Category: 112-63-0

Kayahara, Eiichi; Yamada, Hiroto; Yamago, Shigeru published the artcile< Generation of Carbanions through Stibine-Metal and Bismuthine-Metal Exchange Reactions and Its Applications to Precision Synthesis of ω-End-Functionalized Polymers>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is stibine metal exchange reaction carbanion generation; polyhydroxyethyl methacrylate terminal functionalization stibine metal exchange reaction; polyisopropylacrylamide terminal functionalization stibine metal exchange reaction; polybutyl acrylate terminal functionalization stibine metal exchange reaction; PMMA terminal functionalization stibine metal exchange reaction; magnesium stibine exchange reaction carbanion generation; zinc stibine exchange reaction carbanion generation; bismuthine metal exchange reaction carbanion generation; lithium stibine exchange reaction carbanion generation.

Generation of carbanions from organostibines and organobismuthines through heteroatom-metal exchange reactions was examined from synthetic and mechanistic viewpoints. The exchange reaction proceeded spontaneously upon treatment with various organometallic reagents, such as alkyllithiums, tetraalkylzincates, and alkylmagnesium halides to afford the corresponding carbanions quant. Due to the high reactivity of these heteroatom compounds, the exchange reactions took place exclusively even in the presence of various polar functional groups, which potentially react with organometallic species. The advantage of this method was exemplified by the end-group transformation of living polymers that bear these heteroatom species at the ω-polymer end, prepared by using organostibine- and bismuthine-mediated living radical polymerizations Various polymers that bear polar functional groups and acidic hydrogen-for example, poly(Me methacrylate), poly(Bu acrylate), poly(N-iso-Pr acrylamide), and poly(2-hydroxyethyl methacrylate)-could be used in the exchange reactions, and subsequent trapping with electrophiles afforded the corresponding polymers with controlled mol. weights, mol. weight distributions, and end-group functionalities. Competition experiments showed that organostibines and organobismuthines were among the most reactive heteroatom compounds towards organometallic reagents and that their high reactivity was responsible for the high chemoselectivity in the exchange reaction.

Chemistry – A European Journal published new progress about Carbanions Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kajimoto, Tetsuya; Hidaka, Mitsuharu; Shoyama, Kayoko; Nohara, Toshihiro published the artcile< Iridoids from Scrophularia ningpoensis>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iridoid Scrophularia root structure.

Three new compounds (e.g., I and II) were isolated from Scrophulariae Radix, the dried root of S. ningpoensis, together with the known compounds harpagide and harpagoside. The structure of one was shown to be similar to acetoside and angoroside A; the other two were characterized as iridial derivatives by spectroscopic means.

Phytochemistry published new progress about Scrophularia ningpoensis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Liangliang; Oestreich, Martin published the artcile< Diastereotopic Group-Selective Intramolecular Aldol Reactions Initiated by Enantioselective Conjugate Silylation: Diastereodivergence Controlled by the Silicon Nucleophile>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is silyl benzoyl dihydroxyoctahydroindenone preparation isomerization crystal structure; crystal structure silyl benzoyl dihydroxyoctahydroindenone; mol structure silyl benzoyl dihydroxyoctahydroindenone; aryloxopentenyl cyclopentanedione enantioselective copper catalyzed silylation aldol cyclization; indenone silyl benzoyl preparation.

A reaction sequence consisting of enantioselective Cu-catalyzed conjugate silylation and diastereotopic group-selective aldol cyclization is reported. The diastereoselectivity of the intramol. aldol reaction depends on the Si nucleophile used, either Me2PhSiZnX·2LiX (trans) or Me2PhSiBpin (cis). The more basic Zn reagent and as such the very basic reaction medium also enable thermodynamically driven cis-to-trans isomerization by a retro-aldol-aldol process. A broad range of electron-withdrawing groups including electron-deficient heterocycles is compatible with the different procedures developed.

ACS Catalysis published new progress about Aldehydes, hydroxy Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rasheed, Hafiz Majid; Wahid, Fazli; Ikram, Muhammad; Qaisar, Muhammad; Shah, Abdul Jabbar; Khan, Taous published the artcile< Chemical profiling and anti-breast cancer potential of hexane fraction of Sphaeranthus indicus flowers>, Related Products of 112-63-0, the main research area is Sphaeranthus flower extract anticancer breast cancer.

The current study aimed to determine the phytochems. and anti-breast cancer potential of Sphaeranthus indicus. S. indicus flowers were extracted with methanol followed by fractionation using n-hexane. For the chem. composition of n-hexane fraction, qual. phytochem. and GC-MS anal. were performed. The anti-proliferative activity was measured by MTT assay, whereas, cytotoxic and proapoptotic effects in MCF-7 (breast cancer) cells were determined using propidium iodide, 4,6-diamidino-2-phenylindole, dichlorofluorescin diacetate, and JC-1 staining through fluorescent microscopy. The phytochem. anal. indicated presence of phytosterols, oils and resins in the nhexane fraction. GC-MS anal. showed that n-hexane fraction comprises of 11 compounds including Me esters of caprylic acid, myristic acid, pentadecanoic acid, palmitic acid, margaric acid, stearic acid, oleic acid, elaidic acid, linoleic acid, linolenic acid and behanic acid. The tested fraction showed remarkable cytotoxic activity against breast cancer (MCF-7) cells while it was found less toxic towards non-cancerous (BHK-21) cells. Furthermore, morphol. assessment through fluorescent microscopy revealed cytotoxic and apoptotic effects by improved cell membrane permeability, increased reactive oxygen species level, compromised mitochondrial activity and condensation of chromatin network. Conclusion: The n-hexane fraction of S. indicus contains phytosterols, oils and fatty acid Me esters and produced apoptotic effect against breast cancer cells.

Tropical Journal of Pharmaceutical Research published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Svec, Riley L.; McKee, Sydney A.; Berry, Matthew R.; Kelly, Aya M.; Fan, Timothy M.; Hergenrother, Paul J. published the artcile< Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is imidazotetrazin derivative preparation temozolomide resistant glioblastoma.

Glioblastoma (GBM) is the most lethal primary brain tumor. Currently, frontline treatment for primary GBM includes the DNA-methylating drug temozolomide (TMZ, of the imidazotetrazine class), while the optimal treatment for recurrent GBM remains under investigation. Despite its widespread use, a majority of GBM patients do not respond to TMZ therapy; expression of the O6-methylguanine DNA methyltransferase (MGMT) enzyme and loss of mismatch repair (MMR) function as the principal clin. modes of resistance to TMZ. Here, we describe a novel imidazotetrazine designed to evade resistance by MGMT while retaining suitable hydrolytic stability, allowing for effective prodrug activation and biodistribution. This dual-substituted compound, called CPZ, exhibits activity against cancer cells irresp. of MGMT expression and MMR status. CPZ has greater blood-brain barrier penetrance and comparable hematol. toxicity relative to TMZ, while also matching its maximum tolerated dose in mice when dosed once-per-day over five days. The activity of CPZ is independent of the two principal mechanisms suppressing the effectiveness of TMZ, making it a promising new candidate for the treatment of GBM, especially those that are TMZ-resistant.

ACS Chemical Biology published new progress about Antitumor agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Min, Qing-Qiang; Li, Na; Chen, Guang-Le; Liu, Feng published the artcile< Copper-catalysed C(sp3)-N coupling initiated by selective C-C bond cleavage of cyclobutanone oxime esters>, Category: esters-buliding-blocks, the main research area is arylaminobutanenitrile preparation chemoselective; cyclobutanone oxime ester aryl amine bond cleavage amination copper.

Herein, an efficient copper-catalyzed selective C-C bond cleavage/amination of cyclobutanone oxime esters is reported. This reaction protocol is operationally simple and conducted at ambient temperature, allowing access to a wide range of functionalized 4-(arylamino)butanenitriles in moderate to excellent yields. This transformation shows high chemo-selectivity and wide functional-group compatibility and can be easily scaled up to the gram level with a useful yield. A mechanism involving copper-catalyzed capture of alkyl radical intermediates by amine nucleophiles is proposed.

Organic Chemistry Frontiers published new progress about Amination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Dae-Yon; Kim, In-Jung; Jun, Chul-Ho published the artcile< Synthesis of cycloalkanones from dienes and allylamines through C-H and C-C bond activation catalyzed by a rhodium(I) complex>, SDS of cas: 112-63-0, the main research area is cycloalkanone preparation alkadiene allylamine rhodium catalyzed carbon hydrogen activation; phenylpropenyl pyridinamine alkadiene rhodium catalyzed activation cycloalkanone preparation.

An allylic amine, 3-methyl-N-(3-phenyl-2-propenyl)-2-pyridinamine (I), is used as a masked form of formaldehyde in the rhodium-catalyzed cyclization of dienes. The reaction provides access to various cycloalkanones through chelation-assisted C-H-bond and C-C-bond activation. The di-μ-chlorotetrakis[(1,2-η)-cyclooctene]dirhodium/tricyclohexylphosphine-catalyzed reaction of I with [[(1-ethenyl-3-butenyl)oxy]methyl]benzene gave 4-(phenylmethoxy)cycloheptanone (II) and 2-methyl-4-(phenylmethoxy)cyclohexanone (III) (84% overall yield; 67:33 ratio). Also, allylic amines that have no coordination site could be applied to this reaction; for example, N-(3-Phenyl-2-propenyl)benzenamine reacted with [[(1-ethenyl-3-butenyl)oxy]methyl]benzene in the presence of 3-methyl-2-pyridinamine catalyzed by di-μ-chlorotetrakis[(1,2-η)-cyclooctene]dirhodium/tricyclohexylphosphine gave II and III (72% overall yield; 53:47 ratio).

Angewandte Chemie, International Edition published new progress about Acylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rakkan, Thanaphorn; Chana, Netnapa; Chirapongsatonkul, Nion; U-taynapun, Kittichon; Sangkharak, Kanokphorn published the artcile< Screening and Identification of Newly Isolated Basic Red 9-Degrading Bacteria from Textile Wastewater and Their Ability to Produce Medium-Co-Long-Chain-Length Polyhydroxyalkanoates>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Enterobacter basic red biodegradation wastewater treatment.

Newly isolated Basic Red 9-degrading bacteria were isolated from textile wastewater using a pretreatment method. Nine strains were isolated; however, only five strains accumulated polyhydroxyalkanoates (PHAs). Thereafter, PHA-producing strains were identified through 16S rDNA sequencing anal. and phylogenetic evaluation and were found to belong to Enterobacter with 100% identification. The five isolated strains were incubated with a PHAs-producing medium containing 100 mg/l Basic Red 9 (BR9) to study decolorization efficiency, and PHAs production Enterobacter sp. strains TS3 and TS1L effectively decolorized the BR9 dye with degradation rates of 63.43% and 79.15%, resp. PHAs production from TS3 and TS1L was also observed to be 75.34% and 72.32% of dry cell weight (DCW), resp. Furthermore, Enterobacter sp. strains TS3 and TS1L accumulated medium-co-long-chain-length PHAs (mcl-co-lcl PHAs). This is the first report using Enterobacter strains to degrade BR9 dyes from textile wastewater and to assess their ability to produce mcl-co-lcl PHAs.

Journal of Polymers and the Environment published new progress about Bacteria. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nazarov, I. N.; Semenovskii, A. V. published the artcile< Bromomethylation of aromatic compounds>, Related Products of 112-63-0, the main research area is .

Passage of HBr into 150 ml. MePh, 15 g. paraformaldehyde, 8.5 g. ZnCl2, and a little P 1 hr. at 50° gave after washing with NaHCO3 and H2O, 58% mixed MeC6H4CH2Br isomers (I), b10 82-90°, and some diaryl derivatives b13 145-50°. Passage of HBr into 150 ml. CCl4, 15 g. paraformaldehyde, and 10 g. ZnCl2 with a little P for 35 min. and dropwise addition of 53 g. EtPh at 50° in a continuous stream of HBr over 1.3 hrs. similarly gave 48.3% mixed EtC6H4CH2Br (II), b7.5 96-100°. Passage of HBr 6 hrs. into 90 ml. concentrated HBr, 70 g. MePh, 30 g. paraformaldehyde, and a little P, followed by 19 hrs. at 50° gave, after washing, 71.3% mixed MeC6H4CH2Br, b23 112-20°; similarly, EtPh gave 85% mixed EtC6H4CH2Br, b10 101-4°, while iso-PrPh gave 78% mixed iso-PrC6H4CH2Br (III), b20 126-30°. Hydrolysis of I gave mixed o- and p-MeC6H4CH2OH, b12 106-10°; II gave the corresponding Et analogs, b12 120-4° and III gave mixed iso-Pr analogs, b12 121-5°. The hydrolyses were run with chalk in hot H2O 24 hrs. Oxidation of the alcs. with CrO3 gave mixtures of o- and p-C6H4(CO2H)2; oxidation with 10% HNO3 in an autoclave at 200° gave the same products, in which the p-isomers predominated.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about Bromomethylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Maeda, Kyogo; Uemura, Yohei; Chun, Wang-Jae; Satter, Shazia Sharmin; Nakajima, Kiyotaka; Manaka, Yuichi; Motokura, Ken published the artcile< Controllable Factors of Supported Ir Complex Catalysis for Aromatic C-H Borylation>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is borylation catalyst silica immobilized iridium complex tertiary amine preparation; direct borylation aromatic compound CH activation preparation arylboronic ester.

We have developed a catalyst in which an Ir complex and tertiary amine organic functionalities are coimmobilized on the silica surface. The catalytic activity for aromatic C-H borylation was significantly affected by (i) the linker length of the Ir-bipyridine complex, (ii) the coimmobilized organic functionality, and (iii) the substituents on the aromatic substrate compounds The fine-tuned supported catalyst showed higher activity than the homogeneous Ir-bipyridine complex when using a specific substrate such as benzonitrile. We elucidated this property by conducting solid-state NMR, FT-IR, XAFS, and in situ FT-IR anal.

ACS Catalysis published new progress about Aromatic substitution reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics