Category: 112-63-0

Smith, Hilton A.; Hunt, Paul P. published the artcile< Kinetics of the esterification of the cyclohexanedicarboxylic acids with diphenyldiazomethane>, Category: esters-buliding-blocks, the main research area is .

The rates of esterification of 1,2-, 1,3-, and 1,4-cyclohexanedicarboxylic acids (I) and their monomethyl esters (II) in absolute EtOH with diphenyldiazomethane (III) were determined at 15, 25, 35, and 45° by using a spectrophotometer to determine the extent of reaction. The rate constants are a combination of the rates of reaction of III with the acids or monomethyl ester and the EtOH (acid, average rate constants in l./mole min. at 15, 25, 35, 45°, Εa × 10-4 cal./mole) cis-1,2-, 0.264, 0.696, 1.72, 3.79, 1.63; trans-1,2-, 0.362, 0.889, 2.14, 4.71, 1.56; cis-1,3-, 0.278, 0.730, 1.78, 3.96, 1.62; trans-1,3-, 0.207, 0.525, 1.28, 2.90, 1.62; cis-1,4-, 0.210, 0.541, 1.33, 2.90, 1.59; trans-1,4-, 0.260, 0.678, 1.62, 3.56, 1.58 (monomethyl ester, average rate constants in l./mole min. at 15, 25, 35, 45°, Εa × 10-4 cal./mole) cis-1,2-, 0.158, 0.405, 0.984, 2.21, 1.61; trans-1,2-, 0.228, 0.567, 1.38, 2.99, 1.58; cis-1,3-, 0.150, 0.376, 0.926, 2.11, 1.61; trans-1,3-, 0.115, 0.297, 0.712, 1.63, 1.60; cis-1,4-, 0.117, 0.294, 0.717, 1.61, 1.61; trans-1,4-, 0.137, 0.337, 0.829, 1.87, 1.59. The rate constants for the reaction of III with I or II show a total variation of less than 2, whereas the acid- and base-catalyzed esterifications of I have a total variation of about 20, indicating the relatively minor importance of steric considerations in the reaction of III with I and II. The presence of the Me group does not materially increase the steric hindrance to reaction with III. The large rates for the cis- and trans-1,2-acids and monoesters indicate that the electron-sink properties of the carboxyl or ester group are more important than the steric effects. The acid group is more reactive in II than in I. The cis-1,3 and trans-1,4 compounds behave similarly, as do the trans-1,3 and the cis-1,4 compounds

Journal of the American Chemical Society published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chiu, George; Li, Shengjian; Connolly, Peter J.; Pulito, Virginia; Liu, Jingchun; Middleton, Steven A. published the artcile< (Phenylpiperidinyl)cyclohexylsulfonamides: Development of α1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS)>, HPLC of Formula: 112-63-0, the main research area is phenylpiperidinylcyclohexyl benzenesulfonamide preparation alpha1a alpha1d selective adrenergic receptor antagonist; benign prostatic hyperplasia lower urinary tract drug phenylpiperidinylcyclohexyl benzenesulfonamide.

Although α1 adrenergic receptor blockers can be very effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS), their usage is limited by CV-related side-effects that are caused by the subtype non-selective nature of the current drugs. To overcome this problem, it was hypothesized that a α1a/1d subtype selective antagonist would bring more benefit for the therapy of BPH/LUTS. In developing such selective α1a/1d ligands, (phenylpiperidinyl)cyclohexylsulfonamides (e.g. N-[cis-4-[4-(2-isopropoxyphenyl)piperidin-1-yl]cyclohexyl]-3,4-dimethoxybenzenesulfonamide) were synthesized and evaluated for binding to three cloned human α1-adrenergic receptor subtypes. Many compounds showed equal affinity for both α1a and α1d subtypes with good selectivity vs. the α1b subtype.

Bioorganic & Medicinal Chemistry Letters published new progress about Arenesulfonamides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Dehua; Wang, Liwen; Wu, Yanfei; Qin, Xuemei; Du, Guanhua; Zhou, Yuzhi published the artcile< Metabolomics Based on Peripheral Blood Mononuclear Cells to Dissect the Mechanisms of Chaigui Granules for Treating Depression>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is metabolomic blood mononuclear cell chaigui granule depression inflammation.

Chaigui granules were a traditional Chinese medicine (TCM) preparation with antidepressant effects derived from a famous antidepressant prescription. It was of great significance to clarify the antidepressant mechanism of Chaigui granules for the clin. application of this drug. In this study, a chronic unpredictable mild stress (CUMS) depression model was successfully established, and behavioral indicators were used to evaluate the antidepressant effect. Second, the CD4+, CD8+, and CD4+/CD8+ levels were detected in peripheral blood. Meanwhile, the amount of inflammatory cytokines was determined in serum. Correspondingly, LC/MS-based peripheral blood mononuclear cell (PBMC) metabolomics was used to investigate vital metabolic pathways participating in the antidepressive effects of Chaigui granules. Finally, bioinformatics technol. was further employed to discover the potential antidepressant mechanism of Chaigui granules regulating the immune system. The results suggested that the administration of Chaigui granules significantly improved CUMS-induced depressive symptoms. Chaigui granules could improve immune function by regulating T lymphocyte subsets, increasing anti-inflammatory cytokine levels of IL-2 and IL-10, and reducing pro-inflammatory cytokine levels of TNF-α, IL-1β, and IL-6. In addition, metabolomics results of PBMCs showed that Chaigui granules improved 14 of the 25 potential biomarkers induced by CUMS. Metabolic pathway analyses indicated that purine metabolism was the critical metabolic pathway regulated by Chaigui granules. Furthermore, correlation anal. indicated that 13 key biomarkers were related to immune-related indicators. The metabolite-gene network of 13 key biomarkers was investigated by using bioinformatics. The investigation showed that 10 targets (5′-nucleotidase ecto; 5′-nucleotidase, cytosolic IB; 5′-nucleotidase, cytosolic II; etc.), mainly belong to the purine metabolism, might be potential targets for Chaigui granules to exert their antidepressant effects by improving immune function impairment. Together, our results suggested that Chaigui granules might exert antidepressant effects by improving immune function and regulating the purine metabolic pathway in PBMCs. This work used PBMCs metabolomics as an entry point to study the antidepressant mechanism of Chaigui granules, which provided a new way to elucidate the mechanism of a traditional Chinese medicine prescription.

ACS Omega published new progress about Antidepressants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ambady, Prakash; Wu, Yingjen Jeffrey; Kersch, Cymon N.; Walker, Joshua M.; Holland, Samantha; Muldoon, Leslie L.; Neuwelt, Edward A. published the artcile< Radiation enhances the delivery of antisense oligonucleotides and improves chemo-radiation efficacy in brain tumor xenografts>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is antisense oligonucleotide chemoradiation brain tumor xenografts.

Overexpression of O6-methylguanine DNA methyltransferase (MGMT) contributes to resistance to chemo-radiation therapy (CRT) in brain tumors. We previously demonstrated that non-ablative radiation improved delivery of anti-MGMT morpholino oligonucleotides (AMONs) to reduce MGMT levels in s.c. tumor xenografts. We evaluate this approach to enhance CRT efficacy in rat brain tumor xenograft models. The impact of radiation on targeted delivery was evaluated using fluorescent oligonucleotides (f-ON). In vitro, f-ON was localized to clathrin-coated vesicles, endosomes, and lysosomes using confocal microscopy in T98G glioma cells. In vivo, fluorescence was detected in pre-radiated, but not non-radiated Long Evans (non-tumor bearing) rat brains. Cranial radiation (2 Gy) followed by AMONs (i.v., 10.5 mg/kg) reduced MGMT expression by 50% in both orthotopic cerebellar D283 medulloblastoma and intracerebral H460 non-small cell lung carcinoma (NSCLC) xenograft models. To evaluate the efficacy, AMONs concurrent with CRT (2 Gy radiation plus oral 20 mg/kg temozolomide x4 days) reduced tumor volumes in the medulloblastoma model (p = 0.012), and a similar trend was found in the NSCLC brain metastasis model. We provide proof of concept for the use of non-ablative radiation to guide and enhance the delivery of morpholino oligonucleotides into brain tumor xenograft models to reduce MGMT levels and improve CRT efficacy.

Cancer Gene Therapy published new progress about Allograft inflammatory factor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Linetsky, Mikhail; LeGrand, Roy D.; Mossine, Valeri V.; Ortwerth, B. J. published the artcile< Sugar-mediated crosslinking of α-biotinylated-Lys to cysteamine-agarose support: a method to isolate Maillard Lys-Lys-like crosslinks>, Quality Control of 112-63-0, the main research area is advanced glycation endproduct lysine crosslink Maillard reaction.

Advanced glycation end products (AGEs) and, specifically, protein-protein AGE crosslinks have long been studied for their potential role in aging, diabetic complications and Alzheimer disease. With few exceptions, the chem. nature of these structures remains unknown. We report here a simple approach that allows the preparation and isolation of milligram quantities of sugar-mediated AGE Lys-Lys-like crosslinks from glycation mixtures The method is based on a sugar-dependent incorporation of Nα-biotinyl-L-Lys into cysteaminyldisulfide Sepharose 6B (AE-S-S-Sepharose 6B). Glycation mixtures with six different sugars showed a time- and sugar-dependent decrease in the concentration of the support-bound primary amino groups and accounted for almost 90% loss of cysteaminyl amino groups at the end of the various incubation periods. 4-Hydroxyazobenzene-2-carboxylic acid-avidin assays indicated the incorporation of Nα-biotinyl-L-Lys equal to 8% of the total support amino groups with methylglyoxal after 7 d and 1% with fructose and glucose after 1 mo of incubation. Treatment of the washed, sugar-modified supports with 2-mercaptoethanol released the bulk of the bound AGE modifications and the crosslinks. Subsequent fractionation of these preparations over a monomeric avidin column afforded a complete separation of sugar-mediated AGE modifications and the crosslinks. Depending on the sugar employed, micromolar amounts of biotinylated Lys-Lys-like crosslinks were generated by this two-step procedure from 8 mL of the original AE-S-S-Sepharose 6B.

Applied Biochemistry and Biotechnology published new progress about Advanced glycosylation end products Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Calleros, Erasmo Lopez; Simonovsky, Felix I.; Garty, Shai; Ratner, Buddy D. published the artcile< Crosslinked, biodegradable polyurethanes for precision-porous biomaterials: Synthesis and properties>, Reference of 112-63-0, the main research area is microporous crosslinked biodegradable polyurethane tissue engineering scaffold property biocompatibility.

Crosslinked poly(ester urethane)s and their acrylate derivatives based on trifunctional polycaprolactone and trifunctional aliphatic isocyanates were synthesized. Biodegradable scaffolds with uniform, controlled micron-scale porosity were fabricated with these materials. Mech. and swelling properties of monolithic and microporous materials were studied. Cytotoxicity, hydrolytic, and enzymic degradation and their effects on mech. properties of the biodegradable scaffolds were investigated. The polymer degradation products were found not to be cytotoxic at moderate concentrations and to permit cell attachment and spreading. Degradation rates and mech. properties could be tuned to desired performance criteria for a given application by adjusting crosslink d. and the ratio of hard segment to soft segment. © 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48943.

Journal of Applied Polymer Science published new progress about Biocompatibility. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pistelli, Luisa; Benassi, Sandra; Migliore, Lucia; Papa, Stefania; Andreassi, Maria Grazia published the artcile< Synthesis and biological activity of a series of isoindolone derivatives related to cytochalasins>, Reference of 112-63-0, the main research area is isoindolone derivative preparation lymphocyte binucleation cytostatic; cytochalasin analog preparation lymphocyte binucleation cytostatic.

A series of hydrogenated isoindolone derivatives structurally related to cytochalasin B has been synthesized and their ability to induce binucleation in the human lymphocytes were tested. All compounds were found able to inhibit cell cytokinesis at different extent in the range (3.12-25 μmol/L) respect to the neg. control; however the highest percentage of binucleated cells is induced by Cytochalasin B.

Farmaco published new progress about Cytokinesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xiaojie; Guo, Shanchun; Chen, Chengsheng; Perez, German Ruiz; Zhang, Changde; Patanapongpibul, Manee; Subrahmanyam, Nithya; Wang, Rubing; Keith, Joshua; Chen, Guanglin; Dong, Yan; Zhang, Qiang; Zhong, Qiu; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong published the artcile< Asymmetric 1,5-diarylpenta-1,4-dien-3-ones: Antiproliferative activity in prostate epithelial cell models and pharmacokinetic studies>, Quality Control of 112-63-0, the main research area is bisdiethylphosphonato acetone heteroaryl aldehyde diastereoselective Horner Wadsworth Emmons reaction; oxo heteroarylbutenyl phosphonate preparation aldehyde diastereoselective Horner Wadsworth Emmons; diheteroarylpentadienone preparation antitumor activity SAR apoptosis acute toxicity; 1,5-Diheteroarylpenta-1,4-dien-3-one; Cell apoptosis; Cell proliferation; Pharmacokinetic study; Prostate cancer.

To further engineer dienones with optimal combinations of potency and bioavailability, thirty-four asym. 1,5-diarylpenta-1,4-dien-3-ones I [R1 = 1-(sec-butyl)-1H-imidazol-2-yl, pyridin-2-yl, 1-isopropyl-1H-benzo[d]imidazol-2-yl, etc.; R2 = 3,4-dimethoxyphenyl, thiazol-2-yl, 2-(piperidin-1-yl)thiazol-5-yl, etc.] were designed and synthesized for the evaluation of their in vitro anti-proliferative activity in three human prostate cancer cell lines and one non-neoplastic prostate epithelial cell line. All these asym. dienones I were sufficiently more potent than curcumin and their corresponding sym. counterparts. The optimal dienone I [R1 = 1-isopropyl-1H-benzo[d]imidazol-2-yl; R2 = pyridin-2-yl], with IC50 values in the range of 0.03-0.12 μM, was 636-, 219-, and 454-fold more potent than curcumin in three prostate cancer cell models. Dienones I [R1 = 1-(sec-butyl)-1H-imidazol-2-yl (II), 1-ethyl-1H-benzo[d]imidazol-2-yl; R2 = 2-methyl-4-(trifluoromethyl)thiazol-5-yl] emerged as the most promising asym. dienones that warrant further preclin. studies. The two lead compounds demonstrated substantially improved potency in cell models and superior bioavailability in rats, while exhibiting no acute toxicity in the animals at the dose of 10 mg/kg. Dienones II and I [R1 = 1-propyl-1H-benzo[d]imidazole-2-yl, R2 = 1-propyl-1H-imidazole-2-yl (III)] could induce PC-3 cell cycle regulation at the G0/G1 phase. However, dienone II induced PC-3 cell death in a different way from III even though they share the same scaffold, indicating that terminal heteroaromatic rings were critical to the action of mechanism for each specific dienone.

European Journal of Medicinal Chemistry published new progress about Acute toxicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Steenkamp, Jacobus A.; Ferreira, Daneel; Roux, David G. published the artcile< Stereospecific functionalization of the heterocyxlic ring systems of flavan-3-ol and [4,8]-biflavan-3-ol derivatives with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).>, COA of Formula: C19H34O2, the main research area is stereospecific methoxylation flavanol ether; functionalization stereospecific heterocyclic ring; biflavanol oxidation stereospecific; benzoquinone oxidation heterocyclic stereochemistry.

Efficient stereospecific 4-methoxylation of both 2,3-trans- and 2,3-cis-flavan-3-ol Me ethers with DDQ (I) in CHCl3-MeOH has synthetic and degradative significance in oligomeric flavanoid chem. Thus, (+)-catechin tetra-Me ether and its acetate (II; R = H, OAc) were oxidized by I in CHCl3-MeOH to the MeO derivative III (same R).

Tetrahedron Letters published new progress about Methoxylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yan, Bao-Fei; Chen, Xi; Chen, Ya-Fang; Liu, Sheng-Jin; Xu, Chen-Xin; Chen, Ling; Wang, Wen-Bo; Wen, Ting-Ting; Zheng, Xian; Liu, Jia published the artcile< Aqueous extract of Paeoniae Radix Alba (Paeonia lactiflora Pall.) ameliorates DSS-induced colitis in mice by tunning the intestinal physical barrier, immune responses, and microbiota>, Related Products of 112-63-0, the main research area is Paeonia lactiflora extract DSS induced colitis immune response microbiota; Aqueous extract of paeoniae radix alba; Gut microbiota; IL-23/IL-17 axis; Intestinal barrier; Tight junction; Ulcerative colitis.

Ulcerative colitis (UC) is a chronic non-specific intestinal inflammatory disease, the pathogenesis of which is strongly associated with the compromised intestinal barrier. Paeoniae Radix Alba (PRA), the root of Paeonia lactiflora Pall., is a well-known traditional Chinese medicine and an adaptogen used in Hozai, exhibiting appreciable anti-inflammatory and immunomodulatory activity. Nevertheless, the role and mechanism of PRA in UC have yet to be elucidated. Aim of the study: This study was set out to examine the ameliorative effects of the aqueous extract of PRA (i.e., PRA dispensing granule, PRADG) on dextran sulfate sodium (DSS)-induced colitis. The chem. components of PRADG was analyzed by HPLC. Colitis model mice were induced by free access to water containing 2.5% DSS for 10 consecutive days, and concurrently, PRADG (0.1025 and 0.41 g/kg) or Salazosulfapyridine (SASP, 450 mg/kg) was given orally from day 1-10. Body weight, disease activity index (DAI), colon length, histol. scoring, and inflammatory response were assessed. Addnl., IL-23/IL-17 axis and tight junction (TJ) proteins, as well as gut microbiota were also investigated under the above-mentioned regimen. Eight main chem. constituents of CPT were revealed with HPLC anal. Noticeably, PRADG could effectively lower body weight loss as well as DAI scores, alleviate colon shortening, and reduce the levels of proinflammatory cytokines in mice with colitis. Further exploration found that increment of TJ proteins expression (ZO-1, occludin and claudin-1) and inhibition of IL-23/IL-17 axis-modulated inflammation were observed in PRADG-treated mice. Addnl., the diversity of gut microbiota and the relative abundance of beneficial bacteria were increased following PRADG treatment. PRADG could be sufficient to ameliorate colitis by regulating the intestinal phys. barrier, immune responses, and gut microbiota in mice. Our findings highlight that PRADG might be a prospective remedy for UC.

Journal of Ethnopharmacology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics