Category: 112-63-0

Wang, Lan; Xian, Yan-Fang; Hu, Zhen; Loo, Steven King Fan; Ip, Siu Po; Chan, Wood Yee; Lin, Zhi-Xiu; Wu, Justin Che Yuen published the artcile< Efficacy and action mechanisms of a Chinese herbal formula on experimental models of atopic dermatitis>, Synthetic Route of 112-63-0, the main research area is Chinese herbal formula exptl model atopic dermatitis; Atopic dermatitis; Chinese herbal formula; Epidermal barrier; NF-κB pathway; Skin inflammation; Th1/Th2 balance.

Atopic dermatitis (AD) is a skin inflammatory disease characterized by erythema, eruption, lichenification and pruritus. Shi Zhen Formula (SZF), an empirical Chinese herbal preparation, has clin. efficacy in relieving the symptoms of AD patients. However, the underlying mol. mechanisms of SZF remained unclear. We aimed to investigate the anti-AD effects of SZF and elucidate its underlying mol. mechanisms using in vitro and in vivo models of AD. High-performance liquid chromatog. anal. was performed for quality control of SZF extract The anti-inflammatory effect of SZF was investigated through evaluating the levels of nitric oxide (NO), chemokines and pro-inflammatory cytokines in the lipopolysaccharide (LPS) stimulated RAW264.7 cells. AD-like skin lesions in female BALB/c mice were induced by 2,4-dinitrochlorobenzene (DNCB). SZF (3.15, 6.30 and 9.45 g/kg) and dexamethasone (5 mg/kg) were administered by gavage daily for 15 consecutive days. The body weight, skin thickness, skin dermatitis severity and scratching behaviors were recorded throughout the study. Histol. anal., reverse transcription-quant. polymerase chain reaction (RT-PCR), western blot (WB) and ELISA anal. were used to illuminate the mol. targets associated with the anti-AD effects of SZF. SZF markedly decreased the epidermal thickening and infiltration of mast cells in the ears and dorsal skin of the 2,4-dinitrochlorobenzene (DNCB)-treated mice. SZF not only suppressed the levels of IgE (IgE), histamine, thymic stromal lymphopoietin (TSLP) and IL-4 in the serum but also suppressed the over-production of IL-4 and IL-6 and gene expressions of IL-4, IL-13, IL-31 and TSLP in the dorsal skin. Moreover, SZF improved epidermal barrier by increasing the protein expressions of filaggrin, involucrin and loricrin and inhibited the activation of NF-κB p65 pathway in the dorsal skin of the DNCB-treated mice. SZF alleviates DNCB induced AD-like skin lesions in mice through regulating Th1/Th2 balance, improving epidermal barrier and inhibiting skin inflammation. Our research findings provide scientific footing on the use of this Chinese herbal formula for the treatment of AD.

Journal of Ethnopharmacology published new progress about Atopic dermatitis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Hua; Liu, Liangliang; Liu, Xiao; Jia, Yu; Zhang, Peng; Zhang, Yong published the artcile< Greatly promoted oxygen reduction reaction activity of solid catalysts by regulating the stability of superoxide in metal-O2 batteries>, Application of C19H34O2, the main research area is superoxide solid catalyst stability oxygen battery reduction reaction activity.

Oxygen reduction reactions (ORRs) with one- or two-electron-transfer pathways are the essential process for aprotic metal-oxygen batteries, in which the stability of superoxide intermediates/products (O2-, LiO2, NaO2, etc.) mainly dominates the ORR activity/stability and battery performance. However, little success in regulating the stability of the superoxides has been achieved due to their highly reactive characteristics. Herein, we identified and modulated the stability of superoxides by introducing anthraquinone derivatives as cocatalysts which functioned as superoxide trapper adsorbing the superoxides generated via surface-mediated ORR and then transferring them from the solid catalyst surface into electrolyte. Among the studied trappers, 1,4-difluoroanthraquinone (DFAQ) with electron-withdrawing groups showed the highest adsorption towards superoxides and could efficiently stabilize LiO2 in electrolyte, which greatly promoted the surface-mediated ORR rate and stability. This highlighted the magnitude of adsorption between the trapper and LiO2 on the ORR activity/stability. Using an aprotic Li-O2 battery as a model metal-O2 battery, the overall performance of the cell with DFAQ was substantially improved in terms of cell capacity, rate capability and cyclic stability. These results represent a significant advance in the understanding of ORR mechanisms and promoting the performance of metal-O2 batteries.

Science China Materials published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Duan, Ju; Wang, Wenting; Zou, Degui; Liu, Jing; Li, Na; Weng, Junying; Xu, Li-ping; Guan, Ying; Zhang, Yongjun; Zhou, Pengfei published the artcile< Construction of a Few-Layered COF@CNT Composite as an Ultrahigh Rate Cathode for Low-Cost K-Ion Batteries>, Category: esters-buliding-blocks, the main research area is covalent organic framework carbon nanotube potassium ion battery cathode; cathode materials; covalent organic frameworks; few-layered; potassium-ion batteries; ultrahigh rate performance.

Potassium-ion batteries (PIBs) are attracting great interest for large-scale energy storage owing to the abundant resources and low redox potential of K+/K. However, the large volume changes and slow kinetics caused by the larger ionic radius of K+ for cathode materials remain a critical challenge for PIBs. Herein, we construct few-layered covalent organic frameworks integrated with carboxylated carbon nanotubes (DAAQ-COF@CNT) as cathode materials for PIBs. The synthesized DAAQ-COF@CNT features numerous active sites, a stable conductive framework, and an appropriate surface area with nanopores, which can render high elec. conductivity, shorten the ion/electron diffusion distance, and accelerate K+ diffusion. In consequence, the DAAQ-COF@CNT delivers a high reversible capacity of 157.7 mAh g-1 at 0.1 A g-1, an excellent rate capability of 111.2 mAh g-1 at 1 A g-1, and a long cycling stability of 77.6% capacity retention after 500 cycles at 0.5 A g-1. The integrated characterization of ex situ XPS, Fourier transform IR spectroscopy, and theor. simulation discloses that the storage mechanism of DAAQ-COF@CNT is based on the reversible reaction between electroactive C=O groups and K+ during two successive steps. This work provides a promising high-performance cathode material for PIBs and encourages the development of new types of covalent organic frameworks for PIBs.

ACS Applied Materials & Interfaces published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Childers, Wayne E. Jr.; Havran, Lisa M.; Asselin, Magda; Bicksler, James J.; Chong, Dan C.; Grosu, George T.; Shen, Zhongqi; Abou-Gharbia, Magid A.; Bach, Alvin C. III; Harrison, Boyd L.; Kagan, Natasha; Kleintop, Teresa; Magolda, Ronald; Marathias, Vasilios; Robichaud, Albert J.; Sabb, Annmarie L.; Zhang, Mei-Yi; Andree, Terrance H.; Aschmies, Susan H.; Beyer, Chad; Comery, Thomas A.; Day, Mark; Grauer, Steven M.; Hughes, Zoe A.; Rosenzweig-Lipson, Sharon; Platt, Brian; Pulicicchio, Claudine; Smith, Deborah E.; Sukoff-Rizzo, Stacy J.; Sullivan, Kelly M.; Adedoyin, Adedayo; Huselton, Christine; Hirst, Warren D. published the artcile< The Synthesis and Biological Evaluation of Quinolyl-piperazinyl Piperidines as Potent Serotonin 5-HT1A Antagonists>, Application In Synthesis of 112-63-0, the main research area is quinolinyl piperazinyl piperidine derivative preparation serotonin 5HT1A antagonist.

As part of an effort to identify 5-HT1A antagonists that did not possess typical arylalkylamine or keto/amido-alkyl aryl piperazine scaffolds, prototype compound I was identified from earlier work in a combined 5-HT1A antagonist/SSRI program. This quinolyl-piperazinyl piperidine analog displayed potent, selective 5-HT1A antagonism but suffered from poor oxidative metabolic stability, resulting in low exposure following oral administration. SAR studies, driven primarily by in vitro liver microsomal stability assessment, identified compound II, which displayed improved oral bioavailability and lower intrinsic clearance. Further changes to the scaffold resulted in a loss in potency. Compound II displayed cognitive enhancing effects in a number of animal models of learning and memory, enhanced the antidepressant-like effects of the SSRI fluoxetine, and reversed the sexual dysfunction induced by chronic fluoxetine treatment.

Journal of Medicinal Chemistry published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garzio, Kayla; McElroy, Kelly; Grossman, Stuart; Holdhoff, Matthias; Ozer, Byram; Yankulina, Olga published the artcile< Safety of temozolomide use in adult patients with renal dysfunction>, Electric Literature of 112-63-0, the main research area is Glioblastoma; High grade glioma; Primary central nervous system lymphoma; Renal impairment; Temozolomide.

Abstract: Purpose: Temozolomide (TMZ), a cytotoxic DNA alkylating agent, is the main chemotherapy used for the treatment of high grade astrocytomas. The active alkylator, methylhydrazine, is not recovered in urine and thus renal function is not expected to affect clearance. Prescribing information for TMZ states pharmacokinetics have not been studied in adults with poor renal function, eGFR < 36 mL/min/1.73 m2. We reviewed our clin. experience with TMZ in patients with impaired renal function to evaluate safety of administering full dose TMZ. Methods: The primary endpoint was to characterize the incidence and severity of thrombocytopenia in patients with eGFR < 60 mL/min/1.73 m2 who received TMZ for treatment of high grade gliomas (HGG) or primary CNS lymphoma (PCNSL). Secondary endpoints included incidence and severity of neutropenia, lymphopenia hepatotoxicity, and number of TMZ cycles administered. Medical records of patients with HGG or PCNSL treated with TMZ from Oct. 1, 2016-Sept. 30, 2019 were accessed to identify cases for this study. Results: Thirty-two patients were eligible for this study. Of the seven patients with eGFR < 36 mL/min/1.73m2, 38/39 cycles (97%) were completed without grade 3-4 thrombocytopenia. No patients experienced grade 3-4 neutropenia, and grade 3-4 lymphopenia occurred in 5 cycles (15%). One patient discontinued TMZ 7 days prior to completion of radiation due to thrombocytopenia. Conclusion: Hematol. toxicity in patients with severe renal dysfunction, eGFR < 36 mL/min/1.73m2, is similar to that of patients with normal renal function. Severe renal impairment does not preclude use of temozolomide, but cautious monitoring of blood counts is warranted. Journal of Neuro-Oncology published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Aiqin; Li, Jing; Fan, Haojun; Xiang, Jun; Wang, Li; Yan, Jun published the artcile< Effect of mechanical properties on the self-healing behavior of waterborne polyurethane coatings>, Quality Control of 112-63-0, the main research area is waterborne polyurethane coating mech property effect self healing behavior.

The effect of structural parameters such as hard segment content and crosslinking degree on the mech. properties of waterborne self-healing polyurethane and the effect of tensile strength, self-healing conditions (temperature, time) on the self-healing properties were investigated. These results demonstrated that as the increasing of the content of hard segments/the crosslinking agent, the tensile strength of the sample increased and the self-healing performance exhibited a downward trend. When the tensile strength reached 40 MPa, it could hardly healed, even if prolonging the self-healing time or increasing the self-healing temperature Mechanism study demonstrated that the self-healing ability was attributed to the dynamic exchange of disulfide bonds and the thermal reversibility of hydrogen bonds in the system. Hydrogen bonding could provide the initial self-healing force and promote the dynamic exchange reaction of disulfide bonds, while high hydrogen bonding is not conducive to the movement of macromol. segments, causing a decrease in the self-healing efficiency.

Journal of Applied Polymer Science published new progress about Crack (fracture). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alker, D.; Swanson, A. G. published the artcile< Formation, synthetic utility and structure elucidation of a 2-(bromomethyl)-1,4-dihydropyridine>, Application In Synthesis of 112-63-0, the main research area is bromomethyldihydropyridine derivative preparation nucleophile substitution; pyridine bromomethyldihydro preparation nucleophile substitution.

The structure of the product obtained by reacting the 1,4-dihydropyridine I (R = H) with pyridinium bromide perbromide has been confirmed by NMR spectroscopy as the 2-bromomethyl derivative I (R = Br) (II). The reaction of II with a range of nucleophiles is reported.

Tetrahedron Letters published new progress about Nucleophilic substitution reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wettasinghe, Mahinda; Vasanthan, Thava; Temelli, Feral; Swallow, Kevin published the artcile< Volatiles from Roasted Byproducts of the Poultry-Processing Industry>, Category: esters-buliding-blocks, the main research area is chicken byproduct volatile composition.

Volatiles of roasted chicken breast muscle and byproducts, such as backbones, breastbones, spent bones, and skin, were investigated. Total volatile concentrations ranged from 2030 ppb in the roasted backbones to 4049 ppb in the roasted skin. The major classes of volatile compounds detected in roasted samples were aldehydes (648-1532 ppb) and alcs. (336-1006 ppb). Nitrogen- and/or sulfur-containing compounds were also detected in appreciable quantities (161-706 ppb) in all samples. For all samples, hexanal and 2-methyl-2-buten-1-ol were dominant among the aldehydes and alcs., resp. Among the nitrogen- and sulfur-containing compounds, Maillard reaction products, such as tetrahydropyridazines, piperidines, and thiazoles, were the major contributors to the total volatile content in all samples. The composition of volatiles observed in roasted byproducts was markedly different from that of the roasted breast muscle. Therefore, the blending of the byproducts in appropriate proportions or blending of volatile flavor extracts from different byproducts may be necessary to obtain an aroma that mimics roasted chicken aroma.

Journal of Agricultural and Food Chemistry published new progress about Alcohols Role: BAC (Biological Activity or Effector, Except Adverse), BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Yang; Zhang, Zetian; Fan, Weiwei; Yang, Kaifeng; Li, Zhengjun published the artcile< Preparation of renewable gallic acid-based self-healing waterborne polyurethane with dynamic phenol-carbamate network: toward superior mechanical properties and shape memory function>, Computed Properties of 112-63-0, the main research area is isophorone diisocyanate gallic acid trimethylolpropane polyurethane mech property morphol.

Endowing thermoset self-healing polymers with excellent mech. properties and shape memory function by utilizing bio-based monomers is highly desirable for the development of the next-generation smart materials. To achieve this goal, herein, we developed a novel thermally induced self-healing system with robust mech. properties and shape memory function by incorporating dynamic phenol-carbamate bond formed by the polymerization reaction of the renewable gallic acid (GA) and isocyanate into waterborne polyurethane (GA-WPU) with excellent emulsion stability. Significantly, a good balance can be achieved between desirable self-healing ability (healing efficiency 81.1%) and robust mech. properties (tensile strength 45.1 MPa and elongation at break 576.5%) by adjusting dynamic phenol-carbamate bonds incorporated into the polymer networks, and compared with the reported self-healing polymers, the recovered tensile strength of our target polymer shows an overwhelming superiority. Furthermore, taking the advantage of the crystalline PBA (switching segment) and phenol-carbamate crosslinkages, the prepared GA-WPU polymer can rapidly recover from temporary shape to original shape by thermal energy (less than 30 s, and the shape fixity and recovery ratio remain above 91.5%). We envision that this elaborate strategy is instructive for designing mech. robust polymeric materials with self-healing, shape memory function and environmentally friendly characteristics.

Journal of Materials Science published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Brown, Richard T.; Dauda, Bukar E. N.; Kandasamy, Mythily; Santos, Cid A. M. published the artcile< Lonitoside: a novel monoterpenoid macrolide diglycoside from Lonicea nitida>, Electric Literature of 112-63-0, the main research area is lonitoside Lonicea mol structure.

Lonitoside has been isolated from L. nitida E. H. Wilson (Caprifoliaceae), and its structure elucidated as (E)-(6S)-8-[β-L-arabinopyranosyl-(1”→6′)-β-D-glucopyranosyloxy]-2,6-dimethyloct-2-eno-1,4”-lactone (I) by spectroscopic and degradation methods.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Lonicera nitida. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics