Category: 112-63-0

Pal, R.; Rastogi, G. C.; Khanna, N. M. published the artcile< Chemical examination of Rubus ellipticus Smith>, Electric Literature of 112-63-0, the main research area is Rubus composition saponin biol activity.

A saponin (I) isolated from R. ellipticus was characterized as 3β-hydroxy-urs-12,18-diens-28-oic-acid-3-O-[β-D-glucopyranosyl (1 → 4) α-L-arabinopyranoside. Acuminatic acid, tormentic acid, β-sitosterol, and β-sitosterol-β-D-glucoside were also isolated. I showed weak anti-implantation activity in rats but was inactive when tested in hamsters.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Rubus ellipticus. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Allinger, Norman L.; Freiberg, Leslie A. published the artcile< Conformational analysis. X. Energy of the boat form of the cyclohexane ring>, Quality Control of 112-63-0, the main research area is .

Reduction of 2,4-di-tert-butylphenol over Raney Ni at 180°, followed by CrO3 oxidation of the mixture and reduction of the resulting ketones gave a mixture of hydrocarbons; this was distilled to give cis-1,3-di-tert-butylcyclohexane (I), b. 223.3-3.5°, nD25 1.4531, and trans-I, b. 229.8-30.0°, nD25 1.4563. Equilibrium between cis- and trans-I was established by heating small samples with Pd-C in sealed tubes with the following results (temperature in °K. and % trans-I, resp.): 492.6°, 2.69; 522.0°, 3.61; 555.0°, 5.09; 580.0°, 6.42; 613.0°, 8.23. From these results a ΔH of 5.9 ± 0.6 kcal./mole and ΔS of 4.9 ± 1.0 e.u. were calculated, the latter value indicating that trans-I was in the boat form.

Journal of the American Chemical Society published new progress about Enthalpy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Badiola, Eider; Fiser, Bela; Gomez-Bengoa, Enrique; Mielgo, Antonia; Olaizola, Iurre; Urruzuno, Inaki; Garcia, Jesus M.; Odriozola, Jose M.; Razkin, Jesus; Oiarbide, Mikel; Palomo, Claudio published the artcile< Enantioselective Construction of Tetrasubstituted Stereogenic Carbons through Bronsted Base Catalyzed Michael Reactions: α'-Hydroxy Enones as Key Enoate Equivalent>, Reference of 112-63-0, the main research area is hydroxy enone enoate equivalent Michael acceptor hydrogen bond; chiral bifunctional Bronsted base catalysis diastereoselective enantioselective Michael; Michael addition oxy enone oxindole cyanoester oxazolone thiazolone azlactone.

Catalytic and asym. Michael reactions constitute very powerful tools for the construction of new C-C bonds in synthesis, but most of the reports claiming high selectivity are limited to some specific combinations of nucleophile/electrophile compound types, and only few successful methods deal with the generation of all-carbon quaternary stereocenters. A contribution to solve this gap is presented here based on chiral bifunctional Bronsted base (BB) catalysis and the use of α’-oxy enones as enabling Michael acceptors with ambivalent H-bond acceptor/donor character, a yet unreported design element for bidentate enoate equivalent It is found that the Michael addition of a range of enolizable carbonyl compounds that have been previously demonstrated as challenging (i.e., α-substituted 2-oxindoles, cyanoesters, oxazolones, thiazolones, and azlactones) to α’-oxy enones can afford the corresponding tetrasubstituted carbon stereocenters in high diastereo- and enantioselectivity in the presence of standard BB catalysts [e.g., I + II → III with R = CH2CH2Ph and R1 = Ph]. Experiments show that the α’-oxy ketone moiety plays a key role in the above realizations, as parallel reactions under identical conditions but using the parent α,β-unsaturated ketones or esters instead proceed sluggish and/or with poor stereoselectivity. A series of trivial chem. manipulations of the ketol moiety in adducts can produce the corresponding carboxy, aldehyde, and ketone compounds under very mild conditions, giving access to a variety of enantioenriched densely functionalized building blocks containing a fully substituted carbon stereocenter. A computational investigation to rationalize the mode of substrate activation and the reaction stereochem. is also provided, and the proposed models are compared with related systems in the literature.

Journal of the American Chemical Society published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fabra, F.; Galvez, C.; Gonzalez, A.; Viladoms, P.; Vilarrasa, J. published the artcile< Fluoroazoles. II. Synthesis and proton and fluorine-19 NMR spectra of 2-, 4-, and 5-fluoro-1-methylimidazole>, SDS of cas: 112-63-0, the main research area is imidazole fluoro methyl NMR; NMR fluorine fluoromethylimidazole.

The three possible ring-monofluorinated N-methylimidazoles were prepared by photochem. irradiation of the corresponding diazonium tetrafluoroborates. 5-Fluoro-1-methylimidazole was also obtained by methylation of 1-acetyl-4-fluoroimidazole. The 1H and 19F NMR spectra of these N-methylated fluoroazoles are compared, and the predominance of one tautomeric form in 4(5)-fluoroimidazole is discussed.

Journal of Heterocyclic Chemistry published new progress about NMR (nuclear magnetic resonance). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ouyang, Yani; Yue, Xiaoguang; Peng, Jiehai; Zhu, Jiashun; Shen, Qiuyuan; Li, Wanmei published the artcile< Organic acid catalysed Minisci-type arylation of heterocycles with aryl acyl peroxides>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aryl heterocycle preparation trifluoroacetic acid; heterocycle aryl acyl peroxide arylation.

A metal-free method for the Minisci-type arylation of heterocycles with aryl acyl peroxides has been reported. This strategy enables the rapid and simple synthesis of a series of Minisci-type adducts from com. available starting materials without metal catalysts. A free-radical-pathway mechanism is suggested for this transformation.

Organic & Biomolecular Chemistry published new progress about Arylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Quan-Zhe; Lian, Peng-Fei; Tan, Fu-Xin; Zhu, Guo-Dong; Chen, Chao; Hao, Yu; Jiang, Wei; Wang, Xun-Hui; Zhou, Jia; Zhang, Shu-Yu published the artcile< Organocatalytic Enantioselective Construction of Heterocycle-Substituted Styrenes with Chiral Atropisomerism>, Electric Literature of 112-63-0, the main research area is heterocycle substituted phenylvinylnaphthaleneamine enantioselective preparation; indole arylaminoalkynylnaphthalene enantioselective addition organocatalyst; hydroxycoumarin arylaminoalkynylnaphthalene enantioselective addition organocatalyst.

We have developed a novel π-π interaction and dual H-bond concerted control strategy to construct axially chiral naphthylamine heterocycles. With ortho-alkynyl-naphthylamines as the electrophile, indoles and 4-hydroxycoumarins were efficiently employed to construct axially chiral skeletons in good yields and with excellent enantioselectivities (up to 97% enantiomeric excess). Furthermore, the resulting products could be converted to potential squaramides featuring organic catalysts.

Organic Letters published new progress about 4-Hydroxycoumarins Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Shengju; Jiang, Huajuan; Liu, Qianqian; Zhou, Yongfeng; Cheng, Yanfen; Zhou, Tao; Zhang, Jinming; He, Yao; Ren, Chaoxiang; Pei, Jin published the artcile< A comparative study on the traditional versus modern yellow rice wine processing methods using Taohong Siwu Decoction for pharmaceutical production>, Quality Control of 112-63-0, the main research area is metabolomics yellow rice wine processing method Taohong Siwu decoction; Catalpol; Ferulic acid; Hydroxysafflor yellow A; Metabolomics; Primary dysmenorrhea; Taohong Siwu decoction; Yellow rice wine processing method.

Taohong Siwu Decoction (THSWD) is based on the “”First Recipe of Gynecol””. It is widely used in various blood stasis and deficiency syndromes, mainly in gynecol. blood stasis, irregular menstruation, and dysmenorrhea. THSWD has great demand in traditional Chinese medicine (TCM), gynecol., orthopedics, and internal medicine. According to classical records, three medicinal materials, namely Rehmanniae radix, Angelica sinensis, and Carthamus tinctorius, used in THSWD need to be “”washed with yellow rice wine””. In the study of TCM prescriptions, the processing methods of medicinal materials not only needed to follow traditional records but also should consider modern tech. conditions. Many medicinal materials in the repertoire of classical prescriptions involve yellow rice wine processing. Determining the processing method for medicinal materials is a key and difficult problem in the research and development of classical prescriptions. With THSWD as the representative, this study analyzed differences between no processing method, the modern processing method of “”stir-frying the materials with yellow rice wine,”” and the traditional processing method of “”washing with yellow rice wine””. We focused on three aspects: composition, efficacy, and endogenous metabolism This study aimed to provide a reference for research on the processing methods of medicinal materials used in classical prescriptions. UPLC-Q-Orbitrap HRMS was used to quickly identify and classify the main chem. compounds of THSWD. A model of primary dysmenorrhea (PD) was established using estradiol benzoate combined with oxytocin. The latent period and writhing time; the levels of serum PGF2α, PGE2, ET-1, and β-EP; and the pathol. sections of the uterus were observed to determine their pharmacodynamic differences. GC-TOF/MS was used to analyze the differences in serum metabolites in rats. A total of 54 active compounds were identified, and the results showed that catalpol and rehmapicroside disappeared following yellow rice wine processing. Compared with materials processed by the traditional method, the relative contents of 15 components, such as 5-hydroxymethylfurfural and digitalis C, increased in materials processed by the modern method. However, the relative contents of 16 components, such as hydroxysafflor yellow A, verbascoside, and ferulic acid, decreased in the modern processing method. The modern and classic processing methods acted on PD through different metabolic pathways. THSWD obtained by classical processing methods mainly treated PD through anti-inflammatory and estrogen metabolism pathways, whereas THSWD obtained by modern processing methods mainly treated PD through anti-inflammatory metabolic pathways. The study revealed the differences in different yellow rice wine processing methods in terms of chem. composition of the THSWD obtained, as well as the mechanisms of action for the treatment of PD. This study provides a reference for the clin. application of THSWD and development of classical prescription preparations

Journal of Ethnopharmacology published new progress about Angelica sinensis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jimenez-Garcia, Sandra N.; Garcia-Mier, Lina; Ramirez-Gomez, Xochitl S.; Aguirre-Becerra, Humberto; Escobar-Ortiz, Alexandro; Contreras-Medina, Luis M.; Garcia-Trejo, Juan F.; Feregrino-Perez, Ana A. published the artcile< Pitahaya Peel: A By-Product with Great Phytochemical Potential, Biological Activity, and Functional Application>, Electric Literature of 112-63-0, the main research area is hypertension pitahaya peel byproduct betalain biol activity flavonoid antioxidant; Hylocerous spp.; biological activity; phenolic compounds.

Hylocereus spp. present two varieties of com. interest due to their color, organoleptic characteristics, and nutritional contribution, such as Hylocerous polyrhizus and Selenicerus undatus. The fruit recognized as dragon fruit or Pitahaya is an exotic fruit whose pulp is consumed, while the peel is discarded during the process. Studies indicate that the pulp has vitamin C and betalains, and seeds are rich in essential fatty acids, compounds that can contribute to the prevention of chronic non-communicable diseases (cancer, hypertension, and diabetes). In the present study, polyphenolic compounds, biol. activity, and fatty acids present in the peel of the two varieties of pitahaya peel were evaluated, showing as a result that the variety S. undatus had higher antioxidant activity with 51% related to the presence of flavonoids 357 mgRE/g sample and fatty acids (hexadecanoic acid and linoleate) with 0.310 and 0.248 mg AG/g sample, resp. On the other hand, H. polyrhizuun showed a significant difference in the inhibitory activity of amylase and glucosidase enzymes with 68% and 67%, resp. We conclude that pitahaya peel has potential health effects and demonstrate that methylated fatty acids could be precursors to betalain formation, as well as showing effects against senescence and as a biol. control against insects; in the same way, the peel can be reused as a byproduct for the extraction of important enzymes in the pharmaceutical and food industry.

Molecules published new progress about Alkanes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Drusian, Luca; Nigro, Elisa Agnese; Mannella, Valeria; Pagliarini, Roberto; Pema, Monika; Costa, Ana S. H.; Benigni, Fabio; Larcher, Alessandro; Chiaravalli, Marco; Gaude, Edoardo; Montorsi, Francesco; Capitanio, Umberto; Musco, Giovanna; Frezza, Christian; Boletta, Alessandra published the artcile< mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma>, Related Products of 112-63-0, the main research area is renal cell carcinoma FH gene fumarate accumulation mTORC1; TCA cycle; cancer metabolism; cancer signaling; epithelial transformation; fumarate hydratase; metabolic reprogramming; papillary carcinoma; rapamycin; renal cancer; renal cysts.

Renal cell carcinomas (RCCs) are common cancers diagnosed in more than 350,000 people each year worldwide. Several pathways are de-regulated in RCCs, including mTORC1. However, how mTOR drives tumorigenesis in this context is unknown. The lack of faithful animal models has limited progress in understanding and targeting RCCs. Here, we generated a mouse model harboring the kidney-specific inactivation of Tsc1. These animals develop cysts that evolve into papillae, cystadenomas, and papillary carcinomas. Global profiling confirmed several metabolic derangements previously attributed to mTORC1. Notably, Tsc1 inactivation results in the accumulation of fumarate and in mTOR-dependent downregulation of the TCA cycle enzyme fumarate hydratase (FH). The re-expression of FH in cellular systems lacking Tsc1 partially rescued renal epithelial transformation. Importantly, the mTORC1-FH axis is likely conserved in human RCC specimens. We reveal a role of mTORC1 in renal tumorigenesis, which depends on the oncometabolite fumarate.

Cell Reports published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Dongdong; Liang, Jianwen; Robertson, Stuart J.; Chen, Yingtong; Wang, Naiguang; Shao, Minhua; Shi, Zhicong published the artcile< Heterogeneous Bimetallic Organic Coordination Polymer-Derived Co/Fe@NC Bifunctional Catalysts for Rechargeable Li-O2 Batteries>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is bimetallic organic polymer bifunctional catalyst lithium oxide battery; Li−O2 battery; MOCPs; bifunctional catalyst; dual metal sites; nitrogen-doped carbon.

The Li-O2 battery has attracted substantial attention due to its high theor. energy d. In particular, high-efficiency oxygen catalysts are very important for the design of practical Li-O2 batteries. Herein, we have synthesized heterogeneous crystalline-coated partially crystalline bimetallic organic coordination polymers (PC@C-BMOCPs), which are further pyrolyzed to obtain Co- and Fe-based nanoparticles embedded within rodlike N-doped carbon (Co/Fe@NC) as a bifunctional oxygen reduction reaction/oxygen evolution reaction (ORR/OER) catalyst used in the Li-O2 battery. Owing to excellent ORR/OER catalytic ability, the Co/Fe@NC bifunctional catalyst exhibits an efficient reversible reaction between O2 and Li2O2. Addnl., a large number of mesoporous channels are present in the core-shell Co/Fe@NC nanoparticles. These channels not only promote the diffusion of Li+ and O2, but also create ample room to store insoluble discharge product Li2O2. The Li-O2 batteries utilizing the bifunctional Co/Fe@NC oxygen electrode exhibit a large capacity of 17,326 mAh g-1, a long cycling life of more than 250 cycles, and excellent reversibility. This work provides a universally applicable strategy for designing nonnoble metal ORR/OER catalysts with excellent electrochem. performance for metal-air batteries.

ACS Applied Materials & Interfaces published new progress about Battery cathodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics