Category: 112-63-0

Park, Robin; Amin, Manik; Trikalinos, Nikolaos A. published the artcile< Temozolomide duration and secondary hematological neoplasms: A literature review and implications for patients with neuroendocrine neoplasms>, COA of Formula: C19H34O2, the main research area is MDS; capecitabine; leukemia; myelodysplastic syndrome; myelotoxicity.

Evidence-based recommendations for the optimal duration and sequencing of temozolomide-based treatments in advanced neuroendocrine neoplasms are lacking. Here, we conducted a systematic review of the literature for a descriptive anal. of temozolomide-associated myelodysplasias and leukemias to guide treatment planning. A database search of PubMed and Embase was conducted to identify case reports and/or case series reporting secondary myelodysplasias or leukemias in the setting of temozolomide therapy. Key data items extracted from the studies were the temozolomide dose and duration, latency to hematol. disorder, type of secondary malignancy and cytogenetics. Reported cases were summarized graphically. A total of 16 studies with 27 patient cases of therapy-related hematol. neoplasms were identified, all of which were case reports or case series. The median treatment duration and cumulative dose were 19 mo and 18,000 mg/m2, resp. Most patients (21/27) were diagnosed on, or after, 12 mo, while only one patient was diagnosed before 6 mo of treatment. Most of the patients were diagnosed, while still on treatment with temozolomide. Graphically, cases clustered around a cumulative dose of 10,000 to 30,000 mg/m2 and a latency period of 10 to 40 mo which translates to an approx. treatment duration of 12.5 to 37.5 mo. Taken together, most reported treatment-related hematol. neoplasms appear to develop on or beyond the 12-mo mark, while patients are still on treatment with temozolomide. For patients with neuroendocrine neoplasms, where sequencing of multiple therapies is important, we suggest an approach to optimizing treatment duration by establishing disease response at 6 mo before continuing further treatment and restricting treatment to or establishing closer vigilance beyond 12 mo.

Journal of Neuroendocrinology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tobisu, Mamoru; Yasutome, Ayaka; Yamakawa, Ken; Shimasaki, Toshiaki; Chatani, Naoto published the artcile< Ni(0)/NHC-catalyzed amination of N-heteroaryl methyl ethers through the cleavage of carbon-oxygen bonds>, Computed Properties of 112-63-0, the main research area is Nickel catalyzed amination heteroaryl ether cleavage carbon oxygen bond.

Ni(0)/NHC-based catalyst system can promote the amination of N-heteroaryl Me ethers via the cleavage of normally unreactive carbon-oxygen bonds. Electron-deficient N-heteroarenes including pyridine, quinoline, isoquinoline, and quinoxaline undergo amination to afford aminopyridine and related heteroarenes, which constitute an important class of compounds

Tetrahedron published new progress about Amination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zonouz, Adeleh Moshtaghi; Sadr, Moayad Hossaini; Oskuie, Mina Raisossadat; Bachechi, Fiorella published the artcile< Synthesis and crystal structure of 2-(pyrazol-1-yl)-methyl-3,5-dicarboethoxy-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine>, Product Details of C19H34O2, the main research area is crystal structure pyrazolylmethyldicarboethoxymethylnitrophenyldihydropyridine.

The title compound, 2-(Pyrazol-1-yl)-methyl-3,5-dicarboethoxy-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine, was synthesized and the crystal structure of it (C22H24N4O6, space group P21/c, a 9.050, b 22.259, c 12.253 Å, β 90.07°, Z = 4) was determined by x-ray anal. In the crystal structure compound 3 exhibits orthogonal arrangement of the Ph ring with the nitro substituent synperiplanar respect to the C(4) H of the dihydropyridine ring. The ester groups assume a cis/cis arrangement.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xin; Liu, Yuyang; Yan, Lei published the artcile< On Thiol-Ene Radical Coupling Reaction when Synthesis of ABCL2Type Heteroarm Star Copolymer Containing PDPA Arm>, Electric Literature of 112-63-0, the main research area is polydiisopropylamino ethyl methacrylate star copolymer.

In this paper, we designed novel ABCL2-type heteroarm star copolymers, where A, B and C are poly(ε-caprolactone) (PCL), poly(2-(diisopropylamino) Et methacrylate) (PDPA) and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) arms, resp., and L is 4-([2,2′:6′,2”-terpyridine]-4′-yl) Ph (Tpyp) ligand group. In the final synthesis step, thiol-ene radical coupling was used to link PMPC chain onto PCL/PDPA copolymer to form a heteroarm star copolymer. However, it was found that the presence of the PDPA block with tertiary amine moieties led the thiol-ene radical coupling not to be achieved easily in common conditions. Herein we focus on investigating the photoinitiated thiol-ene coupling reaction. Finally, we achieve the reaction via selecting appropriate solvent. It is expected that the exploration can broaden application of thiol-ene radical reaction in synthesis of polymer architectures.

ChemistrySelect published new progress about Branched polymers, star-branched Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kobayashi, Shigeru published the artcile< Synthesis of pyrimidines and condensed pyrimidines>, COA of Formula: C19H34O2, the main research area is pyrimidine; azarycloalkanopyrimidine; carboxamide lactam reaction formamide.

A new one-step synthesis of pyrimidines, e.g. I (R = alkyl) and condensed pyrimidines, e.g., II (n = 2-4) by heating carboxamides or cyclic lactams with formamide in the presence of POCl3 in a sealed tube is described.

Bulletin of the Chemical Society of Japan published new progress about Condensation reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pairohakul, Supanut; Olive, Peter J. W.; Bentley, Matthew G.; Caldwell, Gary S. published the artcile< Trophic upgrading of long-chain polyunsaturated fatty acids by polychaetes: a stable isotope approach using Alitta virens>, Application of C19H34O2, the main research area is Alitta polychaetes long chain polyunsaturated fatty acid.

Polychaete worms are rich sources of polyunsaturated fatty acids (PUFA) and are increasingly incorporated into aquaculture broodstock diets. Conventionally, the build-up of PUFA in polychaetes was considered passive, with direct accumulation along the food web, originating with microalgae and other primary producers. However, it has been argued that polychaetes (and other multicellular eukaryotes) are capable of PUFA biosynthesis through the elongation and desaturation of precursor lipids. We further test this hypothesis in the ecol. and economically important nereid polychaete Alitta virens by adopting a stable isotope labeling approach. Worms were fed a 13C-1-palmitic acid (C16:0) enriched diet with the resulting isotopically enriched lipid products identified over a 7-day period. The data showed strong evidence of lipid elongation and desaturation, but with a high rate of PUFA turnover. A putative biosynthetic pathway is proposed, terminating with docosahexaenoic acid (DHA) via arachidonic (AA) and eicosapentaenoic acids (EPA) and involving a Δ8 desaturase.

Marine Biology (Heidelberg, Germany) published new progress about Alitta virens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ullah, Mohammad Shahid; Itsuno, Shinichi published the artcile< Cinchona Squaramide-Based Chiral Polymers as Highly Efficient Catalysts in Asymmetric Michael Addition Reaction>, Electric Literature of 112-63-0, the main research area is preparation cinchona squaramide chiral polymer catalyst green chem; asym Michael addition reaction cinchona squaramide chiral polymer catalyst.

We have synthesized novel chiral polymers containing a cinchona-based squaramide in the main chain. We designed a novel cinchona squaramide dimer that contains two cinchona squaramide units connected by diamines. The olefinic double bonds in the cinchona squaramide dimer were used for Mizoroki-Heck (MH) polymerization with aromatic diiodides. The MH polymerization of the cinchona squaramide dimer and aromatic diiodide proceeded well to give the corresponding chiral polymers in good yields. The catalytic activity of the chiral polymers was investigated for asym. Michael addition reactions. The effect of the squaramide structure of the polymeric catalyst on the catalytic performance is discussed in detail. We have surveyed the influence of the chiral polymer structure on the catalytic activity and enantioselectivity of the asym. reaction. The asym. Michael addition of β-ketoesters to nitroolefins was successfully catalyzed by polymeric cinchona squaramide organocatalysts to obtain the corresponding Michael adducts in good yields with excellent enantio- and diastereoselectivities. The polymeric catalysts were insoluble in commonly used organic solvents and easily recovered from the reaction mixture and reused several times without the loss of catalytic activity.

ACS Omega published new progress about Diastereoselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Arend, Rebecca C.; Scalise, Carly B.; Gordon, Emily R.; Davis, Allison M.; Foxall, McKenzie E.; Johnston, Bobbi E.; Crossman, David K.; Cooper, Sara J. published the artcile< Metabolic alterations and WNT signaling impact immune response in HGSOC>, Electric Literature of 112-63-0, the main research area is high grade serous ovarian cancer immune response signalling alteration.

Purpose: Our study used transcriptomic and metabolomic strategies to determine the mol. profiles of HGSOC patient samples derived from primary tumor and ascites cells. These data identified clin. relevant heterogeneity among and within patients and highlighted global and patient-specific cellular responses to neoadjuvant chemotherapy (NACT). Exptl. Design: Tissue from 61 treatment-naïve patients with HGSOC were collected. In addition, 11 benign, 32 ascites, and 18 post-NACT samples (matched to the individual patient′s pre-NACT sample) were collected. RNA sequencing (RNA-seq) was performed on all samples collected. Two-dimensional spatial proteomic data was collected for two pairs of pre- and post-NACT. Untargeted metabolomics data using GCxGC-MS was generated for 30 treatment-naive tissues. Consensus clustering, anal. of differential expression, pathway enrichment, and survival analyses were performed. Treatment-naïve HGSOC tissues had distinct transcriptomic and metabolomic profiles. The mesenchymal subtype harbored a metabolomic profile distinct from the other subtypes. Compared with primary tumor tissue, ascites showed significant changes in immune response and signaling pathways. NACT caused significant alterations in gene expression and WNT activity, and this corresponded to altered immune response. Overall, WNT signaling levels were inversely correlated with immune cell infiltration in HGSOC tissues and WNT signaling post-NACT was inversely correlated with progression-free survival. Our study concluded that HGSOC is a heterogenous disease at baseline and growing mol. differences can be observed between primary tumor and ascites cells or within tumors in response to treatment. Our data reveal potential exploratory biomarkers relevant for treatment selection and predicting patient outcomes that warrant further research.

Clinical Cancer Research published new progress about Adaptive immunity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mekala, Janaki Ramaiah; Ramalingam, Prasanna Srinivasan; Mathavan, Sivagami; Yamajala, Rajesh B. R. D.; Moparthi, Nageswara Rao; Kurappalli, Rohil Kumar; Manyam, Rajasekhar Reddy published the artcile< Synthesis, in vitro and structural aspects of cap substituted Suberoylanilide hydroxamic acid analogs as potential inducers of apoptosis in Glioblastoma cancer cells via HDAC /microRNA regulation>, HPLC of Formula: 112-63-0, the main research area is suberoylanilide hydroxamic acid HDAC microRNA glioblastoma cancer cell apoptosis; Glioblastoma; HDAC; HDAC-8; MicroRNA; Rictor; SAHA analog.

Glioblastoma multiforme (GBM) is a heterogeneous, aggressive brain cancer characterized by chemo-resistance and cancer stemness. Histone deacetylases (HDACs) are a group of enzymes that regulate chromatin epigenetics which were in turn found to be controlled by microRNAs (miRs). The drug employed in chemotherapy for the treatment of GBM is Temozolomide (TMZ). Unfortunately, many GBM patients exhibit chemo-resistance to this drug. Here we have synthesized various Suberoyl anilide hydroxamic acid (SAHA) analogs with many substitutions at the cap site majority of which not yet studied. These SAHA analogs have exhibited profound cytotoxicity at 2 μM, and 4 μM concentrations in GBM cancer cell line U87MG, and 1 μM, and 2 μM concentrations in breast cancer cell line MCF-7. Surprisingly, these analogs have exhibited cytotoxic effects in chronic lymphoid leukemia cells (Raji) at 64 μM, and 128 μM concentrations due to mutated p53. Among all the synthesized analogs 3-Chloro-SAHA, 3-Chloro-4-fluoro SAHA have exhibited effective cytotoxicity in all cancer cells. These potent analogs inhibited HDAC-8 enzyme activity by 2-folds in U87MG, and MCF-7 cell lines and 7-folds decrease in HDAC-8 activity was observed in Raji cell line. These analogs decreased the expression of HDAC-2, HDAC-3 genes and enhanced the expression of p53 tumor suppressor. Interestingly, these compounds decreased the expression of Rictor, the main component of the mTORC2 complex involved cancer cell metabolism Furthermore, these mols. have decreased oncogenic microRNA expression such as miR-21 and enhanced the expression of tumor suppressor microRNAs such as miR-143. The HDAC binding ability of these mols. was highly significant and have exhibited the ability to cross blood-brain barrier (BBB), and followed the Lipinski rule of five. Thus, these mols. need to be taken up further to clinics for better therapy against GBM either singly or combination therapy.

Chemico-Biological Interactions published new progress about Animal gene, TP53 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Jing; Wang, Nan; Qi, Ming; Li, Jianjun; Tan, Bie published the artcile< Glutamine, glutamate, and aspartate differently modulate energy homeostasis of small intestine under normal or low energy status in piglets>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is metabolome glutamine glutamate aspartate energy homeostasis small intestine; Aspartate; Energy metabolism; Glutamate; Glutamine; Small intestine.

Weaning stress may cause reduced energy intake for maintenance of mucosal structure. Gln, Glu, and Asp are major energy sources for the small intestine. This study investigated whether Gln, Glu, and Asp improve the intestinal morphol. via regulating the energy metabolism in weaning piglets. A total of 198 weaned piglets were assigned to 3 treatments: Control (Basal diet + 1.59% L-Ala); T1 (Basal diet + 1% L-Gln + 0.5% L-Glu + 0.1% L-Asp); T2 (Low energy diet + 1% L-Gln + 0.5% L-Glu + 0.1% L-Asp). Jejunum and ileum were obtained on d 5 or 21 post-weaning. T1 enhanced growth performance. T1 and T2 treatments improved small intestinal morphol. by increasing villus height, goblet cell number and decreasing crypt depth. Days post-weaning affected the efficacy of T2, but not T1, on energy metabolism At normal energy supplementation, Gln, Glu, and Asp restored small intestinal energy homeostasis via replenishing the Krebs cycle and down-regulating the AMPK (adenosine monophosphate activated protein kinase) pathway. As these are not sufficient to maintain the intestinal energy-balance of piglets fed with a low energy diet on d 5 post-weaning, the AMPK, glycolysis, beta-oxidation, and mitochondrial biogenesis are activated to meet the high energy demand of enterocytes. These data indicated that Gln, Glu, and Asp could restore the energy homeostasis of intestinal mucosa of weaning piglets under normal energy fed. Low energy feeding may increase the susceptibility of piglets to stress, which may decrease the efficacy of Gln, Glu, and Asp on the restoration of energy balance. These findings provide new information on nutritional intervention for insufficient energy intake in weaning piglets.

Animal Nutrition published new progress about Antioxidants. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics