Category: 112-63-0

Zhang, Yong; Zhou, Yu-Jun; Tang, Jing-Shu; Lan, Jia-Qi; Kang, Yu-Ying; Wu, Lei; Peng, Ying published the artcile< A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is dimethyl itaconate fumarate antiinflammation Nrf electrophilicity; Dimethyl fumarate; NF-E2-related factor 2; dimethyl itaconate; inflammation; oxidative stress.

Di-Me itaconate (DMI) is an analog of di-Me fumarate (DMF), an approved NF-E2-related Factor 2 (Nrf2) activator for multiple sclerosis. This study evaluated the potential of DMI as an anti-inflammatory agent by comparing DMI with DMF in electrophilicity, Nrf2 activation, and anti-inflammation in vitro. The results showed that DMI was less electrophilic but better at inducing a durable activation of Nrf2 when compared with DMF. However, DMI demonstrated poor anti-inflammatory effects in Jurkat cells, bone marrow-derived dendritic cells, and RAW264.7 cells. Our study suggested that DMI was a potent electrophilic Nrf2 activator but was probably not a promising anti-inflammatory agent.

Journal of Asian Natural Products Research published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brandes, Sebastian; Bella, Marco; Kjoersgaard, Anne; Joergensen, Karl Anker published the artcile< Chirally aminated 2-naphthols-organocatalytic synthesis of non-biaryl atropisomers by asymmetric Friedel-Crafts amination>, COA of Formula: C19H34O2, the main research area is hydroxynaphthylhydrazinedicarboxamide enantioselective preparation atropisomer Friedel Crafts amination; modified cinchona alkaloid stereoselective preparation catalyst Friedel Crafts amination; enantioselective Friedel Crafts amination naphthol azodicarboxylate cinchona alkaloid catalyst; racemization barrier hydroxynaphthylhydrazinedicarboxamide; mol crystal structure bromobenzoylamino hydroxynaphthylhydrazinedicarboxamide.

Atropisomeric hydroxynaphthylhydrazinedicarboxamides I (R = H2N, MeNH, PhCH2NH, BuCH2NH; R1 = H, Br; R2 = Me3C, PhCH2), novel non-aryl atropisomers, are prepared in 85-98% yields and in 87-98% ee by amination of 2-naphthols II (R = H2N, MeNH, PhCH2NH, BuCH2NH; R1 = H, Br) with azodicarboxylates Me3CO2CN:NCO2R2 in the presence of cinchona catalysts or modified cinchona alkaloids such as III. III (prepared by addition of a dihydroquinidine-derived alkaloid to di-tert-Bu azodicarboxylate in methylene chloride under forcing conditions) and related atropisomeric hydrazine-substituted cinchona alkaloids are particularly effective catalysts for the enantioselective amination of 2-naphthols II (R = H2N, MeNH, PhCH2NH, BuCH2NH; R1 = H, Br) with di-tert-Bu azodicarboxylate; III and related compounds are configurationally stable when stored as solids at ambient temperature The barrier to racemization of di-tert-Bu (2-hydroxynaphthyl)hydrazinedicarboxylate (IV) is determined exptl. and by computational methods; atropisomers of IV are not stable at ambient temperature (t1/2 = 26 min.). I (R = 4-BrC6H4CONH; R1 = H; R2 = PhCH2) can be acylated to give amides or ureas without loss of atropisomeric purity, while cleavage of either of the carboxylate groups leads to the formation of racemic products. The structure of I (R = 4-BrC6H4CONH; R1 = H; R2 = PhCH2) is determined by X-ray crystallog.

Angewandte Chemie, International Edition published new progress about Amination catalysts (stereoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Majumdar, K. C.; Kundu, U. K.; Ghosh, S. K. published the artcile< Studies in Sigmatropic Rearrangement: Synthesis of a [6,6]Pyranothiopyran Ring System by Sequential Claisen Rearrangement and Pyridine Hydrotribromide Mediated Regioselective ""6-Endo"" Cyclization>, Computed Properties of 112-63-0, the main research area is pyranothiopyran preparation; Claisen rearrangement regioselective cyclization pyranothiopyran preparation.

4-(4′-Aryloxybut-2′-ynylthio)[1]benzopyran-2-ones are refluxed in chlorobenzene to afford 4-aryloxymethylthiopyrano[3,2-c][1]benzopyran-5(2H)-ones, which are subsequently subjected to heating in o-dichlorobenzene in the presence of N,N-diethylaniline and then treated with pyridine hydrotribromide to give [6,6]pyranothiopyrans in almost quant. yield.

Organic Letters published new progress about [3,3]-Sigmatropic rearrangement. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pedras, Bruno M.; Goncalves, Carla; Figueira, Diogo R.; Simoes, Pedro; Goncalves, Paula; Paiva, Alexandre; Barreiros, Susana; Salema-Oom, Madalena published the artcile< White wine grape pomace as a suitable carbon source for lipid and carotenoid production by fructophilic Rhodorotula babjevae>, COA of Formula: C19H34O2, the main research area is genome white wine grape pomace carbon lipid carotenoid Rhodorotula; Rhodorotula babjevae ; PEFA; carotenoids; fructophily; triacyclglycerols; white wine grape pomace.

Aim : We aim to explore the non-structural sugars from white wine grape pomace (WWGP) as the input carbon source for the co-production of multiple high-value products by the non-fastidious yeast Rhodotorula babjevae to create a sustainable and economically appealing process. Methods and Results : Water extraction of unfermented, soluble sugars from WWGP yielded extracts with similar amounts of glucose and fructose, which were used to prepare a growth medium. Rhodorotula babjevae multiplied as fast on WWGP-based medium as on a reference medium but achieved higher cell dry weight (CDW) and lower intracellular triacylglycerol accumulation (22.5% vs. 28.6%) in WWGP-based medium. In addition, R. babjevae produced mannitol and arabitol and carotenoids and secreted polyol esters of fatty acids, a rare type of glycolipid as confirmed by Fourier transform-IR, NMR and high-performance liquid chromatog. analyses. Remarkably, R. babjevae consumed simultaneously both fructose and glucose when on WWGP-based medium and left glucose practically untouched in the reference medium, evidencing a fructophilic character. Conclusions : Rhodorotula babjevae, a metabolic versatile yeast, proliferated on a minimally processed extract and successfully converted glucose and fructose into high-value products. Significance and Impact of Study : Different chems. with market potential can be produced through the valorization of abundant waste feedstocks generated by the wine industry to which R. babjevae can contribute.

Journal of Applied Microbiology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (FFZ1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haehsler, Martin; Mastalerz, Michael published the artcile< A Giant [8+12] Boronic Ester Cage with 48 Terminal Alkene Units in the Periphery for Postsynthetic Alkene Metathesis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is giant cage alkene boronate cage self assembly preparation metathesis; boronic esters; covalent capture; organic cage; ring-closing metathesis; self-assembly.

Dynamic covalent chem. (DCC) is a powerful synthetic tool to construct large defined mols. in one step from rather simple precursors. The advantage of the intrinsic dynamics of the applied reversible reaction steps is a self-correction under the chosen conditions, to achieve high yields of the target compound To date, only a few examples are known, in which DCC was used to build up a mol. defined but larger product that was chem. transferred to a more stable congener in a second (irreversible) step. Here, we present a nanometer-sized [8+12] boronic ester cage containing 48 peripheral terminal alkene units which allows to put a hydrocarbon exoskeleton around the cage via alkene metathesis.

Chemistry – A European Journal published new progress about Boronic acids, esters Role: NAN (Nanomaterial), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (cage compounds). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Pan; Li, Bingqin; Li, Baiyue; Yang, Jing; Xu, Xingran; Yang, Shang-Tian; Zou, Xiang published the artcile< Carbon-economic biosynthesis of poly-2-hydrobutanedioic acid driven by nonfermentable substrate ethanol>, Application In Synthesis of 112-63-0, the main research area is carbon economic biosynthesis polyhydrobutanedioic acid ethanol substrate.

Poly-2-hydrobutanedioic acid (P2HBD), produced by the yeast-like fungus Aureobasidium pullulans, is a new type of water-soluble polyhydroxy acid with potential applications in the biomaterial and biomedical fields. Generally, aerobic P2HBD fermentation with glucose as a carbon source causes carbon loss (releasing CO2) via the decarboxylation of pyruvate to form acetyl-CoA. Compared with sugars, the nonfermentable substrate ethanol exhibits a higher degree of reduction per carbon atom and a shorter route to generate acetyl-CoA. In this study, the carbon-economic biosynthesis of P2HBD driven by ethanol as the sole carbon source was investigated. Ethanol was first found to be efficiently converted into P2HBD via a biosynthetic mechanism, and specially activated the transcription factor Cat8 to regulate the glyoxylic acid shunt in A. pullulans. Based on transcriptomic anal. under ethanol stress, a modular assembly strategy was designed to balance three modules of ethanol oxidation, glyoxylic acid shunt, and the gluconeogenesis pathway, followed by precise regulation with promoter engineering. The congruent strain showed comparable yields with ethanol as the sole substrate. Moreover, an adaptive evolution strategy was performed to enhance ethanol tolerance. As a result, we obtained the mutant strain EGG 47, and resting cell fermentation achieved a comparable P2HBD titer and yield of 66.7 ± 0.77 g L-1 and 0.87 g g-1 ethanol in a 5 L fermenter, resp. Our findings provide new insights into carbon-economic transformation from ethanol substrates into biopolymers and chems. in third-generation biorefineries.

Green Chemistry published new progress about Aureobasidium pullulans. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Chulwoo; Choi, Hyunbong; Paek, Sanghyun; Kim, Jeum-Jong; Song, Kihyung; Kang, Moon-Sung; Ko, Jaejung published the artcile< Molecular engineering of thia-bridged triphenylamine heterohelicenes as novel organic dyes for dye-sensitized solar cells>, Quality Control of 112-63-0, the main research area is thia bridged triphenylamine heterohelicene derivative dye sensitized solar cell.

Three organic sensitizers incorporating thia-bridged heterohelicene unit, thiophene-conjugate bridge, and cyanoacrylic acid were synthesized. The power conversion efficiency was quite sensitive to the substituents on heterohelicene donor group. Under standard global AM 1.5 solar conditions, the JK-206-sensitized cell gave a short-circuit photocurrent d. (Jsc) of 13.44 mA cm-2, an open-circuit voltage (Voc) of 0.71 V, and a fill factor of 0.74, corresponding to an overall conversion efficiency of 7.08%. The device based on the JK-206 with an ionic liquid electrolyte showed an excellent long-term stability. The initial efficiency of 5.6% for JK-206 slightly decreased to only 5.4% after the 1000 h light soaking at 60°.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Dye-sensitized solar cells. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hussien, Nervana; Eldin, Mai Ezz; Abdelaziz, Ahmed; Shaheen, Haitham; El-Kassas, Mohamed; Elzayat, Ibrahim; Elkhatib, Walid F.; Ahmed, Soha published the artcile< Perception and experience of oncologists regarding vaccination of cancer patients on active treatment>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is oncologist vaccination cancer coronavirus disease 2019.

The COVID-19 epidemic has wreaked havoc on individuals of all ages throughout the world. I In unprecedented time frame, its vaccination has been produced and made available to the general population. However, due to varying levels of its acceptance, vaccination did not gain widespread adoption. We aimed to measure the perception and experience of oncologists towards COVID19 vaccination in cancer patients on active therapy. A cross-sectional survey with a self-administered questionnaire was circulated among oncol. specialists in Egypt between Sept. – and Dec. 2021. A total of 83 respondents participated of which 59% had more than 10 years of experience in the oncol. field. The majority of the respondents 75 (90.4%) recommended giving the vaccine once available in case of hormonal treatment meanwhile the lowest percentage 32 (38.5%) was for anti CD20 monoclonal antibody, either as a single agent or combined with chemotherapy. Choices of 49 (59%), 46 (55%), and 43 (51.8%) to vaccinate patients on active treatment with cytotoxic chemotherapy, MoAb (except anti CD20), and immunotherapy resp. were reported. The inactivated COVID-19 virus vaccine was recommended by 39 (47%), followed by Vector vaccines in 20 (24.1%), 8 (9.6%) for the mRNA (mRNA) vaccines, while 16(19.3%) of them were undecided. Thirty-nine (47%) of the participants reported that patients on active treatment developed side effects from vaccination. The most conveyed side effects were fatigue in 34 (87%), fever or a local reaction each in 28 (71.8%), headache and myalgia equally in 19 (48.7%), and chills in 11 (28.2%), and myalgia in10 (25.6%). Strategies to address the practicality of dealing with vaccination in cancer patients are needed. Emphasis on the installation of the latest data in caring for this population and increased awareness of the services provided is crucial. Surveys are a useful tool reflecting real-world practice.

International Journal of Cancer and Biomedical Research published new progress about Antiestrogens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cain, Gary A.; Christos, Thomas E.; Johnson, Alexander L.; Pottorf, Richard S.; Confalone, Pat N.; Tam, S. William; Schmidt, William K. published the artcile< Neurotensin receptor binding and antinociceptive activity for lipophilic Nα-amido neurotensin(9-13) analogs>, Synthetic Route of 112-63-0, the main research area is lipophilic acyl neurotensin pentapeptide analog; receptor neurotensin binding pentapeptide analog; antinociceptive lipophilic acyl neurotensin pentapeptide analog.

Lipophilic Nα-acyl neurotensin(9-13) analogs RCO-X-Pro-Tyr-Ile-Leu-OH [RCO = Me3CO2C (Boc), Ac, Bz, tert-BuCO, tert-BuCH2CO, 1-AdCO, n-C7H15CO, n-C17H35CO, bicyclo[2.2.1]heptane-2-acetyl, bicyclo[3.3.0]octane-2-carbonyl, biotinyl, 4-tert-BuPhCO, 3-pyridylcarbonyl, 4-PhC6H4CO, X = Lys; RCO = Boc, 1-AdCO, X = Orn] were prepared These acylated pentapeptides exhibited good neurotensin receptor binding, as well as in vivo analgesic activity via i.c.v. and even i.v. routes of administration.

Bioorganic & Medicinal Chemistry Letters published new progress about Analgesics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boger, Dale L.; Fink, Brian E.; Hedrick, Michael P. published the artcile< Total Synthesis of Distamycin A and 2640 Analogs: A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is combinatorial library distamycin A analog binding DNA.

The development of a solution-phase synthesis of distamycin A and its extension to the preparation of 2640 analogs are described. Thus, solution-phase synthesis techniques with reaction workup and purification employing acid/base liquid-liquid extractions were used in the multistep preparation of distamycin A (8 steps, 40% overall yield) and a prototypical library of 2640 analogs providing intermediates and final products that are ≥95% pure on conventional reaction scales. The complementary development of a simple, rapid, and high-throughput screen for DNA binding affinity based on the loss of fluorescence derived from displacement of prebound ethidium bromide is disclosed which is applicable for assessing relative or absolute binding affinity to DNA homopolymers or specific sequences (hairpin oligonucleotides). Using hairpin oligonucleotides, this method permits the screening of a library of compounds against a single predefined sequence to identify high affinity binders, or the screening of a single compound against a full library of individual hairpin oligonucleotides to define its sequence selectivity. The combination permits the establishment of the complete DNA binding profile of each member of a library of compounds Screening the prototypical library provided compounds that are 1000 times more potent than distamycin A in cytotoxic assays (I, Boc = tert-butoxycarbonyl; IC50 = 29 nM, L1210), that bind to poly[dA]-poly[dT] with comparable affinity, and that exhibit an altered DNA binding sequence selectivity. Several candidates were identified which bound the five-base-pair AT-rich site of the PSA-ARE-3 sequence, and one (II, R = 4-dimethylaminobutyryl; K = 3.2 × 106 M-1) maintained the high affinity binding (K = 4.5 × 106 M-1) to the ARE-consensus sequence containing a GC base-pair interrupted five-base-pair AT-rich site suitable for inhibition of gene transcription initiated by hormone insensitive androgen receptor dimerization and DNA binding characteristic of therapeutic resistant prostate cancer.

Journal of the American Chemical Society published new progress about Combinatorial library. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics