Category: 112-63-0

Liu, Xing-Ya; Xie, Rui-Yang; Chen, Tao; He, Lei; Wang, Ting; Liao, Wang; Liu, Zhi-Guo; Chen, Ming-Jun published the artcile< Improvement of polyurethane film strength by H-bonding crosslinking with hydroxylated melamine>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hydroxylated melamine filler aqueous polyurethane film strength H bonding.

Due to the condensation reaction of hydroxylated melamine mols. is possible to take place in the whole pH range, especially in acidic water medium or at high temperature, losing its water solubility In this work, freeze drying perfectly removes water at pretty low temperature, avoiding condensation reaction of hydroxylated melamine. Therefore, a hydroxylated melamine in solid form (MOH-S) was prepared It can be not only dissolved in water after storing for 180 days but also well dispersed in waterborne polyurethane emulsion. The addition of hydroxylated melamine significantly improves the tensile strength of polyurethane films by 170%. After soaking the films in water for 24 h, the tensile strength of WPU/30%MOH-S film lost only 6%, but 34% loss for the neat. Fourier transform IR spectroscopy peak fitting demonstrates that the H-bonding degree of N-H in WPU/30%MOH-S film is 20.72 that is much higher than 3.33 in neat WPU. This indicates that H-bonding cross-linked structure is formed between polyurethane chains and hydroxylated melamine mols. This work provides an effective strategy for preparing stable hydroxylated melamine and enhancing the strength of polyurethane film.

Journal of Applied Polymer Science published new progress about Condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mahran, M. R.; Sidky, M. M.; Wamhoff, H. published the artcile< Photolysis of 2-(2-furyl)benzimidazole (Fuberidazole)>, Synthetic Route of 112-63-0, the main research area is photolysis benzimidazole furyl.

The title photolysis in MeOH in the presence and in the absence of singlet O2 was studied. I, II, and III were isolated and identified in both reactions.

Chemosphere published new progress about Photolysis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Daniarta, Sindu; Kolasinski, Piotr; Imre, Attila R. published the artcile< Thermodynamic efficiency of trilateral flash cycle, organic Rankine cycle and partially evaporated organic Rankine cycle>, COA of Formula: C19H34O2, the main research area is evaporated organic Rankine cycle thermodn efficiency.

Emerging and promising ways of utilizing any heat sources from geothermal, solar, combustion, and industrial waste heat may be the application of power plants that are operating according to conventional Rankine cycle (RC), organic Rankine cycle (ORC), trilateral flash cycle (TFC) employing different types of expansion (i.e., volumetric expanders or turbine). In this paper, the studies about partially evaporated ORC (PE-ORC) was carried out; furthermore, it reports on novel results related to the comparison of thermodn. efficiency of TFC, ORC and PE-ORC. These results were obtained by modeling the system operations computed with MATLAB and the thermal properties library taken from CoolProp and REFPROP. The calculation was based on selected different types of working fluid classified by A, C, Z, M, N points (conventionally categorized by dry, wet, and isentropic working fluids) and the upper-lower operating temperature The obtained results explain a new point of view on the efficiency of TFC, ORC and PE-ORC plants, that in some of the conditions (i.e., one can find certain combinations of working fluid quality, maximal and minimal cycle temperature), the efficiency of PE-ORCs outperforms TFC and ORC. It means that at certain temperature ranges and conditions when starting the expansion step from a partially evaporated state, it may be recommended to improve the performance of the cycle. It seems that obtained results offer new insight to scientists and engineers in designing the thermal power plant working under a subcritical cycle with high-temperature heat sources or a low-temperature heat sinks employing the selection of working fluids and different types of expanders.

Energy Conversion and Management published new progress about Engineers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Yi-fan; Yang, Jiashuo; Zhao, Fengguang; Lin, Ying; Han, Shuangyan published the artcile< Comparative transcriptome and metabolome analyses reveal the methanol dissimilation pathway of Pichia pastoris>, Product Details of C19H34O2, the main research area is Pichia methanol dissimilation pathway transcriptome metabolome; Dissimilation pathway; Formaldehyde; Glutathione; Methanol metabolism; Oxidative phosphorylation.

Pichia pastoris (Komagataella phaffii) is a model organism widely used for the recombinant expression of eukaryotic proteins, and it can metabolize methanol as its sole carbon and energy source. Methanol is oxidized to formaldehyde by alc. oxidase (AOX). In the dissimilation pathway, formaldehyde is oxidized to CO2 by formaldehyde dehydrogenase (FLD), S-hydroxymethyl glutathione hydrolase (FGH) and formate dehydrogenase (FDH). The transcriptome and metabolome of P. pastoris were determined under methanol cultivation when its dissimilation pathway cut off. Firstly, Δfld and Δfgh were significantly different compared to the wild type (GS115), with a 60.98% and 23.66% reduction in biomass, resp. The differential metabolites between GS115 and Δfld were mainly enriched in ABC transporters, amino acid biosynthesis, and protein digestion and absorption. Secondly, comparative transcriptome between knockout and wild type strains showed that oxidative phosphorylation, glycolysis and the TCA cycle were downregulated, while alc. metabolism, proteasomes, autophagy and peroxisomes were upregulated. Interestingly, the down-regulation of the oxidative phosphorylation pathway was pos. correlated with the gene order of dissimilation pathway knockdown. In addition, there were significant differences in amino acid metabolism and glutathione redox cycling that raised our concerns about formaldehyde sorption in cells. This is the first time that integrity of dissimilation pathway anal. based on transcriptomics and metabolomics was carried out in Pichia pastoris. The blockage of dissimilation pathway significantly down-regulates the level of oxidative phosphorylation and weakens the methanol assimilation pathway to the point where deficiencies in energy supply and carbon fixation result in inefficient biomass accumulation and genetic replication. In addition, transcriptional upregulation of the proteasome and autophagy may be a stress response to resolve formaldehyde-induced DNA-protein crosslinking.

BMC Genomics published new progress about Absorption (protein). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fawdon, Jack; Ihli, Johannes; Mantia, Fabio La; Pasta, Mauro published the artcile< Characterising lithium-ion electrolytes via operando Raman microspectroscopy>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is lithium ion electrolyte operando raman microspectroscopy.

Knowledge of electrolyte transport and thermodn. properties in Li-ion and beyond Li-ion technologies is vital for their continued development and success. Here, we present a method for fully characterizing electrolyte systems. By measuring the electrolyte concentration gradient over time via operando Raman microspectroscopy, in tandem with potentiostatic electrochem. impedance spectroscopy, the Fickian “”apparent”” diffusion coefficient, transference number, thermodn. factor, ionic conductivity and resistance of charge-transfer were quantified within a single exptl. setup. Using lithium bis(fluorosulfonyl)imide (LiFSI) in tetraglyme (G4) as a model system, our study provides a visualisation of the electrolyte concentration gradient; a method for determining key electrolyte properties, and a necessary technique for correlating bulk intermol. electrolyte structure with the described transport and thermodn. properties.

Nature Communications published new progress about Dielectric spectroscopy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Feng, Qian; Liu, Huan; Peng, Zhigang; Zheng, Yong published the artcile< Synthesis, characterization and evaluation of long-acting hyperbranched cationic polymer clay stabilizer used in water flooding>, Computed Properties of 112-63-0, the main research area is polymer clay stabilizer water flooding.

In the process of waterflooding development, it is of great importance to prevent the clay from hydration swelling and migration dispersion for protecting the formation and improving the water flooding efficiency. For those reasons, we successfully synthesized a cationic clay stabilizer (HBP-QAT) through melting polycondensation and cationic modification with maleic anhydride, diethanolamine, epichlorohydrin, triethylamine, and trimethylolpropane as monomers and p-toluene sulfonic acid as a catalyst. The chem. structure, cation degree, and mol. weight of HBP-QAT were studied by using FTIR, 1H NMR, sodium tetraphenylborate (STBP) back titration, and gel permeation chromatog. (GPC). The obtained results showed that HBP-QAT was a hyperbranched unsaturated polyester amide with a low mol. weight and a high cation degree, with corresponding values of 28400, and 44.2%, resp. The clay stability and durability of HBP-QAT were evaluated by linear anti-swelling, water flushing, and cutting rolling recovery tests. The obtained results showed that HBP-QAT has an excellent anti-washing capacity and a long-term inhibition effect. The initial anti-swelling rate of 1.0 wt% HBP-QAT reached 92.37%, and the anti-swelling rate of 1.0 wt% HBP-QAT also remained at 85% after flushing 10 times with water. Besides, the two cutting rolling recoveries exceed 72%. Most importantly, the inhibition mechanism of HBP-QAT was studied by zeta potential, X-ray diffraction (XRD), XPS, scanning electron microscope (SEM), and contact angles analyses, and thus we proposed an inhibition mechanism, presenting as follows. HBP-QAT inhibited the clay hydration swelling by neutralizing neg. charges on the surface of the clay particles to compress the elec. double layer, strongly adsorbing on the surface of the clay particles, and forming a waterproof polymer membranes, restraining water of intrusion into the clay interlayer.

Polymer Testing published new progress about Contact angle. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ueno, Daiki; Vasquez, Juan C; Sule, Amrita; Liang, Jiayu; van Doorn, Jinny; Sundaram, Ranjini; Friedman, Sam; Caliliw, Randy; Ohtake, Shinji; Bao, Xun; Li, Jing; Ye, Huihui; Boyd, Karla; Huang, Rong Rong; Dodson, Jack; Boutros, Paul; Bindra, Ranjit S; Shuch, Brian published the artcile< Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy.>, Application of C19H34O2, the main research area is FH; PARP inhibitor; SDHB; renal cell carcinoma; temozolomide.

Loss-of-function mutations in genes encoding the Krebs cycle enzymes Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) induce accumulation of fumarate and succinate, respectively and predispose patients to hereditary cancer syndromes including the development of aggressive renal cell carcinoma (RCC). Fumarate and succinate competitively inhibit αKG-dependent dioxygenases, including Lysine-specific demethylase 4A/B (KDM4A/B), leading to suppression of the homologous recombination (HR) DNA repair pathway. In this study, we have developed new syngeneic Fh1- and Sdhb-deficient murine models of RCC, which demonstrate the expected accumulation of fumarate and succinate, alterations in the transcriptomic and methylation profile, and an increase in unresolved DNA double-strand breaks (DSBs). The efficacy of poly ADP-ribose polymerase inhibitors (PARPis) and temozolomide (TMZ), alone and in combination, was evaluated both in vitro and in vivo. Combination treatment with PARPi and TMZ results in marked in vitro cytotoxicity in Fh1- and Sdhb-deficient cells. In vivo, treatment with standard dosing of the PARP inhibitor BGB-290 and low-dose TMZ significantly inhibits tumor growth without a significant increase in toxicity. These findings provide the basis for a novel therapeutic strategy exploiting HR deficiency in FH and SDH-deficient RCC with combined PARP inhibition and low-dose alkylating chemotherapy.

Oncotarget published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abraham, Michael H. published the artcile< Hydrogen bonding. XXVII. Solvation parameters for functionally substituted aromatic compounds and heterocyclic compounds, from gas-liquid chromatographic data>, HPLC of Formula: 112-63-0, the main research area is solvation parameter calculation aromatic compound chromatog; gas chromatog determination solute polarizability parameter; hydrogen bond solvation parameter gas chromatog; heterocyclic compound solvation parameter gas chromatog; retention equation gas chromatog aromatic compound; nonpolar stationary phase gas chromatog retention; linear free energy relationship gas chromatog.

The truncated solvation equation log SP = c + rR2 + l(log L16) was applied to a very large number of sets of gas-liquid chromatog. data on nonpolar stationary phases. The parameter log SP (SP = a solvation parameter) can be log VG (specific retention volume at the column temperature) or can be the retention index I; R2 is the excess molar refraction of the solute and c, r and l are constants A set of solutes of known log L16 values is used to construct the equation, and then further values of log L16 can be obtained for any solute of known log SP value. In this way, new log L16 values for > 1000 solutes were obtained. Known log L16 and R2 values are substituted into the equation log SP = c + rR2 + sπH2 + l(log L16) (s is a constant) so that it can be applied to GLC data on polar non-acidic stationary phases, and the dipolarity/polarizability parameter πH2 is determined in a similar fashion. Values of πH2 for > 700 compounds are reported, including those for functionally substituted aromatic compounds and heterocyclic compounds The πH2 parameter is a blend of dipolarity/polarizability, and cannot be calculated simply from solute dipole moments.

Journal of Chromatography published new progress about Alcohols, unsaturated Role: PRP (Properties). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joshi, Anuradha S.; Shah, Rajvi K.; Suthar, Mona H.; Keharia, Unnati H. published the artcile< Evaluation of rationality of antimicrobial and antidiarrheal fixed dose combination available in Indian market>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is tenofovir antimicrobial fixed dose combination.

Literature reports growing concern on ever-burgeoning list of irrational fixed dose combinations (FDCs) flooding the Indian market. Current study addresses availability and rationality of two most common group of FDC used clin., i.e., antimicrobial (AM) and antidiarrheal (AD). Anal. of rationality of AM and AD, FDCs, and available in Indian market. AM and AD, FDCs listed in Indian Drug Review 2017 and 2018, were analyzed using a validated eight- point criteria tool. Out of 138 FDCs, 102 (73.91%) belonged to AM group and 36 (26.08%) belonged to AD group. Out of 102 AM FDC′s, 46 (45.09%) were rational and 56 (54.90%) were irrational. Out of 36 AD, FDCs, 10 (27.77%) were rational and 26 (72.22%) were irrational. Mean rationality score of AM and AD, FDC′s, was (7.72 ± 0.33) and (7.5 ± 0.78), resp. Anal. reveals that a number of FDCs available in Indian market is irrational.

National Journal of Physiology, Pharmacy and Pharmacology published new progress about Antimicrobial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Yi; Zhang, Heng-Xia; Zeng, Jun-Liang; Nie, Jing; Ma, Jun-An published the artcile< Organocatalytic Asymmetric Decarboxylative Amination of β-Keto Acids: Access to Optically Active α-Amino Ketones and 1,2-Amino Alcohols>, Application of C19H34O2, the main research area is asym decarboxylative amination keto acid; amino ketone preparation; preparation amino alc.

An organocatalytic asym. decarboxylative amination reaction of β-keto acids is described. Under mild reaction conditions, a series of chiral α-amino ketones were obtained in good to high yields (up to 99%) and enantioselectivities (up to 95% ee). A chiral 1,2-amino alc. was synthesized from the corresponding decarboxylative amination product in several steps without loss of enantioselectivity.

Organic Letters published new progress about Amination (decarboxylative). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics