Category: 112-63-0

Kaplan, Fred; Schulz, Carl Ormund published the artcile< Long-range phosphorus-hydrogen spin-spin coupling in aromatic systems>, Quality Control of 112-63-0, the main research area is PHOSPHORUS H SPIN SPIN COUPLING; HYDROGEN P SPIN SPIN COUPLING; SPIN SPIN COUPLING H P; THIONOPHOSPHATES NMR; PHOSPHATE THIONO NMR.

The 60 Mc./sec. proton magnetic resonance spectra for the following series of thionophosphates were recorded: R1OP(S)OMe(NHEt) (I), R2OP(S)OMe(NHMe) (II), R2OP(S)OMe(NHCHMe2) (III), R2OP(S)OMe(NHCMe3) (IV), and R2OP(S)NHMe(NHMe) (V) (where R1 = 2,3,4,6-tetrachlorophenyl and R2 = 2,4,5-trichlorophenyl). P coupling through 4 bonds to the ortho-proton (1.41-1.66 cycles/sec.) and through 5 bonds to the meta-proton (0.88-1.16 cycles/sec.) is exhibited in compounds II-V. Assignment of the smaller of the 2 coupling constants to the interaction between the P and the meta-proton is justified by the results obtained for I which contains only a meta-proton. Substitution of N for O on the thionophosphate group has little effect on the magnitude of coupling constants However, introduction of 2 Cl substituents significantly increases both the ortho and meta H-P interactions. Similar effects were observed when the electropos. nature of the P atom was increased. When P is attached to the aromatic ring by a methylene group rather than an O there is no significant coupling between the P and the meta-proton. This indicates that the coupling, which is dependent on π-electron interactions between the P and the aromatic ring, is facilitated by the presence of O. A change in solvent from CCl4 to acetone causes a greater downfield shift of the meta-proton as compared with the ortho-proton, suggesting that the solvent has a rather intimate effect on the distribution of electrons of the π-system.

Chemical Communications (London) published new progress about NMR (nuclear magnetic resonance). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Palomba, Martina; Pompei, Sara; Roscini, Luca; Bagnoli, Luana published the artcile< Synthesis and biological evaluation of new indole and pyrrole carboxamides based on amino acids>, Formula: C19H34O2, the main research area is indolecarboxamide preparation antifungal; pyrrolecarboxamide preparation antifungal.

A series of indole-carboxamides I [R = H, 5-MeO, 5-F, 7-NO2, 5,6-di-MeO; R1 = i-Pr, CH(Me)Et, Bn, etc.; R2 = Me, Et] and II was synthesized through coupling reactions. Several substitutions on the aromatic ring and on the amino acids were well tolerated, and corresponding indole-carboxamides I and II were obtained with good yields. The same procedure could be also extended to pyrrole-carboxamides III. The compounds I [R = 5-MeO, 5,6-di-MeO, 7-NO2; R1 = i-Pr; R2 = Et] and III [R1 = i-Pr, R2 = Et] were screened for their antimicrobial activity against ten different yeast strains and only compounds I [R = 7-NO2, R1 = i-Pr, R2 = Et] and III [R1 = i-Pr, R2 = Et] showed an antifungal activity. Further explorations were required to clarify a potential applicability in biol. fields.

ARKIVOC (Gainesville, FL, United States) published new progress about Amides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Moon, Hye Hyeon; Park, Ji Eun; Kim, Young-Hoon; Kim, Jeong Hoon; Kim, Ho Sung published the artcile< Contrast enhancing pattern on pre-treatment MRI predicts response to anti-angiogenic treatment in recurrent glioblastoma: comparison of bevacizumab and temozolomide treatment>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is human recurrent glioblastoma bevacizumab temozolomide; Bevacizumab; Contrast enhancement; Glioblastoma; Imaging biomarker; MRI.

To evaluate the value of the contrast enhancing pattern on pre-treatment MRI for predicting the response to anti-angiogenic treatment in patients with IDH-wild type recurrent glioblastoma. This retrospective study enrolled 65 patients with IDH wild-type recurrent glioblastoma who received standard therapy and then received either bevacizumab (46 patients) or temozolomide (19 patients) as a secondary treatment. The contrast enhancing pattern on pre-treatment MRI was visually analyzed and dichotomized into contrast enhancing lesion (CEL) dominant and non-enhancing lesion (NEL) dominant types. Quant. volumetric anal. was used to support the dichotomization. The Kaplan-Meier method and Cox proportional hazards regression anal. were used to stratify progression free survival (PFS) according to the treatment in the entire patients, CEL dominant group, and NEL dominant group. In all patients, the PFS of those treated with bevacizumab was not significantly different from those treated with temozolomide (log-rank test, P = 0.96). When the contrast enhancing pattern was considered, bevacizumab was associated with longer PFS in the CEL dominant group (P = 0.031), whereas temozolomide showed longer PFS in the NEL dominant group (P = 0.022). Quant. anal. revealed mean values for the proportion of solid-enhancing tumor of 13.7% for the CEL dominant group and 4.3% for the NEL dominant group. Patients with the CEL dominant type showed a better treatment response to bevacizumab, whereas NEL dominant types showed a better response to temozolomide. The contrast enhancing pattern on pre-treatment MRI can be used to stratify patients with IDH wild-type recurrent glioblastoma according to the effect of anti-angiogenic treatment.

Journal of Neuro-Oncology published new progress about Antiangiogenic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haecker, Joachim; Nguyen, Duc Hien; Rommel, Tobias; Zhao-Karger, Zhirong; Wagner, Norbert; Friedrich, K. Andreas published the artcile< Operando UV/vis Spectroscopy Providing Insights into the Sulfur and Polysulfide Dissolution in Magnesium-Sulfur Batteries>, COA of Formula: C19H34O2, the main research area is magnesium sulfur battery polysulfide dissolution.

The magnesium-sulfur battery represents a promising post-lithium system with potentially high energy d. and improved safety. However, just as all metal-sulfur systems, it is plagued with the polysulfide shuttle leading to active material loss and surface layer formation on the anode. To gain further insights, the present study aims to shed light on the dissolution characteristics of sulfur and polysulfides in glyme-based electrolytes for magnesium-sulfur batteries. Therefore, operando UV/vis spectroscopy and imaging were applied to survey their concentration in solution and the separator coloration during galvanostatic cycling. The influence of conductive cathode additives (carbon black and titanium nitride) on the sulfur retention and cycling overpotentials were investigated. Thus, valuable insights into the system′s reversibility and the benefit of addnl. reaction sites are gained. On the basis of these findings, a reduction pathway is proposed with S8, S62-, and S42- being the present species in the electrolyte, while the dissolution of S82- and S3•- is unfavored. In addition, the evolution of the sulfur species concentration during an extended rest at open-circuit voltage was investigated, which revealed a three-staged self-discharge.

ACS Energy Letters published new progress about Carbon black Role: TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jaumaux, Pauline; Yang, Xu; Zhang, Bao; Safaei, Javad; Tang, Xiao; Zhou, Dong; Wang, Chunsheng; Wang, Guoxiu published the artcile< Localized Water-In-Salt Electrolyte for Aqueous Lithium-Ion Batteries>, Product Details of C19H34O2, the main research area is water lithium nitrate manganese oxide ion battery electrolyte stability; 1,5-pentanediol; aqueous lithium ion battery; lithium nitrate; localized water-in-salt electrolyte; solid electrolyte interphase.

Water-in-salt (WIS) electrolytes using super-concentrated organic lithium (Li) salts are of interest for aqueous Li-ion batteries. However, the high salt cost, high viscosity, poor wettability, and environmental hazards remain a great challenge. Herein, we present a localized water-in-salt (LWIS) electrolyte based on low-cost lithium nitrate (LiNO3) salt and 1,5-pentanediol (PD) as inert diluent. The addition of PD maintains the solvation structure of the WIS electrolyte, improves the electrolyte stability via hydrogen-bonding interactions with water and NO3- mols., and reduces the total salt concentration By in situ gelling the LWIS electrolyte with tetraethylene glycol diacrylate (TEGDA) monomer, the electrolyte stability window can be further expanded to 3.0 V. The as-developed Mo6S8|LWIS gel electrolyte|LiMn2O4 (LMO) batteries delivered outstanding cycling performance with an average Coulombic efficiency of 98.53% after 250 cycles at 1 C.

Angewandte Chemie, International Edition published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ahmed, Moinuddin Md.; Mortensen, Matthew S.; O’Doherty, George A. published the artcile< De Novo Synthesis of 2-Substituted syn-1,3-Diols via an Iterative Asymmetric Hydration Strategy>, Electric Literature of 112-63-0, the main research area is ester dihydroxy benzylidene protected asym synthesis; dienoate enantioselective regioselective Sharpless dihydroxylation; carbonate cyclic asym synthesis stereoselective reduction palladium catalyst; unsaturated ester hydroxy asym synthesis diastereoselective hydration.

The enantioselective syntheses of several protected 4-substituted syn-3,5-dihydroxy carboxylic esters have been achieved from the corresponding achiral (E,E)- or (E,Z)-1,3-dienoates. The route relies upon an enantio- and regioselective Sharpless dihydroxylation and a palladium-catalyzed reduction to form γ-substituted δ-hydroxy-1-enoates. The resulting δ-hydroxy-1-enoates are subsequently converted into benzylidene-protected 4-substituted syn-3,5-dihydroxy carboxylic esters in one step. The benzylidene-protected 3,5-dihydroxy carboxylic esters are produced in good overall yields (20-54%) and high enantiomeric excess (73-97% ee).

Journal of Organic Chemistry published new progress about Carbonates Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ding, Huai-Wei; Wang, Shu; Qin, Xiao-Chun; Wang, Jian; Song, Hong-Rui; Zhao, Qing-Chun; Song, Shao-Jiang published the artcile< Design, synthesis, and biological evaluation of some novel 4-aminoquinazolines as Pan-PI3K inhibitors>, Product Details of C19H34O2, the main research area is aminoquinazolines PI3K inhibitor anticancer; 4-Aminoquinazolines; Anticancer; PI3K.

A series of 4-aminoquinazolines derivatives containing hydrophilic group were designed and identified as potent Pan-PI3K inhibitors in this study. The results of antiproliferative assays in vitro showed that this series of compounds had strong inhibition of tumor growth, especially compound 7b for MCF-7 cells but weak inhibition to normal cells. PI3K kinase assay showed that 7b had high activity for three PI3K isoforms with the IC50 values of picomole. The western blot assay indicated that 7b could decrease the phospho-Akt (S473) in a dose-dependent manner. Further experiments showed that 7b could induce apoptosis in MCF-7 cells. Four key hydrogen bonding interactions were found in the docking of 7b with PI3K kinase. All these results suggested that 7b is a potent PI3K inhibitor and could be considered as a potential candidate for the development of anticancer agents.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fernandez Gonzalez, Davinia; Brand, Jonathan P.; Mondiere, Regis; Waser, Jerome published the artcile< Ethynylbenziodoxolones (EBX) as Reagents for the Ethynylation of Stabilized Enolates>, Product Details of C19H34O2, the main research area is alkynylation cyclic keto ester amide ethynyl benziodoxolone reagent; safety ethynylbenziodoxolone; enantioselective alkynylation cyclic keto ester ethynylbenziodoxolone; enolate ethynylation ethynylbenziodoxolone.

Herein, we report a detailed study on the electrophilic alkynylation of cyclic keto esters and amides with ethynylbenziodoxolone (EBX) reagents [e.g., tert-Bu 1-oxo-2-indancarboxylate + reagent I in presence of TBAF → II in 57% yield]. The structure and stability of this class of reagents is first described more in details. Differential scanning calorimetry (DSC) experiments showed a strong exothermic decomposition with EBX reagents, leading to guidelines for the safe use of these compounds The extension of the method to aromatic alkynes and a broad range of benziodoxol(on)e reagents is then reported. Based on our preliminary results using Cinchona-based phase-transfer catalysts, the enantioselective alkynylation of cyclic keto esters could be achieved. Binaphthyl-derived ammonium catalysts developed by Maruoka and co-workers gave the highest asym. induction with up to 79% ee for an indanone-derived keto ester. Throughout this work, asym. induction was observed only in the case of benziodoxolone reagents, demonstrating their superiority over conventional alkynyliodonium salts. The deeper understanding gained about the factors leading to higher asym. induction will be very useful in the future to develop a truly general and highly enantioselective alkynylation method.

Advanced Synthesis & Catalysis published new progress about Alkynylation (electrophilic). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Varghese, Reji; George, Subi J.; Ajayaghosh, Ayyappanpillai published the artcile< Anion induced modulation of self-assembly and optical properties in urea end-capped oligo(p-phenylenevinylene)s>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phenylenevinylene urea self assembly tetrabutylammonium fluoride tunable emission.

The non-emissive supramol. assembly of urea end-capped oligo(p-phenylenevinylene) fluorophores turned strongly emissive in the presence of tetrabutylammonium fluoride which has implications in the anion controlled design of supramol. architectures with tunable emission properties.

Chemical Communications (Cambridge, United Kingdom) published new progress about Fluorescence. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Santschi, Nico; Nauser, Thomas published the artcile< Rate of single electron reduction of Togni's reagent>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Togni reagent single electron reduction rate.

We report on the rate of reduction of a popular electrophilic trifluoromethylating agent, Togni’s reagent (T-CF3), with solvated electrons (e-aq) generated by pulse radiolysis. By means of competition experiments against Me viologen (MV2+) and direct observation of the decay of e-aq we determined k(T-CF3 + e-aq) ≈ 2 × 1010 M-1 s-1. To the best of our knowledge, this constitutes the first report on a reduction of T-CF3 with an unambiguously clear outer-sphere mechanism. Furthermore, we studied the oxidation of 2-(2-iodophenyl)propan-2-ol (ROH) by peroxyl-radicals to a presumably cyclic iodanyl radical RI·. This species RI· was not detected during the reduction of T-CF3 with e-aq and therefore, this reduction does not proceed via heterolytic I-CF3 bond cleavage to CF3- and RI·. More likely, a CF3 radical is formed, as was observed in numerous synthesis studies reported to date.

Journal of Fluorine Chemistry published new progress about Intermediates Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), FORM (Formation, Nonpreparative), PROC (Process), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics