyl glucose, and paeonol were predominant compounds in the CM extracts Taken together, CM collected from Apr. to Sept. had better antioxidant and anti-aging effects for external usage.

Molecules published new progress about Amino acids Role: ANT (Analyte), ANST (Analytical Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Jing; Su, Guannan; Huang, Xinyue; Chang, Rui; Chen, Zhijun; Ye, Zi; Cao, Qingfeng; Kijlstra, Aize; Yang, Peizeng published the artcile< Metabolomic analysis of aqueous humor identifies aberrant amino acid and fatty acid metabolism in Vogt-Koyanagi-Harada and Behcet′s disease>, Category: esters-buliding-blocks, the main research area is Behcet disease metabolomic analysis fatty acid metabolism; Behcet’s disease; Vogt-Koyanagi-Harada disease; amino acids; fatty acids; metabolomics; pathway.

To investigate aqueous metabolic profiles in Vogt-Koyanagi-Harada (VKH) and Behcet′s disease (BD), we applied ultra-high-performance liquid chromatog. equipped with quadrupole time-of flight mass spectrometry in aqueous humor samples collected from these patients and controls. Metabolite levels in these three groups were analyzed by univariate logistic regression. The differential metabolites were subjected to subsequent pathway anal. by MetaboAnalyst. The results showed that both partial-least squares discrimination anal. and hierarchical clustering anal. showed specific aqueous metabolite profiles when comparing VKH, BD, and controls. There were 28 differential metabolites in VKH compared to controls and 29 differential metabolites in BD compared to controls. Amino acids and fatty acids were the two most abundant categories of differential metabolites. Furthermore, pathway enrichment anal. identified several perturbed pathways, including pantothenate and CoA biosynthesis when comparing VKH with the control group, and D-arginine and D-ornithine metabolism and phenylalanine metabolism when comparing BD with the control group. Aminoacyl-tRNA biosynthesis was altered in both VKH and BD when compared to controls. Our findings suggest that amino acids metabolism as well as two fatty acids, palmitic acid and oleic acid, may be involved in the pathogenesis of BD and VKH.

Frontiers in Immunology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gyomore, Adam; Bakos, Maria; Foldes, Tamas; Papai, Imre; Domjan, Attila; Soos, Tibor published the artcile< Moisture-Tolerant Frustrated Lewis Pair Catalyst for Hydrogenation of Aldehydes and Ketones>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is moisture tolerant frustrated Lewis pair hydrogenation catalyst aldehyde ketone.

In this paper, we report on the development of a bench-stable borane for frustrated Lewis pair catalyzed reduction of aldehydes, ketones, and enones. The deliberate fine-tuning of structural and electronic parameters of Lewis acid component and the choice of Lewis base provided for the first time, a moisture-tolerant FLP catalyst. Related NMR and DFT studies underpinned the unique behavior of this FLP catalyst and gave insight into the catalytic activity of the resulting FLP catalyst.

ACS Catalysis published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ramadoss, Velayudham; Alonso-Castro, Angel J.; Campos-Xolalpa, Nimsi; Ortiz-Alvarado, Rafael; Yahuaca-Juarez, Berenice; Solorio-Alvarado, Cesar R. published the artcile< Total synthesis of kealiiquinone: the regio-controlled strategy for accessing its 1-methyl-4-arylbenzimidazolone core>, Application In Synthesis of 112-63-0, the main research area is kealiiquinone total synthesis.

A practical, concise and straightforward total synthesis of kealiiquinone, a naphtho[2,3-d]imidazole alkaloid obtained from the Micronesian marine sponge Leucetta sp. was accomplished. The squaric acid chem. to construct the 1,4-quinoid ring and the regioselective N-methylation through a benzo[c][1,2,5]selenadiazolium heterocycle are the key features in this report. The full details of the representative approaches involving the different attempted synthetic strategies are also presented. Finally a successful total synthesis of this complex secondary metabolite is described.

RSC Advances published new progress about Methylation, regioselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shivalingam, Arun; Taemaitree, Lapatrada; El-Sagheer, Afaf H.; Brown, Tom published the artcile< Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly>, Computed Properties of 112-63-0, the main research area is squaramide ureas flexible nucleic acid assembly; RNA detection; ligation; nucleic acids; polymerase chain reaction; squaramide.

Joining oligonucleotides together (ligation) is a powerful means of retrieving information from the nanoscale. To recover this information, the linkages created must be compatible with polymerases. However, enzymic ligation is restrictive and current chem. ligation methods lack flexibility. Herein, a versatile ligation platform based on the formation of urea and squaramide artificial backbones from minimally modified 3′- and 5′-amino oligonucleotides is described. One-pot ligation gives a urea linkage with excellent read-through speed, or a squaramide linkage that is read-through under selective conditions. The squaramide linkage can be broken and reformed on demand, while stable pre-activated precursor oligonucleotides expand the scope of the ligation reaction to reagent-free, mild conditions. The utility of the authors’ system is demonstrated by replacing the enzymically biased RNA-to-DNA reverse transcription step of RT-qPCR with a rapid nucleic-acid-template-dependent DNA chem. ligation system, that allows direct RNA detection.

Angewandte Chemie, International Edition published new progress about DNA Role: ARG (Analytical Reagent Use), BUU (Biological Use, Unclassified), SPN (Synthetic Preparation), ANST (Analytical Study), USES (Uses), BIOL (Biological Study), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rubio-Garrido, Marina; Reina, Gabriel; Ndarabu, Adolphe; Rodriguez-Galet, Ana; Valades-Alcaraz, Ana; Barquin, David; Carlos, Silvia; Holguin, Africa published the artcile< High drug resistance levels could compromise the control of HIV infection in pediatric and adolescent population in Kinshasa, the Democratic Republic of Congo>, Application In Synthesis of 112-63-0, the main research area is human HIV infection drug resistance pediatric adolescent population Congo.

The inadequacy of HIV viremia and resistance monitoring in Africa leads to uncontrolled circulation of HIV strains with drug resistance mutations (DRM), compromising antiretroviral therapy (ART) effectiveness. This study describes the DRM prevalence and its therapeutic impact in HIV-infected pediatric patients from Kinshasa (Democratic Republic of Congo, DRC). From 2016-2018, dried blood were collected from 71 HIV-infected children and adolescents under ART in two hospitals in Kinshasa for HIV-1 DRM pol anal., predicted ARV-susceptibility by Stanford and phylogenetic characterization. HIV-1 sequences were recovered from 55 children/adolescents with 14 years of median-age. All had received nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTI, NNRTI), 9.1% protease inhibitors (PI) and only one integrase inhibitor (INI). Despite the use of ART, 89.1% showed virol. failure and 67.3% carried viruses with major-DRM to one (12.7%), two (47.3%), or three (5.5%) ARV-families. Most children/adolescents harbored DRM to NNRTI (73.5%) or NRTI (61.2%). Major-DRM to PI was present in 8.3% and minor-DRM to INI in 15%. Dual-class-NRTI+NNRTI resistance appeared in 53.1% of patients. Viruses presented high/intermediate resistance to nevirapine (72.9% patients), efavirenz (70.9%), emtricitabine/lamivudine (47.9%), rilpivirine (41.7%), etravirine (39.6%), doravidine (33.3%), zidovudine (22.9%), among others. Most participants were susceptible to INI and PI. Great diversity of variants was found, with a high rate (40%) of unique recombinants. The high DRM prevalence observed among HIV-infected children and adolescents in Kinshasa could compromise the 95-95-95-UNAIDS targets in the DRC. It also reinforces the need for routine resistance monitoring for optimal rescue therapy election in this vulnerable population to control the spread of resistant HIV in the country.

PLoS One published new progress about Adolescent, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peralta Muniz Moreira, Rodrigo; Li Puma, Gianluca published the artcile< CFD modeling of pharmaceuticals and CECs removal by UV/H2O2 process in helical microcapillary photoreactors and evaluation of OH radical rate constants>, Computed Properties of 112-63-0, the main research area is CFD modeling pharmaceutical contaminants removal UV hydrogen peroxide process; helical microcapillary photoreactors evaluation hydroxyl radical rate constant.

Process intensification by tailored secondary flow in helical microcapillary film (MCF) photoreactors was unveiled by computational fluid dynamics, and it was revealed for the removal of six common contaminants of emerging concern CECs (the antiviral Acyclovir, the antiretrovirals Stavudine and Zidovudine, and the biocidal antifungal agents Methylisothiazolinone, Benzisothiazolinone and Isoxazole) in water by UV hydrogen peroxide. The MCF photoreactors consisted of fluoropolymer films containing 10 microchannels with diameter varying from 100 to 1000μm coiled around a UVC lamp. In contrast to a MCF with straight channels, mixing intensification by secondary flow (Dean vortices) caused by the helical shape of the microcapillary strongly enhanced the radial fluid mixing, further supplementing the transport of the reacting species by Taylor-Aris dispersion. The intensity of the Dean vortices formed was correlated to the Dean (De) and Schmidt (Sc) numbers through a new correlation for the radial Peclet, which established that these become significant when De1.94Sc > 67. Thus, the second-order reaction rate constant of the six CECs with OH• radicals (kOH) determined in a helical MCF photoreactor increased (4.4% up to 37.9%) in comparison to those determined assuming a MCF photoreactor with plug flow. In addition, the helical shape of the MCF significantly diminished mass transfer limitations and decreased the CECs Elec. Energy per Order Reduction (EEO), paving the way for scaling-up of helical microcapillary photoreactor technol. This study shows how micromixing can be successfully exploited to design more efficient microcapillary photoreactors.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics