Category: 112-63-0

Wei, Shiyou; Yin, Delong; Yu, Shengnan; Lin, Xiang; Savani, Milan R.; Du, Kuang; Yin, Ku; Wu, Di; Li, Shasha; Liu, Hao; Tian, Meng; Chen, Yaohui; Bowie, Michelle; Hariharan, Seethalakshmi; Waitkus, Matthew; Keir, Stephen T.; Sugarman, Eric T.; Deek, Rebecca A.; Labrie, Marilyne; Khasraw, Mustafa; Lu, Yiling; Mills, Gordon B.; Herlyn, Meenhard; Wu, Kongming; Liu, Lunxu; Wei, Zhi; Flaherty, Keith T.; Abdullah, Kalil; Zhang, Gao; Ashley, David M. published the artcile< Antitumor activity of a mitochondrial-targeted HSP90 inhibitor in gliomas>, Reference of 112-63-0, the main research area is temozolomide mitochondrial targeted HSP90 inhibitor anticancer glioma.

To investigate the antitumor activity of a mitochondrial-localized HSP90 inhibitor, Gamitrinib, in multiple glioma models, and to elucidate the antitumor mechanisms of Gamitrinib in gliomas. A broad panel of primary and temozolomide (TMZ)-resistant human glioma cell lines were screened by cell viability assays, flow cytometry, and crystal violet assays to investigate the therapeutic efficacy of Gamitrinib. Seahorse assays were used to measure the mitochondrial respiration of glioma cells. Integrated analyses of RNA sequencing (RNAseq) and reverse phase protein array (RPPA) data were performed to reveal the potential antitumor mechanisms of Gamitrinib. Neurospheres, patient-derived organoids (PDO), cell line-derived xenografts (CDX), and patient-derived xenografts (PDX) models were generated to further evaluate the therapeutic efficacy of Gamitrinib. Gamitrinib inhibited cell proliferation and induced cell apoptosis and death in 17 primary glioma cell lines, 6 TMZ-resistant glioma cell lines, 4 neurospheres, and 3 PDOs. Importantly, Gamitrinib significantly delayed the tumor growth and improved survival of mice in both CDX and PDX models in which tumors were either s.c. or intracranially implanted. Integrated computational analyses of RNAseq and RPPA data revealed that Gamitrinib exhibited its antitumor activity via (i) suppressing mitochondrial biogenesis, OXPHOS, and cell-cycle progression and (ii) activating the energy-sensing AMP-activated kinase, DNA damage, and stress response. These preclin. findings established the therapeutic role of Gamitrinib in gliomas and revealed the inhibition of mitochondrial biogenesis and tumor bioenergetics as the primary antitumor mechanisms in gliomas.

Clinical Cancer Research published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Jinquan; Li, Yanjie; Sun, Shenlu; Fang, Ting published the artcile< Concentrated green tea soup produced by high-voltage pulsed electric field and freeze concentration>, Reference of 112-63-0, the main research area is freezing pulsed elec field optimization concentration green tea soup; aroma gas chromatog mass spectrometry.

Instant tea powder is completely soluble solid. It has emerged as a new and fast growing product in the world.. The tea powder basically keeps the original color, aroma, and taste of the tea. It has advantages of convenience, health, nutrition, elegance, quality control, and high stability, which is deeply favored by consumers at home and abroad as well as tea beverage manufacturers. However, tea aroma loses during thermal processing of tea beverage production In this paper, the application of integration of pulsed elec. field(PEF) and freeze concentration technol. on tea soup was studied. The hot water extraction was substituted by the PEF extraction to extract green tea soup, and vacuum evaporation was substituted by freeze concentration to concentrate the tea. The optimum conditions of the above two technologies were investigated. Using the combination of gas chromatog.(GC-MS) mass spectrometry and solid-phase micro-extraction(SPME), the differences of the tea soup extracted by pulse elec. field(PEF) and hot water on the aroma composition were investigated resp., and the same anal. was done for concentrated tea soup by freeze concentration and vacuum evaporation, . The optimal conditions of PEF extraction were given as: pulse width of 2.5 μs, elec. field strength of 37 kV/cm, pulse number of 10, pulse frequency of 2 700 Hz and solid-liquid ratio of 1:30. The results of freeze concentration were best under the following conditions: initial solution temperature at 4°C, scraper speed at 150 r/min and coolant temperature at -15∼-18°C. Compared with the hot water extraction, extraction of tea polyphenols by PEF was almost the same. The method of GC-MS with SPME was used to analyze aroma compounds of tea soup extracted by PEF and hot water resp. The results indicated that PEF extraction technol. could effectively keep the main aroma of tea soup. It was better than hot water extraction The results of SPME/GC-MS indicated that freeze concentration technol. could effectively keep most of aroma compounds of tea soup. It was better than vacuum evaporation Both methods have potential applications in industrial production

Nongye Gongcheng Xuebao published new progress about Acids Role: ANT (Analyte), PEP (Physical, Engineering or Chemical Process), ANST (Analytical Study), PROC (Process). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

K. Pagire, Santosh; Kumagai, Naoya; Shibasaki, Masakatsu published the artcile< Highly Enantio- and Diastereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes from α,β-Unsaturated Amides and Stabilized Sulfur Ylides Catalyzed by a Chiral Copper(I) Complex>, COA of Formula: C19H34O2, the main research area is cyclopropane preparation enantioselective diastereoselective; amide sulfur ylide cyclization copper catalyst.

Herein, the previously elusive catalytic asym. cyclopropanation of α,β-unsaturated amides, e.g., (E)-3-(but-2-enoyl)oxazolidin-2-one with stabilized sulfur ylides RC(O)CH=S(Me)2 has been efficiently accomplished utilizing a chiral Cu(I) complex. This Lewis acid catalytic system effectively converts a wide range of electron-deficient alkenes into the corresponding 1,2,3-trisubstituted cyclopropanes, e.g., I under mild reaction conditions in good to excellent yields with both high to excellent enantio- and diastereoselectivities. The resulting enantiomerically enriched cyclopropane amides can be readily diversified into promising synthetic intermediates such as β-aminocyclopropanecarboxylic acids with the facile recovery of the 7-azaindoline auxiliary without influencing the optical purity of the cyclopropane unit, which highlights the synthetic efficacy of this catalytic approach.

ACS Catalysis published new progress about Carboxylic acids Role: FMU (Formation, Unclassified), FORM (Formation, Nonpreparative). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Candiota, Ana Paula; Arus, Carles published the artcile< Establishing Imaging Biomarkers of Host Immune System Efficacy during Glioblastoma Therapy Response: Challenges, Obstacles and Future Perspectives>, Quality Control of 112-63-0, the main research area is PD1 host immune system glioblastoma magnetic resonance spectroscopy imaging; cancer immune cycle; glioblastoma; host immune system; imaging biomarker; immunotherapy; magnetic resonance spectroscopic imaging; metabolomics.

This hypothesis proposal addresses three major questions: (1) Why do we need imaging biomarkers for assessing the efficacy of immune system participation in glioblastoma therapy response (2) Why are they not available yet and (3) How can we produce them. We summarize the literature data supporting the claim that the immune system is behind the efficacy of most successful glioblastoma therapies but, unfortunately, there are no current short-term imaging biomarkers of its activity. We also discuss how using an immunocompetent murine model of glioblastoma, allowing the cure of mice and the generation of immune memory, provides a suitable framework for glioblastoma therapy response biomarker studies. Both magnetic resonance imaging and magnetic resonance-based metabolomic data (i.e., magnetic resonance spectroscopic imaging) can provide non-invasive assessments of such a system. A predictor based in nosol. images, generated from magnetic resonance spectroscopic imaging analyses and their oscillatory patterns, should be translational to clinics. We also review hurdles that may explain why such an oscillatory biomarker was not reported in previous imaging glioblastoma work. Single shot explorations that neglect short-term oscillatory behavior derived from immune system attack on tumors may mislead actual response extent detection. Finally, we consider improvements required to properly predict immune system-mediated early response (1-2 wk) to therapy. The sensible use of improved biomarkers may enable translatable evidence-based therapeutic protocols, with the possibility of extending preclin. results to human patients.

Metabolites published new progress about Behavior (short-term oscillatory). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singh, Rahul; Kumar, Ravinder; Pandrala, Mallesh; Kaur, Parleen; Gupta, Saloni; Tailor, Dhanir; Malhotra, Sanjay V.; Salunke, Deepak B. published the artcile< Facile synthesis of C6-substituted benz[4,5]imidazo[1,2-a]quinoxaline derivatives and their anticancer evaluation>, Computed Properties of 112-63-0, the main research area is benzimidazoquinoxaline preparation anticancer activity; MDA-MB-468; NCI-60; anticancer agents; benzimidazole; breast cancer cell line; heterocycles; quinoxaline.

On the basis of the promising anticancer potential of imidazoquinoxaline as well as the structurally similar imidazoquinoline-derived scaffold, a set of C6-substituted benzimidazo[1,2-a]quinoxaline derivatives I (R = OMe, benzylaminyl, 1H-1,3-benzodiazol-1-yl, etc.) was prepared via two novel synthetic routes using com. available starting materials, with good to excellent yields and evaluated for their anticancer activity against the NCI-60 cancer cell lines. The one-dose (10μM) anticancer screening of the synthesized compounds I in the NCI-60 cell line panel revealed that the substituents have a significant role in the activity. In particular, compounds I (R = 1H-indol-1-yl, 1H-imidazol-1-yl, 1H-1,3-benzodiazol-1-yl) derivatives showed significant activity against the triple-neg. breast cancer cell line, MDA-MB-468. The lead compounds also exhibited notable IC50 values against another breast cancer cell line, MCF-7. Furthermore, synthesized compounds I were relatively nontoxic to normal cell lines: HEK293 (human embryonic kidney cell line) and MCF12A (nontumorigenic human breast epithelial cell line). The IC50 values against healthy cells were at least 5- to 11-fold higher, offering a new class of heterocycles that can be further developed as promising therapeutics for cancer treatment.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ju, Hee Young; Park, Meerim; Lee, Jun Ah; Park, Hyeon Jin; Park, Seog Yun; Kim, June Hyuk; Kang, Hyun Guy; Yang, Hee Chul; Park, Byung-Kiu published the artcile< Vincristine, irinotecan, and temozolomide as a salvage regimen for relapsed or refractory sarcoma in children and young adults>, COA of Formula: C19H34O2, the main research area is vincristine irinotecan temozolomide salvage therapy antitumor agent sarcoma; Irinotecan; Salvage therapy; Sarcoma; Temozolomide; Vincristine.

No standard salvage regimen is available for relapsed or refractory sarcoma. We investigated the efficacy and toxicity of the vincristine, irinotecan, and temozolomide combination (VIT) for relapsed or refractory sarcomas of variable histol. in children and young adults. We retrospectively reviewed data from the relapsed or refractory sarcoma patients who were treated with VIT. The VIT protocol was given every 3 wk as follows: vincristine, 1.5 mg/m2 i.v. on day 1, irinotecan, 50 mg/m2 /day i.v. on days 1-5, and temozolomide, 100 mg/m2 /day orally on days 1-5. A total of 26 patients (12 males) with various sarcoma histol. were included in the study. Most common diagnosis was rhabdomyosarcoma (n=8) followed by osteosarcoma (n=7). Median age at the start of VIT was 18.5 years (range, 2.0 to 39.9). VIT was delivered as 2nd to 7th line of treatment, with 4th line most common (9/26, 34.6%). Median number of VIT courses given was 3 (range, 1 to 18). Of the 25 evaluable patients, there was two partial response (PR) and 11 stable disease (SD) with an overall control rate (complete remission+PR+SD) of 52%. PR was seen in one (50%) of the two evaluable patients with Ewing sarcoma and one (14.3%) of the seven patients with osteosarcoma. Overall survival and progression-free survival rates were 79.3% and 33.9% at 1 yr, and 45.5% and 25.4% at 2 years, resp. There was no treatment-related mortality. Conclusion The VIT regimen was effective and relatively safe in our cohort of sarcoma patients.

Cancer Research and Treatment published new progress about Adolescent, mammalian. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Keller, Valerie A.; Kendall, Beatrice Lin published the artcile< Independent Synthesis Projects in the Organic Chemistry Teaching Laboratories: Bridging the Gap Between Student and Researcher>, Reference of 112-63-0, the main research area is organic chem methanol thionyl chloride review.

A review. Science educators strive to teach students how to be well-rounded scientists with the ability to problem solve, anticipate errors, and adapt to unexpected roadblocks. Traditional organic chem. experiments seldom teach these skills, no matter how novel or contemporary the subject material. This paper reports on the success of a quarter-long organic chem. laboratory experiment that takes the form of a research project designed to teach these real-life skills. Students took a three-step synthetic sequence from a literature source, and changed parameters to improve the yield. This involved library research and two levels of proposals, followed by a written report and a poster presentation. The goal was to simulate the different aspects of a research lab, from literature searches to problem-solving to presenting results. The students experienced unexpected difficulties and were graded on how they overcame these obstacles, rather than on how much they improved the yields.

Journal of Chemical Education published new progress about Education. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ruiz, J. M. J.; Osswald, G.; Petersen, M.; Fessner, W.-D. published the artcile< The ""Natural Strategy"" for the glycosidase-assisted synthesis of simple glycosides>, Application of C19H34O2, the main research area is glycosidase assisted synthesis glycoside.

Anomeric product mixtures obtained from simple acid-catalyzed Fischer glycosidation are conveniently resolved by application of glycosidase hydrolysis in aqueous medium to provide single diastereomers that are easy to isolate. Choosing from an array of inexpensive glycosidases, the hydrolytic strategy offers a flexible access to unprotected anomerically pure α- or β-glycopyranosides in good overall yields.

Journal of Molecular Catalysis B: Enzymatic published new progress about Enzymic kinetic resolution. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yajing; Lv, Shiqun; Cao, Fangzhi; Ding, Ziwei; Liu, Jie; Chen, Qian; Gao, Jun; Huang, Xianfeng published the artcile< Investigations on the influence of the structural flexibility of nanoliposomes on their properties>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioblastoma nanoliposome temozolomide elasticity; Structural flexibility; cellular uptake; cytotoxicity; encapsulation efficiency; in vitro release; nanoliposomes.

In the present study, nanoliposomes with tuneable structure elasticity were prepared by reverse-phase evaporation Both Fluorescence Polarization and Fluorescence Resonance Energy Transfer was employed to characterize the structural elasticity of resultant nanoliposomes. Temozolomide, a kind of hydrophilic drug as the first-line treatment choice for glioblastoma, was encapsulated into nanoliposomes. The results showed that the flexibility of nanoliposomes gradually increased with sodium cholate, while decreasing with cholesterol, Labrafac CC and Labrafac PG adding. Furthermore, the structural flexibility of nanoliposomes was pos. correlated with the encapsulation efficiency and release rate and cellular uptake. Our research reveals the structural flexibility of nanoliposomes could affect in vitro characteristics and thereafter in vivo behaviors of nanoliposomes.

Journal of Liposome Research published new progress about Elasticity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hamby, Taylor B.; LaLama, Matthew J.; Sevov, Christo S. published the artcile< Controlling Ni redox states by dynamic ligand exchange for electroreductive C(sp3)-C(sp2) coupling>, HPLC of Formula: 112-63-0, the main research area is aryl vinyl halide triflate electroreductive coupling alkyl bromide nickel.

Cross-electrophile coupling (XEC) reactions of aryl and alkyl electrophiles are appealing but limited to specific substrate classes. Here, electroreductive XEC of previously incompatible electrophiles including tertiary alkyl bromides, aryl chlorides, and aryl/vinyl triflates are reported. The reactions rely on the merger of an electrochem. active complex that selectively reacts with alkyl bromides through 1e- processes and an electrochem. inactive Ni0(phosphine) complex that selectively reacts with aryl electrophiles through 2e- processes. Accessing Ni0(phosphine) intermediates is critical to the strategy but is often challenging. Here, a previously unknown pathway for electrochem. generating these key complexes at mild potentials through a choreographed series of ligand-exchange reactions has been uncovered. The mild methodol. is applied to the alkylation of a range of substrates including natural products and pharmaceuticals.

Science (Washington, DC, United States) published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics