Category: 112-63-0

Cao, Zhong-Yan; Zhao, Yu-Lei; Zhou, Jian published the artcile< Sequential Au(I)/chiral tertiary amine catalysis: a tandem C-H functionalization of anisoles or a thiophene/asymmetric Michael addition sequence to quaternary oxindoles>, Product Details of C19H34O2, the main research area is diazooxindole anisole diazooxindole gold chiral amine tandem Michael addition; quaternary oxindole enantioselective diastereoselective preparation.

An unprecedented sequential Au(I)/bifunctional tertiary amine catalysis was reported, which enabled a tandem C-H functionalization of weak nucleophiles (anisoles or thiophenes) and asym. Michael addition for the highly enantioselective synthesis of quaternary oxindoles from diazooxindoles and nitroenynes.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenynes Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mala, Zaneta A.; Janicki, Mikolaj J.; Niedzwiecka, Natalia H.; Gora, Robert W.; Konieczny, Krzysztof A.; Kowalczyk, Rafal published the artcile< Stereoselectivity Enhancement During the Generation of Three Contiguous Stereocenters in Tetrahydrothiophenes>, Application of C19H34O2, the main research area is enantioselective diastereoselective sulfa Michael intramol aldol cascade mercaptoacetaldehyde enynone; thiophene tetrahydro enantioselective diastereoselective synthesis.

Application of carefully designed Cinchona alkaloid based squaramides resulted in the formation of three contiguous stereocenters in enantio- and diastereoselective Sulfa-Michael/intramol. aldol reactions cascade [e.g., I + II → III (62%, 96% ee, 20:1 d.r.)]. Increase of the temperature to 333 K in reaction of mercaptoacetic aldehyde and various en-ynones allowed the rise of the reaction rate while not affecting the enantioselectivity nor diastereoselectivity. Stereoselectivity was dependent on the structure of the hydrogen-bonding unit, thus revealing the importance of weak interactions in the formation of the multifunctional tetrahydrothiophenes. Kohn-Sham D. Functional Theory results suggest that a perfect fit of the electrophile and squaramide via tailored (+)N-H hydrogen bonding and π-π stacking interactions were the main factors of the chirality transfer.

ChemCatChem published new progress about Aldol addition, stereoselective (intramol.). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Xiao; Zhao, Na; Li, Zhibo published the artcile< Stereoselective Ring-Opening Polymerization of rac-Lactide Catalyzed by Squaramide Derived Organocatalysts at Room Temperature>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is lactide stereoselective squaramide organocatalyst ring opening polymerization.

Substantial progresses have been made toward the development of metal-free catalysts for stereoselective ring-opening polymerization (ROP) of rac-lactide. Yet the discovery of organic catalysts effective at ambient temperature remains a major challenge. Here, the bifunctional H-bonding catalyst SQ-1 containing a basic tertiary amine and squaramide motif proved to be good candidate for the stereoselective ROP of rac-lactide at room temperature, yielding stereoregular polylactide with controlled mol. weights (up to 21.1 kg/mol) and high tacticity (PiESC up to 0.88). Furthermore, binary H-bonding catalytic system consisting of squaramides (SQ-2 to SQ-6) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) could efficiently promote the ROP of rac-lactide at room temperature within short reaction time. Among them, the most bulky squaramide SQ-2 exhibited the best stereoselectivity towards the ROP of rac-lactide without transesterification side reactions during the polymerization process. The resulting polylactides were proved to have controlled mol. weights as high as 22.2 kg/mol and narrow distributions (1.10-1.24).

Chinese Journal of Chemistry published new progress about Glass transition temperature. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meglaa, Botros; Tawfik, Magda; Morsy, Fatma; Elsherbiny, Samya; Essawy, Hisham published the artcile< Hyperbranched additive into a high solid acrylate coating for automotive application: impact on performance and emission of volatile organic content>, Electric Literature of 112-63-0, the main research area is hyperbranched additive acrylate automotive coating impact performance; emission volatile organic content.

Automotive coating materials are very important items for this industry. However, their performance is limited by the use of excessive amounts of solvents in their formulations, whereas the emission of volatile organic solvents is against the widely ascending principle of green chem. Thus, this study aims to overcome this global problem to save the environment without affecting the properties and performance of the coating. Design/methodol./approach: High solid content paint formulation for automotive applications has been designed with low amount of volatile organic solvents with the aid of a functionalized hyperbranched modifier. Findings: It was found that the presence of a hyperbranched additive allows a high solid content to be designed and facilitate the processing, which indicates its liability to compensate the role played by excessive solvents amounts In addition, the mech. properties and phys. characteristics of the modified coatings showed outstanding performance and preservation of clarity in comparison with the com. counterparts. Practical implications: A high solid content coating with facile processing and improved performance leads to cheaper price beside the pos. impact on the environment considering the limited emission of volatile organic contents. Social implications: Limitation of the used volatile organic compounds in any industry helps to save the health of humans and keep the environment unaffected. Originality/value: The use of functionalized hyperbranched additive to automotive coatings is a very promising additive for automotive coatings with optimized characteristics.

Pigment & Resin Technology published new progress about Acrylic polymers, epoxy-polyester-polyurethane- Role: POF (Polymer in Formulation), PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), USES (Uses), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chandrachud, Preeti P.; Wojtas, Lukasz; Lopchuk, Justin M. published the artcile< Decarboxylative Amination: Diazirines as Single and Double Electrophilic Nitrogen Transfer Reagents>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is decarboxylative amination redox active ester diazirine reagent.

The ubiquity of nitrogen-containing small mols. in medicine necessitates the continued search for improved methods for C-N bond formation. Electrophilic amination often requires a disparate toolkit of reagents whose selection depends on the specific structure and functionality of the substrate to be aminated. Further, many of these reagents are challenging to handle, engage in undesired side reactions, and function only within a narrow scope. Here, we report the use of diazirines as practical reagents for the decarboxylative amination of simple and complex redox-active esters. The diaziridines thus produced are readily diversifiable to amines, hydrazines, and nitrogen-containing heterocycles in one step. The reaction has also been applied in fluorous phase synthesis with a perfluorinated diazirine.

Journal of the American Chemical Society published new progress about Amination (decarboxylative). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reddy, N. J.; Sharma, T. C. published the artcile< Synthesis and reduction of 3-bromoflavanones>, Computed Properties of 112-63-0, the main research area is flavanone bromination; reduction bromoflavanone thiourea; debromination bromoflavanone thiourea.

Bromination of flavanones (I; R1, R2, R3 = H, H, H; H, H, Me; OMe, H, Me; OMe, OMe, Me) with pyridinium tribromide in AcOH give the corresponding 3-bromoflavanones II, which, when refluxed with thiourea in ethanol, undergo reduction to regenerate I.

Bulletin of the Chemical Society of Japan published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Boeseken, J.; Slooff, G.; Hoeffelman, J. M.; Hirsch, H. E. published the artcile< Action of 2-hydroxycyclopentanecarboxylic acids on the electrical conductivity of boric acid. Mobility of the cyclopentane ring>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

Aliphatic α-OH acids exert a very pronounced action on the elec. conductivity of H3BO3, while β-OH acids are indifferent. Although aromatic o-hydroxy carboxylic acids are β-OH acids, they exert a pos. action on the conducting power of H3BO3 comparable with that of aliphatic α-OH acids. Evidently the position of the OH and CO2H groups is very favorable to “”aromatic tension””-the tension due to the fact that all the groups united directly with the benzene ring are forced to lie in the plane of the ring. It was to be expected that the cis-2-hydroxycyclopentanecarboxylic acids, being β-OH acids, could exert a pos. action on the conductivity of H3BO3, not only because the complex activities of the open chain β-OH acids have disappeared, but also because the position of the OH and CO2H groups in the cis-isomers is favorable to the formation of a hexatomic ring. Results obtained by the authors in the investigation of certain acids have confirmed this hypothesis. Two 2-borneol-3-carboxylic acids are known, I (m. 102°) and II (m. 175°). I increases the conductivity of H3BO3 and is therefore the cis-isomer; this is also in accord with the values of the electrolytic dissociation constant The fact that II is difficultly attacked by KMnO4 is proof of its trans-configuration, for in the trans-isomer the OH and CO2H groups are not situated in such a way as to favor the formation of a complex with KMnO4. II does not react with Me2CO or chloral; I reacts with Me2CO to give a solid, m. 124°, and with chloral to give a chloralide, m. 191°. 2-Hydroxycyclohexanecarboxylic acid (III), only 1 form (m. 111°) of which the authors were able to obtain, decreased the conductivity of H3BO3. The cyclohexane ring being much more mobile than the pentatomic ring, the OH and CO2H groups will occupy a much less fixed position in this acid than in the hydroxycyclopentanoic acids. In that case the situation in the cis-isomer may be almost as unfavorable as in the trans-isomer. Although a chloralide (m. 142°) of III was obtained, this is no more a proof that the acid has the cis-configuration than the neg. conduction with reference to H3BO2 is a proof of the trans-configuration. From the mother liquors of some preparations of III was obtained a small quantity of a sirup. After distillation it crystallized slowly to a solid which m. 57-63° and increased the conductivity of H3BO3. At best it may be said that III is probably the trans-acid. Cyclization of Et adipate by Na, reduction of the product with H2 and Ni, treatment with KOH in MeOH and addition of acid gave a viscous oil which would not crystallize. This mixture of cis- and trans-2-hydroxycyclopentanecarboxylic acids was separated by means of Me2CO, since only the cis-isomer forms a volatile cyclic acetal with Me2CO. During acetonization in the presence of P2O5 the trans-acid was transformed into its cis-isomer. The Me2CO compounds when hydrolyzed gave acids which increased the conductivity of H3BO3, indicating their cis-configuration. To Et 3-methyladipate in PhMe was added a few drops of absolute EtOH and some Na wire. After the vigorous reaction had ceased, the solid mass of Na salts was heated for a time at 150°, then suspended in Et2O and acidified. The product b40 130-5° and on reduction with H2 and Ni at 150-60° under pressure gave a mixture of the esters of 4- and 5-methyl-2-hydroxycyclopentanecarboxylic acids, b. 72-82° in cathode vacuum. Saponification of the esters gave a mixture of cis- and trans-acids, which was separated by acetonization in the presence of P2O5. No isomerization of trans-acid to the cis-acid occurred, owing to stabilization by the Me group of the cyclopentane ring. From the Me2CO solution was obtained on distillation the Et ester of 5-methyl-2-hydroxycyclopentanecarboxylic acid, b2 115-7°. The marked difference between the increase in conductivity of H3BO3 (0.5 M) produced by borneolcarboxylic acid and that produced by the simple cyclopentanolcarboxylic acids is attributed by the authors to a much more pronounced rigidity of the pentatomic rings of borneol.

Recueil des Travaux Chimiques des Pays-Bas et de la Belgique published new progress about Acids. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Young, Michael P.; Schug, Zachary T.; Booth, David M.; Yule, David I.; Mikoshiba, Katsuhiko; Hajnοczky, Gyorgy; Joseph, Suresh K. published the artcile< Metabolic adaptation to the chronic loss of Ca2+ signaling induced by KO of IP3 receptors or the mitochondrial Ca2+ uniporter>, HPLC of Formula: 112-63-0, the main research area is mitochondria calcium uniporter signaling IP3 receptor; IP(3) receptor; TCA cycle; bioenergetics; calcium signaling; glycolysis; mitochondrial calcium uniporter; mitochondrial metabolism.

Calcium signaling is essential for regulating many biol. processes. Endoplasmic reticulum inositol trisphosphate receptors (IP3Rs) and the mitochondrial Ca2+ uniporter (MCU) are key proteins that regulate intracellular Ca2+ concentration Mitochondrial Ca2+ accumulation activates Ca2+-sensitive dehydrogenases of the tricarboxylic acid (TCA) cycle that maintain the biosynthetic and bioenergetic needs of both normal and cancer cells. However, the interplay between calcium signaling and metabolism is not well understood. In this study, we used human cancer cell lines (HEK293 and HeLa) with stable KOs of all three IP3R isoforms (triple KO [TKO]) or MCU to examine metabolic and bioenergetic responses to the chronic loss of cytosolic and/or mitochondrial Ca2+ signaling. Our results show that TKO cells (exhibiting total loss of Ca2+ signaling) are viable, displaying a lower proliferation and oxygen consumption rate, with no significant changes in ATP levels, even when made to rely solely on the TCA cycle for energy production MCU KO cells also maintained normal ATP levels but showed increased proliferation, oxygen consumption, and metabolism of both glucose and glutamine. However, MCU KO cells were unable to maintain ATP levels and died when relying solely on the TCA cycle for energy. We conclude that constitutive Ca2+ signaling is dispensable for the bioenergetic needs of both IP3R TKO and MCU KO human cancer cells, likely because of adequate basal glycolytic and TCA cycle flux. However, in MCU KO cells, the higher energy expenditure associated with increased proliferation and oxygen consumption makes these cells more prone to bioenergetic failure under conditions of metabolic stress.

Journal of Biological Chemistry published new progress about Autophagy-related protein ATG8 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghisaidoobe, Amar T.; van den Berg, Richard J. B. H. N.; Butt, Saleem S.; Strijland, Anneke; Donker-Koopman, Wilma E.; Scheij, Saskia; van den Nieuwendijk, Adrianus M. C. H.; Koomen, Gerrit-Jan; van Loevezijn, Arnold; Leemhuis, Mark; Wennekes, Tom; van der Stelt, Mario; van der Marel, Gijsbert A.; van Boeckel, Constant A. A.; Aerts, Johannes M. F. G.; Overkleeft, Herman S. published the artcile< Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors>, Synthetic Route of 112-63-0, the main research area is biphenyl iminosugar preparation glucosylceramide synthase glucosylceramidase inhibitor.

This work details the evaluation of a number of N-alkylated deoxynojirimycin derivatives on their merits as dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. Building on the previous work, the authors synthesized a series of D-gluco and L-ido-configured iminosugars N-modified with a variety of hydrophobic functional groups. The authors found that iminosugars featuring N-pentyloxymethylaryl substituents are considerably more potent inhibitors of glucosylceramide synthase than their aliphatic counterparts. In a next optimization round, the authors explored a series of biphenyl-substituted iminosugars of both configurations (D-gluco and L-ido) with the aim to introduce structural features known to confer metabolic stability to drug-like mols. From these series, two sets of mols. emerge as lead series for further profiling. Biphenyl-substituted L-ido-configured deoxynojirimycin derivatives are selective for glucosylceramidase and the nonlysosomal glucosylceramidase, and the authors consider these as leads for the treatment of neuropathol. lysosomal storage disorders. Their D-gluco-counterparts are also potent inhibitors of intestinal glycosidases, and because of this characteristic, the authors regard these as the prime candidates for type 2 diabetes therapeutics.

Journal of Medicinal Chemistry published new progress about Antidiabetic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sakamoto, Toshihiro; Moriya, Minoru; Haga, Yuji; Takahashi, Toshiyuki; Shibata, Takunobu; Okamoto, Osamu; Nonoshita, Katsumasa; Kitazawa, Hidefumi; Hidaka, Masayasu; Gomori, Akira; Iwaasa, Hisashi; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro; Gao, Ying-Duo; MacNeil, Douglas J.; Yang, Lihu published the artcile< Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is spiro indoline piperidine preparation Y5 receptor antagonist.

A series of spiroindoline-3,4′-piperidine derivatives were synthesized and evaluated for their binding affinities and antagonistic activities at Y5 receptors. Potent Y5 antagonists were tested for their oral bioavailabilities and brain penetration in rats. Some of the antagonists showed good oral bioavailability and/or good brain penetration. In particular, I was orally bioavailable and brain penetrant, and oral administration of I inhibited bPP-induced food intake in rats with a min. ED of 10 mg/kg.

Bioorganic & Medicinal Chemistry Letters published new progress about Neuropeptide Y receptors, Y5 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics