Category: 112-63-0

Li, Linhan; Zhou, Ting; Zhong, Linyu; Zhou, Qian; Gu, Gang; Hu, Mengjun; Chen, Fengping; Lin, Sheng published the artcile< Bioremediation of quinclorac injury on tobacco by a rhizosphere bacterium>, HPLC of Formula: 112-63-0, the main research area is rhizosphere bacterium tobacco quinclorac injury bioremediation; Bioremediation; Herbicide; Klebsiella variicola; Plant growth-promoting bacterium; Tobacco.

The presence of herbicides residues in soil represents a serious problem for agriculture. Quinclorac is a common herbicide applied in rice field, but its residue can cause abnormal growth in successive crop of tobacco in Southern China. Remediation by microorganisms is considered to be an environmentally friendly method to remove such pollutants injury. The aims of this study were to obtain quinclorac remediation isolates and to investigate the possible mechanism(s) of remediation. Six bacterial isolates were obtained from rhizosphere of rice-tobacco rotation fields, and were found to be capable of degrading quinclorac on a mineral salt medium (MSM), with degradation efficiency ranging from 2.1 to 23.7%. Among these isolates, J5 had the highest degradation efficiency, and was identified as Klebsiella variicola based on phylogenetic anal. and a metabolic profile generating by Biolog GEN III system. Bioremediation of quinclorac injury was confirmed using pot assays with tobacco, in which J5 reversed the detrimental effect of quinclorac on leaf area, leaf number, and plant height. The J5 isolate also seemed to promote plant growth, in terms of tobacco seedling growth and seed germination, which were 2.2 times and 1.6 times higher compared to untreated control, resp. The mechanisms of plant growth promoting (PGP) traits were found to involve nitrogen-fixing, indole-3-acetic acid (IAA) production, and phosphate solubilization ability. In addition, proteomic anal. and relative quant. PCR revealed an elevated level of 4-hydroxyphenylacetate 3-monooxygenase (HPMO) in quinclorac-treated J5, suggesting that this enzyme may play an important role in quinclorac remediation. This study showed that the J5 isolate could be exploited to not only assist in soil remediation due to quinclorac residue issues but also promote tobacco growth.

World Journal of Microbiology & Biotechnology published new progress about Germination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thiel, Cora S.; Vahlensieck, Christian; Bradley, Timothy; Tauber, Svantje; Lehmann, Martin; Ullrich, Oliver published the artcile< Metabolic Dynamics in Short- and Long-Term Microgravity in Human Primary Macrophages>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is metabolomics microgravity hypergravity metabolite amino acids glucose ketoleucine rhamnose; immune cells; metabolomics; microgravity; sounding rocket; spaceflight.

Microgravity acts on cellular systems on several levels. Cells of the immune system especially react rapidly to changes in gravity. In this study, we performed a correlative metabolomics anal. on short-term and long-term microgravity effects on primary human macrophages. We could detect an increased amino acid concentration after five minutes of altered gravity, that was inverted after 11 days of microgravity. The amino acids that reacted the most to changes in gravity were tightly clustered. The observed effects indicated protein degradation processes in microgravity. Further, glucogenic and ketogenic amino acids were further degraded to Glucose and Ketoleucine. The latter is robustly accumulated in short-term and long-term microgravity but not in hypergravity. We detected highly dynamic and also robust adaptative metabolic changes in altered gravity. Metabolomic studies could contribute significantly to the understanding of gravity-induced integrative effects in human cells.

International Journal of Molecular Sciences published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondo, Toru published the artcile< Glioblastoma-initiating cell heterogeneity generated by the cell-of-origin, genetic/epigenetic mutation and microenvironment>, SDS of cas: 112-63-0, the main research area is review glioblastoma cell heterogeneity mutation microenvironment; Dihydroorotate dehydrogenase (DHODH); GBM-initiating cells (GICs); Glioblastoma (GBM); Heterogeneity; Temozolomide (TMZ).

A review. Glioblastoma (GBM) and other malignant tumors consist of heterogeneous cancer cells, including GBM-initiating cells (GICs). This heterogeneity is likely to arise from the following: different sets of genetic mutations and epigenetic modifications, which GICs gain in the transformation process; differences in cells of origin, such as stem cells, precursor cells or differentiated cells; and the cancer microenvironment, in which GICs communicate with neural cells, endothelial cells and immune cells. Furthermore, considering that various types of GICs can be generated at different time points of the transformation process, GBM very likely consists of heterogeneous GICs and their progeny. Because cancer cell heterogeneity is responsible for therapy resistance, it is crucial to develop methods of reducing such heterogeneity. Here, I summarize how GIC heterogeneity is generated in the transformation process and present how cell heterogeneity in cancer can be addressed based on recent findings.

Seminars in Cancer Biology published new progress about Genetics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wender, Paul A.; Staveness, Daryl published the artcile< Improved Protein Kinase C Affinity through Final Step Diversification of a Simplified Salicylate-Derived Bryostatin Analog Scaffold>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is protein kinase salicylate bryostatin analog scaffold.

Bryostatin 1, in clin. trials or preclin. development for cancer, Alzheimer’s disease, and a first-of-its-kind strategy for HIV/AIDS eradication, is neither readily available nor optimally suited for clin. use. In preceding work, we disclosed a new class of simplified bryostatin analogs designed for ease of access and tunable activity. Here we describe a final step diversification strategy that provides, in only 25 synthetic steps, simplified and tunable analogs with bryostatin-like PKC modulatory activities.

Organic Letters published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Xiaofeng; Shao, Ying; Sun, Jiangtao published the artcile< Ruthenium-Catalyzed Chemoselective N-H Bond Insertion Reactions of 2-Pyridones/7-Azaindoles with Sulfoxonium Ylides>, HPLC of Formula: 112-63-0, the main research area is alkyl pyridone preparation chemoselective; pyridone sulfoxonium ylide alkylation ruthenium catalyst; azaindole alkyl preparation chemoselective; sulfoxonium ylide azaindole alkylation ruthenium catalyst.

A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones I [R1 = H, 3-Cl, 5-Me, 4-(benzyloxy), etc.] has been developed, affording N-alkylated 2-pyridone derivatives II (R2 = Ph, n-Bu, thiophen-2-yl, etc.) in good yields and excellent N-selectivity. The key to achieve this unprecedented N-H rather than O-H insertion reaction is the use of CpRu(PPh3)2Cl as the catalyst and sulfoxonium ylides R2C(O)CH=S(O)(CH3)2 as the alkylation reagents. Moreover, this protocol is also amenable to 7-azaindoles III (R3 = H, 2-Et-3-Me, 4-Cl, etc.) by slightly varying the reaction conditions. Furthermore, sulfonium ylides are also suitable alkylation reagents, providing the N-alkylated 2-pyridones II in good selectivity.

Organic Letters published new progress about Alkylation catalysts (chemoselective). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Gen; Wu, Jun; Li, Le; Jiang, Peng published the artcile< The p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage>, Product Details of C19H34O2, the main research area is MTHFD2 p53 mutation DNA damage cell proliferation colon cancer; MTHFD2; NHEJ; cell proliferation; folate metabolism; p53.

Cancer cells acquire metabolic reprogramming to satisfy their high biogenetic demands, but little is known about how metabolic remodeling enables cancer cells to survive stress associated with genomic instability. Here, we show that the mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) is transcriptionally suppressed by p53, and its up-regulation by p53 inactivation leads to increased folate metabolism, de novo purine synthesis, and tumor growth in vivo and in vitro. Moreover, MTHFD2 unexpectedly promotes nonhomologous end joining in response to DNA damage by forming a complex with PARP3 to enhance its ribosylation, and the introduction of a PARP3-binding but enzymically inactive MTHFD2 mutant (e.g., D155A) sufficiently prevents DNA damage. Notably, MTHFD2 depletion strongly restrains p53-deficient cell proliferation and sensitizes cells to chemotherapeutic agents, indicating a potential role for MTHFD2 depletion in the treatment of p53-deficient tumors.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (MTHFD2). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Han-Zhang; Luo, Wu-Long; Zeng, Ning-Xi; Li, Hui-Zhen; Li, Ling; Yan, Can; Wu, Li-Li published the artcile< Cerebrospinal fluid proteomics reveal potential protein targets of JiaWeiSiNiSan in preventing chronic psychological stress damage>, Computed Properties of 112-63-0, the main research area is proteome Rps4x HSP90AA1 jiaweisinisan Gardenia chronic psychol stress adult; Chronic Unpredictable Mild Stress model; Stress resilience; hippocampus neurogenesis; neuron loss.

Chinese herbal formula JiaWeiSiNiSan (JWSNS) has been widely used to prevent stress-induced neuropsychiatric ailments in clinics and proven to have therapeutic anti-stress effects on rats. However, the mechanism remains unclear. Based on the proteomics of cerebrospinal fluid (CSF), this study explores the possible mechanism and target proteins of JiaWeiSiNiSan raising stress resilience and preventing stress damage. A 6-wk Chronic Unpredictable Mild Stress (CUMS) model was applied on adult Wistar male rats to observe the effects of JWSNS on improving mental stress resilience. Tandem Mass Tag (TMT) proteomics and bioinformatics anal. were used to screen and analyze differentially expressed proteins (DEPs) in CSF. Parallel Reaction Monitoring (PRM) was used to validate target DEPs. Significantly decreased sucrose preference, locomotion activity level and accuracy of T-maze, as well as increased immobility time, were observed in CUMS rats compared to CON rats while JWSNS improved above depression-like behaviors. The quant. proteomics and bioinformatics anal. showed that JWSNS decreased the expression of Rps4x, HSP90AA1, Rps12, Uba1, Rsp14, Tuba1b in CUMS rats CSF (p < 0.05, FDR < 0.5). Immunofluorescence results showed that the number of BrdU/DCX pos. cells (p < 0.01) and the relative number of neurons (p < 0.01) in the hippocampus dentate gyrus (DG) of the JSWNS group significantly increased, compared with the CUMS group. JWSNS could increase mental stress resilience and prevent stress damage by regulating proteins in CSF. This study provides a scientific basis for further study on Chinese formulas preventing mental illness. Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about Adult, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Zhijie; Chen, Xi; Song, Liying; Yuan, Fang; Yan, Yuanliang published the artcile< Matrix remodeling-associated protein 8 as a novel indicator contributing to glioma immune response by regulating ferroptosis>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioma immune response MXRA8 ferroptosis prognosis; MXRA8; ferroptosis; glioma; immune response; prognosis.

Glioma is a highly malignant brain tumor with a poor survival rate. Novel biomarkers that act as prompt indicators of glioma are urgently needed. In this study, we identified and validated prognosis-related differentially expressed genes by datasets of glioma in the GEO and TCGA databases. Ferroptosis is a newly recognized process of cell death playing a vital role in cancer biol. Pearson correlation coefficient were used to discovery the prognosis-related genes which have the highest correlation with ferroptosis. Matrix remodeling-associated protein 8 (MXRA8) was identified as a novel prognosis indicator which may be involved in ferroptosis. The expression of MXRA8 was significantly higher in glioma compared with normal brain tissue, and increased expression of MXRA8 was associated with unfavorable survivals. Furthermore, in vitro anal. showed that knockdown of MXRA8 inhibited the cell bility in T98G and U251 cells and increased the sensitivity of glioma cells to temozolomide. We further observed that downregulation of MXRA8 elevated the levels of intracellular ferrous iron and lipid peroxidation, accompanied by upregulation of NCOA4 and suppression of FTH1. Moreover, co-expression analyses showed that GO term and KEGG pathways were mainly enriched in immunity-related pathways, such as neutrophil-related immunity, adaptive immune response, and cytokine binding. Through ssGSEA algorithm and TISIDB database, immunol. analyses showed that MXRA8 was significantly correlated with various immune infiltration cells including NK cells, macrophages, and neutrophils. Meanwhile, MXRA8 was also associated with chemokines and multiple immunoinhibitory mols., such as TGF-β1, IL-10, PD-L1, and CTLA4. We also found that MXRA8 was pos. associated with immune infiltration score, and patients with higher immune score underwent worse overall survivals. Moreover, IHC staining indicated a highly pos. correlation of MXRA8 with a macrophage marker CSF1R. The co-cultured models of glioma cells and M2 macrophages showed MXRA8 knockdown glioma cells alleted the infiltration of M2 macrophage, while the reduced M2 macrophage infiltration generated by MXRA8 could be rescued by Fer-1 treatment. These results suggest that MXRA8 promotes glioma progression and highlight the pivotal role of MXRA8 in ferroptosis and immune microenvironment of glioma. Therefore, MXRA8 may serve as a novel prognostic marker and therapeutic target for glioma.

Frontiers in Immunology published new progress about Adaptive immunity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shao, Yuewen; Li, Yue; Sun, Kai; Zhang, Zhanming; Tian, Hongli; Gao, Guoming; Li, Qingyin; Liu, Qianhe; Liu, Qing; Hu, Xun published the artcile< Sulfated Zirconia with Different Crystal Phases for the Production of Ethyl Levulinate and 5-Hydroxymethylfurfural>, SDS of cas: 112-63-0, the main research area is ethyl levulinate sulfated zirconia crystal phase.

Distinct crystal phases of an oxide affect the configuration of surface atoms, which might further affect coordination with sulfate during sulfonation for the preparation of SO42-/MxOy type of acid catalyst. Herein, such an effect is investigated with zirconia of the tetragonal or monoclinic phase as the model catalysts. The results show that sulfonation inhibits the transformation of zirconia from the tetragonal phase to the monoclinic phase, whereas the varied phase of zirconia also affects the bonding patterns of sulfate species with zirconia in sulfonation. The sulfated zirconia of monoclinic phase contains more abundant acidic sites and more Bronsted acid sites than that of sulfated zirconia of tetragonal phase. Consequently, the sulfated zirconia of monoclinic phase is more active than the sulfated zirconia of tetragonal phase for the conversion of furfuryl alc. in ethanol and conversion of fructose in DMSO, achieving the yield of Et levulinate of 96.4% and a high yield of 5-hydroxymethylfurfural. The sulfated zirconia is not stable in protic solvent due to the leaching of sulfur species and the change in configurations of the sulfate species and the zirconium species, but in the aprotic solvent, they show good stability and recyclability.

Energy Technology (Weinheim, Germany) published new progress about Crystals. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lategan, Thomas W.; Wang, Laurene; Sprague, Tiffany N.; Rousseau, Franck S. published the artcile< Pharmacokinetics and Bioavailability of Monomethyl Fumarate Following a Single Oral Dose of Bafiertam (Monomethyl Fumarate) or Tecfidera (Dimethyl Fumarate)>, Synthetic Route of 112-63-0, the main research area is bafiertam bioavailability pharmacokinetics.

Tecfidera (di-Me fumarate [DMF]) is an approved product for the treatment of relapsing forms of multiple sclerosis. Monomethyl fumarate (MMF) is the only active metabolite of DMF and is responsible for its therapeutic efficacy. Objective: The objective of this study was to determine whether two Bafiertam capsules each containing 95 mg of MMF is bioequivalent to one Tecfidera capsule containing 240 mg of DMF, a prodrug of MMF. This was a single-dose, open-label, randomized, two-way crossover study evaluating two treatments over two periods with a washout interval between treatments. Fifty healthy subjects were randomized to receive a single dose of the test drug MMF 190 mg as 2 x 95 mg delayed-release capsules or the reference drug DMF 240 mg as a 1 x 240-mg delayed-release capsule. Blood samples were obtained prior to dosing and at prespecified time points through 24 h post-dose to determine plasma concentrations of MMF. The pharmacokinetic parameters of MMF were calculated including maximum observed concentration, time to reach maximum observed concentration, apparent half-life of the drug in plasma, AUC0-t which is the area under the plasma concentration-time curve (AUC) from time zero (dosing time) to the last time point, t, with measurable analyte concentration, and AUC0-inf, which is AUC0-t plus the extrapolated AUC from time t to infinity. The geometric least-squares mean ratios (90% confidence interval) of the test drug MMF vs the reference drug DMF were 96.80% (92.18-101.64), 96.35% (91.81-101.12), and 104.84% (95.54-115.05) for AUC0-t, AUC0-inf, and maximum observed concentration, resp. Two capsules of Bafiertam was safe and generally well tolerated. The most common adverse event for both products was flushing, 60% and 51%, for Bafiertam and Tecfidera, resp. Conclusions: Based on the statistical anal. results of the pharmacokinetic parameters of MMF, a single oral dose of two Bafiertam DR 95 mg capsules is bioequivalent to a single oral dose of one Tecfidera DR 240 mg capsule. Clin. Trial Registration: This study was retrospectively registered with ClinicalTrials.gov (NCT04570670) on 30 Sept., 2020.

CNS Drugs published new progress about Bioavailability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics