Category: 112-63-0

Ghilardi, Carmen; Moreira-Barbosa, Catarina; Brunelli, Laura; Ostano, Paola; Panini, Nicolo; Lupi, Monica; Anastasia, Alessia; Fiordaliso, Fabio; Salio, Monica; Formenti, Laura; Russo, Massimo; Arrigoni, Edoardo; Chiaradonna, Ferdinando; Chiorino, Giovanna; Draetta, Giulio; Marszalek, Joseph R.; Vellano, Christopher P.; Pastorelli, Roberta; Bani, MariaRosa; Decio, Alessandra; Giavazzi, Raffaella published the artcile< PGC1α/β expression predicts therapeutic response to oxidative phosphorylation inhibition in ovarian cancer>, Quality Control of 112-63-0, the main research area is PGC1alpha beta anticancer oxidative phosphorylation inhibitor ovarian cancer.

Ovarian cancer is the deadliest gynecol. cancer, and novel therapeutic options are crucial to improve overall survival. Here we provide evidence that impairment of oxidative phosphorylation (OXPHOS) can help control ovarian cancer progression, and this benefit correlates with expression of the two mitochondrial master regulators PGC1α and PGC1β. In orthotopic patient-derived ovarian cancer xenografts (OC-PDX), concomitant high expression of PGC1α and PGC1β (PGC1α/β) fostered a unique transcriptional signature, leading to increased mitochondrial abundance, enhanced tricarboxylic acid cycling, and elevated cellular respiration that ultimately conferred vulnerability to OXPHOS inhibition. Treatment with the respiratory chain complex I inhibitor IACS-010759 caused mitochondrial swelling and ATP depletion that consequently delayed malignant progression and prolonged the lifespan of high PGC1α/β-expressing OC-PDX-bearing mice. Conversely, low PGC1α/β OC-PDXs were not affected by IACS-010759, thus pinpointing a selective antitumor effect of OXPHOS inhibition. The clin. relevance of these findings was substantiated by anal. of ovarian cancer patient datasets, which showed that 25% of all cases displayed high PGC1α/β expression along with an activated mitochondrial gene program. This study endorses the use of OXPHOS inhibitors to manage ovarian cancer and identifies the high expression of both PGC1α and β as biomarkers to refine the selection of patients likely to benefit most from this therapy.

Cancer Research published new progress about Acute myeloid leukemia. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lu, Can; Chen, Xi; Yan, Yuanliang; Ren, Xinxin; Wang, Xiang; Peng, Bi; Cai, Yuan; Liang, Qiuju; Xu, Zhijie; Peng, Jinwu published the artcile< Aberrant expression of ADARB1 facilitates temozolomide chemoresistance and immune infiltration in glioblastoma>, Computed Properties of 112-63-0, the main research area is glioblastoma immune infiltration ADARB1 temozolomide chemoresistance tumorigenesis prognosis bioinformatics; ADARB1; akt; glioblastoma; immune; temozolomide.

Chemoresistance, especially temozolomide (TMZ) resistance, is a major clin. challenge in the treatment of glioblastoma (GBM). Exploring the mechanisms of TMZ resistance could help us identify effective therapies. Adenosine deaminases acting on RNA (ADARs) are very important in RNA modification through regulating the A-to-I RNA editing. Recent studies have shown that ADARs regulate multiple neurotransmitter receptors, which have been linked with the occurrence and progress of GBM. Here, data from several bioinformatics databases demonstrated that adenosine deaminase RNA specific B1 (ADARB1), also named ADAR2, was upregulated in both GBM tissues and cells, and had the prognostic value in GBM patients. Moreover, ADARB1 was found to be involved in AKT-mediated TMZ resistance in GBM cells. The KEGG anal. of ADARB1-associated co-expressed genes showed that ADARB1 was potentially involved in the mitochondrial respiratory chain complex. TISIDB and GEPIA databases were further used to analyze the role of ADARB1 in tumor-immune system interactions in GBM. These findings deepened our understanding of the function of ADARB1 in tumorigenesis and therapeutic response in GBM. aberrant expression of ADARB1 facilitates temozolomide chemoresistance and immune infiltration in human with glioblastoma

Frontiers in Pharmacology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (TAP2). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ding, Huai-Wei; Yu, Lu; Bai, Meng-xuan; Qin, Xiao-Chun; Song, Man-tong; Zhao, Qing-Chun published the artcile< Design, synthesis and evaluation of some 1,6-disubstituted-1H-benzo[d]imidazoles derivatives targeted PI3K as anticancer agents>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is sulfonamido methoxypyridinylbenzoimidazolyl pyrazole preparation; phenyl sulfonamido methoxypyridinylbenzoimidazole preparation; antitumor activity kinase inhibition study SAR mol docking; Antitumor; Benzo[d]imidazole; PI3K.

A series of 1,6-disubstituted-1H-benzo[d]imidazoles derivatives I [R5 = Me, (2,4-difluorophenyl)methyl; R2 = 3-hydroxypropyl, 3-methoxy-3-oxopropyl, 3-(morpholin-4-yl)propyl, etc.] and II [R5 = Me, (2,4-difluorophenyl)methyl; R3 = H, methoxy; R4 = 3-hydroxypropyl, 3-methoxy-3-oxopropyl, 3-(morpholin-4-yl)propyl, etc.] designed, synthesized and evaluated their anticancer activity and the compound II [R5 = (2,4-difluorophenyl)methyl; R3 = H; R4 = 3-hydroxypropyl] was identified as a lead compound Compound II [R5 = (2,4-difluorophenyl)methyl; R3 = H; R4 = 3-hydroxypropyl] with the most potent antiproliferative activity was selected for further biol. mechanism. The PI3K kinase assay showed potent efficiency against four subtypes of PI3K with an IC50 of 0.5-1.9 nM. Mol. docking showed a possible formation of H-bonding with essential amino acid residues. Meanwhile, western blot assay indicated that compound II [R5 = (2,4-difluorophenyl)methyl; R3 = H; R4 = 3-hydroxypropyl] inhibited cell proliferation via suppression of PI3K kinase activity and subsequently blocked PI3K/Akt pathway activation in HCT116 cells. In addition, compound II [R5 = (2,4-difluorophenyl)methyl; R3 = H; R4 = 3-hydroxypropyl] inhibited the migration and invasion ability of HCT116 cells and induced apoptosis of HCT116 cells.

Bioorganic Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Binbin; Zhou, Qi; Zhang, Xinwei; Ma, Jiao; Cong, Xin; Wang, Qin; Liao, Yonggui; Yang, Yajiang; Wang, Hong published the artcile< Thermostable fluorescent supramolecular gels constructed from a single gelator and its application in discriminating organic acids>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is thermostable fluorescent supramol gel gelator organic acid.

In this work, 5,5’5″”-(1,3,5-triazine-2,4,6-triyl)tris(azanediyl)triisophthalate (H6L) was used as a gelator to prepare thermostable supramol. gels (H6L gels). The lowest critical gelation concentration of H6L was found to be only 0.14 wt%. H6L gels remained stable after being placed at 85°C for 1 h, indicating that its gel-sol phase transition temperature (Tgel) was not <85°C. H6L gels can be formed in just a few seconds in comparison with the longer gelation time of a conventional thermostable gel. Moreover, a thermostable H6L/Fe3+ gel was also prepared by the coordination interactions of H6L and Fe3+ ions. The studies of FT-IR, UV-vis, XRD and SEM reveal that multiple hydrogen bonds, π-π interactions as well as coordination interactions were the main driving forces for the formation of thermostable three-dimensional network structure of H6L gels. In addition, the fluorescence spectra of H6L gels showed that the dual emission at 396 nm and 469 nm was derived from the structure of melamine and 5-aminoisophthalic acid contained in H6L structure. The gel formed at high temperature had relatively high transparency and strong fluorescence signal, and the fluorescence intensity is affected by the external H+ concentration Using this characteristic, 14 organic acids can be effectively identified with the help of principal component anal. (PCA). L-cysteine can be identified with the naked eye by the color and state changes of H6L/Fe3+ gels. Journal of Molecular Liquids published new progress about Complexation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yeh, Herman J. C.; Kirk, Kenneth L.; Cohen, Louis A.; Cohen, Jack S. published the artcile< Fluorine-19 and proton nuclear magnetic resonance studies of ring-fluorinated imidazoles and histidines>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is imidazole fluoro NMR ionization; histidine fluoro NMR ionization; NMR fluoroimidazole fluorohistidine ionization.

1H and 19F titration curves in D2O and H2O, resp., were obtained for 2- and 4-fluoroimidazole and -histidine. Dissociation pK values were determined by computer-assisted curve fitting. Fluoroimidazoles are weaker bases and stronger acids than bromoimidazoles showing that the inductive effect of the halogen overshadows its resonance effect. Introduction of an alkyl group at C-5 displaces the F-4 and F-2 signals upfield and downfield, resp., indicating C-4 and C-5 are coupled by induction and resonance whereas C-2 and C-5 are coupled by induction only. Introduction of F displaces the H-2 and H-4 signals upfield. The shielding effect of the magnetic anisotropy of 19F counteracts the deshielding effect of its electronegativity. Protonation of the imidazole ring displaces the F-2 and F-4 signals downfield and upfield, resp., the same effect was observed in the imidazole anion. The amino acid side chain charge caused field perturbation of the 19F signal in fluorohistidines.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about Ionization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mahdavian, K. published the artcile< The Role of Organic Acids and Thiol Compounds in Detoxification and Tolerance of Zn Stress in Two Populations of Harmel>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Peganum zinc stress detoxification organic acids thiol compound.

The present study aimed to investigate the effects of Zn exposure (0, 1, 5, 15, 30 ppm Zn) on harmel seedlings. Two populations (metallicolous and non-metallicolous) were compared in terms of the role of soluble sugars, proline, anthocyanin, reducing sugars, cysteine, total free amino acids, ascorbate, dehydroascorbate, glutathione, hydrogen peroxide (H2O2), lipid peroxidation, thiol compounds, organic acids, biomass and Zn concentration The Zn concentration in plants from metallicolous and non-metallicolous populations was similar, not significantly different. The results of hydroponic culture showed that the increase of Zn concentrations in the nutrient solution increased soluble sugars, proline, anthocyanin, reducing sugars, cysteine, total free amino acids, ascorbate, dehydroascorbate, glutathione, thiol compounds, and organic acids. In other words, the contents of H2O2 and lipid peroxidation in metallicolous populations were lower than non-metallicolous populations under Zn stresses. However, with increasing Zn stresses, the concentration of non-protein thiols increased compared to the concentration of glutathione, which indicates the accumulation of phytochelatin. Also, plants exposed to Zn showed a significant increase in malate, citrate, and oxalate but fumarate, and acetate were significantly reduced. These results indicated that the metallicolous population of harmel had a greater capacity than the non-metallicolous population to adapt to oxidative stress caused by Zn stress, and antioxidative defense in the metallicolous population of harmel might play a key role in detoxification and tolerance of Zn. In conclusion, the above results show that harmel may have a detoxification mechanism to counteract high concentrations of Zn.

Russian Journal of Plant Physiology published new progress about Aldehydes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gupta, Dinesh; Mukesh, Chandrakant; Pant, Kamal K. published the artcile< Topotactic transformation of homogeneous phosphotungastomolybdic acid materials to heterogeneous solid acid catalyst for carbohydrate conversion to alkyl methylfurfural and alkyl levulinate>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is phosphotungastomolybdic acid carbohydrate catalytic dehydration etherication.

The strong interaction of higher transition metal oxides with inorganic non-metals can be promising for generating highly acidic three-dimensional materials by design. A comprehensive controlled acidity of heteropolyacid-like catalyst and interpretation of the microstructure and mechanism of the formation of a versatile heterogeneous solid acid catalyst, HPW4Mo10Ox has been heterogenized by biomass-derived cystine as organic linkers to control the acidity of as-synthesized materials, which have greater acidity and complexity in separation from the reaction mixture The new and unique results obtained in catalysis done in biphasic reaction. Cystine binds to the surface of HPW4Mo10Ox, and the topotactic transition occurred, change the morphol. and lattice parameter. We described here a sustainable transformation of highly acidic (0.84 mmol g-1) heteropoly acid (HPW4Mo10Ox) to cystine anchored on the active surface of the heteropoly acid and controlled the acidity (0.63 mmol g-1) and heterogenized the materials. As synthesized materials have been showing that for the direct formation of alkyl levulinate and furanics intermediate from carbohydrates. HPW4Mo10Ox and HPW4Mo10Ox-Cys, act as acidic catalyst, and catalyze the mono- and disaccharides that are dissolved in primary and secondary alcs. to alkyl levulinate (AL) and alkyl methylfurfural at 170°C under microwave irradiation with glucose as the substrate, AL yield reaches 62% with 84.95% selectivity. The catalyst can be easily recovered by filtration and min. five times reused after calcination without any substantial change in the product selectivity. The anal. anal. of as-synthesis materials done by NH3-TPD, BET, XRD, FESEM, TEM, HRTEM, FTIR, ATR, TGA, DTA to stabilized the morphol. and acidity controlled mechanism.

RSC Advances published new progress about Acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tang, Meiling; Chen, Min; Li, Qiang published the artcile< Paeoniflorin ameliorates chronic stress-induced depression-like behavior in mice model by affecting ERK1/2 pathway>, Computed Properties of 112-63-0, the main research area is paeoniflorin chronic stress mice depression behavior ERK pathway; ERK1/2 pathway; Paeoniflorin; chronic restraint stress; depression; in vivo; treatment.

Depression is a mental and emotional disorder that has made an opening great burden to the society. Paeoniflorin showed remarkable antidepressant-like effects in multiple animal models with depressive disorders. However, the mol. of paeoniflorin on depression is less studied. This study aims to explore the effect and the mol. mechanism of paeoniflorin on depression in a chronic restraint stress (CRS) mice model. CRS model of C57BL/6 J mice was set up. Sucrose preference test (SPT), tail suspension test (TST), open field test (OFT) and forced swimming test (FST) were used to assess depression symptoms. Immunofluorescence staining, quant. reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting were implemented to detect the expression changes of the proteins involved in extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway. Results showed that paeoniflorin treatment decreased the degree of depression in the CRS mice. Further anal. showed that the expression of ERK1/2 proteins was significantly downregulated, while paeoniflorin could elevate the expression of ERK1/2 proteins in CRS mice. Finally, it showed that inhibiting signaling ERK1/2 pathway could aggravate the depressive behavior when treatment with ERK-specific inhibitor U0126, while the condition could be partially relieved when treated with paeoniflorin. In conclusion, the present study demonstrated that paeoniflorin attenuated chronic stress-induced depression-like behavior in mice by affecting the ERK1/2 pathway. These findings provided the basis for the mol. mechanism of paeoniflorin on the effect of depression, which support paeoniflorin might act as an important drug in the treatment of depression.

Bioengineered published new progress about Body weight loss. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yuanhui; Hao, Liang; Bai, Minli published the artcile< Modeling studies of the discharge performance of Li-O2 batteries with different cathode open structures>, Product Details of C19H34O2, the main research area is lithium peroxide oxygen cathode open structure discharge performance.

A two-dimensional (2D) transient model is proposed to explore the effect of cathode open structure on the discharge performance of the non-aqueous lithium-oxygen (Li-O2) batteries. It is found that decreasing the cathode open hole width (Whole) enhances the O2 transport ability in the electrode, making O2 concentration and lithium peroxide (Li2O2) deposit uniformly distributed within the electrode. This is conducive to reducing the concentration polarization and extending the discharge capacity of the Li-O2 batteries. The cathode open structure with Whole = 0.2 mm is regarded as the optimized open mode (OOM) as Whole = 0.2 mm gives the battery superior discharge performance, and further reduction of Whole will not increase the battery discharge capacity significantly. The Li-O2 battery with OOM has a pronounced increase in the discharge capacity under both pure O2 and air environments. The battery discharge capacity promotion by OOM is more remarkable if using DMSO electrolyte in the air environment and at a high c.d. of 4.0 A m-2. Therefore, the optimization of the cathode open structure is an effective way to improve the discharge performance of the Li-O2 batteries, especially operating in a low O2 environment.

Journal of the Electrochemical Society published new progress about Batteries (lithium-oxygen). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Umdale, Suraj; Mahadik, Rajashri; Otari, Pranav; Gore, Nitin; Mundada, Pankaj; Ahire, Mahendra published the artcile< Phytochemical composition, and antioxidant potential of Frerea indica Dalz.: A critically endangered, endemic and monotypic genus of the Western Ghats of India>, Synthetic Route of 112-63-0, the main research area is Frerea root stem leaf extract antioxidant phytochem.

Frerea indica Dalz.(Apocynaceae) is a critically endangered, monotypic, and endemic genus of the Western Ghats of Maharashtra, India. In the present study, the phytochem. investigation and antioxidant potential of aqueous and methanolic extracts of root, stem, and leaves were ascertained. The proximate component anal. showed the presence of various phytoconstituents in root, stem, and leaves in considerable amount Methanolic extract of leaves showed the highest amount of Total Phenolic Content (5.01 ± 0.64 mg GAE/g), Total Flavonoid Content (12.31 ± 0.07 mg RE/g), Total Alkaloid Content (18.09 ± 1.76 mg CoE/g), and Total Tannin Content (10.50 ± 0.97 mg TAE/g) content. Furthermore, the highest antioxidant activity (ABTS, DPPH, and FRAP) was observed in the methanolic extract of leaves (except for phosphomolybdenum assay). A significant correlation (P<0.01 and P<0.05) was observed between the phenolic compounds (TPC, TFC) and antioxidant activity. Gas Chromatog. - Mass Spectrometry (GC-MS) anal. showed that the presence of a vast array of bioactive compounds in root, stem, and leaf extracts of F. indica. The results obtained will provide information about the various phytoconstituents and potential antioxidants, which will be useful in understanding the efficacy of this plant for pharmaceutical applications. Biocatalysis and Agricultural Biotechnology published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics