Category: 112-63-0

Chen, Yinyan; Wu, Yiban; Zhu, Yifan; Tian, Saiqi published the artcile< A fluorescent polyurethane foam based on rhodamine derivative as Fe(III) sensor in pure water>, COA of Formula: C19H34O2, the main research area is rhodamine derivative polyurethane foam preparation ferric fluorescent sensor water.

Rhodamine salicylaldehyde was synthesized, and its structure was determined using Fourier transform IR spectroscopy, 1H NMR anal. as well as electrospray ionization mass spectrometry. Then a fluorescent polyurethane foam was obtained via incorporation of the prepared rhodamine salicylaldehyde, and the fluorescence sensing behavior for Fe3+ was systematically investigated. Results showed that the fluorescent polyurethane foam produced higher fluorescence in the presence of Fe3+ in pure water, due to the coordination for Fe3+ binding leading to ring-opened amide form. The limit of detection was calculated to be 1.64 × 10-6 mol L-1. This fluorescent polyurethane foam can also recognize Fe3+ with good selectivity.

Polymer International published new progress about Cations. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Rui; Xu, Yimin; Xie, Sidi; Zhang, Yunxiao; Wang, Hai; Yi, Guo-Zhong; Huang, Guanglong; Ni, Bowen; Song, Haimin; Wang, Ziyu; Qi, Song-Tao; Liu, Yawei published the artcile< Recycling of SLC38A1 to the plasma membrane by DSCR3 promotes acquired temozolomide resistance in glioblastoma>, Formula: C19H34O2, the main research area is glioblastoma SLC38A1 plasma membrane DSCR3 temozolomide resistance; Acquired TMZ resistance; DSCR3; Endosomal sorting; Glioblastoma; Glioma; SLC38A1.

Glioblastoma multiforme (GBM) is a primary brain tumor with devastating prognosis. Although the O6-methylguanine-DNA methyltransferase (MGMT) leads to inherent temozolomide (TMZ) resistance, approx. half of GBMs were sufficient to confer acquired TMZ resistance, which express low levels of MGMT. The purpose of this study was to investigate the underlying mechanisms of the acquired TMZ resistance in MGMT-deficient GBM. The function of Down syndrome critical region protein 3 (DSCR3) on MGMT-deficient GBM was investigated in vitro and in an orthotopic brain tumor model in mice. Purification of plasma membrane proteins by membrane-cytoplasmic separation and subsequent label free-based quant. proteomics were used to identified potential protein partners for DSCR3. Immunofluorescence was performed to show the reverse transport of solute carrier family 38 member 1 (SLC38A1) mediated by DSCR3. DSCR3 is upregulated in MGMT-deficient GBM cells during TMZ treatment. Both DSCR3 and SLC38A1 were highly expressed in recurrent GBM patients. Silencing DSCR3 or SLC38A1 expression can increase TMZ sensitivity in MGMT-deficient GBM cells. Combination of proteomics and in vitro experiments show that DSCR3 directly binds internalized SLC38A1 to mediate its sorting into recycling pathway, which maintains the abundance on plasma membrane and enhances uptake of glutamine in MGMT-deficient GBM cells. DSCR3 is a crucial regulator of acquired TMZ resistance in MGMT-deficient GBM. The DSCR3-dependent recycling of SLC38A1 maintains its abundance on plasma membrane, leading to tumor progression and acquired TMZ resistance in MGMT-deficient GBM.

Journal of Neuro-Oncology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (DSCR3). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Yao; Hu, Yu; Tang, Lingli; Yin, Senlin; Lv, Liang; Zhou, Peizhi published the artcile< Targeting CXCR4 to suppress glioma-initiating cells and chemoresistance in glioma>, Formula: C19H34O2, the main research area is Bcl2-Like 12; C-X-C motif chemokine receptor 4; KLF5; chemotherapy; glioma-initiating cells (GICs).

Glioma initiating cells (GICs), also known as glioma stem cells, display the capacity to recapitulate the functional diversity within the tumor. Despite the great progress achieved over the last decades, defining the key mol. regulators of GICs has represented a major obstacle in this field. In our study, data from The Cancer Genome Atlas database illustrated a relationship between C-X-C motif chemokine receptor 4 (CXCR4) expression and the survival of glioma patients. Mechanistically, we further indicated that CXCR4 mediated the upregulation of Kruppel like factor 5 (KLF5), a zinc-finger-containing transcription factor, to facilitate the proliferation of GICs. What′s more, CXCR4 also enhanced the chemoresistance through KLF5/Bcl2-like 12 (BCl2L12) in glioma. The elevated expression of KLF5 and BCL2L12 induced by CXCR4 was dependent on phosphoinositide 3-kinases (PI3K)/serine/threonine kinase (AKT) signaling. Importantly, combined application of temozolomide and a CXCR4 inhibitor efficiently reversed CXCR4 mediated drugs resistance and improved anticancer effects in vivo. Collectively, our findings confirmed that CXCR4 promoted GICs proliferation via the KLF5/BCL2L12 dependent pathway, which may enrich the understanding of GICs and help drive the design of efficacious therapeutic strategies.

Cell Biology International published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Barton, Nick; Convery, Maire; Cooper, Anthony W. J.; Down, Kenneth; Hamblin, J. Nicole; Inglis, Graham; Peace, Simon; Rowedder, James; Rowland, Paul; Taylor, Jonathan A.; Wellaway, Natalie published the artcile< Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach>, Reference of 112-63-0, the main research area is inhibitor phosphoinositide kinase delta.

A deconstruction of previously reported phosphoinositide 3-kinase δ (PI3Kδ) inhibitors and subsequent regrowth led to the identification of a privileged fragment for PI3Kδ, which was exploited to deliver a potent, efficient, and selective lead series with a novel binding mode observed in the PI3Kδ crystal structure.

Journal of Medicinal Chemistry published new progress about Crystal structure (of phosphoinositide 3-kinase δ and inhibitor). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hoeben, Freek J. M.; Wolffs, Martin; Zhang, Jian; De Feyter, Steven; Leclere, Philippe; Schenning, Albertus P. H. J.; Meijer, E. W. published the artcile< Influence of Supramolecular Organization on Energy Transfer Properties in Chiral Oligo(p-phenylene vinylene) Porphyrin Assemblies>, HPLC of Formula: 112-63-0, the main research area is excitation energy transfer chiral oligophenylenevinylene appended porphyrin supramol organization.

A comparative study on oligo(p-phenylene vinylene) (OPV)-appended porphyrins containing all trans-vinylene (either hydrophilic or lipophilic) or amide linkages (lipophilic) is presented. The type of supramol. arrangement obtained in organic solvents proves to be strongly dependent on the nature of the covalent connection. In the case of all trans-vinylene linkages, a J-type intermol. packing is obtained and the assemblies are only of moderate stability. Conversely, the supramol. structures obtained from the amide-linked system display an H-type stacking arrangement of enhanced stability and chirality as a consequence of intermol. hydrogen bonding along the stack direction, favorably interlocking the stacked building blocks. Interestingly, the observed differences in stability and organization are qual. illustrated by monitoring the sequential energy transfer process in both types of assemblies. Efficient intramol. energy transfer from the OPVs (donors) to the resp. porphyrin cores is followed by energy transfer from Zn-porphyrin (donor) to free-base porphyrin (acceptor) in both systems. However, the improved intermol. organization for the amide-linked system increases the energy transfer efficiency along the stack direction. In addition, the water-soluble (OPV)-appended porphyrin system forms highly stable assemblies in an aqueous environment. Nevertheless, the poor energy transfer efficiency along the stack direction reveals a relative lack of organization in these assemblies.

Journal of the American Chemical Society published new progress about Chirality. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bailey, William J.; Barclay, Robert Jr. published the artcile< Cyclic dienes. XXIII. 1,4-Dimethylene-2-cyclohexene>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

p-C6H4(CO2Me)2 (I) (643 g.), 40 cc. absolute EtOH, and 36 g. W-2 Raney Ni hydrogenated 1.8 hrs. at 140-85°/3 atm., the mixture dissolved in hot EtOH and filtered, the filtrate cooled overnight at about 5° and filtered from 48 g. unchanged I, and the final filtrate distilled gave 54 g. forerun, b7 68-119°, and 512 g. di-Me cis- and trans-1,4-cyclohexanedicarboxylate (II), b6-7 122.5-6.5°, n31D 1.4560; the forerun refractionated yielded 15 g. impure Me 4-methylcyclohexanecarboxylate, b3.0 50-8.5°, n25D 1.4490, 26 g. (crude) p-MeC6H4CO2Me (III), b3.7-4.0 77-80°, n25D 1.5120, m. 32-5°, and 11 g. impure II, b3.6-3.8 104.5-17.5°, n25D 1.4579. The III (4.7 g.) saponified gave 3.12 g. p-MeC6H4CO2H, m. 180-1°. II (522 g.), 200 cc. H2O, and 4500 cc. MeOH treated with stirring during 7.5 hrs. with 121 g. KOH in 300 cc. H2O, stirred 13.5 hrs., concentrated with the removal of about 4000 cc. solvent, the residue diluted with 1300 cc. H2O and extracted with Et2O, and the extract evaporated on the steam bath in a stream of air gave 165 g. unreacted II; the aqueous phase cooled to 15°, acidified with 180 cc. concentrated HCl, and extracted with 1100 cc. Et2O, and the extract worked up gave 310 g. mono-Me ester (IV) of cis- and trans-1,4-cyclohexanedicarboxylic acid. IV (380 g.) and 450 cc. SOCl2, b. 75.8°, heated during 2.2 hrs. to 87°, heated 1.75 hrs. at 87-96°, treated during about 8 hrs. with 110 cc. Br at 96-103°, stirred 9 hrs. at 100-5°, cooled, and evaporated in vacuo, the residue added during 28 min. to 300 cc. absolute MeOH, refluxed 1 hr., cooled, poured into about 2 l. H2O, and extracted with Et2O, and the extract worked up yielded 520 g. 1-Br derivative (V) of IV, b0.12-0.25 92.5-99°, n25D 1.4914. Crude V (553 g.) added during 6.3 hrs. with stirring to 528 g. KOH pellets in 1500 cc. MeOH at reflux temperature, refluxed an addnl. 50 min., kept overnight, about 700 cc. solvent removed in vacuo, the pasty residue dissolved in 2 l. H2O, and the solution acidified with 800 cc. concentrated HCl, cooled to about 27°, and filtered yielded 250 g. crude 1-cyclohexene-1,4-dicarboxylic acid (VI). Crude VI, 240 cc. SOCl2, and 300 cc. CHCl3 refluxed 5.8 hrs., cooled, diluted during 40 min. with 300 cc. absolute MeOH, heated, diluted with 10 cc. concentrated H2SO4 in 200 cc. absolute MeOH, refluxed 11 hrs., cooled, and poured into 1.5 l. H2O, and the product isolated with CHCl3 yielded 233 g. semisolid product which recrystallized from 500 cc. petr. ether gave 208 g. di-Me ester (VII) of VI, m. 34-6°. VII (220 g.) in 600 cc. dry Et2O added during 6 hrs. to 62 g. LiAlH4 in 1800 cc. dry Et2O, heated 58 hrs., and worked up yielded 142 g. impure 1-cyclohexene-1,4-dimethanol (VIII), b3.2-3.8 115-48°. The crude VIII in 65 cc. AcOH added during 55 min. to 525 cc. refluxing Ac2O, refluxed 9.4 hrs., and distilled gave 177 g. mixed acetate, b3.5-3.7 115.5-39°; the acetate mixture reduced with 40 g. LiAlH4 and acetylated with 426 cc. Ac2O and 55 cc. AcOH yielded 154 g. diacetate (IX) of VIII, b3.0 133-3.5°. IX (21.1 g.) pyrolyzed at 490-5° over Pyrex helices, the pyrolyzate washed several times with H2O, combined with the product from 2 parallel batches, and distilled gave 13.0 g. 1,4-dimethylene-2-cyclohexene (X), b47 57°, n25D 1.5398, 8.8 g. mixture of diene acetates, b3.0-3.2 73.5-9.5°, n25D 1.4795, and 5.6 g. mixture of olefin diacetates, b3.0-3.3 128.5-36°. X (2.72 g.), 0.20 g. 10% Pd-C, and 0.19 g. hydroquinone heated during 2.25 hrs. from 135 to 180°, kept 10.75 hrs. at 174-80°, cooled somewhat, and distilled, and the distillate collected in 2 Dry Ice traps gave 0.79 g. crude p-xylene, n24D 1.4890, m. 5.3-11.2° (trinitro derivative m. 137.5-41°). X (1.08 g.) in 100 cc. EtOAc ozonized at 0° with O containing 0.0013 mole O3/l. during 8 hrs. at 6.8 l./hr. and the effluent passed through H2O gave from the aqueous solution the dimedon derivative of CH2O, m. 190.5-1.5°; the mixture evaporated, the residual ozonide heated 5 hrs. with 25 cc. 30% H2O2 and 40 cc. glacial AcOH on the steam bath, the solution stirred 40 hrs. while being heated, diluted at intervals with H2O to maintain the volume, and evaporated at atm. pressure, the gummy residue extracted with aqueous Me2CO, and the extract worked up gave 0.32 g. (CH2CO2H)2, m. 179-83°; N,N’-bis(p-tolylsuccinamide) m. 255.5-9.5°. X (0.48 g.), 0.0077 g. Bz2O2, and 7 cc. C6H6 refluxed 46 hrs., an addnl. 0.0303 g. Bz2O2 added in 4 portions during the heating, filtered, poured slowly into 100 cc. MeOH, treated with a small amount of 2-C10H7NHPh, allowed to stand 3 days, and filtered, and the residual polymer washed with MeOH and dried 2 days at about 2 mm. yielded 0.018 g. polymeric X, softens at about 150-5°. X (0.45 g.) and 5 cc. CS2 treated at -78° with BF3, kept 19.5 hrs. at -78° with occasional shaking, diluted with 1 cc. cold MeOH, warmed with stirring to room temperature, poured into 55 cc. MeOH, and filtered, and the residue washed with MeOH, and dried 36 hrs. at about 2 mm. gave 0.08 g. polymeric X.

Journal of the American Chemical Society published new progress about Unsaturated compounds. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Perpetuini, Giorgia; Battistelli, Noemi; Tittarelli, Fabrizia; Suzzi, Giovanna; Tofalo, Rosanna published the artcile< Influence of FLO1 and FLO5 genes on aroma profile of sparkling wines>, Quality Control of 112-63-0, the main research area is sparkling wine aroma FLO gene influence.

This study investigated the influence of S. cerevisiae F6789A strain and its derivative mutants – harbouring FLO1 gene deletion (F6789A-ΔFLO1) and FLO5 gene deletion (F6789A-ΔFLO5) – on secondary fermentation, autolysis outcome and aroma compounds production Data revealed differences in terms of metabolic behavior leading to the production of sparkling wines with different characteristics. F6789A showed the best fermentation kinetic reaching a pressure of 5 bar inside the bottle, while F6789A-ΔFLO1 and F6789A-ΔFLO5 reached 4 bar and 3.8 bar, resp. Cell viability was in agreement with fermentation kinetics. In fact, F6789A showed the highest number of cells. An early autolysis was observed for F6789A-ΔFLO5. Differences were observed especially for esters in terms of number and quantity of esters released. In particular, the parental strains produced 39 different esters while F6789A-ΔFLO1 and F6789A-ΔFLO5 27 and 35, resp. F6789A-ΔFLO5 was the main ester producer with a total amount of about 89 mg/L. Sensory anal. showed that all the strains produced balanced sparkling wines with neg. and pos. attributes arranged in good proportions, showing good aroma descriptors. Obtained data suggested that FLO1 or FLO5 genes had a pleiotropic effect affecting not only flocculation ability but also other metabolic traits.

LWT–Food Science and Technology published new progress about Acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Yang; Oldenhius, Nathan J.; Buchwald, Stephen L. published the artcile< Mild and general conditions for Negishi cross-coupling enabled by the use of palladacycle precatalysts>, COA of Formula: C19H34O2, the main research area is biaryl preparation; biheteroaryl preparation; heteroarylzinc preparation aryl halide Negishi cross coupling palladacycle catalyst.

A palladacycle-catalyzed Negishi cross coupling between in situ generated heteroaryl zinc reagents and aryl or heteroaryl halides is described. A series of biaryls and biheteroaryls were obtained in good to excellent yields.

Angewandte Chemie, International Edition published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Qi; Zhang, Xin-Peng; Duan, Xiu; Qin, Long-Zhou; Yuan, Xin; Wu, Meng-Yu; Liu, Jie; Zhu, Shan-Shan; Qiu, Jiang-Kai; Guo, Kai published the artcile< Photoinduced Merging with Copper- or Nickel-Catalyzed 1,4-Cyanoalkylarylation of 1,3-Enynes to Access Multiple Functionalizatized Allenes in Batch and Continuous Flow>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is functionalized tetrasubstituted allene chemoselective regioselective diastereoselective preparation; enyne cyclobutanone oxime phenylboronic acid cyanoalkylarylation photoredox nickel catalysis.

A three-component reaction of 1,3-enynes and cyclobutanone oxime esters in the presence of phenylboronic acids or organozinc reagents via the photoredox/copper or photoredox/nickel catalysis was established. This redox-neutral 1,4-cyanoalkylarylation reaction was demonstrated mild condition, high catalytic reactivity and wide functional group compatibility, allowing access to a variety of functionalized tetra-substituted allene derivatives I [R1 = H, Me, Ph; R2 = cyclopropyl, n-Bu, Ph, etc.; R3 = H, Ph, OBn, etc.; R4 = H, Me; R5 = H, Et, Bn, etc.; Ar = C6H5, 2-MeC6H4, 3-BrC6H4, etc.] with high chemo- and regioselectivity. Moreover, using photocatalytic continuous flow technique to promote this process would result in increased yields (70% in flow vs. 61% in batch), reduced reaction times (7 min in flow vs. 6 h in batch), and easy scale-up (upgrade to gram scale), showcasing its potential as a synthetic platform.

Chinese Journal of Chemistry published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cao, Xianting; Zhong, Haizhen A.; Zhang, Pengfei; Zheng, Hui published the artcile< The simple system of fixing CO2 to synthesize benzimidazolones at atmospheric pressure>, SDS of cas: 112-63-0, the main research area is carbondioxde benzimidazolone pressure catalysts.

A simple chem. fixation of CO2 at atm. pressure to make valuable benzimidazolones derivates via the o-phenylene-diamines carbonylation reaction catalyzed by DBU/S was developed. Different reaction conditions were examined and optimized. A series of benzimidazolones derivatives were synthesized using NMP as solvent at 413K with excellent yields (80-94%). Various substrates were employed and the results suggested the wide application of our method. The quantum mechanics calculations demonstrated that the complexation of DBU with sulfur significantly enhanced the reaction. This protocol rovides a novel approach of fixing CO2 at atm. pressure into a series of 2-benzimidazolones derivates.

Journal of CO2 Utilization published new progress about Catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics