Category: 112-63-0

Nagy, Sandor; Feher, Zsuzsanna; Kisszekelyi, Peter; Huszthy, Peter; Kupai, Jozsef published the artcile< Cinchona derivatives as sustainable and recyclable homogeneous organocatalysts for aza-Markovnikov addition>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is cinchona alkaloid organocatalyst preparation; heterocyclylalkyl ester green preparation regioselective; nitrogen heterocycle vinyl ester aza Markovnikov cinchona alkaloid catalyst.

A new application of cinchona alkaloids as organocatalysts in the synthesis of 1-(N-heterocyclyl)alkyl esters, e.g., I was reported via aza-Markovnikov addition reaction of N-heterocycles to vinyl esters. The synthesis of aza-Markovnikov adducts I possessing valuable biol. activity was thoroughly optimized. By studying the ratio of the starting materials, bases and solvents, this new and efficient protocol was achieved which was performed under mild conditions with a small excess of vinyl ester affording products I with excellent yields and high regioselectivity. This optimization reduced Sheldon’s E-factor of the reaction by 42%. Furthermore, membrane separation for catalyst recycling was assessed to further improve the sustainability of the synthesis.

New Journal of Chemistry published new progress about Addition reaction catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adams, J. Howard; Cook, Ronald M.; Hudson, Derek; Jammalamadaka, Vasu; Lyttle, Matthew H.; Songster, Michael F. published the artcile< A Reinvestigation of the Preparation, Properties, and Applications of Aminomethyl and 4-Methylbenzhydrylamine Polystyrene Resins>, HPLC of Formula: 112-63-0, the main research area is aminomethylpolystyrene resin preparation property application; benzhydrylamine resin preparation property application; solid phase peptide synthesis benzhydrylamine resin; oligonucleotide synthesis solid phase benzhydrylamine resin.

Mild, efficient conditions have been developed for the preparation of 4-methylbenzhydrylamine polystyrene (MBHA) and aminomethyl polystyrene (AMPS) resins by a two-step procedure with synthons I (R = H, 4-MeC6H4). The products possess excellent swelling characteristics and acylate readily with linkers yielding useful derivatives, which retain good swelling and reactivity. Comparative studies with these resins, and their poly(ethylene glycol) (PEG) derivatives, yield insights into the role of spacer arm and environment effects in synthesis facilitation.

Journal of Organic Chemistry published new progress about Solid phase synthesis, oligonucleotide. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Smiley, Shelby B.; Zarrinmayeh, Hamideh; Das, Sudip K.; Pollok, Karen E.; Vannier, Michael W.; Veronesi, Michael C. published the artcile< Novel therapeutics and drug-delivery approaches in the modulation of glioblastoma stem cell resistance>, Reference of 112-63-0, the main research area is review glioblastoma temozolomide stem cell drug delivery nanomedicine; CD44; CD133; CSC; GBM; aptamers; cancer stem cells; glioblastoma; idasanutlin; liposome; nanomedicine; nanoparticle; nestin; paclitaxel; solid-lipid nanoparticle; temozolomide; theranostics.

A review. Glioblastoma (GBM) is a deadly malignancy with a poor prognosis. An important factor contributing to GBM recurrence is high resistance of GBM cancer stem cells (GSCs). While temozolomide (TMZ), has been shown to consistently extend survival, GSCs grow resistant to TMZ through upregulation of DNA damage repair mechanisms and avoidance of apoptosis. Since a single-drug approach has failed to significantly alter prognosis in the past 15 years, unique approaches such as multidrug combination therapy together with distinctive targeted drug-delivery approaches against cancer stem cells are needed. In this review, a rationale for multidrug therapy using a targeted nanotechnol. approach that preferentially target GSCs is proposed with discussion and examples of drugs, nanomedicine delivery systems, and targeting moieties.

Therapeutic Delivery published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Loh, Joanna K.; Asad, Naeem; Samarakoon, Thiwanka B.; Hanson, Paul R. published the artcile< Modular, One-Pot, Sequential Aziridine Ring Opening-SNAr Strategy to 7-, 10-, and 11-Membered Benzo-Fused Sultams>, Product Details of C19H34O2, the main research area is aziridine ring opening intramol nucleophilic aromatic substitution; medium sized benzo fused sultam preparation.

The generation of common and stereochem. rich medium-sized benzo-fused sultams via complementary pairing of heretofore-unknown (o-fluoroaryl)sulfonyl aziridine building blocks with an array of amino alcs./amines in a modular one-pot, sequential protocol using an aziridine ring opening and intramol. nucleophilic aromatic substitution is reported. The strategy employs a variety of amino alcs./amines and proceeds with 6 + 4/6 + 5 and 6 + 1 cycloetherification pathways in a highly chemo- and regioselective fashion to obtain skeletally and structurally diverse, polycyclic, 10- to 11- and 7-membered benzo-fused sultams, e.g. I, for broad-scale screening.

Journal of Organic Chemistry published new progress about Aziridines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Qi; Rao, Sijia; Vummaleti, Sai Vikrama Chaitanya; Poh, Eng Tuan; Dai, Wenrui; Cui, Xinhang; Wu, Jishan; Zhang, Jia; Chen, Wei published the artcile< High-performance Li-O2 batteries enabled by dibenzo-24-crown-8 aldehyde derivative as electrolyte additives>, Synthetic Route of 112-63-0, the main research area is lithium ion battery electrolyte additive aldehyde derivative.

Aprotic Li-O2 batteries (LOB) with high theor. energy d. usually experience cathode clogging by insoluble Li2O2, along with high charge overpotential from its insulating nature. A dibenzo-24-crown-8 aldehyde derivative (DB24C8A) is employed as an additive to enhance the binding strength with Li+, hence promoting the solubility of Li2O2. The generated [DB24C8A•Li+] avoids the parasitic reactions caused by reactive O2-. Thus, the LOB achieves a large discharge capacity of 6939 mAh g-1 at 200 mA g-1 and a high Li2O2 yield (≈93%). Moreover, DB24C8A facilitates the efficient decomposition of Li2O2 via Li+ coordination during the charge process, reducing the charge overpotential to 0.77 V and prolonging the lifetime of the LOB over 213 cycles at 1000 mAh g-1 and 500 mA g-1. This work provides a novel approach to boost the performance of LOB by incorporation of crown ether-based compounds to regulate the Li2O2 growth and decomposition pathway.

Advanced Energy Materials published new progress about Battery electrolytes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chmielewski, Frank-M.; Goetz, Klaus-P. published the artcile< Metabolites in Cherry Buds to Detect Winter Dormancy>, Category: esters-buliding-blocks, the main research area is cherry bud metabolite winter dormancy; Prunus avium L.; beginning of ontogenetic development; cv. ‘Summit’; endodormancy release; global metabolite profiling; phenological modelling; plant metabolites; sweet cherry; winter dormancy.

Winter dormancy is still a “”black box”” in phenol. models, because it evades simple observation. This study presents the first step in the identification of suitable metabolites which could indicate the timing and length of dormancy phases for the sweet cherry cultivar ′Summit′. Global metabolite profiling detected 445 named metabolites in flower buds, which can be assigned to different substance groups such as amino acids, carbohydrates, phytohormones, lipids, nucleotides, peptides and some secondary metabolites. During the phases of endo- and ecodormancy, the energy metabolism in the form of glycolysis and the tricarboxylic acid (TCA) cycle was shut down to a min. However, the beginning of ontogenetic development was closely related to the up-regulation of the carbohydrate metabolism and thus to the generation of energy for the growth and development of the sweet cherry buds. From the 445 metabolites found in cherry buds, seven were selected which could be suitable markers for the ecodormancy phase, whose duration is limited by the date of endodormancy release (t1) and the beginning of ontogenetic development (t1*). With the exception of abscisic acid (ABA), which has been proven to control bud dormancy, all of these metabolites show nearly constant intensity during this phase.

Metabolites published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guan, Tianyue; Li, Shuoshuo; Guan, Qijie; Shi, Jin-Song; Lu, Zhen-Ming; Xu, Zheng-Hong; Geng, Yan published the artcile< Spore Powder of Paecilomyces hepiali Shapes Gut Microbiota to Relieve Exercise-Induced Fatigue in Mice>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Paecilomyces fatigue gut microbiota spore powder; Paecilomyces hepiali; anti-fatigue; functional food; gut microbiota; spore.

Paecilomyces hepiali, a fungal strain isolated from natural Ophiocordyceps sinensis, contains similar pharmacol. active components, has been used widely as a substitute of O. sinensis in functional food and medicine. However, the components and anti-fatigue effects of P.hepiali spores and their mechanisms of action are largely unknown. Here, we compared the chem. composition in P.hepiali spore (HPS) and mycelium (HPM) by liquid chromatog. with tandem mass spectrometry anal. We found 85 metabolites with significant differences, and HPS contains more L-Malic acid, Oxalacetic acid, Fructose-1,6-bisphosphate, and L-Arginine than HPM. Then we evaluated their anti-fatigue effects and regulatory effects on the gut microbiota in mice. The forced swimming time (SW) was only significantly increased in HPS groups: the high and low dose of the HPS group was 101% and 72% longer than the control group, resp. Both HPS and HPM treatment decreased lactic acid, blood urea nitrogen, creatine kinase while increased lactate dehydrogenase (LDH) levels in the blood. Moreover, mice treated with HPS and HPM showed less skeletal muscle fiber spacing and breakage. The relative abundance of Alistips, Eubacterium, Bacterium, Parasutterella, and Olsenella in the gut microbiota of the HPS group was higher than that in the HPM group through 16S rRNA gene sequencing anal. These changes may be related to the regulation of nucleotide, amino acid, and carbohydrate metabolism Correlation anal. between the gut microbiota and fatigue-related indicators suggested that Alistips, Clostridium, Akkermansia, Olsenella, and Lactobacillus were pos. correlated with the SW and LDH content. Our findings demonstrated that HPS has beneficial anti-fatigue effects by regulating gut microbiota.

Nutrients published new progress about Actinobacteria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Dilan; Kodikara, Mahesh S.; Morshedi, Mahbod; Moxey, Graeme J.; Wang, Huan; Wang, Genmiao; Quintana, Cristobal; Zhang, Chi; Stranger, Rob; Cifuentes, Marie P.; Humphrey, Mark G. published the artcile< Syntheses and Optical Properties of Azo-Functionalized Ruthenium Alkynyl Complexes>, COA of Formula: C19H34O2, the main research area is azo functionalized ruthenium alkynyl complex preparation crystal mol structure; electrochem redox azo functionalized ruthenium alkynyl complex; alkene ligands; alkyne ligands; electrochemistry; nonlinear optics; transition metals.

The syntheses of trans-[Ru(CC-1-C6H4-4-N:N-1-C6H4-4-CC-1-C6H4-4-NO2)Cl(L2)2] (L2 = dppm (Ru1), dppe) (Ru2), trans-[Ru(CC-1-C6H4-4-N:N-1-C6H4-4-(E)-CH:CH-1-C6H4-4-NO2)Cl(dppe)2] (Ru3), and trans-[Ru(CC-1-C6H4-4-(E)-CH:CH-1-C6H2-2,6-Et2-4-N:N-1-C6H4-4-NO2)Cl(dppe)2] (Ru4) are reported, together with those of precursor alkynes. Their electrochem. properties were assessed by cyclic voltammetry (CV), linear optical and quadratic nonlinear optical (NLO) properties assayed by UV/Vis-NIR spectroscopy and hyper-Rayleigh scattering studies at 1064 nm, resp., and their linear optical properties in the formally RuIII state examined by UV/Vis-NIR spectroelectrochem. These data were compared to those of analogs with E-ene and yne linkages in place of the azo groups. Computational studies using time-dependent d. functional theory were undertaken on model compounds (Ru2′-Ru4′) to rationalize the optical behavior of the exptl. complexes.

ChemPlusChem published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dai, Shiyao; Wu, Jinchuan; Wang, Zunsheng; Chen, Yongzheng; Li, Zhi published the artcile< Highly chemo- and regio-selective hydroxylations of o- and m-substituted toluenes to benzyl alcohols with Cellulosimicrobium cellulans EB-8-4>, Product Details of C19H34O2, the main research area is Cellulosimicrobium hydroxylations substituted toluene benzyl alc.

Highly chemo- and regio-selective benzylic hydroxylations of o- and m-substituted toluenes were achieved with the easily available and easy-to-handle resting cells of Cellulosimicrobium cellulans EB-8-4 as biocatalysts, giving the corresponding benzyl alcs. as single product. Benzyl alcs. were obtained in 78-94% yield, demonstrating the first green, clean, and simple method for the preparation of benzyl alcs. via hydroxylations. Biotransformation of 4-methylbenzyl chloride with the same strain gave 4-methylbenzyl alc. in 67-81% yield, suggesting a novel dehalogenation activity of the cells and providing a novel, green, and efficient method for the preparation of 4-methylbenzyl alc. as well as the application potential in biodegradation of chlorine-containing aromatics

Tetrahedron published new progress about Biochemical reaction kinetics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lasolle, Helene; Vasiljevic, Alexandre; Jouanneau, Emmanuel; Ilie, Mirela Diana; Raverot, Gerald published the artcile< Aggressive corticotroph tumors and carcinomas>, Product Details of C19H34O2, the main research area is Cushing’s disease; aggressive pituitary tumor; corticotroph tumor; pituitary carcinoma; temozolomide.

Pituitary tumors are generally benign, although in rare cases aggressive pituitary tumors (APTs) and carcinomas present important diagnostic and therapeutic challenges and are associated with a high mortality rate. Almost half of these APTs and carcinomas are corticotroph tumors, suggesting a specific prognosis. Clin., pathol. and mol. prognostic markers are limited and do not allow early management of these tumors. Temozolomide remains the first-line treatment once a diagnosis of aggressive pituitary tumor or carcinoma has been made. Novel alternative treatments exist, including immune checkpoint inhibitors, which can be used in the case of temozolomide treatment failure. The aim of this review is to present the clin., pathol. and mol. characteristics of aggressive corticotroph tumors and carcinomas, and to describe the results obtained with currently available treatments.

Journal of Neuroendocrinology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics