Category: 112-63-0

Alanazi, Rahmah; Nakatogawa, Hirokazu; Wang, Haitao; Ji, Delphine; Luo, Zhengwei; Golbourn, Brian; Feng, Zhong-Ping; Rutka, James T; Sun, Hong-Shuo published the artcile< Inhibition of TRPM7 with carvacrol suppresses glioblastoma functions in vivo.>, Synthetic Route of 112-63-0, the main research area is TRPM7; carvacrol; drug target; glioblastoma; in vivo; ion channels.

Glioblastoma (GBM) is the most prevalent and aggressive type of primary human brain tumours originating in the central nervous system. Despite the fact that current treatments involve surgery, chemotherapy (Temozolomide), and radiation therapy, the prognosis for patients diagnosed with GBM remains extremely poor. The standard treatment is not only unable to completely eradicate the tumour cells, but also tumour recurrence after surgical resection presents a major challenge. Furthermore, adjuvant therapies including radiation and chemotherapy have high cytotoxicity which causes extensive damage to surrounding healthy tissues and treatment is usually halted before GBM is fully eradicated. Finally, most GBM cases demonstrate temozolomide resistance, a common reason for GBM treatment failure. Therefore, there is an urgent need to develop a suitable alternative therapy that targets GBM specifically and has low cytotoxicity for healthy cells. We previously reported that transient receptor potential melastatin 7 (TRPM7) channels are aberrantly upregulated in GBM, and inhibition of TRPM7 reduced GBM cellular functions including proliferation, migration, and invasion. This suggests TRPM7 is a potential therapeutic target for GBM treatment. In this study, we investigated the effects of the TRPM7 inhibitor, carvacrol, on human GBM cell lines U87 and U251 in vivo. With the use of a flank xenograft GBM mouse model, we demonstrated that carvacrol significantly reduced the tumour size in both mice injected with U87 and U251 cells, decreased p-Akt protein level and increased p-GSK3β protein levels. Therefore, these results suggest that carvacrol may have therapeutic potential for GBM treatment.

The European journal of neuroscience published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xuejing; Deng, Xingwang; Coyne, Anthony G.; Srinivasan, Rajavel published the artcile< meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C-H Borylation>, HPLC of Formula: 112-63-0, the main research area is meta nitroarene regioselective preparation; arene borylation nitration tandem iridium catalyst copper; C−H borylation; copper catalysis; nitration; nitro(hetero)arenes; one-pot reactions.

The meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C-H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes RNO2 [R = 4,5-di-ClC6H3, 3,4-di-BrC6H3, 5-Cl-3-pyridyl, etc.] in a one-pot fashion was reported. The reaction tolerated a wide array of ortho/para-directing groups, such as -F, -Cl, -Br, -CH3, -Et, -iPr -OCH3 and -OCF3. It also provided regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives The application of this method was demonstrated in the late-stage modification of complex mols. and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, showed that the nitro product obtained by this strategy could also be directly converted to the aniline or hindered amine through Baran’s amination protocol.

Chemistry – A European Journal published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Van Lijsebetten, Filip; De Bruycker, Kevin; Winne, Johan M.; Du Prez, Filip E. published the artcile< Masked Primary Amines for a Controlled Plastic Flow of Vitrimers>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is masked primary amine controlled plastic flow vitrimer.

We present a simple method for increasing the reprocessability of vinylogous urethane (VU) vitrimers while decreasing the possibility of creep deformation at lower temperatures In particular, varying amounts of triethylenetetramine were added as a comonomer to the curing VU formulation to ensure that all of the primary amines reacted to form enaminone cross-links, resulting in a network without reactive primary amine chain-ends. As a result, transamination was significantly slowed down because secondary amines are much less reactive to VU exchange. On the other hand, at higher temperatures, pendent primary amines can be released via a dynamic, endothermic exchange with a nearby less-reactive secondary amine, thereby (re)activating material flow. As a result, ambivalent viscoelastic behavior could be achieved without depolymerization by dynamically releasing pendent primary amines from vinylogous urethane polymer chains. Through careful comonomer selection, VU vitrimers with low viscosity at processing temperatures and at the same time high viscosity at service temperatures could be prepared without the use of catalysts or additives, leveraging the synergistic effects of mildly reactive functionalities through neighboring group participation.

ACS Macro Letters published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhanjiang; Shen, Guang; Yang, Yihua; Li, Cui; Chen, Xiaoying; Yang, Xiaonan; Guo, Xiaoyun; Miao, Jianhua; Li, Li; Lei, Ming published the artcile< Metabolic and Transcriptomic Analyses Reveal the Effects of Ethephon on Taraxacum kok-saghyz Rodin>, Related Products of 112-63-0, the main research area is Taraxacum ethephon transcriptomic analyses; Taraxacum kok-saghyz Rodin; metabolomics; transcriptomics.

The roots of Taraxacum kok-saghyz Rodin (TKS) are well-known and valued for their rubber-producing ability. Therefore, research on the anal. and detection of metabolites from the roots of TKS have been reported in previous studies. However, all of these studies have the shortcoming of focusing on only the rubber of TKS, without profiling the other metabolites in a systematic and comprehensive way. Here, the primary and secondary metabolites from the leaves of TKS were investigated using UPLC-ESI-MS/MS, and a total of 229 metabolites were characterized. Carboxylic acid derivatives, fatty acyls, phenols, and organooxygen compounds were found to be the major metabolites of TKS. The transcriptome data indicated that ribosomal, glycolysis/gluconeogenesis, phenylpropanoid biosynthesis, and linoleic acid metabolism genes were significantly differentially expressed. This study is the first to report the differences in the metabolic and transcriptome profiles of TKS leaves under exogenous ethephon spray, which improves our understanding of the main metabolites and their mol. mechanisms in TKS leaves.

Molecules published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Toda, Fumio; Schmeyers, Jens published the artcile< Selective solid-state bromination of anilines and phenols>, COA of Formula: C19H34O2, the main research area is aniline solid state bromination; phenol solid state bromination.

Environmentally benign solid-state bromination of anilines and phenols with gaseous Br2 and solid bromination reagents is described. In most cases the reactions proceeded in the absence of solvents with higher yields and selectivity than in solution

Green Chemistry published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crich, David; Eustace, K. Angeline; Fortt, Simon M.; Ritchie, Timothy J. published the artcile< Acyl radical cyclizations in synthesis. Part 2. Further substituent effects on the mode and efficiency of cyclization of 6-heptenoyl radicals>, Quality Control of 112-63-0, the main research area is cyclization heptenoyl radical; selenol ester cyclization stereochem.

In an attempt to determine the factor affecting exo/endo- selectivity in the cyclization of 6-heptenoyl radicals various heteroatom substituted selenol esters were prepared and reacted with tributyltin hydride. The incorporation of a 7-phenylthio moiety results in clean, high yielding, cyclization in the exo- mode. Evidence is given for the reversibility of 6-heptenoyl radical cyclizations.

Tetrahedron published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dove, Stefan published the artcile< Picolinic acids as inhibitors of dopamine β-monooxygenase: QSAR and putative binding site>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is dopamine monooxygenase picolinic acid derivative inhibitor QSAR.

Dopamine β-monooxygenase (DBM, EC 1.14.17.1) catalyzes the oxidation of dopamine into (R)-noradrenaline. DBM inhibitors may act as antihypertensive drugs. A series of 22 picolinic acids substituted in 4- and 5-position was previously synthesized and tested for inhibition of DBM from bovine adrenal medulla. The QSAR of these compounds were investigated by Hansch anal. and comparative mol. field anal. (CoMFA). The correlation of pI50 values with electronic (nucleophilic substituent constant σp-, oxygen net charges and HOMO energy calculated by AMPAC-AM1), hydrophobic (π values of R4) and steric descriptors (molar refraction and Sterimol parameters of R5) indicated that a more neg. charged carboxylate moiety, more lipophilic R4 groups as well as wider bulk and higher molar refraction of 5-substituents increase DBM inhibition. The CoMFA approach generally reproduced these QSAR in terms of steric and electrostatic field variables, the latter restricted to the carboxylate area. To predict a putative binding site, dopamine and fusaric acid were docked into a partial homol. model of DBM derived from a crystal structure of peptidylglycine α-hydroxylating monooxygenase (EC 1.14.17.3). The inhibitor is suggested to interact by its carboxylate group with the copper site CuB and the protonated amino group of dopamine according to the uncompetitive type of inhibition. R4 points to a tyrosine side chain. R5 protrudes into the fringe of the catalytic crevice. It may “”freeze”” to the solvated surface of polar amino acids and addnl. contact an isoleucine residue. Taken together, the model explains the QSAR results by corresponding types of interaction.

Archiv der Pharmazie (Weinheim, Germany) published new progress about QSAR (quantitative structure-activity relationship) (dopamine β-monooxygenase inhibition). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Wenbiao; Jiang, Shangxu; Xie, Yuan; Yan, Xiaoqing; Zhao, Fugang; Pang, Xinchang; Zhang, Kai; Jia, Zhongfan published the artcile< Anthraquinone-Catalyzed TEMPO Reduction to Realize Two-Electron Energy Storage of Poly(TEMPO-methacrylate)>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is anthraquinone catalyzed reduction electron energy storage poly methacrylate.

2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) functional polymers are a type of organic electroactive material featuring a two-electron redox process. However, the electrochem. reduction of TEMPO (TEMPO•/-) is rarely adopted for energy storage due to its slow reaction kinetics. Here, we report using anthraquinone (AQ) as an organic redox mediator to promote TEMPO reduction kinetics. The catalytic effect of AQ is verified by electrochem. in situ FTIR spectroscopy in a model three-electrode system and further evidenced by cyclic voltammetry and chronoamperometry, providing a turnover frequency of 69 h-1. To exemplify the AQ catalytic effect in energy storage performance, we incorporate AQ groups into a typical TEMPO polymer (i.e., poly(TEMPO-methacrylate), PTMA). The AQ-catalyzed TEMPO reduction and AQ/carbon π-π interaction synergistically reduce the heterogeneous charge transfer resistance and accelerate the kinetics of the TEMPO•/- process in the PTMA electrode. The half-cell tests of the AQ functional PTMA show two prominent discharge plateaus with an initial capacity of 174 mAh g-1 and a 0.18% capacity loss per cycle. Moreover, the discharge capacity based on the TEMPO•/- couple is about 85 mAh g-1, 30% higher than that of the pristine PTMA. This new strategy could be widely applied to various organic redox systems to enhance their electrochem. kinetics and particularly improve the energy storage performance of organic polymer redox materials.

ACS Energy Letters published new progress about Carbon black Role: TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

de Souza, I.; Monteiro, L. K. S.; Guedes, C. B.; Silva, M. M.; Andrade-Tomaz, M.; Contieri, B.; Latancia, M. T.; Mendes, D.; Porchia, B. F. M. M.; Lazarini, M.; Gomes, L. R.; Rocha, C. R. R. published the artcile< High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation>, Computed Properties of 112-63-0, the main research area is .

Abstract: Glioblastoma patients have a poor prognosis mainly due to temozolomide (TMZ) resistance. NRF2 is an important transcript factor involved in chemotherapy resistance due to its protective role in the transcription of genes involved in cellular detoxification and prevention of cell death processes, such as ferroptosis. However, the relation between NRF2 and iron-dependent cell death in glioma is still poorly understood. Therefore, in this study, we analyzed the role of NRF2 in ferroptosis modulation in glioblastoma cells. Two human glioblastoma cell lines (U251MG and T98G) were examined after treatment with TMZ, ferroptosis inducers (Erastin, RSL3), and ferroptosis inhibitor (Ferrostatin-1). Our results demonstrated that T98G was more resistant to chemotherapy compared to U251MG and showed elevated levels of NRF2 expression. Interestingly, T98G revealed higher sensitivity to ferroptosis, and significant GSH depletion upon system xc- blockage. NRF2 silencing in T98G cells (T98G-shNRF2) significantly reduced the viability upon TMZ treatment. On the other hand, T98G-shNRF2 was resistant to ferroptosis and reverted intracellular GSH levels, indicating that NRF2 plays a key role in ferroptosis induction through GSH modulation. Moreover, silencing of ABCC1, a well-known NRF2 target that diminishes GSH levels, has demonstrated a similar collateral sensitivity. T98G-siABCC1 cells were more sensitive to TMZ and resistant to Erastin. Furthermore, we found that NRF2 pos. correlates with ABCC1 expression in tumor tissues of glioma patients, which can be associated with tumor aggressiveness, drug resistance, and poor overall survival. Altogether, our data indicate that high levels of NRF2 result in collateral sensitivity on glioblastoma via the expression of its pro-ferroptotic target ABCC1, which contributes to GSH depletion when the system xc- is blocked by Erastin. Thus, ferroptosis induction could be an important therapeutic strategy to reverse drug resistance in gliomas with high NRF2 and ABCC1 expression.

Cell Death & Disease published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Prabhu, C.; Rajasekar, V.; Prakash, T. published the artcile< Characterisation and assessment of physicochemical properties of grapeseed methyl ester using predictive correlations and ASTM standards for CI engine application>, Electric Literature of 112-63-0, the main research area is grape seed methyl ester physicochem property CI engine application.

In the present work, a detailed investigation of the physio-chem. characteristics of grapeseed Me ester (GSME) obtained from winery biomass waste has been carried out to evaluate its suitability as an energy alternate, for CI engines. GSME was subjected to Gas chromatog. and mass spectrometry anal. from which fatty acids compositions were determined followed by other interpretations such as carbon number, number of double bonds, etc. Two different predictive correlations were identified from the literature for predicting the properties that are considered important, for using GSME as a fuel. The predicted properties of GSME are compared with the exptl. results obtained through standard ASTM procedures, for diesel, neat grapeseed oil (GSO) and GSME, resp. Further, the influence of the structural and compositional characteristics of GSME on the physicochem. properties like d., kinematic viscosity, lower calorific value, etc. has been evaluated and found to be closer to diesel.

Nature, Environment and Pollution Technology published new progress about Cetane number. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics