Category: 112-63-0

Gerlach, Samantha L.; Dunlop, Rachael A.; Metcalf, James S.; Banack, Sandra A.; Cox, Paul Alan published the artcile< Cyclotides Chemosensitize Glioblastoma Cells to Temozolomide>, Application In Synthesis of 112-63-0, the main research area is cyclotides chemosensitizer glioblastoma temozolomide.

Glioblastoma multiforme (GBM) is the most aggressive cancer originating in the brain, with a median survival of 12 mo. Most patients do not respond to or develop resistance to the only effective chemotherapeutic drug, temozolomide (TMZ), used to treat gliomas. Novel treatment methods are critically needed. Cyclotides are plant peptides that may be promising adjuvants to TMZ chemotherapy. They exhibit antitumor activity and chemosensitize cells to doxorubicin in breast cancer studies. During this research, we optimized cyclotide isolation techniques, and several cyclotides (CyO2, CyO13, kalata B1, and varv peptide A) exhibited dose-dependent cytotoxicity in MTT assays with IC50 values of 2.15-7.92 μM against human brain astrocytoma cells (U-87 MG) and human bone marrow derived neuroblastoma cells (SH-SY5Y). CyO2 and varv peptide A increased TMZ-induced cell death in U-87 MG cultures alone and when coexposed with CyO2 or varv peptide A plus TMZ. Phase contrast microscopy of glioblastoma cells exposed to cyclotides alone and coexposed to TMZ indicated shrunken, granular cells with blebbing, and the most pronounced effects were observed with coexposure treatments of cyclotides and TMZ. Cumulative results provide the proof-of-concept that cyclotides may enhance TMZ chemotherapy, and in vivo pharmacokinetic investigations of cyclotides are warranted with respect to GBM.

Journal of Natural Products published new progress about Antitumor agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Rui; Cheng, Jun; Song, Wenlu; Qiu, Yi; Guo, Hao; Yang, Weijuan published the artcile< Physicochemical characterizations of microalgal methyl esters extracted with hexane and refined by vacuum distillation at different temperatures>, Related Products of 112-63-0, the main research area is hexane microalgal methyl ester vacuum distillation.

To prepare quality biodiesel from microalgal lipids in pilot-scale reactors, Me esters from microalgal cells were extracted with hexane after direct transesterification and then refined by vacuum distillation The refined Me esters were comprehensively characterized via gas chromatog.-mass spectrometry, Fourier transform IR spectroscopy, NMR, and thermogravimetric anal. The Me ester refined at 255°C-259°C was found to be the ideal fuel with a high fatty acid Me ester content of 94.6%, a low combustion activation energy of 42.1 kJ/mol, and a proper carbon-chain length distributed in C14-C18. Impurities extracted with hexane, such as alkanes and short-chain esters, were separated at 105°C-254°C owing to their low polarity and mol. weight Highly unsaturated Me esters with a long carbon-chain were collected at 260°C-280°C owing to their high b.p. Separation of alkanes, short-chain esters, and highly unsaturated Me esters through vacuum distillation effectively improved the properties of the Me esters extracted with hexane as a fuel and enhanced the economic feasibility of microalgal lipids.

Fuel published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Verma, Vipin Kumar; Prakash, Om; Kumar, R. Shiva Raj; Rani, Kumari Vandana; Sehgal, Neeta published the artcile< Water hyacinth (Eichhornia crassipes) leaves enhances disease resistance in Channa punctata from Vibrio harveyi infection>, Electric Literature of 112-63-0, the main research area is Channa Vibrio Eichhornia infection leaf disease resistance.

Channa punctata, Indian spotted snakehead, has a great economic value in south and south-east Asia being an important protein source for humans. Fish cultures are affected due to various bacterial and viral infections. Vibrio harveyi is a fish pathogenic bacteria which causes several outbreaks throughout the world and leads to huge mortalities. In this study, leaves of Eichhornia crassipes (water hyacinth) were used to investigate its immunostimulatory potential in Channa punctata. The immunostimulatory effects of water hyacinth leaves were studied in fish fed with 2.5% and 5% supplementary feed (exptl. groups) in comparison to normal feed (control groups). Gas chromatog. mass spectrometry (GC-MS) anal. of E. crassipes methanol extract showed presence of various components which have immunostimulatory, antioxidant, antibacterial, and anti-inflammatory activities. The antibacterial activity, antioxidant potential, and presence of phenol and flavonoids in methanol and ethanol extracts supported its use in fish feed. The healthy acclimatized fish were challenged with V. harveyi weekly. Liver function tests, alk. phosphatase levels, and Ig content in the exptl. groups were improved with respect to those in the pos. control group. The spleen and head kidney were obtained at the final day of experiment, and macrophages were isolated; higher percentage of phagocytosis and phagocytic index indicated enhanced cell-mediated immune response in fish due to supplemented feed. Plant-infused feed with leaves of E. crassipes can be recommended as a regular feed supplement to enhance fish immunity and disease resistance against the V. harveyi infection.

Journal of Basic & Applied Zoology published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balmaseda, Aitor; Rozes, Nicolas; Bordons, Albert; Reguant, Cristina published the artcile< Molecular adaptation response of Oenococcus oeni in non-Saccharomyces fermented wines: A comparative multi-omics approach>, Formula: C19H34O2, the main research area is Saccharomyces Metschnikowia Torulaspora Oenococcus carbohydrate amino acid Hsp20 wine; Malolactic fermentation; Non-Saccharomyces; Oenococcus oeni; Proteomics; Transcriptomics; Wine.

Oenococcus oeni is the main agent responsible for malolactic fermentation (MLF) in wine. This usually takes place in red wines after alc. fermentation (AF) carried out by Saccharomyces cerevisiae. In recent years, there is an increasing interest in using non-Saccharomyces yeast, usually in combination with S. cerevisiae, to improve wine quality. Current studies report a stimulatory effect of non-Saccharomyces on MLF, generally related to a decrease in the inhibitor compounds found in wine. In this work, we followed a comparative multi-omics approach, including transcriptomic and proteomic anal., to study the mol. adaptation of O. oeni in wines fermented with Torulaspora delbrueckii and Metschnikowia pulcherrima, two of the most frequently used non-Saccharomyces, in sequential inoculation with S. cerevisiae. We compared the results to the adaptation of O. oeni in S. cerevisiae wine to determine the main changes arising from the use of non-Saccharomyces. The duration of MLF was shortened when using non-Saccharomyces, to half the time with T. delbrueckii and to a quarter with M. pulcherrima. In this work, we observed for the first time how O. oeni responds at mol. level to the changes brought about by non-Saccharomyces. We showed a differential adaptation of O. oeni in the wines studied. In this regard, the main mol. functions affected were amino acid and carbohydrate transport and metabolism, from which peptide metabolism appeared as a key feature under wine-like conditions. We also showed that the abundance of Hsp20, a well-known stress protein, depended on the duration time. Thus, the use of non-Saccharomyces reduced the abundance of Hsp20, which could mean a less stressful wine-like condition for O. oeni.

International Journal of Food Microbiology published new progress about Adaptation, microbial. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chan, Pui Ying; Phillips, Melissa M.; Ellis, Stephen; Johnston, Amanda; Feng, Xiaoxing; Arora, Amit; Hay, Gordon; Cohen, Victoria M. L.; Sagoo, Mandeep S.; Bomalaski, John S.; Sheaff, Michael T.; Szlosarek, Peter W. published the artcile< A Phase 1 study of ADI-PEG20 (pegargiminase) combined with cisplatin and pemetrexed in ASS1-negative metastatic uveal melanoma>, COA of Formula: C19H34O2, the main research area is pemetrexed cisplatin ADIPEG20 anticancer agent metastatic uveal melanoma; ADI-PEG20; ASS1; arginine auxotrophy; cisplatin; pemetrexed; uveal melanoma.

Metastatic uveal melanoma (UM) is a devastating disease with few treatment options. We evaluated the safety, tolerability and preliminary activity of arginine depletion using pegylated arginine deiminase (ADI-PEG20; pegargiminase) combined with pemetrexed (Pem) and cisplatin (Cis) chemotherapy in a phase 1 dose-expansion study of patients with argininosuccinate synthetase (ASS1)-deficient metastatic UM. Eligible patients received up to six cycles of Pem (500 mg/m2) and Cis (75 mg/m2) every 3 wk plus weekly i.m. ADI (36 mg/m2), followed by maintenance ADI until progression (NCT02029690). Ten of fourteen ASS1-deficient patients with UM liver metastases and a median of one line of prior immunotherapy received ADIPemCis. Only one ≥ grade 3 adverse event of febrile neutropenia was reported. Seven patients had stable disease with a median progression-free survival of 3.0 mo (range, 1.3-8.1) and a median overall survival of 11.5 mo (range, 3.2-36.9). Despite anti-ADI-PEG20 antibody emergence, plasma arginine concentrations remained suppressed by 18 wk with a reciprocal increase in plasma citrulline. Tumor rebiopsies at progression revealed ASS1 re-expression as an escape mechanism. ADIPemCis was well tolerated with modest disease stabilization in metastatic UM. Further investigation of arginine deprivation is indicated in UM including combinations with immune checkpoint blockade and addnl. anti-metabolite strategies.

Pigment Cell & Melanoma Research published new progress about Antimetabolites. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Krajewska, Anna M.; Powers, John J. published the artcile< Isolation of naturally occurring capsaicinoids by reversed-phase low-pressure liquid chromatography>, Synthetic Route of 112-63-0, the main research area is low pressure liquid chromatog capsaicinoid; reversed phase liquid chromatog capsaicinoid.

A reversed-phase low-pressure liquid chromatog. method is described for isolation of major capsaicinoids, i.e., capsaicin  [404-86-4], dihydrocapsaicin  [19408-84-5], nordihydrocapsaicin  [28789-35-7], and homodihydrocapsaicin  [20279-06-5]. The stationary phase was octadecyl-silica (40 μm), the mobile phase was MeOH-H2O, and N from a cylinder served as a driving force for the mobile phase. To sep. nordihydrocapsaicin and capsaicin, an intermediate bromination step with pyridinium bromide perbromide  [39416-48-3] was required. This method is simple and less costly than preparative-scale HPLC.

Journal of Chromatography published new progress about Capsaicinoids Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ham, Jin Su; Park, Bohyun; Son, Mina; Roque, Jose B.; Jurczyk, Justin; Yeung, Charles S.; Baik, Mu-Hyun; Sarpong, Richmond published the artcile< C-H/C-C Functionalization Approach to N-Fused Heterocycles from Saturated Azacycles>, SDS of cas: 112-63-0, the main research area is indolizidine preparation diastereoselective; hydroxy lactam preparation diastereoselective rhodium catalyst; ketoamide preparation Norrish Yang photochem.

The synthesis of substituted indolizidines and related N-fused bicycles e.g., 1R,2S,8aS/1R,2R,8aS-I from simple phenyl(2-piperidinyl)methanone hydrochloride through sequential C-H and C-C bond functionalizations was reported. Inspired by the Norrish-Yang Type II reaction, C-H functionalization of azacycles is achieved by forming α-hydroxy-β-lactams e.g., II from precursor α-ketoamide derivatives RC(O)C(O)C6H5 (R = piperidin-1-yl, morpholin-4-yl, 3-azaspiro[5.5]undecan-3-yl, etc.) under mild, visible light conditions. Selective cleavage of the distal C(sp2)-C(sp3) bond in α-hydroxy-β-lactams e.g., II using a Rh-complex leads to α-acyl intermediates which undergo sequential Rh-catalyzed decarbonylation, 1,4-addition to an electrophile, and aldol cyclization, to afford N-fused bicycles including indolizidines. Computational studies provide mechanistic insight into the observed positional selectivity of C-C cleavage, which depends strongly on the groups bound to Rh trans to the phosphine ligand.

Journal of the American Chemical Society published new progress about 1,4-Addition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russell, Glen A.; Ros, Francisco; Hershberger, J.; Tashtoush, Hasan published the artcile< Electron transfer processes. 30. Participation of anions of dialkyl phosphites and thiophosphites in aliphatic SRN1 reactions>, COA of Formula: C19H34O2, the main research area is phosphite nitrous compound reaction; thiophosphite nitrous compound reaction; nitrous compound phosphite reaction; phosphonate nitroalkyl; thiophosphonate nitroalkyl; phosphate alkyl.

Dialkyl phosphite or thiophosphite anions react with 2-chloro- or 2-(p-tolylsulfonyl)-2-nitropropane, p-nitrobenzyl chloride, and α,α-dimethyl-p-nitrobenzyl chloride to form, in a free radical chain process, the α-nitroalkyl or p-nitrobenzyl phosphonates or thiophosphonates which may be reduced to the amino derivatives 2,2-Dinitropropane reacts with dialkyl phoshite or di-Me thiophosphite ions to form the dialkyl phosphate or thiophosphate esters of acetone oxime. The relative reactivities of a series of anions towards (O2N)Me2C•, p-O2C6H4CH2• and p-O2NC6H4CMe2• are reported.

Journal of Organic Chemistry published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Valea, Ana; Sandru, Florica; Petca, Aida; Dumitrascu, Mihai Cristian; Carsote, Mara; Petca, Razvan-Cosmin; Ghemigian, Adina published the artcile< Aggressive prolactinoma (review)>, COA of Formula: C19H34O2, the main research area is review prolactin succinate dehydrogenase AIP temozolomide ipilimumab aggressive prolactinoma; aggressive pituitary tumor; aggressive prolactinoma; cabergoline; hypophysectomy; menses; menstrual cycle; pituitary carcinoma; prolactin; prolactinoma; temozolomide.

A review. Aggressive prolactinoma (APRL) is a subgroup of aggressive pituitary tumors (accounting for 10% of all hypophyseal neoplasia) which are defined by: invasion based on radiol. and/or histol. features, a higher proliferation profile when compared to typical adenomas and rapidly developing resistance to standard medication/protocols in addition to an increased risk of early recurrence. This is a narrative review focusing on APRL in terms of both presentation and management. Upon admission, the suggestive features may include increased serum prolactin with a large tumor diameter (mainly >4 cm), male sex, early age at diagnosis (<20 years), and genetic predisposition [multiple endocrine neoplasia type 1 (MEN1), aryl hydrocarbon receptor interacting protein (AIP), succinate dehydrogenase (SDHx) gene mutations]. Potential prognostic factors are indicated by assessment of E-cadherin, matrix metalloproteinase (MMP)-9, and vascular endothelial growth factor (VEGF) status. Furthermore, during management, APRL may be associated with dopamine agonist (DA) resistance (described in 10-20% of all prolactinomas), post-hypophysectomy relapse, mitotic count >2, Ki-67 proliferation index ≥3%, the need for radiotherapy, lack of response in terms of controlling prolactin levels and tumor growth despite multimodal therapy. However, none of these as an isolated element serves as a surrogate of APRL diagnosis. A fourth-line therapy is necessary with temozolomide, an oral alkylating chemotherapeutic agent, that may induce tumor reduction and serum prolactin reduction in 75% of cases but only 8% have a normalization of prolactin levels. Controversies surrounding the duration of therapy still exist; also regarding the fifth-line therapy, post-temozolomide intervention. Recent data suggest alternatives such as somatostatin analogs (pasireotide), checkpoint inhibitors (ipilimumab, nivolumab), tyrosine kinase inhibitors (TKIs) (lapatinib), and mTOR inhibitors (everolimus). APRL represents a complex condition that is still challenging, and multimodal therapy is essential.

Experimental and Therapeutic Medicine published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (AIP). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Uribe-Echeverria, Teresa; Beiras, Ricardo published the artcile< Acute toxicity of bioplastic leachates to Paracentrotus lividus sea urchin larvae>, Application of C19H34O2, the main research area is Paracentrotus lividus acute toxicity bioplastic leachates; Additives; Bioplastic; Ecotoxicology; Larval bioassay; Microplastic; Paracentrotus lividus; Polyhydroxybutyrate; Polylactic acid.

In an attempt to ensure that bioplastics, progressively replacing petrochem.-derived plastics, do not release any harmful compound to the environment, the study assessed the toxic effects of three innovative bioplastic products: polyhydroxybutyrate resin (PHB), polylactic acid cups (PLA) and a polylactic acid/polyhydroxyalkanoate 3D printing filament (PLA/PHA), together with a synthetic polyvinyl chloride (PVC) toy in Paracentrotus lividus sea urchin larvae. PVC toy was the most toxic material, likely due to the added plasticizers; remarkably, even if PHB is conceived as a nontoxic polymer, it showed a slight toxicity and Gas Chromatog.-Mass Spectometry anal. (GC-MS) revealed the presence of a wide range of additives. Conversely, PLA cups and PLA/PHA filament were innocuous for the larvae, a pos. outcome for these renewable solutions Proven that additives are also used in some bioplastic formulations, they should be carefully addressed to ensure that they are as safe as regarded.

Marine Environmental Research published new progress about Acute toxicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics