Category: 112-63-0

Shultz, Zachary; Shan, Chuan; Wojtas, Lukasz; Lopchuk, Justin M. published the artcile< A modular approach for the installation of functionalized phosphonates to heterocycles>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phosphonate heterocycle preparation.

Phosphonic acids and esters are pervasive throughout the discovery sciences, from medicine and agriculture, to materials and asym. synthesis. The ability to install and construct mol. architecture containing phosphonic functionality has led to the development of new medicines and catalyst systems in the field of organo- and organometallic catalysis. To continue the advancement in the field, improved synthetic access to phosphorous-containing motifs is required. In particular, heterocyclic phosphonates and their acid derivatives are so far underdeveloped. The method described herein provides a robust and operationally simple procedure for the installation of various phosphonates to a wide range of electrophilic heterocycles.

ARKIVOC (Gainesville, FL, United States) published new progress about Heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Lei published the artcile< Robust thiol-branched all-solid-state polymer electrolyte featuring high ionic conductivity for lithium-metal batteries>, Formula: C19H34O2, the main research area is solid state polymer electrolyte lithium metal battery.

The high energy d. of lithium metal batteries (LMBs) causes great attention of researchers. However, side effects of liquid electrolytes and dendrite growth problem limit the development of LMBs. Solid electrolytes with high ionic conductivity, good film-forming ability, and compatible interface with electrodes are highly desired yet remain to be explored. Herein, we design and fabricate a thiol-branched all-solid-state polymer electrolyte (SPE) with high ionic conductivity (1.09 x 10-4 S cm-1, 40°C) and good film-forming ability for the first time. The SPE is prepared via covalently crosslinking hyperbranched poly(glycidol) (chem. decorated by -SH, named as HPG-SH) and trimethylolpropane propoxylate triacrylate through multiple -C-S-C bonds. Specifically, the HPG is synthesized by anionic polymerization, followed by esterification reaction of HPG with mercaptoacetic acid to obtain HPG-SH. The SPE also exhibits an impressive lithium-ion transference number (0.31). Such design and prepare strategy makes the Li/SPE/LiFePO4 cell successfully cycle and the capacity reaches 145 mAh g-1 with average coulombic efficiency close to 100% over 70 cycles at low temperature This work offers a new perspective to design high-performance SPEs at the mol. level.

Ionics published new progress about Anionic polymerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fei, Yan-Qing; Shi, Ru-Ting; Zhou, Yang-Fan; Wu, Jin-Ze; Song, Zhi published the artcile< Mannose inhibits proliferation and promotes apoptosis to enhance sensitivity of glioma cells to temozolomide through Wnt/β-catenin signaling pathway>, Synthetic Route of 112-63-0, the main research area is mannose anticancer agent Wnt beta catenin glioma; Glioma; MGMT; Mannose; Temozolomide; Wnt/β-catenin pathway.

Temozolomide (TMZ) is generally applied for glioma treatment, while drug resistance of TMZ limits its therapeutic efficacy. Mannose exerts evident anti-tumor effect. We intended to investigate whether mannose enhanced TMZ sensitivity to glioma and examined the underlying mechanism. MTT and clone formation assays were performed to detect cell viability and proliferation. Cell apoptosis was measured by flow cytometry. The protein and gene expression levels were detected by Western blot and qRT-PCR assays. Xenograft glioma model was established to explore the influence of mannose in vivo. Mannose inhibited glioma cell growth, which was facilitated by knockdown of phosphomannose isomerase (PMI) while reversed by overexpression of PMI. Mannose enhanced the sensitivity of glioma cells to TMZ, indicated by the further inhibited cell viability and colony formation and the aggravated cell apoptosis, which was reversed by overexpression of O6-methylguanine DNA methyltransferase (MGMT). Furthermore, mannose and TMZ inhibited MGMT expression and Wnt/β-catenin activation. Moreover, activating Wnt/β-catenin pathway blocked anti-proliferative effect induced by mannose and TMZ, which was further suppressed by overexpressed MGMT. Mannose inhibited glioma growth, suppressed Ki67 and downregulated MGMT and β-catenin in vivo. Mannose inhibited MGMT to enhance sensitivity of glioma cells to TMZ, with Wnt/β-catenin pathway involvement. Our data suggested that mannose could be an innovative agent to improve glioma treatment, particularly in TMZ-resistant glioma with high MGMT.

Neurochemistry International published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jaffett, Victor A.; Nerurkar, Alok; Cao, Xufeng; Guzei, Ilia A.; Golden, Jennifer E. published the artcile< Telescoped synthesis of C3-functionalized (E)-arylamidines using Ugi-Mumm and regiospecific quinazolinone rearrangements>, Electric Literature of 112-63-0, the main research area is arylamidine stereoselective preparation; azidobenzoic acid isocyanide aldehyde bismethylaminoethane Ugi Mumm regiospecific rearrangement.

An efficient four-step, six-transformation protocol was developed to afford bioactive N-alkyl- or N-arylamide (E)-arylamidines I (R1 = Cy, 4-OMeC6H4, i-Pr, etc.; R2 = i-Pr, i-Bu, H, etc.; R3 = H, 5-CH3, 5-F, etc.) featuring strategic amidine C3 modifications which were inaccessible or low yielding by previous methods. This synthetic approach, exemplified with 24 amidines and requiring only a single purification, highlights a multicomponent Ugi-Mumm rearrangement to afford highly diversified quinazolinones which undergo regiospecific rearrangement to afford new amidines. The method extensively broadens the structural scope of this new class of trisubstituted amidines and demonstrates the tolerance of regional C3 amidine steric bulk, visualized with X-ray crystallog. anal.

Organic & Biomolecular Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Park, Deborah Y.; Tom, Martin C.; Wei, Wei; Tewari, Surabhi; Ahluwalia, Manmeet S.; Yu, Jennifer S.; Chao, Samuel T.; Suh, John H.; Peereboom, David; Stevens, Glen H. J.; Barnett, Gene H.; Angelov, Lilyana; Mohammadi, Alireza M.; Hogan, Thomas; Kissel, Courtney; Lapin, Brittany; Schuermeyer, Isabel; Parsons, Michael W.; Naugle, Richard; Murphy, Erin S. published the artcile< Quality of life following concurrent temozolomide-based chemoradiation therapy or observation in low-grade glioma>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is quality life following concurrent temozolomide based chemoradiation therapy; Chemoradiation; EQ-5D; Low grade glioma; PHQ-9; Quality of life; Temozolomide.

Low-grade glioma (LGG) exhibits longer median survival than high-grade brain tumors, and thus impact of our therapies on patient quality of life remains a crucial consideration. This study evaluated the effects of concurrent temozolomide-based chemoradiation (RT + TMZ) or observation on quality of life (QOL) in patients with low-grade glioma. We completed a retrospective cross-sectional study of adults with LGG who underwent surgery with known mol. classification from 1980 to 2018. Postoperatively, patients were either observed or received adjuvant concurrent temozolomide-based chemoradiation. EQ-5D and PHQ-9 depression screen were completed before outpatient visits every 2-3 mo. Baseline score was defined as ± 30 days within initial operation. Of the 63 patients (mean age 44 ± 17 years, 51% female) with baseline EQ-5D or PHQ-9 depression screen data and at least one follow-up measure, 30 (48%) were observed and 33 (52%) received RT + TMZ. No significant decline was seen in EQ-5D or PHQ-9 scores at 3, 6, 9, 12, and 24 mo compared to baseline scores for all patients. At each time point, there was no significant difference between those who were observed or received adjuvant therapy. The linear mixed model estimating PHQ-9 value or EQ-5D index demonstrated that there was no significant difference in PHQ-9 or EQ-5D index between treatment groups (p = 0.42 and p = 0.54, resp.) or time points (p = 0.24 and p = 0.99, resp.). Our study found no significant decline in patient QOL or depression scores as assessed by patient- reported outcome measures for patients with low-grade glioma up to 2 years following surgery. We found no difference between RT + TMZ compared to observation during this time frame. Addnl. follow-up can help identify the longer-term impact of treatment strategy on patient experience.

Journal of Neuro-Oncology published new progress about Astrocytoma (mol.). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Suri, Deepa; Kothari, Seema; Banerji, Kalyan K. published the artcile< Kinetics and mechanism of the oxidation of formic and oxalic acids by pyridinium hydrobromide perbromide>, Reference of 112-63-0, the main research area is oxidation formic acid pyridinium hydrobromide perbromide; oxalic acid oxidation pyridinium hydrobromide perbromide; kinetics mechanism oxidation carboxylic acid; LFER Grunwald Winstein solvent effect.

Oxidation of formic and oxalic acids by pyridinium hydrobromide perbromide proceeds via acyclic and cyclic intermediates resp. to give carbon dioxide.

Journal of Chemical Research, Synopses published new progress about Isotope effect. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Winkler, Dirk F. H.; McGeer, Patrick L. published the artcile< Protein labeling and biotinylation of peptides during spot synthesis using biotin p-nitrophenyl ester (biotin-ONp)>, Application In Synthesis of 112-63-0, the main research area is protein labeling biotinylation peptide MALDI TOF mass spectrometry.

Biotin-labeled peptides are used for numerous biochem. and microbiol. applications. Due to the strong affinity of biotin to streptavidin, the detection of biotinylated mols. is very sensitive. A powerful technique for parallel synthesis and high-throughput screening of peptides is the spot synthesis. One example for the use of spot synthesis is the screening of biotinylated peptides synthesized on cellulose membranes, which is particularly favorable for the investigation of protease cleavage sites. Addnl., in combination with biotinylated protein samples, the spot technique can be used for investigations of peptide-protein and protein-protein interactions. Here, we present our results of the use biotin p-nitrophenyl ester (biotin-ONp) in spot synthesis and as a reagent for biotin-labeling of protein samples.

Proteomics published new progress about Biotinylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Basarab, Gregory S.; Brassil, Patrick; Doig, Peter; Galullo, Vincent; Haimes, Howard B.; Kern, Gunther; Kutschke, Amy; McNulty, John; Schuck, Virna J. A.; Stone, Gregory; Gowravaram, Madhusudhan published the artcile< Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization>, Electric Literature of 112-63-0, the main research area is benzisoxazole spiropyrimidinetrione preparation DNA gyrase inhibitor scaffold SAR.

The compounds described herein with a spirocyclic architecture fused to a benzisoxazole ring represent a new class of antibacterial agents that operate by inhibition of DNA gyrase as corroborated in an enzyme assay and by the inhibition of precursor thymidine into DNA during cell growth. Activity resided in the configurationally lowest energy (2S,4R,4aR) diastereomer. Highly active compounds against Staphylococcus aureus had sufficiently high solubility, high plasma protein free fraction, and favorable pharmacokinetics to suggest that in vivo efficacy could be demonstrated, which was realized with compound I in S. aureus mouse infection models. A high drug exposure NOEL on oral dosing in the rat suggested that a high therapeutic margin could be achieved. Importantly, I was not cross-resistant with other DNA gyrase inhibitors such as fluoroquinolone and aminocoumarin antibacterials. Hence, this class shows considerable promise for the treatment of infections caused by multidrug resistant bacteria, including S. aureus.

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nogales-Delgado, Sergio; Encinar Martin, Jose Maria published the artcile< Cardoon biolubricant through double transesterification: Assessment of its oxidative, thermal and storage stability>, Electric Literature of 112-63-0, the main research area is cardoon biolubricant transesterification oxidation thermal storage stability.

Biolubricants could be a suitable replacement for industrial lubricants, due to their good performance and environmental-friendly quality, showing better flash and combustion points. However, depending on the raw material, the quality of biolubricants can vary, especially concerning oxidative and storage stability. The aim of this research work was to assess the stability of cardoon biolubricant, paying attention to oxidation and thermal and storage stability (by using the Rancimat method, thermogravimetry and viscosity during storage, resp.). The high linoleic acid content in cardoon oil (exceeding 25%) could influence the low oxidative stability of cardoon biolubricant (3 h), implying changes in quality parameters during storage (viscosity increased above 15% and viscosity index decreased about 23%). Thus, the use of antioxidants is advisable to keep its properties over time.

Materials Letters published new progress about Artichoke. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zhiyong; Guan, Qian; Xu, Haiyan; Lei, Tingzhou; Lin, Lu; Wang, Zhiwei; He, Xiaofeng; Zhu, Jinling published the artcile< Study on the formation of ethyl levulinate from wheat straw based on a model compound>, Application In Synthesis of 112-63-0, the main research area is ethyl levulinate wheat straw glucose microcrystalline cellulose.

Glucose and microcrystalline cellulose were selected as model compounds to investigate the formation of Et levulinate (EL). Optimal glucose and microcrystalline cellulose transformation conditions resulted in yields of 41.05 weight% and 38.56 weight% for EL, 0.73 weight% and 2.63 weight% for ethyl-glucoside (EG), 0.42 weight% and 0.36 weight% for 5-hydroxymethylfurfural (HMF), and 2.18 weight% and 2.16 weight% for 5-ethoxy Me furfural (EMF), resp. Increasing the reaction time and temperature resulted in an optimized yield of EL. These increases also resulted in decreased EG and EMF yield, and the change trend of HMF was not significant. EMF, HMF, and EG are intermediates in the formation of EL. Finally, we concluded that biomass conversion occurs first through cellulose degradation to glucose followed by the production of EG through alcoholysis and hydrolysis and dehydration of the reaction products to produce EL.

Journal of Biobased Materials and Bioenergy published new progress about Liquefaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics